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| 1 | Percutaneous ablation of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma is a highly aggressive tumor with an overall 5-year survival rate of less than 5%. Prognosis and treatment depend on whether the tumor is resectable or not, which mostly depends on how quickly the diagnosis is made. Chemotherapy and radiotherapy can be both used in cases of nonresectable pancreatic cancer. In cases of pancreatic neoplasm that is locally advanced, non-resectable, but non-metastatic, it is possible to apply percutaneous treatments that are able to induce tumor cytoreduction. The aim of this article will be to describe the multiple currently available treatment techniques(radiofrequency ablation, microwave ablation, cryoablation, and irreversible electroporation), their results, and their possible complications, with the aid of a literature review. | Mirko D'Onofrio Valentina Ciaravino Riccardo De Robertis Emilio Barbi Roberto Salvia Roberto Girelli Salvatore Paiella Camilla Gasparini Nicolò Cardobi Claudio Bassi | 2016 | World Journal of Gastroenterology2016，22，44： | 7 |
| 2 | 脑血管疾病继发癫痫:实验回顾和临床危险因素的荟萃分析显示文摘癫痫发作可能发生在刚刚卒中发生以后或在很久以后。此外,癫痫也常发生在患有脑白质疏松的患者。尽管卒中后早期痫性发作被广泛研究,卒中后癫痫(Post-stroke epilepsy,PSE)和与脑白质疏松相关癫痫(Epilepsy associated with leukoaraiosis,EAL)研究较少。文章目的是回顾PSE和EAL相关病理生理学,预后和治疗情况。并进行了广泛的文献检索,以筛选关于PSE和EAL的动物实验和临床文章。同时,还对纳入研究中PSE和EAL发生的风险因素进行了系统的回顾分析。PSE是由于瘢痕组织内和其附近神经元兴奋性增加引起的。白质改变在EAL中的作用尚待阐明。荟萃分析显示皮质受累[OR=3.71,95%CI(2.34,5.90),P<0.001],脑出血[OR=2.41,95%CI(1.57,3.70),P<0.001]和早期痫性发作[OR=4.43,95%CI(2.36,8.32),P<0.001]显著增加PSE发生风险。关于EAL,没有前瞻性、基于人群的研究评估不同变量对癫痫发作风险的影响。关于PSE治疗的研究相对有限。PSE药物控制效果通常良好。有关危险因素、预后和EAL治疗的资料较缺乏。PSE的病理生理学和危险因素是明确的,但在EAL中仍需进一步阐明。PSE和EAL的治疗依赖于临床医生的判断,并应在个人基础上进行调控。 | Ferlazzo E Gasparini S Beghi E 迟潇洒 慕洁 | 2017 | 癫痫杂志2017，0，3： | 3 |
| 3 | Assessing Ebola-related web search behaviour: insights and implications from an analytical study of Google Trends-based query volumes显示文摘Background:The 2014 Ebola epidemic in West Africa has attracted public interest worldwide,leading to millions of Ebola-related Internet searches being performed during the period of the epidemic.This study aimed to evaluate and interpret Google search queries for terms related to the Ebola outbreak both at the global level and in all countries where primary cases of Ebola occurred.The study also endeavoured to look at the correlation between the number of overall and weekly web searches and the number of overall and weekly new cases of Ebola.Methods:Google Trends(GT)was used to explore Internet activity related to Ebola.The study period was from 29 December 2013 to 14 June 2015.Pearson’s correlation was performed to correlate Ebola-related relative search volumes(RSVs)with the number of weekly and overall Ebola cases.Multivariate regression was performed using Ebola-related RSV as a dependent variable,and the overall number of Ebola cases and the Human Development Index were used as predictor variables.Results:The greatest RSV was registered in the three West African countries mainly affected by the Ebola epidemic.The queries varied in the different countries.Both quantitative and qualitative differences between the affected African countries and other Western countries with primary cases were noted,in relation to the different flux volumes and different time courses.In the affected African countries,web query search volumes were mostly concentrated in the capital areas.However,in Western countries,web queries were uniformly distributed over the national territory.In terms of the three countries mainly affected by the Ebola epidemic,the correlation between the number of new weekly cases of Ebola and the weekly GT index varied from weak to moderate.The correlation between the number of Ebola cases registered in all countries during the study period and the GT index was very high.Conclusion:Google Trends showed a coarse-grained nature,strongly correlating with global epidemiological data,but was weaker at country level,as it was prone to distortions induced by unbalanced media coverage and the digital divide.Global and local health agencies could usefully exploit GT data to identify disease-related information needs and plan proper communication strategies,particularly in the case of health-threatening events. | Cristiano Alicino Nicola Luigi Bragazzi Valeria Faccio Daniela Amicizia Donatella Panatto Roberto Gasparini Giancarlo Icardi Andrea Orsi | 2015 | Infectious Diseases of Poverty2015，4，1： | 3 |
