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| 1 | 基于2002-2018年MODIS数据的黄海叶绿素a时空变化研究显示文摘浮游植物作为食物链的基础,对海洋生态系统具有重要影响。黄海作为我国重要的渔场,渔业资源面临枯竭的危险,因此对该区浮游植物进行研究具有重要意义。叶绿素a浓度是反映浮游植物生物量的重要指标。利用谷歌地球引擎平台对2002-2018年的MODIS Aqua叶绿素a浓度数据进行处理,并研究其时空分布与变化特征,然后结合区域气候、水文与地理特征以及海洋表面温度、风速、盐度、光合有效辐射和混合层厚度数据分析了其分布与变化的原因。研究发现:受陆源营养物质输入、近岸上升流以及黄海中央冷水团影响,叶绿素a浓度分布呈现由近岸向黄海中部递减特征;在季风、气候、水文的控制下,受风速、海洋表面温度、光合有效辐射、中央冷水团的影响,叶绿素a浓度的最大值出现在4月份,而最小值出现在6、7月份;受苏北沿岸海域海水污染和水体富营养化影响,沿岸海域盐度明显增加,海州湾叶绿素a浓度增速较大;影响黄海叶绿素a浓度变化的环境因子较复杂,除了部分月份存在显著的相关影响因子外,在全年和各季中不存在主导影响因子。 | 田洪阵 刘沁萍 Joaquim I.Goes Helga do Rosario Gomes 杨萌萌 | 2020 | 海洋通报2020，39，1： | 11 |
| 2 | Cholangiocarcinoma and malignant bile duct obstruction: A review of last decades advances in therapeutic endoscopy显示文摘In the last decades many advances have been achieved in endoscopy, in the diagnosis and therapy of cholangiocarcinoma, however blood test, magnetic resonance imaging, computed tomography scan may fail to detect neoplastic disease at early stage, thus the diagnosis of cholangiocarcinoma is achieved usually at unresectable stage. In the last decades the role of endoscopy has moved from a diagnostic role to an invaluable therapeutic tool for patients affected by malignant bile duct obstruction. One of the major issues for cholangiocarcinoma is bile ducts occlusion, leading to jaundice, cholangitis and hepatic failure. Currently, endoscopy has a key role in the work up of cholangiocarcinoma, both in patients amenable to surgical intervention as well as in those unfit for surgery or not amenable to immediate surgical curative resection owing to locally advanced or advanced disease, with palliative intention. Endoscopy allows successful biliary drainage and stenting in more than 90% of patients with malignant bile duct obstruction, and allows rapid reduction of jaundice decreasing the risk of biliary sepsis. When biliary drainage and stenting cannot be achieved with endoscopy alone, endoscopic ultrasound-guided biliary drainage represents an effective alternative method affording successful biliary drainage in more than 80% of cases. The purpose of this review is to focus on the currently available endoscopic management options in patients with cholangiocarcinoma. | Helga Bertani Marzio Frazzoni Santi Mangiafico Angelo Caruso Mauro Manno Vincenzo Giorgio Mirante Flavia Pigò Carmelo Barbera Raffaele Manta Rita Conigliaro | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 8 |
| 3 | 近20年渤海叶绿素a浓度时空变化显示文摘浮游植物作为食物链的基础,对海洋生态系统具有重要作用。渤海作为我国最大的内海和重要渔业生物的产卵场、育幼场和索饵场,该区浮游植物研究具有重要意义。叶绿素a浓度是反映浮游植物生物量的重要指标。利用Google Earth Engine平台,对1997–2010年的宽视场海洋观测传感器(SeaWiFS)叶绿素a浓度数据和2002–2018年的水色卫星中分辨率成像光谱仪传感器(MODISAqua)叶绿素a浓度数据进行合并,并研究其时空变化特征。研究表明,近20年来,渤海全年叶绿素a浓度增加了14.1%,且增加显著。叶绿素a浓度在所有季节都呈现增加趋势;除11月外,其他各月都呈现稳定或增加趋势。从滦河入河口沿岸至渤海海峡的渤海中部,叶绿素a浓度增加较明显。同时也分析了海洋表面温度、风速和降水量数据。夏季渤海周边区域降水量和风速增加以及秋季海表温度的降低都有助于同季叶绿素a浓度的升高。渤海浮游植物可能受陆源营养物质输入影响较大。 | 田洪阵 刘沁萍 Joaquim I.Goes Helga do Rosario Gomes 杨萌萌 | 2019 | 海洋学报2019，41，8： | 8 |
