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| 1 | Hepatocellular carcinoma in viral and autoimmune liver diseases:Role of CD4+CD25+Foxp3+regulatory T cells in the immune microenvironment显示文摘More than 90%of cases of hepatocellular carcinoma(HCC)occurs in patients with cirrhosis,of which hepatitis B virus and hepatitis C virus are the leading causes,while the tumor less frequently arises in autoimmune liver diseases.Advances in understanding tumor immunity have led to a major shift in the treatment of HCC,with the emergence of immunotherapy where therapeutic agents are used to target immune cells rather than cancer cells.Regulatory T cells(Tregs)are the most abundant suppressive cells in the tumor microenvironment and their presence has been correlated with tumor progression,invasiveness,as well as metastasis.Tregs are characterized by the expression of the transcription factor Foxp3 and various mechanisms ranging from cell-to-cell contact to secretion of inhibitory molecules have been implicated in their function.Notably,Tregs amply express checkpoint molecules such as cytotoxic T lymphocyte-associated antigen 4 and programmed cell-death 1 receptor and therefore represent a direct target of immune checkpoint inhibitor(ICI)immunotherapy.Taking into consideration the critical role of Tregs in maintenance of immune homeostasis as well as avoidance of autoimmunity,it is plausible that targeting of Tregs by ICI immunotherapy results in the development of immune-related adverse events(irAEs).Since the use of ICI becomes common in oncology,with an increasing number of new ICI currently under clinical trials for cancer treatment,the occurrence of irAEs is expected to dramatically rise.Herein,we review the current literature focusing on the role of Tregs in HCC evolution taking into account their opposite etiological function in viral and autoimmune chronic liver disease,and we discuss their involvement in irAEs due to the new immunotherapies. | Alessandro Granito Luigi Muratori Claudine Lalanne Chiara Quarneti Silvia Ferri Marcello Guidi Marco Lenzi Paolo Muratori | 2021 | World Journal of Gastroenterology2021，27，22： | 11 |
| 2 | Genetic distinctions between autoimmune hepatitis in Italy and North America显示文摘AIM: Our goals were to analyze the known genetic predispositions for autoimmune hepatitis (AIH) in AIH Italian population and to compare them with North American counterparts.METHODS: Human leukocyte antigens (HLA) B8, C7, DR3,DR4, DR7, DR11, DR13, DQ2 and the B8-DR3-DQ2phenotype were determined by microlymphocytotoxicity and polymerase chain reaction in 74 Italian patients (57with type 1 and 17 with type 2 AIH) and 149 North American patients with type 1 AIH, and in adequate controls.RESULTS: B8-DR3-DQ2 occurred more frequently in Italian patients with type 1 AIH than in Italian controls (30% vs 7%, P<0.0001), but less frequently than in North American counterparts (30% vs48%, P = 0.02). DR4 occurred less frequently in Italian patients with type 1 AIH (23% vs43%,P= 0.01) and in controls (16% vs34%, P= 0.0003) than in North American counterparts. No differences were found in alleles' frequency between type 1 and type 2Italian AIH patients. DR11 had a frequency lower in type 1 Italian AIH patients than controls (17% vs35%, P= 0.01).CONCLUSION: HLA DR4 is not associated with AIH in Italy. The known HLA risk factors for ATH occur similarly in Italian patients with type 1 and type 2 AIH, and they are less frequent than in North American patients. B8-DR3-DQ2 is the predominant phenotype of type 1 AIH also in Italy, and HLA DR11 may be a regionally distinctive protective factor against type 1 AIH. | Paolo Muratori Albert J.Czaja Luigi Muratori Georgios Pappas Silvana Maccariello Fabio Cassani Alessandro Granito Rodolfo Ferrari Vilma Mantovani Marco Lenzi Francesco B.Bianchi | 2005 | World Journal of Gastroenterology2005，11，12： | 2 |
