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| 1 | Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer显示文摘Angiogenesis,从先存在的新血容器的形成 vasculature,为许多生理的过程,和异常 angiogenesis 是必要的贡献一些最流行的人的疾病,包括癌症。Angiogenesis 被在 pro-angiogenic 和 anti-angiogenic 信号之间的精细的平衡控制。当发信号的 pro-angiogenic 广泛地被调查了时,怎么发展地调整了,自然地发生的 anti-angiogenic 分子阻止过多的生长脉管并且淋巴管仍然糟糕被理解。在这评论,我们总结上的当前的知识 semaphorins 和他们的受体, plexins 和 neuropilins,控制正常和病理学的 angiogenesis,与在脉管、淋巴的 endothelial 房间表明电路的调整 semaphorin 的 anti-angiogenic 上的一个重音。信息的这新兴的身体可以负担得起机会开发新奇 anti-angiogenic 治疗学的策略。 | Atsuko Sakurai Colleen Doci J Silvio Gutkind | 2012 | Cell Research2012，22，1： | 15 |
| 2 | Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD),the most important being Crohn's disease and ulcerative colitis,results from chronic dysregulation of the mucosal immune system in the gastrointestinal tract.Although the pathogenesis of IBD remains unclear,it is widely accepted that genetic,environmental,and immunological factors are involved.Recent studies suggest that intestinal epithelial defenses are important to prevent inflammation by protecting against microbial pathogens and oxidative stresses.To investigate the etiology of IBD,animal models of experimental colitis have been developed and are frequently used to evaluate new anti-inflammatory treatments for IBD.Several models of experimental colitis that demonstrate various pathophysiological aspects of the human disease have been described.In this manuscript,we review the characteristic features of IBD through a discussion of the various chemically induced experimental models of colitis(e.g.dextran sodium sulfate-,2,4,6-trinitrobenzene sulfonic acid-,oxazolone-,acetic acid-,and indomethacin-induced models).We also summarize some regulatory and pathogenic factors demonstrated by these models that can,hopefully,be exploited to develop future therapeutic strategies against IBD. | Mayumi Kawada Atsuko Arihiro Emiko Mizoguchi | 2007 | World Journal of Gastroenterology2007，13，42： | 12 |
| 3 | Risk factors for proximal migration of biliary tube stents显示文摘AIM: To analyze the risk factors for biliary stent migration in patients with benign and malignant strictures. METHODS: Endoscopic stent placement was performed in 396 patients with bile duct stenosis, at our institution, between June 2003 and March 2009. The indications for bile duct stent implantation included common bile duct stone in 190 patients, malignant lesions in 112, chronic pancreatitis in 62, autoimmune pancreatitis in 14, trauma in eight, surgical complications in six, and primary sclerosing cholangitis(PSC) in four. We retrospectively examined the frequency of stent migration, and analyzed the patient factors(disease, whether endoscopic sphincterotomy was performed, location of bile duct stenosis and diameter of the bile duct) and stent characteristics(duration of stent placement, stent type, diameter and length). Moreover, we investigated retrieval methods for migrated stents and their associated success rates. RESULTS: The frequency of tube stent migration inthe total patient population was 3.5%. The cases in which tube stent migration occurred included those with common bile duct stones(3/190; 1.6%), malignant lesions(2/112; 1.8%), chronic pancreatitis(4/62; 6.5%), autoimmune pancreatitis(2/14; 14.3%), trauma(1/8; 12.5%), surgical complications(2/6; 33.3%), and PSC(0/4; 0%). The potential risk factors for migration included bile duct stenosis secondary to benign disease such as chronic pancreatitis and autoimmune pancreatitis(P = 0.030); stenosis of the lower bile duct(P = 0.031); bile duct diameter > 10 mm(P = 0.023); duration of stent placement > 1 mo(P = 0.007); use of straight-type stents(P < 0.001); and 10-Fr sized stents(P < 0.001). Retrieval of the migrated stents was successful in all cases. The grasping technique, using a basket or snare, was effective for pig-tailed or thin and straight stents, whereas the guidewire cannulation technique was effective for thick and straight stents. CONCLUSION: Migration of tube stents within the bile duct is rare but possible, and it is important to determine the risk factors involved in stent migration. | Yoshiaki Kawaguchi Masami Ogawa Yohei Kawashima Hajime Mizukami Atsuko Maruno Hiroyuki Ito Tetsuya Mine | 2014 | World Journal of Gastroenterology2014，20，5： | 4 |
