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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | The bHLH Transcription Factor MYC3 Interacts with the Jasmonate ZIM-Domain Proteins to Mediate Jasmonate Response in Arabidopsis显示文摘Arabidopsis Jasmonate ZIM 域蛋白质(JAZ ) 充当复杂的 SCFCOI1 的底层镇压他们的下游地指向,它为调整 JA 的植物开发和防卫是必要的。bHLH 抄写因素 MYC2 被发现 JA 回答包括与 JAZ 交往并且调停 JA 禁止的根生长。这里,我们识别了直接由它的 N 终端区域的优点与 JAZ 交往了调整 JA 回答的另一 bHLH 抄写因素 MYC3。有 MYC3 的 overexpression 的转基因的植物在 JA 禁止的根延伸和幼苗开发展出了超敏性。交往 JAZ 模式和 MYC3 的导致 JA 的表示模式从 MYC2 的那些是可区分的。我们推测那 MYC3, MYC2 可以在 JA 回答的规定有冗余而且可区分的功能。 | Zhiwei Cheng Li Sun Tiancong Qi Bosen Zhang Wen Peng Yule Liu Daoxin Xie | 2011 | Molecular Plant2011，4，2： | 35 |
| 3 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 4 | Klf7 modulates the differentiation and proliferation of chicken preadipocyte显示文摘Kr? | Zhiwei Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，4： | 34 |
| 5 | Large-scale atmospheric singularities and summer long-cycle droughts-floods abrupt alternation in the middle and lower reaches of the Yangtze River显示文摘The daily precipitation data at 720 sta- tions over China for the 1957―2003 period during summer (May―August) are used to investigate the summer subseasonal long-cycle droughts-floods abrupt alternation (LDFA) phenomenon and a long-cycle droughts-floods abrupt alternation index (LDFAI) in the middle and lower reaches of the Yangtze River (MLYRV) is defined to quantify this phenomenon. The large-scale atmospheric circula- tion features in the anomalous LDFA years are ex- amined statistically. Results demonstrate that the summer droughts-to-floods (DTF) in the MLYRV usually accompany with the more southward western Pacific subtropical high (WPSH), negative vorticity, strong divergence, descending movements develop- ing and the weak moisture transport in the low level, the more southward position of the South Asia high (SAH) and the westerly jets in the high level during May―June, but during July―August it is in the other way, northward shift of the WPSH, positive vorticity, strong convergence, ascending movements and strong moisture transport in the low level, and the northward shift of the SAH and the westerly jets in the high level. While for the summer floods-to-droughts (FTD) in the MLYRV it often goes with the active coldair mass from the high latitude, positive vorticity, strong convergence, ascending movement develop- ing and the strong moisture transport in the low level, and the SAH over the Tibetan Plateau in the high level, but during July―August it is often connected with the negative vorticity, strong divergence, de- scending movements developing and the weak moisture transport in the low level, the remarkable northward shift of the WPSH, the SAH extending northeastward to North China and the easterly jets prevailing in the high level over the MLYRV. In addi- tion, the summer LDFA in the MLYRV is of significant relationship with the Southern Hemisphere annual mode and the Northern Hemisphere annual mode in the preceding February, which offers some predictive signals for the summer LDFA forecasting in the MLYRV. | WU Zhiwei LI Jianping HE Jinhai JIANG Zhihong | 2006 | Chinese Science Bulletin2006，51，16： | 30 |
| 6 | Preoperative neutrophil-to-lymphocyte ratio plus platelet-to-lymphocyte ratioin predicting survival for patients with stage Ⅰ-Ⅱgastric cancer显示文摘Background:The preoperative neutrophil-to-lymphocyte ratio(NLR) and the platelet-to-lymphocyte ratio(PLR) are associated with poor prognosis of gastric cancer.We aimed to determine whether the combination of NLR and PLR(NLR-PLR) could better predict survival of patients after curative resection for stage Ⅰ-Ⅱ gastric cancer.Methods:We collected data from the medical records of patients with stage Ⅰ-Ⅱ gastric cancer undergoing curative resection between December 2000 and November 2012 at the Sun Yat-sen Cancer Center.The preoperative NLRPLR was calculated as follows:patients with both elevated NLR(≥2.1) and PLR(≥ 120) were given a score of 2,and patients with only one or neither were given a score of 1 or 0,respectively.Results:Kaplan-Meier analysis and log-rank tests revealed significant differences in overall survival(OS) among patients with NLR-PLR scores of 0,1 and 2(P < 0.001).Multivariate analysis showed that OS was independently associated with the NLR-PLR score[hazard ratio(HR) = 1.51,95%confidence interval(CI) 1.02-2.24,P = 0.039]and TNM stage(HR = 1.36,95%CI 1.01-1.83,P= 0.041).However,other