| 3 | Comparison of thoracic kyphosis degree,trunk muscle strength and joint position sense among healthy and osteoporotic elderly women:a cross-sectional preliminary study显示文摘 | Granito RN Aveiro MC Renno AC | 2012 | Arch Gerontol Geriatr2012，54，2： | 1 |
| 4 | Patterns of appearance and risk of misdiagnosis of intrahepatic cholangiocarcinoma in cirrhosis at contrast enhanced ultrasound显示文摘 | Marzia Galassi Massimo Iavarone Sandro Rossi Simona Bota Sara Vavassori Laura Rosa Simona Leoni Laura Venerandi Sara Marinelli Angelo Sangiovanni Letizia Veronese Mirella Fraquelli Alessandro Granito Rita Golfieri Massimo Colombo Luigi Bolondi Fabio Pisca | 2013 | Liver Int2013，，5： | 1 |
| 5 | High Prevalence of Celiac Disease in Italian General Population显示文摘 | Umberto Volta Stefano Bellentani Francesco Bianco Bianchi Giovanni Brandi Lucia De Franceschi Lucia Miglioli Alessandro Granito Fiorella Balli Claudio Tiribelli | 2001 | Digestive Diseases and Sciences2001，，7： | 1 |
| 6 | Autoimmune enteropathy and rheumatoid arthritis: a new association in the field of autoimmunity 显示文摘 | Volta U De Angelis GL Granito A | 2006 | Dig Liver Dis2006，38，12： | 1 |
| 7 | Contrastenhanced sonography in early kidney graft dysfunction显示文摘 | Benozzi L Cappelli G Granito M | | 0，，04： | 1 |
| 8 | Comparison of thoracic kyphosis degree, trunk muscle strength and joint position sense among healthy and osteoporotic elderly women: A cross-sectional preliminary study显示文摘 | Renata Neves Granito Mariana Chaves Aveiro Ana Claudia Muniz Renno Jorge Oishi Patricia Driusso | 2011 | Archives of Gerontology and Geriatrics2011，，： | 1 |
| 9 | Contrast-enhanced sonography in early kidney graft dysfunction 显示文摘 | Benozzi L Cappelli G Granito M | 2009 | Transpl Proc2009，41，12： | 1 |
| 10 | Antinuclear antibodies as ancillary markers in primary biliary cirrhosis显示文摘 | Granito A1 Muratori P Quarneti C | 2012 | Expert Rev Mol Diagn2012，12，1： | 1 |
| 11 | Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis: diagnostic and prognostic value显示文摘 | Muratori L Granito A Muratori P | 2008 | Clin Liver Dis2008，12，2： | 1 |
| 12 | Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis:diagnostic and prognostic value显示文摘 | Muratori L Granito A Muratori P | 2008 | Clin Liver Dis2008，12，2： | 1 |
| 13 | Auto- immune hepatitis in Italy:the Bologna experience显示文摘 | Muratori P Granito A Quarneti C | 2009 | J Hepatol2009，50，6： | 1 |
| 14 | Impact of gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance on the non-invasivediagnosis of small hepatocellular carcinoma: a prospective study 显示文摘 | Granito A Galassi M Piscaglia F | 2013 | Aliment Pharmacol Ther2013，37，： | 1 |
| 15 | Diagnosis and therapy of autoimmune hepatitis显示文摘 | Granito A Muratori P Ferri S | | 0，，： | 1 |
| 16 | Prevalence of MTHFR gene polymorphisms (C677T and A1298C) among Tamilians显示文摘 | Angeline T Jeyaraj N Granito S | 2004 | Exp Mol Pathol2004，77，2： | 1 |
| 17 | Review article: autoimmune hepatitis – current management and challenges显示文摘 | K. Zachou P. Muratori G. K. Koukoulis A. Granito N. Gatselis A. Fabbri G. N. Dalekos L. Muratori | 2013 | Aliment Pharmacol Ther2013，，8： | 1 |
| 18 | VEGF and VEGFR genotyping in the prediction of clinical outcome for HCC patients receiving sorafenib: The ALICE‐1 study显示文摘 | Mario Scartozzi Luca Faloppi Gianluca Svegliati Baroni Cristian Loretelli Fabio Piscaglia Massimo Iavarone Pierluigi Toniutto Giammarco Fava Samuele De Minicis Alessandra Mandolesi Maristella Bianconi Riccardo Giampieri Alessandro Granito Floriana Facchet | 2014 | Int. J. Cancer2014，，： | 1 |
| 19 | Autoimmune hepatitis in Italy: The Bologna experience显示文摘 | Paolo Muratori Alessandro Granito Chiara Quarneti Silvia Ferri Rita Menichella Fabio Cassani Georgios Pappas Francesco B. Bianchi Marco Lenzi Luigi Muratori | 2009 | Journal of Hepatology2009，，6： | 1 |
| 20 | Antimitochondrial antibodies and other antibodies in primary biliary cirrhosis:Diagnostic and prognostic value显示文摘 | Muratori L Granito A | 2008 | Clin Liver Dis2008，12，2： | 1 |
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