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| 1 | Computed tomography attenuation values of ascites are helpful to predict perforation site显示文摘AIM:To evaluate the effect of computed tomography(CT) attenuation values of ascites on gastrointestinal(GI) perforation site prediction.METHODS:The CT attenuation values of the ascites from 51 patients with GI perforations were measured by volume rendering to calculate the mean values.The effect of the CT attenuation values of the ascites on perforation site prediction and postoperative complications was evaluated.RESULTS:Of 24 patients with colorectal perforations,the CT attenuation values of ascites were significantly higher than those in patients with perforations at other sites [22.5 Hounsfield units(HU) vs 16.5 HU,respectively,P = 0.006].Colorectal perforation was significantly associated with postoperative complications(P = 0.038).The prediction rate of colorectal perforation using attenuation values as an auxiliary diagnosis improved by 9.8% compared to that of CT findings alone(92.2% vs 82.4%).CONCLUSION:The CT attenuation values of ascites could facilitate the prediction of perforation sites and postoperative complications in GI perforations,particularly in cases in which the perforation sites are difficult to predict by CT findings alone. | Ryo Seishima Koji Okabayashi Hirotoshi Hasegawa Masashi Tsuruta Hiroki Hoshino Toru Yamada Yuko Kitagawa | 2015 | World Journal of Gastroenterology2015，21，5： | 3 |
| 2 | Chemoprevention of colorectal cancer by targeting obesity-related metabolic abnormalities显示文摘Obesity and its related metabolic disorders, including insulin resistance and chronic inflammation, increase the risk of colorectal cancer(CRC). This observation suggests that the metabolic abnormalities associated with obesity can be effective targets for preventing the development of CRC in obese individuals. In recent years, many studies using obese and diabetic animal models have been conducted to investigate the chemoprevention of CRC using pharmaceutical or nutritional interventions. Pitavastatin, a medicine used to treat hyperlipidemia, prevents the development of obesityrelated colorectal carcinogenesis by attenuating chronic inflammation. Anti-hypertensive medicines, such as captopril and telmisartan, also suppress the formation of colonic preneoplastic lesions in obese and diabetic mice. In addition, several phytochemicals, including green tea catechins, have been reported to improve metabolic disorders and prevent the development of various cancers, including CRC. Moreover, the administration of branched-chain amino acids, which improves protein malnutrition and prevents the progression of hepatic failure, is effective for suppressing obesityrelated colon carcinogenesis, which is thought to be associated with improvements in insulin resistance. In the present article, we summarize the detailed relationship between metabolic abnormalities and the development of CRC. This review also outlines recent evidence, in particular drawing from basic and clinical examinations using either pharmaceutical or nutritional intervention that suggests that targeting metabolic alterations may be an effective strategy for preventing the development of CRC in obese individuals. | Yohei Shirakami Masahito Shimizu Masaya Kubota Hiroshi Araki Takuji Tanaka Hisataka Moriwaki Mitsuru Seishima | 2014 | World Journal of Gastroenterology2014，20，27： | 2 |