systemic inflammation-based prognostic scores,including the modified Glasgow prognostic score,the prognostic nutritional index,and the combination of platelet count and NLR,were not.In TNM stage-stratified analysis,the prognostic significance of NLR-PLR was maintained in patients with stage Ⅰ(P < 0.001) and stage Ⅱ cancers(P= 0.022).In addition,the area under the receiver operating characteristic curve for the NLR-PLR score was higher than those of other systemic inflammation-based prognostic scores(P = 0.001).Conclusion:The preoperative NLR-PLR score is a useful predictor of postoperative survival in the patients with stage l-ll gastric cancer and may help identify high-risk patients for rational therapy and timely follow-up. | Xiaowei Sun Xuechao Liu Jianjun Liu Shangxiang Chen Dazhi Xu Wei Li Youqing Zhan Yuanfang Li Yingbo Chen Zhiwei Zhou | 2016 | Chinese Journal of Cancer2016，35，7： | 25 |
| 7 | Study on the flow field and concentration characteristics of the multiple tandem jets in crossflow显示文摘The characteristics of single and multiple tandem jets(n=2,3,4) in crossflow have been investigated using the realizable k-ε model.The results of this model agree well with experimental measurements using PIV(Particle Image Velocimetry) or LIF(Laser Induced Fluorescence).We analyzed the calculated results and obtained detailed properties of velocity and concentration of the multiple jets in the pre-merging and post-merging regions.When the velocity ratio is identical,the bending degree of the leading jet is greater than that of the rear jets.The last jet penetrates deeper as the jet number increases,and the shielding effect of the front jet declines with jet spacing increase.Interaction of the jet and crossflow induces formation and development of a counter-rotating vortex pair(CVP).CVP makes the distribution of concentration appear kidney-shaped(except in the merging region),and maximum concentration is at the center of the counter-rotating vortex.Concentration at the CVP center is 1.03-1.4 times that of the local jet trajectory.Post-merging velocity and concentration characteristics differ from those of the single jet because of the shielding effect and mixing of all jets.This paper presents a unified formula of trajectory,concentration half-width and trajectory dilution,by introducing a reduction factor. | LI ZhiWei HUAI WenXin QIAN ZhongDong | 2012 | Science China(Technological Sciences)2012，55，10： | 22 |
| 8 | Clinicopathologic characteristics and prognosis of gastroenteropancreatic neuroendocrine neoplasms: a multicenter study in South China显示文摘Background: Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs) are a heterogeneous group of rare tumors. Many issues in terms of epidemiologic features, pathogenesis, and treatment of GEP-NENs are still under discussion. Our study aimed to analyze the clinicopathologic characteristics and prognosis of Chinese patients with GEP-NENs.Methods: Complete clinicopathologic data and survival information of 1183 patients with GEP-NENs treated between 2005 and 2015 were collected from five medical centers in Guangdong Province, China. Patient survival was estimated using the Kaplan–Meier method and analyzed using the log-rank test; prognostic factors were analyzed using the Cox proportional hazards model.Results: The most common tumor location was the rectum(37.4%), followed by the pancreas(28.1%), stomach(20.7%), small intestine(7.2%), appendix(3.4%), and colon(3.3%). After initial definitive diagnosis, 1016(85.9%) patients underwent surgery. The 1-, 3-, and 5-year overall survival(OS) rates for the entire cohort were 87.9%, 78.5%, and 72.8%, respectively. The 3-year OS rates of patients with G1, G2, and G3 tumors were 93.1%, 82.7%, and 43.1%, respectively(P < 0.001). The 3-year OS rates of patients with stage I, II, III, and IV tumors were 96.0%, 87.3%, 64.0%, and 46.8%, respectively(P < 0.001). Patients with distant metastasis who underwent palliative surgery had a longer survival than those who did not(P = 0.003). Similar survival benefits of palliative surgery were observed in patients with neuroendocrine tumor(P y, M category, and sur= 0.031) or neuroendocrine carcinoma(P gery were found to be independent prog= 0.046). In multivariate analysis, age, grade, N categornostic factors.Conclusions: Patients with GEP-NENs who are women, younger than 50 years old, have smaller tumor size, have lower tumor grade, have lower T/N/M category, and who undergo surgery can have potentially longer survival time. Our data showed that surgery can improve the prognosis of GEP-NEN patients with distant metastasis. However, randomized controlled trials need to be conducted to establish the optimal criteria for selecting patients to undergo surgery. | Cheng Fang Wei Wang Yu Zhang Xingyu Feng Jian Sun Yujie Zeng Ye Chen Yong Li Minhu Chen Zhiwei Zhou Jie Chen | 2017 | Chinese Journal of Cancer2017，36，10： | 23 |
