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| 1 | Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats显示文摘AIM: To investigate the total cytochrome P450 (CYP) content, microsomal mixed-function oxidase (MFO) activity, and expression of mRNAs for various CYP isozymes in a simple rat model of reversible obstructive jaundice. METHODS: Obstructive jaundice was created in male rats by causing bile duct obstruction with polyester tape. In another group of rats, bile duct obstruction was followed by internal biliary drainage after releasing the tape. The expression of various CYP isozyme mRNAs was semi-quantitatively assessed by competitive RT- PCR. RESULTS: The total CYP content and microsomal MFO activity showed a significant decrease after biliary obstruction, but returned to respective control levels after biliary drainage. A marked reduction in the expression of CYP1A2, 2B1/2, 2C11, 2E1, 3A1, and 3A2 mRNA was detected during biliary obstruction, while expression increased significantly toward the control level after biliary drainage. Although expression of CYP4A1 mRNA showed no reduction during biliary obstruction, it still increased significantly after biliary drainage. CONCLUSION: These results suggest that not only obstructive jaundice, but also the subsequent internal biliary drainage may affect regulatory medications of the synthesis of individual CYP isozymes differently. | Shintaro Fukushima Hiroyasu Okuno Nobuyuki Shibatani Yoshitsugu Nakahashi Toshihito Seki Kazuichi Okazaki | 2008 | World Journal of Gastroenterology2008，14，16： | 7 |
| 2 | Clinical relevance of fluorodeoxyglucose positron emission tomography/computed tomography and magnifying endoscopy with narrow band imaging in decision-making regarding the treatment strategy for esophageal squamous cell carcinoma显示文摘BACKGROUND Recent advances in endoscopic technology,especially magnifying endoscopy with narrow band imaging(ME-NBI)enable us to detect superficial esophageal squamous cell carcinoma(ESCC),but determining the appropriate method of resection,endoscopic resection(ER)vs surgical resection,is often challenging.Recently,several studies have reported that 18F-fluorodeoxyglucose positron emission tomography(FDG-PET)is a useful indicator for decision-making regarding treatment for superficial ESCC.Although,there are not enough reports on association between FDG-PET uptake and clinicopathological characteristics of superficial ESCC.And,there are not enough reports on evaluating the usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.This study evaluated clinical relevance of FDG-PET and ME-NBI in decision-making regarding the treatment strategy for ESCC.AIM To investigate the association between FDG uptake and the clinicopathological characteristics of superficial ESCC and its usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.METHODS A database of all patients with superficial ESCC who had undergone both MENBI and FDG-PET for pre-treatment staging at Aichi Cancer Center Hospital between January 2008 and November 2018 was retrospectively analyzed.FDG uptake was defined positive or negative whether the primary lesion was visualized or could be distinguished from the background,or not.The invasion depth of ESCC was classified according to the Japan Esophageal Society.Primary endpoint is to evaluate the association between FDG uptake and clinicopathological characteristics of superficial ESCC.Secondary endpoint is to investigate the efficacy of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.RESULTS A total of 82 lesions in 82 patients were included.FDG-PET showed positive uptake in 29(35.4%)lesions.Univariate analysis showed that uptake of FDG-PET had significant correlations with circumferential extension(P=0.014),pathological depth of tumor invasion(P<0.001),infiltrative growth