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| 1 | Safety and efficacy of carbon dioxide insufflation during gastric endoscopic submucosal dissection显示文摘AIM: To compare the safety and efficacy of carbon dioxide(CO2) and air insufflation during gastric endoscopic submucosal dissection(ESD).METHODS: This study involved 116 patients who underwent gastric ESD between January and December 2009.After eliminating 29 patients who fit the exclusion criteria,87 patients,without known pulmonary dysfunction,were randomized into the CO2 insufflation(n = 36) or air insufflation(n = 51) groups.Standard ESD was performed with a CO2 regulation unit(constant rate of 1.4 L/min) used for patients undergoing CO2 insufflation.Patients received diazepam for conscious sedation and pentazocine for analgesia.Transcutaneous CO2 tension(Ptc CO2) was recorded 15 min before,during,and after ESD with insufflation.Ptc CO2,the correlation between Ptc CO2 and procedure time,and ESD-related complications were compared between the two groups.Arterial blood gases were analyzed after ESD in the first 30 patients(12 with CO2 and 18 with air insufflation) to assess the correlation between arterial blood CO2 partial pressure(Pa CO2) and Ptc CO2.RESULTS: There were no differences in respiratoryfunctions,median sedative doses,or median procedure times between the groups.Similarly,there was no significant difference in post-ESD blood gas parameters,including Pa CO2,between the CO2 and air groups(44.6 mm Hg vs 45 mm Hg).Both groups demonstrated median p H values of 7.36,and none of the patients exhibited acidemia.No significant differences were observed between the CO2 and air groups with respect to baseline Ptc CO2(39 mm Hg vs 40 mm Hg),peak Ptc CO2 during ESD(52 mm Hg vs 51 mm Hg),or median Ptc CO2 after ESD(50 mm Hg vs 50 mm Hg).There was a strong correlation between Pa CO2 and Ptc CO2(r = 0.66; P < 0.001).The incidence of Mallory-Weiss tears was significantly lower with CO2 insufflation than with air insufflation(0% vs 15.6%,P = 0.013).CO2 insufflation did not cause any adverse events,such as CO2 narcosis or gas embolisms.CONCLUSION: CO2 insufflation during gastric ESD results in similar blood gas levels as air insufflation,and also reduces the incidence of Mallory-Weiss tears. | Jun Takada Hiroshi Araki Fumito Onogi Takayuki Nakanishi Masaya Kubota Takashi Ibuka Masahito Shimizu Hisataka Moriwaki | 2015 | World Journal of Gastroenterology2015，21，26： | 6 |
| 2 | Diagnosis of the jejunoileal lymphoma by double-balloon endoscopy显示文摘AIM:To investigate the feasibility of double-balloon endoscopy(DBE) to detect jejunoileal lymphoma,compared with fluorodeoxyglucose positron emission tomography(FDG-PET).METHODS:Between March 2004 and January 2011,we histologically confirmed involvement of malignant lymphoma of the jejunoileum in 31 patients by DBE and biopsy.In 20 patients of them,we performed with FDGPET.We retrospectively reviewed the records of these 20 patients.Their median age was 64 years(range 50-81).In the 20 patients,the pathological diagnosis of underlying non-Hodgkin's lymphoma(NHL) comprised follicular lymphoma(FL,n = 12),diffuse large B cell lymphoma(DLBCL,n = 4),mantle cell lymphoma(MCL,n = 2),enteropathy associated T cell lymphoma(ETL,n = 1) and anaplastic large cell lymphoma(ALCL,n = 1).RESULTS:Ten cases showed accumulation by FDGPET(50%).FDG-PET was positive in 3 of 12 FL cases(25%) while in 7 of 8 non-FL cases(88%,P < 0.05).Intestinal FL showed a significantly lower rate of positive FDG-PET,in comparison with other types of lymphoma.Cases with endoscopically elevated lesions(n = 10) showed positive FDG-PET in 2(20%),but those with other type NHL did in 8 of 10(80%,P < 0.05).When the cases having elevated type was compared with those not having elevated type lesion,the number of cases that showed accumulation of FDG was significantly smaller in the former than in the latter.CONCLUSION:In a significant proportion,small intestinal involvement cannot be pointed out by FDG-PET.Especially,FL is difficult to evaluate by FDG-PET but essentially requires DBE. | Takashi Ibuka Hiroshi Araki Tomohiko Sugiyama Takayuki Nakanishi Fumito Onogi Masahito Shimizu Takeshi Hara Tsuyoshi Takami Hisashi Tsurumi Hisataka Moriwaki | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 4 |