| 4 | 单个汽球 enteroscopy : 技术方面和临床的应用显示文摘 The small bowel has long been considered a black box for endoscopists because of its long length and the presence of multiple complex loop. Most of the small bowel is inaccessible by traditional endoscopic means. In addition, radiographic studies have significant limitations with regard to diagnostic yield, and surgery is an invasive alternative. This limitation was overcome through the development of balloon enteroscopy that becomes established throughout the world for diagnostic and therapeutic examinations of the small bowel. The single-balloon enteroscope (SBE) system (Olympus, Tokyo, Japan) was introduced into the commercial market in 2007. Several study demonstrated its efficacy and safety. Early reports on the use of singleballoon enteroscopy have suggested a high diagnostic yield and similar therapeutic potential to that of the double-balloon endoscope. SBE is viable technique for in the management of small bowel disease. Technically, it is easy to perform, may be efficient, and in the literature data available, seems to provide high diagnostic and therapeutic yield. | Mauro Manno Carmelo Barbera Helga Bertani Raffaele Manta Vincenzo Giorgio Mirante Emanuele Dabizzi Angelo Caruso Flavia Pigo Giampiero Olivetti Rita Conigliaro | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，2： | 8 |
| 5 | Linear endoscopic ultrasonography vs magnetic resonance imaging in ampullary tumors显示文摘AIM:To assess linear endoscopic ultrasound (L-EUS) and magnetic resonance imaging (MRI) in biliary tract dilation and suspect small ampullary tumor.METHODS:L-EUS and MRI data were compared in 24 patients with small ampullary tumors;all with subsequent histological confirmation.Data were collected prospectively and the accuracy of detection,histological characterization and N staging were assessed retrospectivelyusing the results of surgical or endoscopic treatment as a benchmark.RESULTS:A suspicion of ampullary tumor was present in 75% of MRI and all L-EUS examinations,with 80% agreement between EUS and histological findings at endoscopy.However,L-EUS and histological TN staging at surgery showed moderate agreement (κ=0.54).CONCLUSION:L-EUS could be a useful adjunct as a diagnostic tool in the evaluation of patients with sus-pected ampullary tumors. | Raffaele Manta Rita Conigliaro Danilo Castellani Alessandro Messerotti Helga Bertani Giuseppe Sabatino Elena Vetruccio Luisa Losi Vincenzo Villanacci Gabrio Bassotti | 2010 | World Journal of Gastroenterology2010，16，44： | 6 |
| 6 | 全球罗非鱼的生产与消费显示文摘全球罗非鱼的生产概况
全球罗非鱼的产量在最近十年呈爆发性地增长。1990年全球罗非鱼产量为83万吨,1999年增加到160万吨,2008年增加至350万吨。2005年, | 郝向举 Helga Josupeit | 2012 | 中国水产2012，，3： | 4 |
| 7 | A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V显示文摘 | István Vermes Clemens Haanen Helga Steffens-Nakken Chris Reutellingsperger | 1995 | Journal of Immunological Methods1995，，1： | 4 |
