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| 1 | Combined assessment of myocardial damage and electrical disturbance in chronic heart failure显示文摘AIM To investigate feasibility of combined assessment of biochemical and electrophysiological myocardial impairment markers risk-stratifying patients with chronic heart failure(CHF). METHODS Serum levels of heart-type fatty acid binding protein(H-FABP) as a marker of ongoing myocardial damage and QRS duration on electrocardiogram were measured at admission in 322 consecutive patients with CHF. A prolonged QRS duration was defined as 120 ms or longer. The cut-off value for H-FABP level(4.5 ng/mL) was determined from a previous study. Patients were prospectively followed during a median follow up period of 534 d. The primary endpoint was cardiac deaths and rehospitalization for worsening CHF.RESULTS There were 117 primary events, including 27 cardiac deaths and 90 rehospitalizations. Patients were stratified into four groups according to H-FABP level and QRS duration(≥ 120 ms). Multivariate analysis demonstrated that high H-FABP levels [hazard ratio(HR) = 1.745, P = 0.021] and QRS prolongation(HR1.612, P = 0.0258) were independent predictors of cardiac events. Kaplan-Meier analysis demonstrated that the combination of high H-FABP levels and QRS prolongation could be used to reliably stratify patients at high risk for cardiac events(log rank test P < 0.0001).CONCLUSION Combined assessment of myocardial damage and electrical disturbance can be used to risk-stratify patients with CHF. | Shinpei Kadowaki Tetsu Watanabe Yoichiro Otaki Taro Narumi Yuki Honda Hiroki Takahashi Takanori Arimoto Tetsuro Shishido Takuya Miyamoto Isao Kubota | 2017 | World Journal of Cardiology2017，9，5： | 14 |
| 2 | Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming显示文摘以前的研究揭示了初发的细菌房间(PGC ) 经历的那只老鼠为 totipotency 重设 epigenome 的染色体宽的 DNA methylation reprogramming。然而,有 5-hydroxymethylcytosine (5hmC ) 的产生的精确 5-methylcytosine (5mC ) 动力学和它的关系不是清楚的。这里,我们在 PGC reprograming 和细菌房间开发期间分析了 5mC 和 5hmC 的动力学。出人意料地,我们在 5mC 和 5hmC 层次在哪个期间是低的期间发现了一个特定的时期(E8.5-9.5 ) 。随后, 5hmC 层次增加在 E11.5 到达它的山峰并且逐渐地由复制依赖者冲淡多半减少直到 E13.5。有趣地, 5hmC 在这个时期期间在 chromocenters 被充实。当时这个细菌房间特定的 5hmC subnuclear 本地化模式甚至在成熟卵母细胞在女细菌房间被维持,当有丝分裂的增长在新生的阶段期间恢复,如此的模式逐渐地在男细菌房间被失去。Pericentric 5hmC 在 silencing 起一个重要作用主要卫星重复,特别在女 PGC。由 RNA-seq 的全球 transcriptome 分析表明差别的大多数从 E9.5 表示了基因到 13.5 是在男、女的 PGC 的 upregulated。尽管仅仅女 PGC 在出生前的阶段期间进入成熟分裂,成熟分裂相关并且印的基因的一个子集是显著地在在 E13.5 的男、女的 PGC 的 upregulated。因此,我们的学习不仅在 PGC reprogramming 和细菌房间期间揭示 5mC 和 5hmC 的动力学开发,而且他们在 epigenetic reprogramming 和 meiotic 和印的基因的 transcriptional 规定的潜在的角色。 | Shinpei Yamaguchi Kwonho Hong Rui Liu Azusa Inoue Li Shen Kun Zhang Yi Zhang | 2013 | Cell Research2013，23，3： | 10 |
| 3 | Reactive lymphoid hyperplasia of the liver:Perinodular enhancement on contrast-enhanced computed tomography and magnetic resonance imaging显示文摘We report the case of a 69-year-old woman with reactive lymphoid hyperplasia(RLH) of the liver.She underwent partial hepatectomy under a preoperative diagnosis of hepatocellular carcinoma; however,histopathological analysis revealed RLH.The liver nodule showed the imaging feature of perinodular enhancement in the arterial dominant phase on contrast-enhanced computed tomography and magnetic resonance imaging,which could be a useful clue for identifying RLH in the liver.Histologically,the perinodular enhancement was compatible with prominent sinusoidal dilatation surrounding the liver nodule. | Tetsuo Sonomura Shinpei Anami Taizo Takeuchi Motoki Nakai Shinya Sahara Hirohiko Tanihata Kazuki Sakamoto Morio Sato | 2015 | World Journal of Gastroenterology2015，21，21： | 7 |
