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| 1 | Cancer risk in IBD: How to diagnose and how to manage DALM and ALM显示文摘The risk of developing neoplasia leading to colorectal cancer is significantly increased in ulcerative colitis (UC) and most likely in Crohn's disease. Several endoscopic surveillance strategies have been implemented to identify these lesions. The main issue is that colitisassociated neoplasms often occurs in flat mucosa, often being detected on taking random biopsies rather than by identification of these lesions via endoscopic imaging. The standard diagnostic procedure in long lasting UC is to take four biopsies every 10 cm. Image enhancement methods, such as chromoendoscopy and virtual histology using endomicroscopy, have greatly im- proved neoplasia detection rates and may contribute toreduced random biopsies by taking targeted 'smart' biopsies. Chromoendoscopy may effectively be performed by experienced endoscopists for routine screening of UC patients. By contrast, endomicroscopy is often only available in selected specialized endoscopic centers. Importantly, advanced endoscopic imaging has the poten- tial to increase the detection rate of neoplasia whereas the interplay between endoscopic experience and interpretation of histological biopsy evaluation allows the physician to make a proper diagnosis and to find the appropriate therapeutic approach. Colitis-associated intraepithelial neoplasms may occur in flat mucosa of endoscopically normal appearance or may arise as dysplasia-associated lesion or mass (DALM), which may be indistinguishable from sporadic adenomas in healthy or non-colitis mucosa [adenoma-like mass (ALM)]. The aim of this review was to summarize endoscopic and histological characteristics of DALM and ALM in the context of therapeutic procedures. | Helmut Neumann Michael Vieth Cord Langner Markus F Neurath Jonas Mudter | 2011 | World Journal of Gastroenterology2011，17，27： | 6 |
| 2 | i-Scan染色在消化内镜检查中的应用显示文摘本文通过回顾分析i-Scan染色的原理、与NBI染色对比存在的优势及其在上下消化道疾病的诊断中应用的相关文献,体现i-Scan染色在消化内镜检查中的应用价值,有利于发现微小病灶,大致预测病理诊断,指导靶向活检,在临床工作中值得推广。 | 尚辉辉 宋文先 陈欣 | 2014 | 胃肠病学和肝病学杂志2014，23，8： | 6 |
| 3 | 细胞内镜在炎症性肠病诊治中的应用进展显示文摘炎症性肠病(IBD)是一种与宿主遗传因素、免疫系统失调和环境因素紧密相关的非特异性肠道炎症性疾病,可累及回肠、直肠、结肠等器官,包括溃疡性结肠炎(UC)和克罗恩病(CD)。消化内镜在UC和CD的诊断,以及在对抗炎治疗、黏膜愈合程度、炎性肠病相关癌症的密切监测中发挥着重要作用。与传统的白光内镜检查相比,细胞内镜系统(ECS)能更精确地表征病变,可对活体组织进行类似于显微镜下的观察,确定病变的部位和性质,增加内镜下诊断的准确性,减少诊断步骤,以期能为IBD诊断和临床监测开辟新的途径。本文对ECS在IBD诊治中的应用进展进行总结。 | 尹跃霏 陈亚丽 李赟 金正旭 李小丽 王晓娟 张德奎 | 2018 | 解放军医学杂志2018，43，11： | 5 |
| 4 | Endoscopic imaging:How far are we from real-time histology?显示文摘Currently,in gastrointestinal endoscopy there is increasing interest in high resolution endoscopic technologies that can complement high-definition white light endoscopy by providing real-time subcellular imaging of the epithelial surface.These 'optical biopsy' technologies offer the potential to improve diagnostic accuracy and yield,while facilitating real-time decision-making.Although many endoscopic techniques have preliminarily shown high accuracy rates,these technologies are still evolving.This review will provide an overview of the most promising high-resolution imaging technologies,including high resolution microendoscopy,optical coherence tomography,endocytoscopy and confocal laser endoscopy.This review will also discuss the application and current limitations of these technologies for the early detection of neoplasia in Barrett's esophagus,ulcerative colitis and colorectal cancer. | Richa Shukla Wasif M Abidi Rebecca Richards-Kortum Sharmila Anandasabapathy | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，10： | 3 |
| 5 | 色素内镜在溃疡性结肠炎癌变监测中的应用显示文摘长程溃疡性结肠炎(ulcerative colitis,UC)患者有着较高的癌变风险,规律内镜检查是重要的监测其癌变的手段。传统的方法是白光内镜下随机取活检,而色素内镜可以明显提高癌变检出率。本文就色素内镜在UC癌变监测中的应用作一概述。 | 万健 吴开春 | 2018 | 胃肠病学和肝病学杂志2018，27，12： | 2 |
| 6 | 内窥镜检查在克罗恩病诊治中的应用及克罗恩病活动性分级显示文摘随着内窥镜检查技术的进步,诸如色素内镜、窄带成像内镜、细胞内窥镜、聚焦放大内镜、蓝激光放大内镜等多种内窥镜成像系统通过对黏膜、血管等增强显示及对图像的处理,在评估克罗恩病炎症活动性方面相较于传统白光检查表现出不同优势。目前可应用不同的评分系统评估克罗恩病的临床活动性、内镜下活动性及组织学活动性,其中以克罗恩病活动指数(CDAI)用于克罗恩病临床活动性的判断较常见,主要依据患者1周内出现水样或稀便次数、腹痛、腹部包块等的天数,乘以相应的倍增因子,得到疾病活动指数总评分,评分越高,病情严重程度越高。将克罗恩病内镜严重层程度指数(CDEIS)及克罗恩病简单内镜评分(SES-CD)用于克罗恩病内镜下活动性的判断,结肠镜所能观察到的病变分为五个部分:直肠、乙状结肠、左半结肠、横结肠、回肠及右半结肠,根据内镜检查时所观察到的黏膜、血管病变进行评分,分值越高,病情越严重。在结肠镜检查期间,根据内窥镜医师对肠道黏膜病变的评估,在可疑病变黏膜区域钳取活检标本,送病理检查,有经验的病理医师对标本进行处理分析,评估疾病的组织学活动性。临床活动性、内镜下活动性、组织学活动性是评估克罗恩病疾病活动性的三大重要因素,随着内窥镜技术及设备不断发展,使达到镜下评估的疾病活动性与组织学活动性保持一致成为可能。 | 刘鸣 刘香 王子烨 陈婷婷 | 2022 | 现代医学与健康研究电子杂志2022，6，23： | 1 |
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