| 3 | Clinical trial: rebamipide promotes gastric ulcer healing by proton pump inhibitor after endoscopic submucosal dissection—a randomized controlled study显示文摘 | Tomohiro Kato Hiroshi Araki Fumito Onogi Takashi Ibuka Akihiko Sugiyama Eiichi Tomita Masahito Nagaki Hisataka Moriwaki | 2010 | Journal of Gastroenterology2010，，3： | 2 |
| 4 | Cloning and Nucleotide Sequence of the Pullulanase Gene of Thermus thermophilus HB8 and Production of the Enzyme in Escherichia coli显示文摘 | Tomiyasu K Yato K Yasuda M Tonozuka T Ibuka A Sakai H | | 0，，09： | 1 |
| 5 | Clinical trial: rebamipide promotes gastric ulcer healing by proton pump inhibitor after endoscopic submucosal dissection—a randomized controlled study显示文摘 | Tomohiro Kato Hiroshi Araki Fumito Onogi Takashi Ibuka Akihiko Sugiyama Eiichi Tomita Masahito Nagaki Hisataka Moriwaki | 2010 | Journal of Gastroenterology2010，，3： | 1 |
| 6 | Suprachiasmatic nuclei influence torpor and circadian temperature rhythms in hamsters显示文摘 | RUBY NF IBUKA N BARNES BM | 1989 | Am J Physiol1989，257，12： | 1 |
| 7 | The P2Y (2) receptor pro- motes Wnt3a - and EGF - induced epithelial tubular formation by IEC6 ceils by binding to integrins 显示文摘 | Ibuka S Matsumoto S Fujii S | 2015 | J Cell Sci2015，128，11： | 1 |
| 8 | Crystal structure of extended-spectrum beta-lactamase Toho-1: insights into the molecular mechanism for catalytic reaction and substrate specificity expansion 显示文摘 | Ibuka A S Ishii Y Galleni M | 2003 | Biochemistry2003，42，10： | 1 |
| 9 | Clinical significance of jeju- noileal involvement of non-Hodgkin' s lymphoma detected by double-balloon enteroseopy显示文摘 | Ibuka T Tsurumi H Araki H | 2013 | Int J Hematol2013，97，3： | 1 |
| 10 | A barium marking method u- sing an uhrathin bronchoscope with virtual bronchoscopic naviga- tion 显示文摘 | Asano F Matsuno Y Ibuka T | 2004 | Respirology2004，9，3： | 1 |
| 11 | Kinetic properties of four plasmid-mediated AmpC β-lactamases显示文摘 | Bauvois C Ibuka AS Celso A | 2005 | Antimicrob Agents Chemother2005，49，10： | 1 |
| 12 | ' Transmural air leak':a computed tomographic finding following endoscopicsubmucosal dissection of gastric tumors 显示文摘 | Onogi F Araki H Ibuka T | 2010 | Endoscopy2010，42，6： | 1 |
| 13 | Kinetic properties of four plasmid-mediated ampC β-lactamases 显示文摘 | Bauvois C Ibuka A S Celso A etal | 2005 | Antimicrob Agents Chemother2005，49，10： | 1 |
| 14 | Total Synthesis of the Alkaloid (±)-Dendrobine显示文摘 | Inubushi Y Kikuchi T Ibuka T | 1974 | Chemical & pharmaceuticalbulletin1974，22，2： | 1 |
| 15 | Epstein-Barr virus in pyothorax-associated pleural lymphoma显示文摘 | FUKAYAMA M IBUKA T HAYASHI Y | 1993 | Am J Pathol1993，143，4： | 1 |
| 16 | First-trimester findings associated with twin reversed arterial perfusion sequence显示文摘 | Kamitomo M Kouno S Ibuka K | 2004 | Fetal Diagn Ther2004，19，2： | 1 |
| 17 | A novel and efficient macrolactonization of ω-hydroxycarboxylic acids using 2- methyl-6-nitrobenzoic anhydride ( MNBA ) 显示文摘 | Shiina I Kubota M Ibuka R | 2002 | Tetrahedron Letter2002，43，42： | 1 |
| 18 | Structure-antimicrobial activity relationshipsamong the sesquiterpene lac tones and related compounds显示文摘 | Lee K H Ibuka T Wu R Y | 1977 | Phytochemistry1977，16，： | 1 |
| 19 | Condensate under ultraviolet excitation: application to the study of ultrathin SOI layers显示文摘 | Michio Tajima Shigeo Ibuka Shigenori Arai | 2002 | Materials Science and Engineering2002，9192，2002： | 1 |
| 20 | ' Transmural air leak' : a computed tomographic finding following endoscopic submucosal dissection of gas- tric tumors 显示文摘 | Onogi F Araki H Ibuka T | 2010 | Endoscopy2010，42，6： | 1 |
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