pattern(P<0.001),histological grade(P=0.002),vascular invasion(P=0.001),and lymphatic invasion(P<0.001).On multivariate analysis,only depth of tumor invasion was independently correlated with FDG-PET/computed tomography visibility(P=0.018).The sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy of Type B2 in ME-NBI for the invasion depth of T1a muscularis mucosae and T1b upper submucosal layer were 68.4%/79.4%/50.0%/89.3%/76.8%,respectively,and those of Type B3 for the depth of T1b middle and deeper submucosal layers(SM2 and SM3)were 46.7%/100%/100%/89.3%/90.2%,respectively.On the other hand,those of FDGPET for SM2 and SM3 were 93.3%/77.6%/48.2%/98.1%/80.5%,respectively,whereas,if the combination of positive FDG uptake and type B2 and B3 was defined as an indicator for radical esophagectomy or definitive chemoradiotherapy,the sensitivity,specificity,PPV,NPV,and accuracy were 78.3%/91.5%/78.3%/91.5%/87.8%,respectively.CONCLUSION FDG uptake was correlated with the invasion depth of superficial ESCC.Combined use of FDG-PET and ME-NBI,especially with the microvascular findings of Type B2 and B3,is useful to determine whether ER is indicated for the lesion. | Kazuhiro Toriyama Masahiro Tajika Tsutomu Tanaka Makoto Ishihara Yutaka Hirayama Sachiyo Onishi Nobumasa Mizuno Takamichi Kuwahara Nozomi Okuno Shinpei Matsumoto Eiichi Sasaki Tetsuya Abe Yasushi Yatabe Kazuo Hara Keitaro Matsuo Tsuneo Tamaki Yasumasa Niwa | 2019 | World Journal of Gastroenterology2019，25，46： | 7 |
| 3 | Regulation of immune cell responses by semaphorins and their receptors显示文摘Semaphorins 原来作为涉及 neuronal 系统的开发的轴突指导因素被识别。然而,积累证据显示那 semaphorins 的几个成员,所谓的鈥榠m mune semaphorins 鈥吗?关键地涉及有免疫力的回答的各种各样的阶段。这些 semaphorins 在生理、病理学的有免疫力的回答期间调整两个有免疫力的房间相互作用和有免疫力的房间 trafficking。这里,我们在有免疫力的回答考察 semaphorins 和他们的受体的下列二个功能的方面:他们在在有免疫力的房间 trafficking 的房间鈥揷e ll 相互作用和他们的参与的功能。 | Hyota Takamatsu Tatsusada Okuno Atsushi Kumanogoh | 2010 | Cellular & Molecular Immunology2010，7，2： | 6 |
| 4 | Transnasal endoscopic retrograde chalangiopancreatography using an ultrathin endoscope: A prospective comparison with a routine oral procedure显示文摘AIM: To investigate if transnasal endoscopic retrograde cholangiopancreatography (n-ERCP) using an ultrathin forward-viewing scope may overcome the disadvantages of conventional oral ERCP (o-ERCP) related to the large- caliber side-viewing duodenoscope. METHODS: The study involved 50 patients in whom 25 cases each were assigned to the o-ERCP and n-ERCP groups. We compared the requirements of esophagogastroduodenoscopy (EGD) prior to ERCP, rates and times required for successful cannulation into the pancreatobiliary ducts, incidence of post-procedure hyperamylasemia, cardiovascular parameters during the procedure, the dose of a sedative drug, and successful rates of endoscopic naso-biliary drainage (ENBD). RESULTS: Screening gastrointestinal observations were easily performed by the forward-viewing scope and thus no prior EGD was required in the n-ERCP group. There was no significant difference in the rates or times for cannulation, or incidence of hyperamylasemia between the groups. However, the cannulation was relatively difficult in n-ERCP when the scope appeared U-shape under fluoroscopy. Increments of blood pressure and the amount of a sedative drug were significantly lower in the n-ERCP group. ENBD was successfully performed succeeding to the n-ERCP in which mouth-to-nose transfer of the drainage tube was not required. CONCLUSION: n-ERCP is likely a well-tolerable methodwith less cardiovascular stress and no need of prior EGD or mouth-to-nose transfer of the ENBD tube. However, a deliberate application is needed since its performance is difficult in some cases and is not feasible for some endoscopic treatments such as stenting. | Akihiro Mori Noritsugu Ohashi Takako Maruyama Hideharu Tatebe Katsuhisa Sakai Takashi Shibuya Hiroshi Inoue Shoudou Takegoshi Masataka Okuno | 2008 | World Journal of Gastroenterology2008，14，10： | 6 |