| 4 | Spatial and temporal regulation of collagenases-3, -4,and stromelysin -3 implicates distinct functions in apoptosis and tissue remodeling during frog metamorphosis显示文摘Matrix metalloproteinases (MMPs) are a family of extracellular proteases capable of degrading various proteinaceous components of the extracellular matrix (ECM).They have been implicated to play important roles in a number of developmental and pathological processes, such as tumor metastasis and inflammation. Relatively few studies have been carried out to investigate the function of MMPs during postembryonic organ-development. Using Xenopus laevis development as a model system, we demonstrate here that three MMPs, stromelysin-3 (ST3),collagenases-3 (Col3), and Col4, have distinct spatial and temporal expression profiles during metamorphosis as the tadpole transforms into a frog. In situ hybridizations reveal a tight, but distinct, association of individual MMPs with tissue remodeling in the tail and intestine during metamorphosis. In particular, ST3 expression is strongly correlated with apoptosis in both organs as demonstrated by analyses of serial sections with in situ hybridization for ST3 mRNA and TUNEL (terminal deoxyribonucleotidyl transferase-mediated dUTP-biotin nick end labeling) for apoptosis, respectively. On the other hand, Col3 and Col4 MMPs in Xenopus laevis development are present in regions where extensive connective tissue remodeling take place. These results indicate that ST3 is likely to play a role in ECM-remodeling that facilitateapoptotic tissue remodeling or resorption while Col3 and Col4 appear to participate in connective tissue degradation during development. | DAMJANOVSKI SASHKO ATSUKO ISHIZUYAOKA YUN-BO SHI (Laboratory of Molecular Embryology, Building 18T, Rm. 106, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA)(Department Of Histology and | 1999 | Cell Research1999，9，2： | 3 |
| 5 | Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma显示文摘AIM To evaluate the usefulness of frozen section diagnosis(FSD) of bile duct margins during surgery for extrahepatic cholangiocarcinoma(CCA). METHODS We retrospectively analyzed 74 consecutive patients who underwent surgery for extrahepatic CCA from 2012 to 2017, during which FSD of bile duct margins was performed. They consisted of 40 distant and 34 perihilar CCAs(45 and 55 bile duct margins, respectively). The diagnosis was classified into three categories: negative, borderline(biliary intraepithelial neoplasia-1 and 2, and indefinite for neoplasia), or positive. FSD in the epithelial layer, subepithelial layer, and total layer was compared with corresponding permanent section diagnosis(PSD) postoperatively.Then, association between FSD and local recurrence was analyzed with special reference to borderline.RESULTS Analysis of 100 duct margins revealed that concordance rate between FSD and PSD was 68.0% in the total layer, 69.0% in the epithelial layer, and 98.0% in the subepithelial layer. The extent of remaining biliary epithelium was comparable between FSD and PSD, and more than half of the margins lost > 50% of the entire epithelium, suggesting low quality of the samples. In FSD, the rate of negative margins decreased and that of borderline and positive margins increased according to the extent of the remaining epithelium. Diagnostic discordance between FSD and PSD was observed in 31 