| 9 | Dental stem cell and dental tissue regeneration显示文摘The teeth are highly differentiated chewing organs formed by the development of tooth germ tissue located in the jaw and consist of the enamel, dentin, cementum, pulp, and periodontal tissue. Moreover, the teeth have a complicated regulatory mechanism, special histologic origin, diverse structure, and important function in mastication, articulation, and aesthetics. These characteristics, to a certain extent, greatly complicate the research in tooth regeneration. Recently, new ideas for tooth and tissue regeneration have begun to appear with rapid developments in the theories and technologies in tissue engineering. Numerous types of stem cells have been isolated from dental tissue, such as dental pulp stem cells (DPSCs), stem cells isolated from human pulp of exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), stem cells from apical papilla (SCAPs), and dental follicle cells (DFCs). All these cells can regenerate the tissue of tooth. This review outlines the cell types and strategies of stem cell therapy applied in tooth regeneration, in order to provide theoretical basis for clinical treatments. | Qiming Zhai Zhiwei Dong Wei Wang Bei Li Yan Jin | 2019 | Frontiers of Medicine2019，13，2： | 23 |
| 10 | Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle显示文摘在到最糟的最高的注意在航线上吸烟以及薄雾侮辱的全球付钱的时间,所有人知道两个外长、显著。然而,包括许多医药人员,人们主要不知道 gastroesophageal 倒流(GER ) 怎么糟糕在我们的自己的航线上侮辱。GER 的症状通常被看作心痛和流回,它能主要被容忍。不管多么起来在它出现的地方,去的胃的内容相对地传递食管然后远侧的咽象苛评一样的鸟喙,用作一张嘴,以便生产众多微粒子并且到达oro鼻的洞并且另外引起的航线过敏鼻炎和气喘的攻击,甚至肺的实质损害。它将减少生活质量或甚至使受危险生活。内长的侮辱在呼吸系统出现,但是从消化的道发源的点不是众所周知的并且经常 undiagnosed 并且不正确地对待。导致的航线挑战是的 GER 一个可对待、预防的实体一旦诊断被做,好消除能通过 radiofrequency 或 fundoplication 借助于张开的贲门的生活方式调整,药,或固定被期望。作者王忠高博士承受了它为长并且症状在反倒流外科以后消失了 8 年。这是王忠高博士和他的队工作的一个演讲并且将引起注意到公众以便认出作为吸烟或薄雾从人的本身,然而并非从外面的环境发生的一个可对待的条件做的这个相对未知的实体。 | Zhonggao Wang Zhiwei Hu Jimin Wu Feng Ji Hongtao Wang Yungang Lai Xiang Gao Yachan Ning Chengchao Zhang Zhitong Li Weitao Liang Jianjun Liu | 2015 | Frontiers of Medicine2015，9，1： | 21 |
| 11 | Mineralization episode of porphyry copper deposits in the Jinshajiang-Red River mineralization belt: Re-Os dating显示文摘Re-Os isotopic dating for the molybdenites from the porphyry copper deposits of the Jinshajiang-Red River mineralization belt in Yunnan Province yields isochron ages of 33.9±1.1 Ma for the Machangqing deposit and 34.4±0.5 Ma for the Tongchang deposit. This result shows that both the Machangqing and the Tongchang porphyry Cu-Mo deposits from two different ore-fields formed simultaneously. This new data and the published Re-Os model ages of molybdenite (35.4 Ma, 35.9 Ma, 36.2 Ma) of the Yulong porphyry copper deposit in Tibet, which is located in the same Jinshajiang-Red River mineralization belt as the Machangqing deposit and the Tongchang deposit, suggest that these three Cenozoic porphyry copper deposits in the Jinshajiang-Red River mineralization belt were contemporary for their mineralization episode. That is to say, even their present locality is far away and nearly iso-distantly distributed, these three porphyry Cu(Mo) deposits belong to the same mineralization episode at the end of Eocene. | WANG Denghong, QU Wenjun, LI Zhiwei, YIN Hanlong4 & CHEN Yuchuan Institute of Mineral Resources, Chinese Academy of Geological Sciences, Beijing 100037, China National Center of Rock and Mineral Analysis, Chinese Academy of Geological Sciences, Beijing 100037, China Resource Assessment Center of Yunnan, Kunming 650011, China Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China Chinese Academy of Geological Sciences, Beijing 100037, China | 2005 | Science China Earth Sciences2005，48，2： | 21 |