| 5 | Factors associated with residual gastroesophageal reflux disease symptoms in patients receiving proton pump inhibitor maintenance therapy显示文摘AIM To elucidate the factors associated with residual gastroesophageal reflux disease(GERD) symptoms in patients receiving proton pump inhibitor(PPI) maintenance therapy in clinical practice.METHODS The study included 39 GERD patients receiving maintenance PPI therapy. Residual symptoms were assessed using the Frequency Scale for Symptoms of GERD(FSSG) questionnaire and the Gastrointestinal Symptom Rating Scale(GSRS). The relationships between the FSSG score and patient background factors, including the CYP2C19 genotype, were analyzed.RESULTS The FSSG scores ranged from 1 to 28 points(median score: 7.5 points), and 19 patients(48.7%) had a score of 8 points or more. The patients' GSRS scores were significantly correlated with their FSSG scores(correlation coefficient = 0.47, P < 0.005). In erosive esophagitis patients, the FSSG scores of the CYP2C19 rapid metabolizers(RMs) were significantly higher than the scores of the poor metabolizers and intermediate metabolizers(total scores: 16.7 ± 8.6 vs 7.8 ± 5.4, P < 0.05; acid reflux-related symptom scores: 12 ± 1.9 vs 2.5 ± 0.8, P < 0.005). In contrast, the FSSG scores of the CYP2C19 RMs in the non-erosive reflux disease patients were significantly lower than those of the other patients(total scores: 5.5 ± 1.0 vs 11.8 ± 6.3, P < 0.05; dysmotility symptom-related scores: 1.0 ± 0.4 vs 6.0 ± 0.8, P < 0.01). CONCLUSION Approximately half of the GERD patients receiving maintenance PPI therapy had residual symptoms associated with a lower quality of life, and the CYP2C19 genotype appeared to be associated with these residual symptoms. | Fumiaki Kawara Tsuyoshi Fujita Yoshinori Morita Atsushi Uda Atsuhiro Masuda Masaya Saito Makoto Ooi Tsukasa Ishida Yasuyuki Kondo Shiei Yoshida Tatsuya Okuno Yoshihiko Yano Masaru Yoshida Hiromu Kutsumi Takanobu Hayakumo Kazuhiko Yamashita Takeshi Hirano Midori Hirai Takeshi Azuma | 2017 | World Journal of Gastroenterology2017，23，11： | 5 |
| 6 | Electroacupuncture improves neuronal function by stimulation of ascending peripheral nerve conduction in rats with spinal cord injury显示文摘OBJECTIVE: To establish a method of transient sciatic nerve blockade and to examine the involvement of the ascending peripheral nerve pathway in the therapeutic effect of electroacupuncture at Zusanli(ST 36) in rats with spinal cord injury(SCI).METHODS: We examined the transient effect of daily lidocaine administration into the posteromedial part of the greater trochanter on sciatic nerve function using electrophysiological examination and histopathology of the sciatic nerve. Rats were divided into three groups: an SCI group(SCI without treatment), an SCI with electroacupuncture treatment(SCI-EA) group, and an SCI with nerve block and electroacupuncture(SCI-NB-EA) group(nerve block was achieved by lidocaine administration to transiently block the ascending peripheral nerve pathway). Behavioral tests and electrophysiological examinations were performed to evaluate recovery of neurological function.RESULTS: Sciatic nerve conduction was normal immediately before daily lidocaine administration.Histopathological analysis also indicated normal sciatic nerve, confirming that lidocaine nerve blockade was suitable and reversible for transiently eliminating nerve transmission. Neurological function in the SCI-EA group was superior to that in the SCI group, while no differences were found between the SCI and SCI-NB-EA groups.CONCLUSION: Electroacupuncture treatment can promote recovery of neurological function. Facilitation of nerve conduction may play an important role in this recovery. | Song Meng Chen Wu Kamiie Junichi Okuno Seiichi Orito Kensuke | 2019 | Journal of Traditional Chinese Medicine2019，39，4： | 5 |
