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| 1 | Brain-derived neurotrophic factor and inflammation in depression:Pathogenic partners in crime?显示文摘Major depressive disorder is a debilitating disorder affecting millions of people each year.Brain-derived neurotrophic factor(BDNF)and inflammation are two prominent biologic risk factors in the pathogenesis of depression that have received considerable attention.Many clinical and animal studies have highlighted associations between low levels of BDNF or high levels of inflammatory markers and the development of behavioral symptoms of depression.However,less is known about potential interaction between BDNF and inflammation,particularly within the central nervous system.Emerging evidence suggests that there is bidirectional regulation between these factors with important implications for the development of depressive symptoms and antidepressant response.Elevated levels of inflammatory mediators have been shown to reduce expression of BDNF,and BDNF may play an important negative regulatory role on inflammation within the brain.Understanding this interaction more fully within the context of neuropsychiatric disease is important for both developing a fuller understanding of biological pathogenesis of depression and for identifying novel therapeutic opportunities.Here we review these two prominent risk factors for depression with a particular focus on pathogenic implications of their interaction. | Grace A Porter Jason C O’Connor | 2022 | World Journal of Psychiatry2022，12，1： | 4 |
| 2 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 3 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason B Drake Ralph O Dubayah David B Clark Robert G Knox J.Bryan Blair Michelle A Hofton Robin L Chazdon John F Weishampel Steve Prince | 2001 | Remote Sensing of Environment2001，，2： | 1 |
| 4 | When Outgroups Fail; Phylogenomics of Rooting the Emerging Pathogen, Coxiella burnetii显示文摘 | Talima Pearson Heidie M. Hornstra Jason W. Sahl Sarah Schaack James M. Schupp Stephen M. Beckstrom-Sternberg Matthew W. O’Neill Rachael A. Priestley Mia D. Champion James S. Beckstrom-Sternberg Gilbert J. Kersh James E. Samuel Robert F. Massung Paul Keim | 2013 | Systematic Biology2013，，5： | 1 |
| 5 | Essential role for Dicer during skeletal muscle development显示文摘 | Jason R. O’Rourke Sara A. Georges Howard R. Seay Stephen J. Tapscott Michael T. McManus David J. Goldhamer Maurice S. Swanson Brian D. Harfe | 2007 | Developmental Biology2007，，2： | 1 |
| 6 | Fatigue does not correlate with the degree of hepatitis or the presence of autoimmune disorders in chronic hepatitis C infection显示文摘 | Jason Goh Barbara Coughlan John Quinn J. Conor O?Keane John Crowe | 1999 | European Journal of Gastroenterology & Hepatology1999，，8： | 1 |
| 7 | Relation of Increased Prebeta-1 High-Density Lipoprotein Levels to Risk of Coronary Heart Disease显示文摘 | Lin T. Guey Clive R. Pullinger Brian Y. Ishida Patricia M. O’Connor Christian Zellner Omar L. Francone Jason M. Laramie Josefina M. Naya-Vigne Ketevan A. Siradze Prakash Deedwania Rita F. Redberg Philip H. Frost Albert B. Seymour John P. Kane Mary J. Mall | 2011 | The American Journal of Cardiology2011，，3： | 1 |
| 8 | Characterization of an allelic series in the MONOPTEROS gene of Arabidop- sis显示文摘 | OSAMA O JASON G MEGAN G S | 2013 | Genesis2013，52，2： | 1 |
| 9 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason Drake B Dubayah Ralph O Clark David B | 2002 | Remote Sensing of Environment2002，79，： | 1 |
| 10 | Lidar Remote Sensing for Forestry Applications显示文摘 | Ralph O D Jason B D | | 0，，： | 1 |
| 11 | Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4^sup +^ T cell loss is associated with double-negative T cells显示文摘 | Milush Jeffrey M Mir Kiran D Sundaravaradan Vasudha Gordon Shari N Engram Jessica Cano Christopher A Reeves Jacqueline F Anton Elizabeth O’Neill Eduardo Butler Eboneé Hancock Kathy Cole Kelly S Brenchley Jason M Else James G Silvestri Guido | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 12 | Impact of gold mining on the environment and human health:a case study in the Migori gold belt,Kenya显示文摘 | Jason S O Winnie V M Monica A O | 2002 | Environmental Geochemistry and Health2002，24，： | 1 |
| 13 | Seasonal incidence of hospital admissions for Stanford type A aortic dissection显示文摘 | Jimmy T. Efird Wesley T. O’Neal Stephen W. Davies Jason B. O’Neal Alan P. Kypson | 2014 | Chronobiology International2014，，9： | 1 |
| 14 | Fungal community analysis by large-scale sequencing of environmental samples显示文摘 | Heath E O Jeri L P Jason A J | 2005 | Appl Environ Microbiol2005，71，： | 1 |
| 15 | Network Dy- namics and Field Evolution : The Growth of Interorganizational Col- laboration in the Life Sciences 显示文摘 | Powell W W White D R Koput K W Jason O S | 2005 | American Journal of Sociology2005，110，4： | 1 |
| 16 | Autonomous evolution of topographic regularities in artificial neural net works 显示文摘 | Jason Gauci Kenneth O Stanley | 2010 | Neural Computation2010，，22： | 1 |
| 17 | The molecular basis for apoptotic defects in patients with CD95 (Fas/APO-1) mutations显示文摘 | AKSHAY K V JASON R O JIA L C | 1999 | J Clin Invest1999，103，： | 1 |
| 18 | Energy-efficient information rou-ting in sensor networks for robotic target tracking显示文摘 | O'Kane Jason M Xu Wenyuan | | 0，，06： | 1 |
| 19 | Center variation and outcomes associated with delayed sternal closure after stage 1 palliation for hypoplastic left heart syndrome显示文摘 | Jason N. Johnson James Jaggers Shuang Li Sean M. O’Brien Jennifer S. Li Jeffrey P. Jacobs Marshall L. Jacobs Karl F. Welke Eric D. Peterson Sara K. Pasquali | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，5： | 1 |
| 20 | Relation of Increased Prebeta-1 High-Density Lipoprotein Levels to Risk of Coronary Heart Disease显示文摘 | Lin T. Guey Clive R. Pullinger Brian Y. Ishida Patricia M. O'Connor Christian Zellner Omar L. Francone Jason M. Laramie Josefina M. Naya-Vigne Ketevan A. Siradze Prakash Deedwania Rita F. Redberg Philip H. Frost Albert B. Seymour John P. Kane Mary J. Mall | 2011 | The American Journal of Cardiology2011，，3： | 1 |
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