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| 1 | RANKL,a necessary chance for clinical application to osteoporosis and cancer-related bone diseases显示文摘Osteoporosis is a common bone disease characterized by reduced bone and increased risk of fracture. In postmenopausal women, osteoporosis results from bone loss attributable to estrogen deficiency. Osteoclast differentiation and activation is mediated by receptor activator of nuclear factor-κB ligand(RANKL), its receptor receptor activator of nuclear factor-κB(RANK), and a decoy receptor for RANKL, osteoprotegerin(OPG). The OPG/RANKL/RANK system plays a pivotal role in osteoclast biology. Currently, a fully human antiRANKL monoclonal antibody named denosumab is being clinically used for the treatment of osteoporosis and cancer-related bone disorders. This review describes recent advances in RANKL-related research, a story from bench to bedside. First, the discovery of the key factors, OPG/RANKL/RANK, revealed the molecular mechanism of osteoclastogenesis. Second, we established three animal models:(1) a novel and rapid bone loss model by administration of glutathione-S transferase-RANKL fusion protein to mice;(2) a novel mouse model of hypercalcemia with anorexia by overexpression of soluble RANKL using an adenovirus vector; and(3) a novel mouse model of osteopetrosis by administration of a denosumab-like anti-mouse RANKL neutralizing monoclonal antibody. Lastly, anti-human RANKL monoclonal antibody has been successfully applied to the treatment of osteoporosis and cancer-related bone disorders in many countries. This is a real example of applying basic science to clinical practice. | Hisataka Yasuda | 2013 | World Journal of Orthopedics2013，4，4： | 22 |
| 2 | Safety and efficacy of carbon dioxide insufflation during gastric endoscopic submucosal dissection显示文摘AIM: To compare the safety and efficacy of carbon dioxide(CO2) and air insufflation during gastric endoscopic submucosal dissection(ESD).METHODS: This study involved 116 patients who underwent gastric ESD between January and December 2009.After eliminating 29 patients who fit the exclusion criteria,87 patients,without known pulmonary dysfunction,were randomized into the CO2 insufflation(n = 36) or air insufflation(n = 51) groups.Standard ESD was performed with a CO2 regulation unit(constant rate of 1.4 L/min) used for patients undergoing CO2 insufflation.Patients received diazepam for conscious sedation and pentazocine for analgesia.Transcutaneous CO2 tension(Ptc CO2) was recorded 15 min before,during,and after ESD with insufflation.Ptc CO2,the correlation between Ptc CO2 and procedure time,and ESD-related complications were compared between the two groups.Arterial blood gases were analyzed after ESD in the first 30 patients(12 with CO2 and 18 with air insufflation) to assess the correlation between arterial blood CO2 partial pressure(Pa CO2) and Ptc CO2.RESULTS: There were no differences in respiratoryfunctions,median sedative doses,or median procedure times between the groups.Similarly,there was no significant difference in post-ESD blood gas parameters,including Pa CO2,between the CO2 and air groups(44.6 mm Hg vs 45 mm Hg).Both groups demonstrated median p H values of 7.36,and none of the patients exhibited acidemia.No significant differences were observed between the CO2 and air groups with respect to baseline Ptc CO2(39 mm Hg vs 40 mm Hg),peak Ptc CO2 during ESD(52 mm Hg vs 51 mm Hg),or median Ptc CO2 after ESD(50 mm Hg vs 50 mm Hg).There was a strong correlation between Pa CO2 and Ptc CO2(r = 0.66; P < 0.001).The incidence of Mallory-Weiss tears was significantly lower with CO2 insufflation than with air insufflation(0% vs 15.6%,P = 0.013).CO2 insufflation did not cause any adverse events,such as CO2 narcosis or gas embolisms.CONCLUSION: CO2 insufflation during gastric ESD results in similar blood gas levels as air insufflation,and also reduces the incidence of Mallory-Weiss tears. | Jun Takada Hiroshi Araki Fumito Onogi Takayuki Nakanishi Masaya Kubota Takashi Ibuka Masahito Shimizu Hisataka Moriwaki | 2015 | World Journal of Gastroenterology2015，21，26： | 6 |
| 3 | Obesity and hepatocellular carcinoma: targeting obesity-related inflammation for chemoprevention of liver carcinogenesis显示文摘 | Masahito Shimizu Takuji Tanaka Hisataka Moriwaki | 2013 | Seminars in Immunopathology2013，，2： | 5 |