| 4 | MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer显示文摘 | Nicola Valeri Chiara Braconi Pierluigi Gasparini Claudio Murgia Andrea Lampis Viola Paulus-Hock Jonathan R. Hart Lynn Ueno Sergei I. Grivennikov Francesca Lovat Alessio Paone Luciano Cascione Khlea M. Sumani Angelo Veronese Muller Fabbri Stefania Carasi H | 2014 | Cancer Cell2014，，： | 2 |
| 5 | Comparison of the survival and tolerability of radioembolization in elderly vs. younger patients with unresectable hepatocellular carcinoma<!-- Doctopic: CAN -->显示文摘 | Rita Golfieri Josè Ignacio Bilbao Livio Carpanese Roberto Cianni Daniele Gasparini Samer Ezziddin Philipp Marius Paprottka Francesco Fiore Alberta Cappelli Macarena Rodriguez Giuseppe Maria Ettorre Adelchi Saltarelli Onelio Geatti Hojjat Ahmadzadehfar Ale | 2013 | Journal of Hepatology2013，，： | 2 |
| 6 | Prospective evaluation of anticoagulation and transjugular intrahepatic portosistemic shunt for the management of portal vein thrombosis in cirrhosis显示文摘 | Marco Senzolo Teresa M. Sartori Valeria Rossetto Patrizia Burra Umberto Cillo Patrizia Boccagni Daniele Gasparini Diego Miotto Paolo Simioni Emmanuel Tsochatzis Kenneth A. Burroughs | 2012 | Liver Int2012，，6： | 2 |
| 7 | A phase II study of neoadjuvant bevacizumab plus capecitabine and concomitant radiotherapy in patients with locally advanced rectal cancer显示文摘 | Giampietro Gasparini Francesco Torino Takayuki Ueno Stefano Cascinu Teresa Troiani Alberto Ballestrero Rossana Berardi Junichi Shishido Akihiko Yoshizawa Yukiko Mori Satoshi Nagayama Paola Morosini Masakazu Toi | 2012 | Angiogenesis2012，，1： | 2 |
| 8 | Identification of a chemical marker of environmental exposure to formaldehyde 显示文摘 | CARRARO E GASPARINI S GILLI G | 1999 | Environ Res1999，80，2： | 1 |
| 9 | Metronomic scheduling : the future of chemotherapy? 显示文摘 | Gasparini G | 2001 | Lancet Oncol2001，2，12： | 1 |
| 10 | 2-Me/hyl-6- (phenylethynyl)-pyridine (MPEP), a potent selective and systemically active mGlu5 receptor antagonist 显示文摘 | Gasparini F Lingenhohl K Stoehr N | 1999 | Neurophamlacology1999，38，： | 1 |
| 11 | Prognostic value of vascular endothelial growth factor in breast cancer显示文摘 | Gasparini G | 2000 | Oncologist2000，5，1： | 1 |
| 12 | Expression of vascu- larendothelial growth factor can predict event -free survival in stage Ⅱ colon cancer显示文摘 | Cascinu S Staccioli MP Gasparini G | 2000 | Clin Cancer Res2000，6，7： | 1 |
| 13 | Modulation of mismatch repair and genomic stability by miR-155显示文摘 | Valeri N Gasparini P Fabbri M | 2010 | Proc Natl Acad Sci U S A2010，107，15： | 1 |
| 14 | (R,S)-4-phosphonophenylglycine,a potent and selective group Ⅲ metabotropic glutamate receptor agonist,is anticonvulsive and neuroprotective in vivo显示文摘 | Gasparini F Bruno V Battaglia G | 1999 | J Pharmacol Exp Ther1999，289，3： | 1 |
| 15 | Clinical relevance of vascular endothelial growth factor and thymidine phosphorylase in patients with node-positive breast cancer treated with either adjuvant chemotherapy or hormone therapy显示文摘 | Gasparini G Toi M Miceli R | 1999 | Cancer J Sci Am1999，5，2： | 1 |
| 16 | Relief of drag refractory angina by ventricalar pacing in heart failure显示文摘 | GASPARINI M GULIZIA M MANTICA M | 2003 | Pacing Clin Electrophysiol2003，26，12： | 1 |
| 17 | Female'varicocele':two cases diagnosied by labeled red blood cell angioscintigraphy and treated by percutaneous phlebography and embolization显示文摘 | Gasparini D Geatti O Orsolon PG | 1998 | Clin Nucl Med1998，23，7： | 1 |
| 18 | 显示文摘 | Cascinu S Staccioli MP Gasparini G | 2000 | Clin Cancer Res2000，6，7： | 1 |
| 19 | Prognostic value of vascular endothelial growth factor in breast cancer显示文摘 | Gasparini G | 2000 | Oncologist2000，5，1： | 1 |
| 20 | Plantar fat pad atrophy after corticosteroid injection for an interdigital neuroma: a case report显示文摘 | Basadonna PT Rucco V Gasparini D | 1999 | Am J Phys Med Rehabil1999，78，3： | 1 |
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