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| 1 | Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI显示文摘AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVueüà-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrastenhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The f inal diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVueüà -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specif icity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specif icity of CEUS for the identif ication of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVueüà-enhanced sonography emerges as the most sensitive, most specif ic and thus most accurate imaging modality for the characterization of focal liver lesions. | Hervé Trillaud Jean-Michel Bruel Pierre-Jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis | 2009 | World Journal of Gastroenterology2009，15，30： | 34 |
| 2 | Contrast-enhanced ultrasonography in the evaluation of incidental focal liver lesions: A cost-effectiveness analysis显示文摘AIM To determine whether contrast-enhanced ultrasonography(CEUS) as the first-line method is more costeffective in evaluating incidentally discovered focal liver lesions(FLLs) than is computed tomography(CT) and magnetic resonance imaging(MRI). METHODS Between 2010 and 2015, our prospective study enrolled 459 patients with incidentally found FLLs. The biological nature of FLLs was assessed by CEUS in all patients. CT or MRI examinations were added in unclear cases. The sensitivity and specificity of CEUS were calculated. The total costs of CEUS examinations and of the added examinations performed in inconclusive cases were calculated. Afterwards, the theoretical expenses for evaluating incidentally discovered FLLs using CT or MRI as the first-line method were calculated. The resultswere compared. RESULTS The total cost of the diagnostic process using CEUS for all enrolled patients with FLLs was 75884 USD. When the expenses for additional CT and MRI examinations performed in inconclusive cases were added, the total cost was 90540 US dollar(USD). If all patients had been examined by CT or MR as the first-line method, the costs would have been 78897 USD or 384235 USD, respectively. The difference between the cost of CT and CEUS was 3013 USD(4%) and that between MRI and CEUS was 308352 USD(406.3%). We correctly described 97.06% of benign or malignant lesions, with 96.99% sensitivity and 97.09% specificity. Positive predictive value was 94.16% and negative predictive value was 98.52%. In cases with 4 and more lesions, malignancy is significantly more frequent and inconclusive findings significantly less frequent(P < 0.001).CONCLUSION While the costs of CEUS and CT in evaluating FLLs are comparable, CEUS examination is far more costeffective in comparison to MRI. | Miriama Smajerova Hana Petrasova Jirina Little Petra Ovesna Tomas Andrasina Vlastimil Valek Eva Nemcova Barbora Miklosova | 2016 | World Journal of Gastroenterology2016，22，38： | 4 |
| 3 | Percutaneous Intraductal Radiofrequency Ablation is a Safe Treatment for Malignant Biliary Obstruction: Feasibility and Early Results显示文摘 | Malkhaz Mizandari Madhava Pai Feng Xi Vlastimil Valek Andrasina Tomas Pietro Quaretti Rita Golfieri Cristina Mosconi Ao Guokun Charis Kyriakides Robert Dickinson Joanna Nicholls Nagy Habib | 2013 | CardioVascular and Interventional Radiology2013，，3： | 3 |
| 4 | Percutaneous Intraductal Radiofrequency Ablation for Clearance of Occluded Metal Stent in Malignant Biliary Obstruction: Feasibility and Early Results显示文摘 | Madhava Pai Vlastimil Valek Andrasina Tomas Attila Doros Pietro Quaretti Rita Golfieri Cristina Mosconi Nagy Habib | 2014 | CardioVascular and Interventional Radiology2014，，1： | 2 |
| 5 | Brachytherapy and percutaneous stenting in the treatment of cholangiocarcinoma: a prospective randomised study显示文摘 | VALEK V KYSELA P KALA Z | 2007 | Eur J Radiol2007，62，2： | 1 |
| 6 | Catechin antioxidant action at various pH studied by cyclic voltammetry and PM3 semiempirical calculations显示文摘 | MARTINEZ S VALEK L PETROVI | 2005 | J Electroanal Chem2005，584，2： | 1 |
| 7 | Brachytherapy and percutan- eous stenting in the treatment of cholangiocarcinoma:A prospective randomised study显示文摘 | Valek V Kysela P Kala Z Kiss I | 2010 | Eur J Radiol2010，62，2： | 1 |
| 8 | The metabolic syndrome, its heredity, methods of detection and clinical significance 显示文摘 | Valek J Vlasakova Z | 1997 | Vnitr Lek1997，43，9： | 1 |
| 9 | Percutaneous intraductal radiofrequency ablation for clearance of occluded metal stent in malignant biliary obstruction:feasibility and early results显示文摘 | Pai M Valek V Tomas A | 2014 | Cardiovasc Intervent Radiol2014，37，： | 1 |
| 10 | The role of CT and endoscopic ultrasoundin pre-operative staging of pancreatic cancer显示文摘 | Valek V Hlavsa J | 2007 | Eur J Badiol2007，62，2： | 1 |
| 11 | Scanning X-ray microdiffraction with submicrometer white beam for strain/stress and orientation mapping in thin films 显示文摘 | TAMURA N MACDOWELL A A SPOLENAK R VALEK B C BRAVMAN J C BROWN W L CELESTRE R S PADMORE H A BATTERMAN B W PATEL J R | 2003 | J Synchrotron Radiat2003，10，： | 1 |
| 12 | Arteriovenous fistula, blood flow, cardiac output, and left ventricle load in hemodialysis patients 显示文摘 | VALEK M LOPOT F POLAKOVIC V | 2010 | ASAIOJ2010，56，3： | 1 |
| 13 | Electrocatalytic properties of electrodeposited Ni-15Mo cathodes for the HER in acid solutions:Synergistic electronic effect显示文摘 | MARTINEZ S METIKOˇS-HUKOVI′C M VALEK L | 2006 | Journal of Molecular Catalysis A:Chemical2006，245，： | 1 |
| 14 | Percutaneous intraductal radiofre- quency ablation for clearance of occluded metalstent in malignant bil- iary obstruction :feasibility and early results显示文摘 | Pai M Valek V Tomas A | 2014 | Cardiovasc Intervent Radio12014，37，： | 1 |
| 15 | Corrosion evaluation and surface characterization of the corrosion product layer formed on Cu-6Sn bronze in aqueous Na2SC>4 solution 显示文摘 | SATOVlC D VALEK ZULJ L DESN1CA V FAZ1NIC S MARTINEZ S | 2009 | Corrosion Science2009，51，： | 1 |
| 16 | Percutaneous intraductal radiofrequency ablation for clearance of occluded metal stent in malignant biliary obstruction: feasibility and early results显示文摘 | Pai M Valek V Tomas A | 2014 | Cardiovasc Intervent Radiol2014，37，： | 1 |
| 17 | Metal stents in patients with malignant and benign esophageal stenoses显示文摘 | Hrobar P Mrazova J | 1997 | Rozhl Chir1997，76，7： | 1 |
| 18 | Finite element analysis of customized reconstruction plates for mandibular continuity defect therapy显示文摘 | Narra N Valek J Hannula M | 2014 | J Biomech2014，47，1： | 1 |
| 19 | Brachytherapy and percutaneous stenting in the treatment of cholangiocarcinoma: a prospective randomised study显示文摘 | Valek V Kysela P Kala Z | 2007 | Eur J Radiol2007，62，： | 1 |
| 20 | The zinc finger protein A20 inhibits TNF- induced NF - kappa B dependent gene expression by interfering with an RIP or TRAF2 -mediated transaetivation signal and direetly binds to a novel NF- kappa B- inhibiting protein ABIN显示文摘 | Heyninck K De Valek D Vanden Berghe W | 1999 | J Cell Biol1999，145，7： | 1 |
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