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| 1 | 在心血管的疾病的先进 glycation 结束产品的角色显示文摘 Advanced glycation end products(AGEs) are produced through the non enzymatic glycation and oxidation of proteins,lipids and nucleic acids.Enhanced formation of AGEs occurs particularly in conditions associated with hyperglycaemia such as diabetes mellitus(DM).AGEs are believed to have a key role in the development and progression of cardiovascular disease in patients with DM through the modif ication of the structure,function and mechanical properties of tissues through crosslinking intracellular as well as extracellular matrix proteins and through modulating cellular processes through binding to cell surface receptors [receptor for AGEs(RAGE)].A number of studies have shown a correlation between serum AGE levels and the development and severity of heart failure(HF).Moreover,some studies have suggested that therapies targeted against AGEs may have therapeutic potential in patients with HF.The purpose of this review is to discuss the role of AGEs in cardiovascular disease and in particular in heart failure,focussing on both cellular mechanisms of action as well as highlighting how targeting AGEs may represent a novel therapeutic strategy in the treatment of HF. | Zeinab Hegab Stephen Gibbons Ludwig Neyses Mamas A Mamas | 2012 | World Journal of Cardiology2012，4，4： | 58 |
| 2 | PBL在英国护理高等教育的发展和现状显示文摘 | 叶旭春 Carolyn Gibbon | 2006 | 现代护理2006，12，1： | 27 |
| 3 | PBL在英国护理高等教育中的应用研究现状显示文摘 | 张华 Carolyn Gibbon | 2009 | 海南医学院学报2009，15，8： | 10 |
| 4 | Glutamate transporters, EAAT1 and EAAT2, are potentially important in the pathophysiology and treatment of schizophrenia and affective disorders显示文摘Glutamate is the predominant excitatory neurotransmitter in the human brain and it has been shown that prolonged activation of the glutamatergic system leads to nerve damage and cell death. Following release from the pre-synaptic neuron and synaptic transmission, glutamate is either taken up into the presynaptic neuron or neighbouring glia by transmembrane glutamate transporters. Excitatory amino acid transporter(EAAT) 1 and EAAT2 are Na+-dependant glutamate transporters expressed predominantly in glia cells of the central nervous system. As the most abundant glutamate transporters, their primary role is to modulate levels of glutamatergic excitability and prevent spill over of glutamate beyond the synapse. This role is facilitated through the binding and transportation of glutamate into astrocytes and microglia. The function of EAAT1 and EAAT2 is heavily regulated at the levels of gene expression, post-transcriptional splicing, glycosylation states and cell-surface trafficking of the protein. Both glutamatergic dysfunction and glial dysfunction have been proposed to be involved in psychiatric disorder. This review will present an overview of the roles that EAAT1 and EAAT2 play in modulating glutamatergic activity in the human brain, and mount an argument that these two transporters could be involved in the aetiologies of schizophrenia and affective disorders as well as represent potential drug targets for novel therapies for those disorders. | Georgia M Parkin Madhara Udawela Andrew Gibbons Brian Dean | 2018 | World Journal of Psychiatry2018，8，2： | 9 |
| 5 | 实现基于IP核技术的SoC设计显示文摘 | John Biggs Alan Gibbons | 2002 | 电子产品世界2002，9，09A： | 9 |
| 6 | 现代中国人群形成与分化的形态证据--中国与非洲和欧洲人群头骨非测量特征分析显示文摘现代人群形成与分化导致生活在世界不同地区的人类形成了具有明显体质特征差别的人群(或种族)。对更新世末期及全新世以来不同地理区域近代和现代人群体质特征差别、相互亲缘关系的分析是现代人群形成与分化研究的重要组成部分。本文通过对21项头骨非测量特征在近代和现代中国人群,以及现代非洲和欧洲人群共330例标本的出现率和表现特点的观察和数据分析,发现绝大多数特征的出现率或表现特点在三个人群间都具有不同程度的差异,有些特征在人群间的差异甚至非常明显。与非洲及欧洲人群相比,现代中国人头骨总体显得纤细,眉弓、角圆枕、颧三角、颧结节等反映头骨粗壮程度的特征在现代中国人群的发育明显弱于非洲和欧洲人群。此外,现代中国人群还具有一些明显不同于非洲和欧洲人群的头骨非测量特征,包括锐利的眶外下缘、相对平坦的眉间鼻根点、较圆隆的颅侧壁、平坦的顶孔人字区、深弧形的上颌颧突下缘,梯形和左右不一的鼻额-额颌缝走向等。采用判别分析可以将67.0%—79.5%的标本正确地判别归入其原来所属的组群。其中对中国人群的正确判别率分别达到70.4%和82.9%。个体标本分布显示非洲人群表现较大的分散性,而中国和欧洲人群样本的分布明显密集集中,提示中国和欧洲人群似乎具有更多的衍生性特征。本研究还发现多数在人群间差别显著的头骨非测量特征与头骨粗壮程度有关,作者对相关的问题进行了分析探讨。 | 刘武 吴秀杰 邢松 Victoria GIBBON Ronald CLARKE | 2011 | 人类学学报2011，30，3： | 6 |