| 4 | Diagnosis of the jejunoileal lymphoma by double-balloon endoscopy显示文摘AIM:To investigate the feasibility of double-balloon endoscopy(DBE) to detect jejunoileal lymphoma,compared with fluorodeoxyglucose positron emission tomography(FDG-PET).METHODS:Between March 2004 and January 2011,we histologically confirmed involvement of malignant lymphoma of the jejunoileum in 31 patients by DBE and biopsy.In 20 patients of them,we performed with FDGPET.We retrospectively reviewed the records of these 20 patients.Their median age was 64 years(range 50-81).In the 20 patients,the pathological diagnosis of underlying non-Hodgkin's lymphoma(NHL) comprised follicular lymphoma(FL,n = 12),diffuse large B cell lymphoma(DLBCL,n = 4),mantle cell lymphoma(MCL,n = 2),enteropathy associated T cell lymphoma(ETL,n = 1) and anaplastic large cell lymphoma(ALCL,n = 1).RESULTS:Ten cases showed accumulation by FDGPET(50%).FDG-PET was positive in 3 of 12 FL cases(25%) while in 7 of 8 non-FL cases(88%,P < 0.05).Intestinal FL showed a significantly lower rate of positive FDG-PET,in comparison with other types of lymphoma.Cases with endoscopically elevated lesions(n = 10) showed positive FDG-PET in 2(20%),but those with other type NHL did in 8 of 10(80%,P < 0.05).When the cases having elevated type was compared with those not having elevated type lesion,the number of cases that showed accumulation of FDG was significantly smaller in the former than in the latter.CONCLUSION:In a significant proportion,small intestinal involvement cannot be pointed out by FDG-PET.Especially,FL is difficult to evaluate by FDG-PET but essentially requires DBE. | Takashi Ibuka Hiroshi Araki Tomohiko Sugiyama Takayuki Nakanishi Fumito Onogi Masahito Shimizu Takeshi Hara Tsuyoshi Takami Hisashi Tsurumi Hisataka Moriwaki | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 4 |
| 5 | Characterization of CD133 + hepatocellular carcinoma cells as cancer stem/progenitor cells显示文摘 | Atsushi Suetsugu Masahito Nagaki Hitomi Aoki Tsutomu Motohashi Takahiro Kunisada Hisataka Moriwaki | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 4 |
| 6 | Questionnaire survey regarding the current status of superextended lymph node dissection in Japan显示文摘AIM To verify the current status of super-extended lymph node dissection for advanced gastric cancer according to a questionnaire survey.METHODS One-hundred and five institutions responded to the questionnaire.The survey included the following items: Number of experiences,whether performed prophylactically and/or therapeutically,whether preoperative chemotherapy was provided,number of preoperative chemotherapy rounds,and therapeutic options after chemotherapy.RESULTS Eighty-seven of the 105 institutions(83%) had performed D3 gastrectomy in the past or continued to perform D3 gastrectomy at present.However,D3 gastrectomy was rarely performed prophylactically in clinical practice.Seventy-eight institutions(74%) indicated that preoperative chemotherapy with curative intent was required for patients suspected of having para-aortic node(PAN) metastases.After chemotherapy,a D3 gastrectomy was scheduled for patients with a complete or partial response,stable disease,and progressive disease at 36(46%),28(36%),and 13(17%) of the institutions,respectively.CONCLUSION For patients with apparent PAN metastasis,a D3 gastrectomy is typically planned if a few courses of preoperative chemotherapy yield at least a stable disease condition. | Shinji Morita Takeo Fukagawa Hisataka Fujiwara Hitoshi Katai | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 3 |
| 7 | Gene Body CG and CHG Methylation and Suppression of Centromeric CHH Methylation are Mediated by DECREASE IN DNA METHYLATION1 in Rice显示文摘Dear Editor, DECREASE IN DNA METHYLATION1 (DDM1) is a chromatin remodeling protein required for maintenance of cytosine and histone H3K9 methylation in heterochromatin regions in the genome of Arabidopsis thaliana (Gendrel et al.,2002).A ddm 1 mutant also increases the rate of meiotic recombination in euchromatic but not heterochromatic regions of A.thaliana (Melamed-Bessudo and Levy,2012),and changes the state of cytosine methylation of agene flanked by a LINE element located in a region of euchromatin (Saze and Kakutani,2007). | Hisataka Numa Katsushi Yamaguchi Shuji Shigenobu Yoshiki Habu | 2015 | Molecular Plant2015，8，10： | 2 |
| 8 | Use of Samples From Endoscopic Ultrasound–Guided 19-Gauge Fine-Needle Aspiration in Diagnosis of Autoimmune Pancreatitis显示文摘 | Takuji Iwashita Ichiro Yasuda Shinpei Doi Nobuhiro Ando Masanori Nakashima Seiji Adachi Yoshinobu Hirose Tsuyoshi Mukai Keisuke Iwata Eiichi Tomita Takao Itoi Hisataka Moriwaki | 2012 | Clinical Gastroenterology and Hepatology2012，，3： | 2 |
| 9 | Prognostic value of energy metabolism in patients with viral liver cirrhosis显示文摘 | Masahiro Tajika Masahiko Kato Hiromi Mohri Yoshiyuki Miwa Tomohiro Kato Hiroo Ohnishi Hisataka Moriwaki | 2002 | Nutrition2002，，3： | 2 |
| 10 | EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells显示文摘 | Masahito Shimizu Atsuko Deguchi Yukihiko Hara Hisataka Moriwaki I. Bernard Weinstein | 2005 | Biochemical and Biophysical Research Communications2005，，3： | 2 |