| 7 | endoscopic ultrasonography-guided biliary drainage:Who,when,which,and how?显示文摘Both endoscopic ultrasonography(EUS)-guided choledochoduodenostomy( EUS- CDS) and EUS-guided hepaticogastrostomy(EUS-HGS) are relatively well established as alternatives to percutaneous transhepatic biliary drainage(PTBD). Both EUSCDS and EUS-HGS have high technical and clinical success rates(more than 90%) in high-volume centers. Complications for both procedures remain high at 10%-30%. Procedures performed by endoscopists who have done fewer than 20 cases sometimes result in severe or fatal complications. When learning EUSguided biliary drainage(EUS-BD), we recommend a mentor's supervision during at least the first 20 cases. For inoperable malignant lower biliary obstruction, a skillful endoscopist should perform EUS-BD before EUS-guided rendezvous technique(EUS-RV) and PTBD. We should be select EUS-BD for patients having altered anatomy from malignant tumors before balloon-enteroscope-assisted endoscopic retrograde cholangiopancreatography, EUS-RV, and PTBD. If both EUS-CDS and EUS-HGS are available, we should select EUS-CDS, according to published data. EUSBD will potentially become a first-line biliary drainage procedure in the near future. | Kazuo Hara Kenji Yamao Nobumasa Mizuno Susumu Hijioka Hiroshi Imaoka Masahiro Tajika Tutomu Tanaka Makoto Ishihara Nozomi Okuno Nobuhiro Hieda Tukasa Yoshida Yasumasa Niwa | 2016 | World Journal of Gastroenterology2016，22，3： | 4 |
| 8 | Addition of docetaxel to S-1 without platinum prolongs survival of patients with advanced gastric cancer: a randomized study (START)显示文摘 | Wasaburo Koizumi Yeul Hong Kim Masashi Fujii Hoon Kyo Kim Hiroshi Imamura Kyung Hee Lee Takuo Hara Hyun Cheol Chung Taroh Satoh Jae Yong Cho Hisashi Hosaka Akihito Tsuji Akinori Takagane Mikito Inokuchi Kazuaki Tanabe Tatsuya Okuno Mariko Ogura Kazuhiro Y | 2014 | Journal of Cancer Research and Clinical Oncology2014，，2： | 2 |
| 9 | Last deglacial relative sea level variations in Antarctica derived from glacial isostatic adjustment modelling显示文摘We present relative sea level(RSL)curves in Antarctica derived from glacial isostatic adjustment(GIA)predictions based on the melting scenarios of the Antarctic ice sheet since the Last Glacial Maximum(LGM)given in previous works.Simultaneously,Holocene-age RSL observations obtained at the raised beaches along the coast of Antarctica are shown to be in agreement with the GIA predictions.The differences from previously published ice-loading models regarding the spatial distribution and total mass change of the melted ice are signifcant.These models were also derived from GIA modelling;the variations can be attributed to the lack of geological and geographical evidence regarding the history of crustal movement due to ice sheet evolution.Next,we summarise the previously published ice load models and demonstrate the RSL curves based on combinations of different ice and earth models.The RSL curves calculated by GIA models indicate that the model dependence of both the ice and earth models is signifcantly large at several sites where RSL observations were obtained.In particular,GIA predictions based on the thin lithospheric thickness show the spatial distributions that are dependent on the melted ice thickness at each sites.These characteristics result from the short-wavelength deformation of the Earth.However,our predictions strongly suggest that it is possible to fnd the average ice model despite the use of the different models of lithospheric thickness.By sea level and crustal movement observations,we can deduce the geometry of the post-LGM ice sheets in detail and remove the GIA contribution from the crustal deformation and gravity change observed by space geodetic techniques,such as GPS and GRACE,for the estimation of the Antarctic ice mass change associated with recent global warming. | Jun’ichi Okuno Hideki Miura | 2013 | Geoscience Frontiers2013，4，6： | 2 |