epithelial layers and two subepithelial layers. Alteration from borderline to negative was the most frequent(20 of the 31 epithelial layers). Patients with positive margin in the total and epithelial layers by FSD demonstrated a significantly worse local recurrence-free survival(RFS) compared with patients with borderline and negative margins, which revealed comparable local RFS. Patients with borderline and negative margins in the epithelial layer by PSD also revealed comparable local RFS. These results suggested that epithelial borderline might be regarded substantially as negative. When classifying the status of the epithelial layer either as negative or positive, concordance rates between FSD and PSD in the total, epithelial, and subepithelial layers were 95.0%, 93.0%, and 98.0%, respectively.CONCLUSION During intraoperative assessment of bile duct margin, borderline in the epithelial layer can be substantially regarded as negative, under which condition FSD is comparable to PSD. | Takayuki Shiraki Hajime Kuroda Atsuko Takada Yoshimasa Nakazato Keiichi Kubota Yasuo Imai | 2018 | World Journal of Gastroenterology2018，24，12： | 3 |
| 6 | Post-stroke affective or apathetic depression and lesion location: left frontal lobe and bilateral basal ganglia显示文摘 | Seiji Hama Hidehisa Yamashita Masaya Shigenobu Atsuko Watanabe Kaoru Kurisu Shigeto Yamawaki Tamotsu Kitaoka | 2007 | European Archives of Psychiatry and Clinical Neuroscience2007，，3： | 3 |
| 7 | A ruptured large extraluminal ileal gastrointestinal stromal tumor causing hemoperitoneum显示文摘We describe an 87-year-old woman with a large ileal gastrointestinal stromal tumor (GIST) causing hemoperitoneum. A CT scan demonstrated a large heterogeneous mass measuring about 13 cm × 11 cm in the pelvis and hemoperitoneum, with a non-uniform enhancement pattern. The mass was diagnosed as a GIST originating from the gastrointestinal tract. She underwent an urgent laparotomy and an ileal GIST with a rupture was found 130 cm from the anal to the Treitz’s ligament. Hemoperitoneum caused by ileal GIST rupture is a rare condition. Bleeding in the large tumor leading to rupture of the capsule might cause hemoperitoneum in the present case. | Shoji Hirasaki Kohei Fujita Minoru Matsubara Hiromitsu Kanzaki Hiromichi Yamane Masato Okuda Seiyuu Suzuki Atsuko Shirakawa Hideyuki Saeki | 2008 | World Journal of Gastroenterology2008，14，18： | 3 |
| 8 | EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells显示文摘 | Masahito Shimizu Atsuko Deguchi Yukihiko Hara Hisataka Moriwaki I. Bernard Weinstein | 2005 | Biochemical and Biophysical Research Communications2005，，3： | 2 |
| 9 | Differential effects on D 2 dopamine receptor and prolactin gene expression by haloperidol and aripiprazole in the rat pituitary显示文摘 | Atsuko Inoue Mayumi Seto Sayori Sugita Izumi Hide Tsuyoshi Hirose Nobuyuki Koga Tetsuro Kikuchi Yoshihiro Nakata | 1998 | Molecular Brain Research1998，，2： | 2 |
| 10 | Amenorrhea as a rare drug-related adverse event associated with everolimus for pancreatic neuroendocrine tumors显示文摘The patient was an asymptomatic 43-year-old woman. Abdominal ultrasonography and enhanced computed tomography showed a tumor lesion accompanied by multiple cystic changes in the liver and the pancreatic tail. Endoscopic ultrasound-fine needle aspiration was performed on the pancreatic tumor lesion and revealed pancreatic neuroendocrine tumor(PNET). As it was unresectable due to multiple liver metastases, the decision was made to initiate treatment with everolimus and transcatheter arterial chemoembolization. The patient ceased menstruating after the start of everolimus administration. When the administration was discontinued due to interstitial lung disease, menstruation resumed, but then again stopped with everolimus resumption. An association between everolimus and amenorrhea was highly suspected. Amenorrhea occurred as a rare adverse event of everolimus. As the younger women might be included in PNETs patients, we should put this adverse event into consideration. | Yoshiaki Kawaguchi Atsuko Maruno Yohei Kawashima Hiroyuki Ito Masami Ogawa Tetsuya Mine | 2014 | World Journal of Gastroenterology2014，20，42： | 2 |