| 4 | Clinical relevance of fluorodeoxyglucose positron emission tomography/computed tomography and magnifying endoscopy with narrow band imaging in decision-making regarding the treatment strategy for esophageal squamous cell carcinoma显示文摘BACKGROUND Recent advances in endoscopic technology,especially magnifying endoscopy with narrow band imaging(ME-NBI)enable us to detect superficial esophageal squamous cell carcinoma(ESCC),but determining the appropriate method of resection,endoscopic resection(ER)vs surgical resection,is often challenging.Recently,several studies have reported that 18F-fluorodeoxyglucose positron emission tomography(FDG-PET)is a useful indicator for decision-making regarding treatment for superficial ESCC.Although,there are not enough reports on association between FDG-PET uptake and clinicopathological characteristics of superficial ESCC.And,there are not enough reports on evaluating the usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.This study evaluated clinical relevance of FDG-PET and ME-NBI in decision-making regarding the treatment strategy for ESCC.AIM To investigate the association between FDG uptake and the clinicopathological characteristics of superficial ESCC and its usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.METHODS A database of all patients with superficial ESCC who had undergone both MENBI and FDG-PET for pre-treatment staging at Aichi Cancer Center Hospital between January 2008 and November 2018 was retrospectively analyzed.FDG uptake was defined positive or negative whether the primary lesion was visualized or could be distinguished from the background,or not.The invasion depth of ESCC was classified according to the Japan Esophageal Society.Primary endpoint is to evaluate the association between FDG uptake and clinicopathological characteristics of superficial ESCC.Secondary endpoint is to investigate the efficacy of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial ESCC.RESULTS A total of 82 lesions in 82 patients were included.FDG-PET showed positive uptake in 29(35.4%)lesions.Univariate analysis showed that uptake of FDG-PET had significant correlations with circumferential extension(P=0.014),pathological depth of tumor invasion(P<0.001),infiltrative growth pattern(P<0.001),histological grade(P=0.002),vascular invasion(P=0.001),and lymphatic invasion(P<0.001).On multivariate analysis,only depth of tumor invasion was independently correlated with FDG-PET/computed tomography visibility(P=0.018).The sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy of Type B2 in ME-NBI for the invasion depth of T1a muscularis mucosae and T1b upper submucosal layer were 68.4%/79.4%/50.0%/89.3%/76.8%,respectively,and those of Type B3 for the depth of T1b middle and deeper submucosal layers(SM2 and SM3)were 46.7%/100%/100%/89.3%/90.2%,respectively.On the other hand,those of FDGPET for SM2 and SM3 were 93.3%/77.6%/48.2%/98.1%/80.5%,respectively,whereas,if the combination of positive FDG uptake and type B2 and B3 was defined as an indicator for radical esophagectomy or definitive chemoradiotherapy,the sensitivity,specificity,PPV,NPV,and accuracy were 78.3%/91.5%/78.3%/91.5%/87.8%,respectively.CONCLUSION FDG uptake was correlated with the invasion depth of superficial ESCC.Combined use of FDG-PET and ME-NBI,especially with the microvascular findings of Type B2 and B3,is useful to determine whether ER is indicated for the lesion. | Kazuhiro Toriyama Masahiro Tajika Tsutomu Tanaka Makoto Ishihara Yutaka Hirayama Sachiyo Onishi Nobumasa Mizuno Takamichi Kuwahara Nozomi Okuno Shinpei Matsumoto Eiichi Sasaki Tetsuya Abe Yasushi Yatabe Kazuo Hara Keitaro Matsuo Tsuneo Tamaki Yasumasa Niwa | 2019 | World Journal of Gastroenterology2019，25，46： | 7 |
| 5 | Pneumatosis cystoides intestinalis associated with massive free air mimicking perforated diffuse peritonitis显示文摘当时积气 cystoides 肠(一种总线标准) 一个稀罕疾病实体与许多胃肠、非胃肠的混乱,与巨大的内联系的一种总线标准和制动火箭腹被联系释放空气是极其不平常的,并且是困难的从穿孔腹膜炎诊断差别。我们在场一种总线标准的二个盒子把免费空气或模仿了穿孔腹膜炎的制动火箭腹空气与巨大的腹联系了。这些盒子强调模仿穿孔腹膜炎的一种总线标准的临床的重要性,它要求紧急情况外科。外科手术前的成像形式和诊断腹腔镜检查是有用的做精确诊断。 | Yoichi Sakurai Masahiro Hikichi Jun Isogaki Shinpei Furuta Risaburo Sunagawa Kazuki Inaba Yoshiyuki Komori Ichiro Uyama | 2008 | World Journal of Gastroenterology2008，14，43： | 6 |