| 8 | Needle-based confocal endomicroscopy in the discrimination of mucinous from non-mucinous pancreatic cystic lesions显示文摘BACKGROUND Pancreatic cystic lesions(PCLs)are considered a precursor of pancreatic cancer.Needle-based confocal endomicroscopy(nCLE)is an imaging technique that enables visualization of the mucosal layer to a micron resolution.Its application has demonstrated promising results in the distinction of PCLs.This study evaluated the utility of nCLE in patients with indeterminate PCLs undergoing endoscopic ultrasound fine-needle aspiration(EUS-FNA)to distinguish mucinous from non-mucinous lesions.AIM To evaluate the accuracy of nCLE in indeterminate PCLs undergoing EUS-FNA to distinguish mucinous from non-mucinous lesions.METHODS Patients who required EUS-FNA between 2015 and 2017 were enrolled prospectively.During EUS-FNA,confocal imaging,analyses of the tumor markers carcinoembryonic antigen and amylase,and cytologic examination were conducted.All patients were followed for at least 12 mo and underwent laboratory testing and computed tomography scanning or magnetic resonance imaging.nCLE videos were independently reviewed by 6 observers to reach a final diagnosis(mucinous vs non-mucinous)based on criteria derived from previous studies;if there was disagreement>20%,a final diagnosis was discussed after consensus re-evaluation.The sensitivity,specificity,and accuracy of nCLE were calculated.Adverse events were recorded.RESULTS Fifty-nine patients were included in this study.Final diagnoses were derived from surgery in 10 patients,cytology in 13,and imaging and multidisciplinary team review in 36.Three patients were excluded from final diagnosis due to problems with nCLE acquisition.Fifty-six patients were included in the final analysis.The sensitivity,specificity,and accuracy of nCLE were 80%[95%confidence interval(CI):65-90],100%(95%CI:72-100),and 84%(95%CI:72-93),respectively.Postprocedure acute pancreatitis occurred in 5%.CONCLUSION EUS-nCLE performs better than standard EUS-FNA for the diagnosis of indeterminate PCL. | Helga Bertani Raffaele Pezzilli Flavia Pigo Mauro Bruno Claudio De Angelis Guido Manfredi Gabriele Delconte Rita Conigliaro Elisabetta Buscarini | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，11： | 4 |
| 9 | Plasma Total Cysteine as a Risk Factor for Vascular Disease: The European Concerted Action Project显示文摘 | Lina El-Khairy Per M. Ueland Helga Refsum Ian M. Graham Stein E. Vollset | 2001 | Circulation: Journal of the American Heart Association2001，，21： | 2 |
| 10 | Imaging-based diagnosis of acute renal allograft rejection显示文摘Kidney transplantation is the best available treatment for patients with end stage renal disease. Despite the introduction of effective immunosuppressant drugs, episodes of acute allograft rejection still endanger graft survival. Since efficient treatment of acute rejection is available, rapid diagnosis of this reversible graft injury is essential. For diagnosis of rejection, invasive core needle biopsy of the graft is the 'gold-standard'. However, biopsy carries the risk of significant graft injury and is not immediately feasible in patients taking anticoagulants. Therefore, a non-invasive tool assessing the whole organ for specific and fast detection of acute allograft rejection is desirable. We herein review current imaging-based state of the art approaches for non-invasive diagnostics of acute renal transplant rejection. We especially focus on new positron emission tomography-based as well as targeted ultrasoundbased methods. | Gerold Th?lking Katharina Schuette-Nuetgen Dominik Kentrup Helga Pawelski Stefan Reuter | 2016 | World Journal of Transplantation2016，6，1： | 2 |