| 12 | Inferring three-dimensional surface displacement field by combining SAR interferometric phase and amplitude information of ascending and descending orbits显示文摘Conventional Interferometric Synthetic Aperture Radar(InSAR) technology can only measure one-dimensional surface displacement(along the radar line-of-sight(LOS) direction).Here we presents a method to infer three-dimensional surface displacement field by combining SAR interferometric phase and amplitude information of ascending and descending orbits.The method is realized in three steps:(1) measuring surface displacements along the LOS directions of both ascending and descending orbits based on interferometric phases;(2) measuring surface displacements along the azimuth directions of both the ascending and descending orbits based on the SAR amplitude data;and(3) estimating the three-dimensional(3D) surface displacement field by combining the above four independent one-dimensional displacements using the method of least squares and Helmert variance component estimation.We apply the method to infer the 3D surface displacement field caused by the 2003 Bam,Iran,earthquake.The results reveal that in the northern part of Bam the ground surface experienced both subsidence and southwestward horizontal movement,while in the southern part uplift and southeastward horizontal movement occurred.The displacement field thus determined matches the location of the fault very well with the maximal displacements reaching 22,40,and 30 cm,respectively in the up,northing and easting directions.Finally,we compare the 3D displacement field with that simulated from the Okada model.The results demonstrate that the method presented here can be used to generate reliable and highly accurate 3D surface displacement fields. | HU Jun LI ZhiWei ZHU JianJun REN XiaoChong DING XiaoLi | 2010 | Science China Earth Sciences2010，53，4： | 21 |
| 13 | Identification of coastal wetlands of international importance for waterbirds:a review of China Coastal Waterbird Surveys 2005–2013显示文摘Background:China's coastal wetlands belong to some of the most threatened ecosystems worldwide.The loss and degradation of these wetlands seriously threaten waterbirds that depend on wetlands.Methods:The China Coastal Waterbird Census was organized by volunteer birdwatchers in China's coastal region.Waterbirds were surveyed synchronously once every month at 14 sites,as well as irregularly at a further 18 sites,between September 2005 and December 2013.Results:A total of 75 species of waterbirds met the 1 % population level Ramsar listing criterion at least once at one site.The number of birds of the following species accounted for over 20 % of the total flyway populations at a single site:Mute Swan(Cygnus olor),Siberia Crane(Grus leucogeranus),Far Eastern Oystercatcher(Haematopus osculans),Bar-tailed Godwit(Limosa lapponica),Spotted Greenshank(Tringa guttifer),Great Knot(Calidris tenuirostris),Spoon-billed Sandpiper(Calidris pygmeus),Saunders' s Gull(Larus saundersi),Relict Gull(Larus relictus),Great Cormorant(Phalacrocorax carbo),Eurasian Spoonbill(Platalea leucorodia),Black-faced Spoonbill(Platalea minor) and Dalmatian Pelican(Pelecanus crispus).A total of 26 sites supported at least one species of which their number met the1 % criterion.Forty-two species met the 1 % criterion in the Yellow River Delta,Shandong;29 at the Cangzhou coast,Hebei and 26 species at the Lianyungang coast,Jiangsu.Conclusions:The results highlight the international importance of China's coastal wetlands for waterbirds.This study also demonstrates that participation of local birdwatchers in waterbird surveys results in data that are invaluable not only for understanding the current status of waterbirds in China's coastal regions but also for waterbird conservation and management. | Qingquan Bai Jianzhong Chen Zhihong Chen Guotai Dong Jiangtian Dong Wenxiao Dong Vivian Wing Kan Fu Yongxiang Han Gang Lu Jing Li Yang Liu Zhi Lin Derong Meng Jonathan Martinez Guanghui Ni Kai Shan Renjie Sun Suixing Tian Fengqin Wang Zhiwei Xu Yat-tung Yu Jin Yang Zhidong Yang Lin Zhang Ming Zhang Xiangwu Zeng | 2015 | Chinese Birds2015，，3： | 20 |
| 14 | Thermal energy storage:Challenges and the role of particle technology显示文摘Thermal energy is at the heart of the whole energy chain providing a main linkage between the primary and secondary energy sources.Thermal energy storage(TES)has a pivotal role to play in the energy chain and hence in future low carbon economy.However,a competitive TES technology requires a number of scientific and technological challenges to be addressed including TES materials,TES components and devices,and integration of TES devices with energy networks and associated dynamic optimization.This paper provides a perspective of TES technology with a focus on TES materials challenges using molten salts based