| 11 | A low-operating-temperature solid oxide fuel cell in hydrocarbon-air mixtures 显示文摘 | TAKASHI H ATSUKO H TAKAO I | 2000 | Science2000，28，： | 2 |
| 12 | Occurrence of N-methyl-l-aspartate in bivalves and its distribution compared with of N-methyl-D-aspartate and D, L-aspartate 显示文摘 | Kimihiko S Atsuko T | 2001 | Compar Biochem Physiol Part B2001，130，： | 2 |
| 13 | Biochemical properties of acid-soluble collagens extracted from the skins of underutilised fishes显示文摘 | Inwoo Bae Kiyoshi Osatomi Asami Yoshida Kazufumi Osako Atsuko Yamaguchi Kenji Hara | 2007 | Food Chemistry2007，，1： | 2 |
| 14 | Long-term outcomes of combination of endoscopic submucosal dissection and laparoscopic lymph node dissection without gastrectomy for early gastric cancer patients who have a potential risk of lymph node metastasis显示文摘 | Nobutsugu Abe Hirohisa Takeuchi Atsuko Ohki Osamu Yanagida Tadahiko Masaki Toshiyuki Mori Masanori Sugiyama | 2011 | Gastrointestinal Endoscopy2011，，4： | 2 |
| 15 | High-temperature formation phases and crystal structure of hot-pressed thermoelectric compounds with chalcopyrite-type structure显示文摘In this study, we introduced the temperaturedependent formation phases and crystallographic parameters of hot-pressed silver gallium telluride AgGaTe_2 and copper gallium telluride CuGaTe_2 with chalcopyrite structure from 300 to 800 K. These two compounds are potential thermoelectric materials in the intermediate temperature range; however, the temperature-dependent formation phases and crystallographic parameters of hotpressed samples have not yet been analyzed in detail. The crystal structure analysis based on synchrotron X-ray diffraction(SXRD) measurements clarifies that impurity phases such as Te and Ag_2 Te in the AgGaTe_2 matrix and Te and CuTe in the CuGaTe_2 matrix appear at some temperature regions above 300 K. The existence of such impurity phases could be correlated with the increases of the electrical resistivity and Seebeck coefficient of the samples after multiple measurement cycles of the temperature-dependent transport properties from 300 to 800 K.The tetragonal lattice parameters a and c, tetragonal lattice volume, thermal expansion coefficients, tetragonal distortion, anion displacement parameter, and isotropic displacement parameter of the hot-pressed AgGaTe_2 and CuGaTe_2 were also analyzed. These crystallographic parameters are expected to substantially affect the thermoelectric properties of AgGaTe_2 and CuGaTe_2. Our results provide prospect of the long-term high-temperature stability and clues of the detailed analysis on the transport properties of hot-pressed AgGaTe_2 and CuGaTe_2, which should aid their development for thermoelectric applications. | Atsuko Kosuga Yosuke Fujii Akito Horie | 2018 | Rare Metals2018，37，4： | 2 |
| 16 | Role of animal models in glaucoma research显示文摘Glaucoma is a neurodegenerative disease of the eye,and it presents with visual field defects accompanied by progressive degeneration of the optic nerve and retinal ganglion cells(RGCs).It is one of the major causes of blindness worldwide and affects 1 in 20 people over the age of 40.Glaucoma is caused by multiple factors,but it is usually associated with elevated intraocular pressure(IOP).Extensive studies have been carried out to discover therapeutic targets and to develop new drugs to treat ocular hypertension using experimental models of rodents(rats and mice)and non-human primates(e.g.,cynomologus,rhesus,or marmoset monkeys). | Atsuko Kimura Takahiko Noro Takayuki Harada | 2020 | Neural Regeneration Research2020，15，7： | 2 |