| 11 | A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V显示文摘 | István Vermes Clemens Haanen Helga Steffens-Nakken Chris Reutellingsperger | 1995 | Journal of Immunological Methods1995，，1： | 2 |
| 12 | Growth Differentiation Factor-15 as Biomarker in Uterine Sarcomas显示文摘 | Jone Trovik Helga Birgitte Salvesen Tine Cuppens Frederic Amant Anne Cathrine Staff | 2014 | International Journal of Gynecological Cancer2014，，2： | 2 |
| 13 | 生态农业和有机农业的创新显示文摘现代农业系统在明显提高产量、保证粮食安全的同时,也对人类健康和地球的可持续性产生了影响。在持续不断的严重环境破坏和自然资源毁坏的背景下,建立可持续的农业生产方式至关重要。生态农业和有机农业是减少生态可持续性和生产力及社会可持续之间权衡关系的重要方法。这两种农业方法都属生态集约化范畴,均具有减少环境污染的巨大潜力;然而,生态农业和有机农业常导致产量降低。虽然产量降低带来的损失可以通过改变人们的饮食习惯来弥补(如减少食物浪费、减少食用精饲料喂养的肉类),但是,由于全球的发展趋势与之相反,因此本文探讨了通过科学研究寻求新的解决方案前景来提高低投入农业系统作物产量的可能性。为权衡生产力与可持续发展的关系,使生态农业和有机农业有助于粮食安全,我们对未来研究提出5点建议:1)农场和田地的景观设计与复合种植模式、2)数字化技术的应用、3)以农田低投入为目标的作物育种、4)农业废弃物的高质量循环利用和5)非化学作物保护。 | Urs Niggli Qiyan Wang-Muller Helga Willer Jacques Fuchs | 2021 | 中国生态农业学报(中英文)2021，29，3： | 2 |
| 14 | 鸟类交通致死原因的种间行为差异分析(英文)显示文摘鸟类和其他动物经常死于车撞, 每年因车撞而死亡的个体可达数百万只。为什么有的物种比其他物种更易于死于车撞的问题,迄今未研究过。该文推测物种本身所具有的冒险行为可能是这些物种的某些个体更常死于车撞的一个原因。此外,不同物种个体在公路上的行为、个体数量、栖息地偏好、繁殖社会性以及健康状况都可能是影响个体车撞风险的潜在因素。2001—2006 年,对丹麦一个农村地区进行定期统计取样, 得到该地区不同种鸟类个体被车撞死事件发生的频率,以及周边环境中 50 种鸟类的个体数量数据, 并利用这些数据来检验我们的预测。车撞频率随鸟类个体数量线性增加和位于道路上或者低空飞越道路的个体所占比例增加,这两个因素几乎无法解释鸟类车撞频率差异。在考虑到丰富度这个因素后,发现那些鸟类惊飞距离短、面对潜在危险而更具有冒险性的物种个体更易遭遇车撞而亡。另外, 独居的物种、疟原虫感染率高的物种及因体型大而拥有大法氏囊的物种个体死于车撞的频率更高。这些发现表明, 一系列反映冒险行为、视敏度和健康状况的因子导致某些鸟类物种易受到车撞影响。 | Anders Pape Mller Helga Erritze Johannes Erritze | 2011 | Zoological Research2011，32，2： | 2 |
| 15 | 熔融静电纺聚丙烯纤维的亲水改性显示文摘为对静电纺聚丙烯纤维进行亲水改性,采用表面活性剂吐温20,通过熔融微螺杆挤出机对等规聚丙烯进行熔融共混亲水改性,并通过静电纺丝的方法制备了聚丙烯纤维。通过傅里叶变换红外光谱分析、X射线光电子能谱分析和静态接触角测试对表面活性剂改性聚丙烯纤维的表面化学性质进行了表征,并使用差示扫描量热法对静电纺聚丙烯纤维进行了热力学性能测试。红外图谱显示表面活性剂吐温20已与聚丙烯共混成功,且改性后的聚丙烯纤维在表面活性剂吐温20添加量达到3%之后,静态水接触角明显降低,添加量达到5%时,接触角瞬间为零,展现出极好的吸湿性。X射线光电子能谱分析结果表明,表面活性剂吐温20富集在聚丙烯纤维的表面。 | 梁超 胡春艳 阎克路 朱晓敏 THOMAS Helga | 2016 | 纺织学报2016，37，10： | 2 |
| 16 | Loss of nucleal p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis显示文摘 | Helga B Salvesen Soma Das | 2000 | Clin Cancer Res2000，6，1： | 1 |
| 17 | Staining of different tissues in thick epoxy resin- impregnated sections of human fetuses 显示文摘 | Helga F | 1989 | Stain Technology1989，64，2： | 1 |
| 18 | Single impact trauma in human early-stage osteoarthritic cartilage:Implication of prostaglandin D2 but no additive effect of IL-1β on cell survival显示文摘 | Helga Joos Cathrin Hogrefe Lucia Rieger Lutz Dürselen Anita Ignatius Rolf Brenner | 2011 | International Journal of Molecular Medicine2011，，： | 1 |
| 19 | Total homocysteine in plasma or serum: methods and clinical implications 显示文摘 | Per MU Helga R Sally P S | 1993 | Clin Chem1993，39，： | 1 |
| 20 | Statistics and future perspectives 显示文摘 | Minou Yussfi Helga Willer | 2003 | The World of Organic Agricultur2003，，4： | 1 |
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