| 6 | Detection of fusion gene in cell-free DNA of a gastric synovial sarcoma显示文摘Synovial sarcoma(SS) is genetically characterized by chromosomal translocation, which generates SYT-SSX fusion transcripts. Although SS can occur in any body part, primary gastric SS is substantially rare. Here we describe a detection of the fusion gene sequence of gastric SS in plasma cell-free DNA(cf DNA). A gastric submucosal tumor was detected in the stomach of a 27-year-old woman and diagnosed as SS. Candidate intronic primers were designed to detect the intronic fusion breakpoint and this fusion sequence was confirmed in intron 10 of SYT and intron 5 of SSX2 by genomic polymerase chain reaction(PCR) and direct sequencing. A locked nucleic acid(LNA) probe specificto the fusion sequence was designed for detecting the fusion sequence in plasma and the fusion sequence was detected in preoperative plasma cfD NA, while not detected in postoperative plasma cfD NA. This technique will be useful for monitoring translocation-derived diseases such as SS. | Shinpei Ogino Hirotaka Konishi Daisuke Ichikawa Junichi Hamada Katsutoshi Shoda Tomohiro Arita Shuhei Komatsu Atsushi Shiozaki Kazuma Okamoto Sanae Yamazaki Satoru Yasukawa Eiichi Konishi Eigo Otsuji | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 7 | Use of Samples From Endoscopic Ultrasound–Guided 19-Gauge Fine-Needle Aspiration in Diagnosis of Autoimmune Pancreatitis显示文摘 | Takuji Iwashita Ichiro Yasuda Shinpei Doi Nobuhiro Ando Masanori Nakashima Seiji Adachi Yoshinobu Hirose Tsuyoshi Mukai Keisuke Iwata Eiichi Tomita Takao Itoi Hisataka Moriwaki | 2012 | Clinical Gastroenterology and Hepatology2012，，3： | 2 |
| 8 | Overexpression of cyclin dependent kinase inhibitor P27/Kip1 increases oligodendrocyte differentiation from induced pluripotent stem cells显示文摘 | Shinpei Tamaki Yasuhito Tokumoto | 2014 | In Vitro Cellular & Developmental Biology - Animal2014，，8： | 2 |
| 9 | Comparison of long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation: a propensity score-based cohort analysis显示文摘 | Shinpei Doi Ichiro Yasuda Tsuyoshi Mukai Takuji Iwashita Shinya Uemura Takahiro Yamauchi Masanori Nakashima Seiji Adachi Masahito Shimizu Eiichi Tomita Takao Itoi Hisataka Moriwaki | 2013 | Journal of Gastroenterology2013，，9： | 2 |
| 10 | Metallic stents are more efficacious than plastic stents in unresectable malignant hilar biliary strictures: a randomized controlled trial显示文摘 | Tsuyoshi Mukai Ichiro Yasuda Masanori Nakashima Shinpei Doi Takuji Iwashita Keisuke Iwata Tomohiro Kato Eiichi Tomita Hisataka Moriwaki | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，2： | 2 |
| 11 | Treatment strategy for hepatocellular carcinoma: expanding the indications for radiofrequency ablation显示文摘 | Ryosuke Tateishi Shuichiro Shiina Takamasa Ohki Takahisa Sato Ryota Masuzaki Jun Imamura Eriko Goto Tadashi Goto Hideo Yoshida Shuntaro Obi Shinpei Sato Fumihiko Kanai Haruhiko Yoshida Masao Omata | 2009 | Journal of Gastroenterology2009，，19： | 1 |
| 12 | Unprecedented intraspecific diversity of the MHC class I region of a teleost medaka, Oryzias latipes显示文摘 | Kentaro T Shinpei H Megumi Y | 2005 | Immunogenetics2005，57，： | 1 |
| 13 | Genotyping of benz- imidazole-resistant and dicarboximide-resistant mutations in Botrytis cinerea using real-time polymerase chain reaction as- says 显示文摘 | Shinpei B Fumiyasu F Akihiko I | 2008 | Phytopathology2008，98，： | 1 |
| 14 | Application of diamond films from CO-H2 plasma to tool blade coating显示文摘 | Yukio Saito Kouji Sato Shinpei Matuda Hideomi Koinuma | 1991 | Journal of Materials Science1991，，11： | 1 |
| 15 | Synthetic Use of Molecular Iodine for Organic Synthesis显示文摘 | Hideo Togo Shinpei Iida | 2006 | Synlett2006，，14： | 1 |
| 16 | Nanog expression in mouse germ cell development显示文摘 | Shinpei Yamaguchi Hironobu Kimura Masako Tada Norio Nakatsuji Takashi Tada | 2005 | Gene Expression Patterns2005，，5： | 1 |
| 17 | A new visualization technique for the study of the accumulation of photoassimilates in wheat grains using CO2 显示文摘 | Shinpei Matsuhashi Shu Fujimaki Hiroshi Uchida | 2006 | Ap plied Radiation and Isotopes2006，64，： | 1 |
| 18 | Direct Oxidative Conversion of Alcohols and Amines to Nitriles with Molecular Iodine and DIH in aq NH3 显示文摘 | Shinpei L Togo H | 2007 | Tetrahedron2007，63，34： | 1 |
| 19 | Studies of adsorption for heavy metal ions and gradation of methyl orange based on the surface of ion-imprinted adsorbent显示文摘 | TATSUO K K SHINPEI H NORIAKI S | 2007 | Process Biochemistry2007，42，3： | 1 |
| 20 | Endoscopic Ultrasound-Guided Antegrade Treatments for Biliary Disorders in Patients with Surgically Altered Anatomy显示文摘 | Takuji Iwashita Ichiro Yasuda Shinpei Doi Shinya Uemura Masatoshi Mabuchi Mitsuru Okuno Tsuyoshi Mukai Takao Itoi Hisataka Moriwaki | 2013 | Digestive Diseases and Sciences2013，，8： | 1 |
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