| 11 | Chemoprevention of colorectal cancer by targeting obesity-related metabolic abnormalities显示文摘Obesity and its related metabolic disorders, including insulin resistance and chronic inflammation, increase the risk of colorectal cancer(CRC). This observation suggests that the metabolic abnormalities associated with obesity can be effective targets for preventing the development of CRC in obese individuals. In recent years, many studies using obese and diabetic animal models have been conducted to investigate the chemoprevention of CRC using pharmaceutical or nutritional interventions. Pitavastatin, a medicine used to treat hyperlipidemia, prevents the development of obesityrelated colorectal carcinogenesis by attenuating chronic inflammation. Anti-hypertensive medicines, such as captopril and telmisartan, also suppress the formation of colonic preneoplastic lesions in obese and diabetic mice. In addition, several phytochemicals, including green tea catechins, have been reported to improve metabolic disorders and prevent the development of various cancers, including CRC. Moreover, the administration of branched-chain amino acids, which improves protein malnutrition and prevents the progression of hepatic failure, is effective for suppressing obesityrelated colon carcinogenesis, which is thought to be associated with improvements in insulin resistance. In the present article, we summarize the detailed relationship between metabolic abnormalities and the development of CRC. This review also outlines recent evidence, in particular drawing from basic and clinical examinations using either pharmaceutical or nutritional intervention that suggests that targeting metabolic alterations may be an effective strategy for preventing the development of CRC in obese individuals. | Yohei Shirakami Masahito Shimizu Masaya Kubota Hiroshi Araki Takuji Tanaka Hisataka Moriwaki Mitsuru Seishima | 2014 | World Journal of Gastroenterology2014，20，27： | 2 |
| 12 | Comparison of long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation: a propensity score-based cohort analysis显示文摘 | Shinpei Doi Ichiro Yasuda Tsuyoshi Mukai Takuji Iwashita Shinya Uemura Takahiro Yamauchi Masanori Nakashima Seiji Adachi Masahito Shimizu Eiichi Tomita Takao Itoi Hisataka Moriwaki | 2013 | Journal of Gastroenterology2013，，9： | 2 |
| 13 | Clinical trial: rebamipide promotes gastric ulcer healing by proton pump inhibitor after endoscopic submucosal dissection—a randomized controlled study显示文摘 | Tomohiro Kato Hiroshi Araki Fumito Onogi Takashi Ibuka Akihiko Sugiyama Eiichi Tomita Masahito Nagaki Hisataka Moriwaki | 2010 | Journal of Gastroenterology2010，，3： | 2 |
| 14 | Metallic stents are more efficacious than plastic stents in unresectable malignant hilar biliary strictures: a randomized controlled trial显示文摘 | Tsuyoshi Mukai Ichiro Yasuda Masanori Nakashima Shinpei Doi Takuji Iwashita Keisuke Iwata Tomohiro Kato Eiichi Tomita Hisataka Moriwaki | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，2： | 2 |
| 15 | Inhibitory effect of acyclic retinoid (polyprenoic acid) on hepatic fibrosis in CCl4-treated rats显示文摘 | Masataka Okuno Akio Noma Yasutoshi Muto M.D. Hisataka Moriwaki Michimasa Kato Osamu Tagaya Yoshimi Nozaki Yoshikazu Suzuki | 1990 | Gastroenterologia Japonica1990，，2： | 1 |
| 16 | Clinical trial: rebamipide promotes gastric ulcer healing by proton pump inhibitor after endoscopic submucosal dissection—a randomized controlled study显示文摘 | Tomohiro Kato Hiroshi Araki Fumito Onogi Takashi Ibuka Akihiko Sugiyama Eiichi Tomita Masahito Nagaki Hisataka Moriwaki | 2010 | Journal of Gastroenterology2010，，3： | 1 |
| 17 | Role of V α 14 NKT cells in the development of impaired liver regeneration In Vivo显示文摘 | Hiroyasu Ito Kazuki Ando Toshinori Nakayama Masaru Taniguchi Takayuki Ezaki Kuniaki Saito Masao Takemura Kenji Sekikawa Michio Imawari Mitsuru Seishima Hisataka Moriwaki | 2003 | Hepatology2003，，5： | 1 |
| 18 | Morphologic Changes in Acute Central Serous Chorioretinopathy Evaluated by Fourier-Domain Optical Coherence Tomography显示文摘 | Hisataka Fujimoto Fumi Gomi Taku Wakabayashi Miki Sawa Motokazu Tsujikawa Yasuo Tano | 2008 | Ophthalmology2008，，： | 1 |
| 19 | Canine endothelial progenitor cell-lined hybrid vascular graft with nonthrombogenic potential显示文摘 | Hangbing M Toshihiko S Hisataka Y | 2003 | Journa of thoracic and cardiovascular surgery2003，126，2： | 1 |
| 20 | Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG):A mechanism by which OPG/OCIF Inhibits osteoclastogenesis in vitro显示文摘 | Hisataka Yasuda Nobuyuka Shima Nobuyuka Nakagawa | 1998 | Endocrinology1998，139，3： | 1 |
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