phase change materials for medium and high temperature applications.Two key challenges for the molten salt based TES materials are chemical incompatibility and low thermal conductivity.The use of composite materials provides an avenue to meeting the challenges.Such composite materials consist of a phase change material,a structural supporting material,and a thermal conductivity enhancement material.The properties of the supporting material could determine the dispersion of the thermal conductivity enhancement material in the salt.A right combination of the salt,the structural supporting material,and the thermal conductivity enhancement material could give a hierarchical structure that is able to encapsulate the molten salt and give a substantial enhancement in the thermal conductivity.Understanding of the structure-property relationships for the composite is essential for the formulation design and fabrication of the composite materials.Linking materials properties to the system level performance is recommended as a key future direction of research. | Zhiwei Ge Yongliang Li Dacheng Li Ze Sun Yi Jin Chuanping Liu Chuan Li Guanghui Leng Yulong Ding | 2014 | Particuology2014，12，4： | 20 |
| 15 | Fission-track-age records of the Mesozoic tectonic-events in the southwest margin of the Ordos Basin, China显示文摘Based on the analysis of apatite and zircon fission track (FT), the FT age distribution and the peck-ages of the Mesozoic tectonic events in the southwest margin of the Ordos Basin (OB) were discussed. (1) The early event mainly occurred at 213-194 Ma with a peck-age of 205 Ma, and corresponded to the tectonic uplift and the mega-clastic deposit in the southwest OB during the Late Triassic. (2) The middle event included at least two episodes. One was at 165-141 Ma with a peck-age of 150 Ma, and the other was at 115-113 Ma with a peck-age of 114 Ma, corresponding to the over-thrusting and the mega- clastic deposits in the southwest OB during the Late Jurassic to the Early Cretaceous. (3) The late event mainly demonstrated the regional uplifting and included at least two episodes. One was at 100-81 Ma with a peck-age of 90 Ma, and the other was at 66-59 Ma with a peck-age of 63 Ma. Additionally, the relationship analysis of the tectonic event and the mineralizing chronology revealed that the extreme environment of the peck-age event and the subsequent moderate activity could be the key factors of the multiple resources coupling and coexistence in the OB. | CHEN Gang SUN JianBo ZHOU LiFa ZHANG HuiRuo LI XiangPing WANG ZhiWei | 2007 | Science China Earth Sciences2007，50，z2： | 19 |
| 16 | Bow-tie topological features of metabolic networks and the functional significance显示文摘Exploring the structural topology of genome-based large-scale metabolic network is essential for in- vestigating possible relations between structure and functionality.Visualization would be helpful for obtaining immediate information about structural organization.In this work,metabolic networks of 75 organisms were investigated from a topological point of view.A spread bow-tie model was proposed to give a clear visualization of the bow-tie structure for metabolic networks.The revealed topological pattern helps to design more efficient algorithm specifically for metabolic networks.This coarse- grained graph also visualizes the vulnerable connections in the network,and thus could have important implication for disease studies and drug target identifications.In addition,analysis on the reciprocal links and main cores in the GSC part of bow-tie also reveals that the bow-tie structure of metabolic networks has its own intrinsic and significant features which are significantly different from those of random networks. | ZHAO Jing TAO Lin YU Hong LUO JianHua CAO ZhiWei LI YiXue | 2007 | Chinese Science Bulletin2007，52，8： | 19 |
