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| 1 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 2 | Adherence to AASLD guidelines for the treatment of hepatocellular carcinoma in clinical practice: Experience of the Bologna Liver Oncology Group显示文摘 | Simona Leoni Fabio Piscaglia Ilaria Serio Eleonora Terzi Irene Pettinari Luca Croci Sara Marinelli Francesca Benevento Rita Golfieri Luigi Bolondi | 2014 | Digestive and Liver Disease2014，，： | 2 |
| 3 | Carbon nanotube films as electron field emitters 显示文摘 | Jean-Marc Bonard mirko Croci Christian Klinke | 2002 | Carbon2002，，： | 2 |
| 4 | Evaluation of different polyrnerase chain reaction methods for the identification of Vibrio parahaemolyticus strains isolated by culturalmethods 显示文摘 | CROCI L SUFFREDINI E COZZI L | 2007 | JAOAC Int2007，90，： | 1 |
| 5 | Pattern of cerebral edema and hemorrhage in a mice model of diffuse brain injury显示文摘 | HELLAL F BONNEFONT ROUSSELOT D CROCI N | 2004 | Neurosci Lett2004，357，1： | 1 |
| 6 | Growth inhibition by gamma rays affects lipids and fatty acids in garlic sprouts during storage显示文摘 | Mónica B. Pérez Marta I. Avelda?o Clara A. Croci | 2007 | Postharvest Biology and Technology2007，，2： | 1 |
| 7 | Carbon Nanotube Films as Electron Field Emitters 显示文摘 | Bonard J Croci M Klinke C | 2002 | Carbon2002，，40： | 1 |
| 8 | Small urban woodlands as biodiversity conservation hot-spot:a multi-taxon approach显示文摘 | Croci S Butet A Georges A | 2008 | Landscape Ecology2008，，23： | 1 |
| 9 | Pattern of cerebral edema and hemorrhage in amaice model of diffuse braininjury显示文摘 | Hellal F Bonnefont - Roussselot D Croci N | 2004 | Neurosci Lett2004，357，1： | 1 |
| 10 | Tolerogenic sig-nals delivered by dendritic cells to T cells through a ga-lectin-1-driven immunoregulatory circuit involving inter-leukin 27 and interleukin 10显示文摘 | Ilarregui JM Croci DO Bianco GA | | 0，，9： | 1 |
| 11 | Targeting galectin-1 overcomes breast Cancer-Associated immunosuppression and pre- vents metastatic disease显示文摘 | Dalotto-Moreno T Croci DO Cerliani JP | 2013 | Cancer Res2013，73，： | 1 |
| 12 | Inhibition of connective tissue growth factor (CTGF/CCN2) expression decreases the survival and myogenic differentiation of human rhabdomyosarcoma cells 显示文摘 | Croci S LanduzziL AstolfiA | 2004 | CancerRes2004，64，5： | 1 |
| 13 | A Cde7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity显示文摘 | Montagnoli A Valsasina B Croci V | 2008 | Nat Chem Biol2008，4，6： | 1 |
| 14 | Silencing surviving gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway 显示文摘 | Croci D O Cogno I S Vittar N B | 2008 | J Cell Bio- chem2008，105，2： | 1 |
| 15 | Synovial sarcoma of the extremities:prognostic factors for 20 nonmetastatic cases and a new histologic grading system with prognostic significance显示文摘 | CAMARGO O P CROCI A T | 2006 | Clinics2006，61，5： | 1 |
| 16 | Isometric ann counter-pressure maneuvers to abort impending vasovagal syncope 显示文摘 | Brignole M Croci F Menozzi C | 2002 | J Am Coil Cardiol2002，40，： | 1 |
| 17 | Blood loss in the minimally invasive posterior approach to total hip arthroplasty:a comparative study显示文摘 | Vicente J Croci AT Camargo OP | 2008 | Clinics2008，3，： | 1 |
| 18 | Respiratory system me- chanics in sedated,paralyzed,morbidly obese patients显示文摘 | Pelosi P Croci M Ravagnan I | 1977 | J Appl Physiol1977，82，3： | 1 |
| 19 | Tolerogenic signals delivered by dendritic cells to T cells through a galectin-l-driven immunoregulatory circuit involving interleukin 27 and interleukin 10显示文摘 | Ilarregui JMI Croci DO Bianeo GA | 2009 | Nat hnmunol2009，10，9： | 1 |
| 20 | L-NAME reduces infarction,neurological deficit and blood-brain barrier disruption following cerebral ischemia in mice显示文摘 | Ding-Zhou L Marchand-Verrecchia C Croci N | 2002 | Eur J Pharmacol2002，457，23： | 1 |
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