| 10 | Endoscopic resection for residual lesion of metastatic gastric cancer:A case report显示文摘BACKGROUND Chemotherapy is a standard strategy for stage IV gastric cancer patients.However, some cases cannot undergo conversion surgery because of their frailty,even if the patients had response to chemotherapy. For these patients, local tumor progression is a problem. We report here the case of a patient whose residual gastric cancer was resected through endoscopic submucosal dissection(ESD)after concomitant chemotherapy for metastatic gastric cancer.CASE SUMMARY An 85-year-old male complained of difficulty swallowing, and examination revealed gastric cancer with multiple liver metastases. Although he received concomitant chemotherapy, a residual tumor was observed in the primary lesion while the metastatic lesions disappeared completely. Conversion surgery was considered optional treatment; however, he could not undergo that because of advanced age and comorbidities. Thus, we performed ESD to treat the residual tumor. As a result, we resected the residual lesion completely. The patient has been alive for 29 mo since ESD, without recurrence.CONCLUSION We achieved local control using ESD, and these findings may provide therapeutic improvements both in local control and patient survival outcomes. | Kaori Hayashi Sho Suzuki Hisatomo Ikehara Hiroaki Okuno Akira Irie Mitsuru Esaki Chika Kusano Takuji Gotoda Mitsuhiko Moriyama | 2019 | World Journal of Clinical Cases2019，7，4： | 2 |
| 11 | Reinfection rate of Helicobacter pylori after eradication treatment: a long-term prospective study in Japan显示文摘 | Susumu Take Motowo Mizuno Kuniharu Ishiki Takayuki Imada Tetsuji Okuno Tomowo Yoshida Kenji Yokota Keiji Oguma Masahide Kita Hiroyuki Okada Kazuhide Yamamoto | 2012 | Journal of Gastroenterology2012，，6： | 2 |
| 12 | Dynamic Changes of Adiponectin and S100A8 Levels by the Selective Peroxisome Proliferator–Activated Receptor-γ Agonist Rivoglitazone显示文摘 | Aki Hiuge-Shimizu Norikazu Maeda Ayumu Hirata Hideaki Nakatsuji Kouichi Nakamura Akira Okuno Shinji Kihara Tohru Funahashi Iichiro Shimomura | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，4： | 2 |
| 13 | Role of Sialyl Lewis X in Liver Metastasis in View of Liver2assbeiated Immunity显示文摘 | Okuno K Kawai I Hirai N | 2003 | Hepatogast roenterology2003，50，51： | 1 |
| 14 | Intestinal subepithelial myofibroblasts in inflammatory bowel diseases 显示文摘 | Andoh A Fujino S Okuno T | 2002 | J Gastroenterol2002，37，14： | 1 |
| 15 | Effect of cisapride on gastric emptying of indigestible solids and plasma matilin concentration in diabetic autonomic neuropathy显示文摘 | Kawagishi T Nishizawa Y Okuno Y | 1993 | Am J Gastroenterol1993，88，6： | 1 |
| 16 | Antimutagenic activity of polymethoxyflavonoids from Citrus aurantium 显示文摘 | Miyazawa M Okuno Y Fukuyama M etal | 1999 | J AgricFoodChem1999，47，12： | 1 |
| 17 | Direct wafer bonding of m v compound semiconductor for free-material and free- orientation integration 显示文摘 | Okuno Y Uomi K Aoki M | 1997 | IEEE Journal of Quantum Electronics1997，33，6： | 1 |
| 18 | Role of matrix metalloproteinase- 9 in the basement membrane destruction of superficial urothelial carci- noma显示文摘 | Ozdemir E Kakehi Y Okuno H | 1999 | J Urol1999，161，4： | 1 |
| 19 | Retinoids in cancer chemoprevention显示文摘 | Okuno M Kojima S Matsushima-Nishiwaki R | 2004 | Curr Cancer Drug Targets2004，4，3： | 1 |
| 20 | Distribution of PCDDs, PCDFs and PCBs in the atmosphere显示文摘 | Nakano T Tsuji M Okuno T | 1990 | Atmospheric Envi- ronment1990，24，6： | 1 |
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