| 17 | A review of ecological restoration techniques in fluvial rivers显示文摘Rivers play an important role in people's living and agricultural production,however,intense human activities have broken the original ecological balance,and affected structures and functions of the river ecosystem.To restore the damaged river ecosystem back to a healthy status,effective ecological restoration measures need to be implemented.The main problems that the damaged rivers face are either the locally altered hydrological processes affected by construction of hydraulic facilities,or the deterioration of water quality resulted from pollution emissions,or both.In this study,ecological restoration techniques of the rivers affected by engineering control or pollution are reviewed respectively.In addition,three kinds of methods,i.e.physical,chemical and biological-ecological methods are introduced in details for the rivers affected by water pollution.At present,the development of river restoration techniques shows the following trends:1) the scale of ecological restoration is becoming larger;2) ecological restoration measures are required to meet multiple objectives;and 3) the management of water environment is changing from water quality management to aquatic ecosystem management. | Baozhu Pan Jianping Yuan Xinhua Zhang Zhaoyin Wang Jiao Chen Jinyou Lu Wenjun Yang Zhiwei Li Na Zhao Mengzhen Xu | 2016 | International Journal of Sediment Research2016，31，2： | 18 |
| 18 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 19 | Ground settlement of Chek Lap Kok Airport,Hong Kong,detected by satellite synthetic aperture radar interferometry显示文摘Satellite synthetic aperture radar (SAR) inter-ferometry is used to investigate the slowly accumulating ground settlement at the new Chek Lap Kok Airport in Hong Kong. Most of the land occupied by the airport was reclaimed from the sea and therefore certain ground settlement in the area has been expected. A pair of ERS-2 SAR images spanning nearly a year is used in the study. The high spatial resolution (20 m×20 m) ground settlement map derived indicates that the settlement that occurred in the area over the time period is as large as 50 mm. The SAR measurement results agree with the levelling measurements at some benchmarks in the area to well within 1 cm(rms error),and the overall correlation between the two types of results is 0.89. The paper presents some brief background of inter-ferometric SAR, and outlines the data processing methods and results. | LIU Guoxiang DING Xiaoli CHEN Yongqi LI Zhilin LI Zhiwei | 2001 | Chinese Science Bulletin2001，46，21： | 16 |
| 20 | Uppermost mantle structure of the North China Craton: Constraints from interstation Pn travel time difference tomography显示文摘The uppermost mantle is the key area for exchange of heat flux and material convection between the crust and lithospheric mantle. Spatial variations of lithospheric thinning and dynamic processes in the North China Craton could inevitably induce the velocity heterogeneity in the uppermost mantle.In this study,we used Pn arrivals from permanent seismic stations in North China and surrounding regions to construct a tomographic image of the North China Craton.The tomographic method with Pn travel time difference data were used to study the velocity variations in the uppermost mantle.Pn velocities in the uppermost mantle varied significantly in the Eastern,Central and Western blocks of the North China Craton.This suggests that the lithosphere beneath different blocks of the North China Craton have experienced distinct tectonic evolutions and dynamic processes since the Paleo- zoic.The current uppermost mantle has been imprinted by these tectonic and dynamic processes.Fast Pn velocities are prominent beneath the Bohai Bay Basin in the Eastern Block of the North China Craton,suggesting residuals of the Archean lithospheric mantle.Beneath the Tanlu Fault Zone and Bohai Sea,slow Pn velocities are present in the uppermost mantle,which can be attributed to significant lithospheric thinning and asthenospheric upwelling.The newly formed lithospheric mantle beneath Yanshan Mountain may be the dominant reason for the existence of slow Pn velocities in this region.Conversely,the ancient lower crust and lithospheric mantle already have been delaminated.In the Central Block,significant slow Pn velocities are present in Taihangshan Mountain,which also extends northward to the Yinchuan-Hetao Rift on the northern margin of the Ordos Block and Yinshan Orogen.This characteristic probably is a result of hot asthenospheric upwelling along the active tectonic boundary on the margin of the Western Block.The protracted thermal erosion and underplating of hot asthenospheric upwelling may induce lithospheric thinning and significant slow velocities in the uppermost mantle.Fast velocities beneath the Western Block suggest that the thick,cold and refractory Archean lithospheric keel of craton still is retained without apparent destruction. | LI ZhiWei HAO TianYao XU Ya | 2011 | Chinese Science Bulletin2011，56，16： | 16 |
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