| 17 | Novel zinc alloys for biodegradable surgical staples显示文摘BACKGROUND The development of biodegradable surgical staples is desirable as non-biodegradable Ti alloy staples reside in the human body long after wound healing, which can cause allergic/foreign-body reactions, adhesion, or other adverse effects. In order to develop a biodegradable alloy suitable for the fabrication of surgical staples, we hypothesized that Zn, a known biodegradable metal, could be alloyed with various elements to improve the mechanical properties while retaining biodegradability and biocompatibility. Considering their biocompatibility, Mg, Ca, Mn, and Cu were selected as candidate alloying elements, alongside Ti, the main material of clinically available surgical staples.AIM To investigate the in vitro mechanical properties and degradation behavior and in vivo safety and feasibility of biodegradable Zn alloy staples.METHODS Tensile and bending tests were conducted to evaluate the mechanical properties of binary Zn alloys with 0.1–6 wt.% Mg, Ca, Mn, Cu, or Ti. Based on the results,three promising Zn alloy compositions were devised for staple applications(wt.%): Zn-1.0Cu-0.2Mn-0.1Ti(Zn alloy 1), Zn-1.0Mn-0.1Ti(Zn alloy 2), and Zn-1.0Cu-0.1Ti(Zn alloy 3). Immersion tests were performed at 37℃ for 4 wk using fed-state simulated intestinal fluid(Fe SSIF) and Hank’s balanced salt solution(HBSS). The corrosion rate was estimated from the weight loss of staples during immersion. Nine rabbits were subjected to gastric resection using each Zn alloy staple, and a clinically available Ti staple was used for another group of nine rabbits. Three in each group were sacrificed at 1, 4, and 12 wk post-operation.RESULTS Additions of ≤1 wt.% Mn or Cu and 0.1 wt.% Ti improved the yield strength without excessive deterioration of elongation or bendability. Immersion tests revealed no gas evolution or staple fracture in any of the Zn alloy staples. The corrosion rates of Zn alloy staples 1, 2, and 3 were 0.02 mm/year in HBSS and 0.12, 0.11, and 0.13 mm/year, respectively, in Fe SSIF. These degradation times are sufficient for wound healing. The degradation rate is notably increased under low pH conditions. Scanning electron microscopy and energy dispersive spectrometry surface analyses of the staples after immersion indicated that the component elements eluted as ions in Fe SSIF, whereas corrosion products were produced in HBSS, inhibiting Zn dissolution. In the animal study, none of the Zn alloy staples caused technical failure, and all rabbits survived without complications. Histopathological analysis revealed no severe inflammatory reaction around the Zn alloy staples.CONCLUSION Staples made of Zn-1.0Cu-0.2Mn-0.1Ti, Zn-1.0Mn-0.1Ti, and Zn-1.0Cu-0.1Ti exhibit acceptable in vitro mechanical properties, proper degradation behavior,and in vivo safety and feasibility. They are promising candidates for biodegradable staples. | Hizuru Amano Koichi Miyake Akinari Hinoki Kazuki Yokota Fumie Kinoshita Atsuko Nakazawa Yujiro Tanaka Yasuhiro Seto Hiroo Uchida | 2020 | World Journal of Clinical Cases2020，8，3： | 2 |
| 18 | Facework competence in intercultural conflict: an updated face-negotiation theory显示文摘 | Stella Ting-toomey Atsuko Kurogi | 1998 | International Journal of Intercultural Relations1998，，2： | 2 |
| 19 | Antihypertensive Effects of Different Kinds of Fermented Milk in Spontaneously Hypertendive Rats 显示文摘 | Naoyuki Yamamoto Atsuko Akino Toshiaki Taka- no | 1994 | Biosci Biotech Biochem1994，58，4： | 1 |
| 20 | Zaltoprofen inhibits bradykinin-induced responses by blocking the activation of second messenger signaling cascades in rat dorsal root ganglion cells显示文摘 | TANG H B ATSUKO I KYOKO O | 2005 | Neuropharm2005，48，： | 1 |
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