| 3 | Role of V α 14 NKT cells in the development of impaired liver regeneration In Vivo显示文摘 | Hiroyasu Ito Kazuki Ando Toshinori Nakayama Masaru Taniguchi Takayuki Ezaki Kuniaki Saito Masao Takemura Kenji Sekikawa Michio Imawari Mitsuru Seishima Hisataka Moriwaki | 2003 | Hepatology2003，，5： | 1 |
| 4 | Serum lipid and apolipoprotein levels in patients with psoriasis显示文摘 | Seishima M Saishima M Mari S | 1999 | Br J Dermatol1999，130，： | 1 |
| 5 | Reactivation of human herpesvirus (HHV) family members other than HHV-6 in drug-induced hypersensitivity syndrome 显示文摘 | Seishima M Yamanaka S Fujisawa T | 2006 | Br J Dermatol2006，155，2： | 1 |
| 6 | Plasma Fas ligand,an inducer of apoptosis,and plasma soluble Fas, an inhibitor of apoptosis,in patients with chronic congestive heart failure显示文摘 | Kazuhiko Nishigaki Shinya Minatoguehi Mitsuru Seishima | 1997 | J Am Coll Cardiol1997，29，6： | 1 |
| 7 | Efficacy of granulocyte and monocyte adsorption apheresis for three cases of refractory pyoderma gangrenosum 显示文摘 | Seishima M Mizutani Y Shibuya Y | 2007 | Ther Apher Dial2007，11，3： | 1 |
| 8 | Plasma Fas Ligand,an inducer of apoptosis,and Plasma soluble Fas,an inhibitor of apoptosis,in patients with chronic congestive heart failure显示文摘 | Nishigaki K Minatoguchi S Seishima M | 1997 | J Am Coll cardiol1997，29，6： | 1 |
| 9 | Serum lipid and apolipoprotein levels in patients with psoriasis显示文摘 | Seishima M Saishima M Mari S | 1994 | Br J Dermatol1994，130，： | 1 |
| 10 | Reactivation of human herpesvirus (HHV) family members other than HHV-6 in drug-induced hypersensitivity syndrome显示文摘 | SEISHIMA M YAMANAKA S FUJISAWA T | 2006 | Br J Dermatol2006，155，2： | 1 |
| 11 | A refractory case of secondary erythermalgia successfully treated with lumbar sympathetic ganglion block 显示文摘 | Seishima M Kanoh H Izumi T | 2000 | BrJ Dermatol2000，143，4： | 1 |
| 12 | Hypogammaglobulinemia as an early sign of drug-induced hypersensitivity syndrome显示文摘 | Kano Y Seishima M Shiohara T | 2006 | J Am Acad Dermatol2006，55，4： | 1 |
| 13 | Plasma Fas ligand, an inducer of apoptosis, and plasma soluble Fas,an inhibitor of apoptosis, in patients with chronic congestive heart failure显示文摘 | Minatoguchi S Seishima M | 1997 | JACC1997，29，： | 1 |
| 14 | Is laparoscopic colorectal surgery beneficial for elderly patients? A systematic review and meta-analysis 显示文摘 | Seishima R Okabayashi K Hasegawa H | 2015 | J Gastrointest Surg2015，19，4： | 1 |
| 15 | Reactivation of human herpesvirus(HHV)family members other than HHV-6 in drug-induced hypersensitivity syndrome显示文摘 | Seishima M Yamanaka S Fujisawa T | 2006 | Br J Dermatol2006，155，2： | 1 |
| 16 | Plasma fas ligand,an inducer of apoptosis,and plasma soluble Fas,and inhibitor of apoptosis,in patients with chronic congestive heart failure显示文摘 | Nishigaki K Minatoguchi S Seishima M | 1997 | J Am Coll Cardiol1997，29，： | 1 |
| 17 | Plasma F Induced of Apoptosis, and Plasma Soluble Fas, an Inhiba in Patient Chromic Congestive Heart Failure显示文摘 | Minatoguchi S Seishima M | 1997 | J Am C1997，29，： | 1 |
| 18 | A 10 novel diacylglycerol acyhransferase (DGAT2) is decreased in human psoriatic skin and increased in diabeic mice显示文摘 | Wakimoto K Chiba H Michibata H Seishima M Kawasaki S Okubo K Mitsui H Torii H Imai Y | 2003 | Biochem Biophys Res Commun2003，310，2： | 1 |
| 19 | Overexpression of monocyte chemoattractant protein - 1 in the overlying epidermis of multicentric reticulohistiocytosis lesions: a case report 显示文摘 | Iwata H Okumura Y Seishima M | 2012 | Int J Dermatol2012，51，4： | 1 |
| 20 | Guideline for hyperlipidemia 显示文摘 | Seishima M | 2003 | Rinsho Byori2003，51，6： | 1 |
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