| 7 | Management of achilles tendon injury: A current concepts systematic review显示文摘Achilles tendon rupture has been on the rise over recent years due to a variety of reasons. It is a debilitating injury with a protracted and sometimes incomplete recovery. Management strategy is a controversial topic and evidence supporting a definite approach is limited. Opinion is divided between surgical repair and conservative immobilisation in conjunction with functional orthoses. A systematic search of the literature was performed. Pubmed, Medline and EmB ase databases were searched for Achilles tendon and a variety of synonymous terms. A recent wealth of reporting suggests that conservative regimens with early weight bearing or mobilisation have equivalent or improved rates of re-rupture to operative regimes. The application of dynamic ultrasound assessment of tendon gap may prove crucial in minimising re-rupture and improving outcomes. Studies employing functional assessments have found equivalent function between operative and conservative treatments. However, no specific tests in peak power, push off strength or athletic performance have been reported and whether an advantage in operative treatment exists remains undetermined. | Vivek Gulati Matthew Jaggard Shafic Said Al-Nammari Chika Uzoigwe Pooja Gulati Nizar Ismail Charles Gibbons Chinmay Gupte | 2015 | World Journal of Orthopedics2015，6，4： | 5 |
| 8 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 9 | 节奏研究的语料库及研究方法探讨显示文摘近年来出现了大量有关节奏的描述性统计研究。本文首先介绍了几个重要的节奏测量模型,随后进一步指出各模型的固有缺陷以及在实际语言对比中存在的若干问题,充分论证这些模型并未捕捉到节奏的全部本质,即规律性、复现性及交替性。最后提出了一种新的节奏时长测量模型,并讨论节奏未来研究的方向及研究中应注意的问题。 | 于珏 Dafydd GIBBON | 2016 | 当代语言学2016，18，1： | 3 |
| 10 | The active badge location system显示文摘 | Roy Want Andy Hopper Veronica Falc?o Jonathan Gibbons | 1992 | ACM Transactions on Information Systems (TOIS)1992，，1： | 3 |
| 11 | Aerosol transmission of human pathogens:From miasmata to modern viral pandemics and their preservation potential in the Anthropocene record显示文摘Ongoing uncertainty over the relative importance of aerosol transmission of COVID-19 is in part rooted in the history of medical science and our understanding of how epidemic diseases can spread through human populations. Ancient Greek medical theory held that such illnesses are transmitted by airborne pathogenic emanations containing particulate matter(“miasmata”). Notable Roman and medieval scholars such as Varro, Ibn al-Khatib and Fracastoro developed these ideas, combining them with early germ theory and the concept of contagion. A widely held but vaguely defined belief in toxic miasmatic mists as a dominant causative agent in disease propagation was overtaken by the science of 19th century microbiology and epidemiology, especially in the study of cholera, which was proven to be mainly transmitted by contaminated water. Airborne disease transmission came to be viewed as burdened by a dubious historical reputation and difficult to demonstrate convincingly. A breakthrough came with the classic mid-20th century work of Wells, Riley and Mills who proved how expiratory aerosols(their “droplet nuclei”)could transport still-infectious tuberculosis bacteria through ventilation systems. The topic of aerosol transmission of pathogenic respiratory diseases assumed a new dimension with the mid-late 20th century “Great Acceleration” of an increasingly hypermobile human population repeatedly infected by different strains of zoonotic viruses, and has taken centre stage this century in response to outbreaks of new respiratory infections that include coronaviruses. From a geoscience perspective, the consequences of pandemic-status diseases such as COVID-19, produced by viral pathogens utilising aerosols to infect a human population currently approaching 8 billion, are far-reaching and unprecedented. The obvious and sudden impacts on for example waste plastic production, water and air quality and atmospheric chemistry are accelerating human awareness of current environmental challenges. As such, the “anthropause”lockdown enforced by COVID-19 may come to be seen as a harbinger of change great enough to be preserved in the Anthropocene stratal record. | Teresa Moreno Wes Gibbons | 2022 | Geoscience Frontiers2022，13，6： | 3 |
| 12 | Preparation of active carbons from corn stalk for butanol vapor adsorption显示文摘Active carbons(ACs) were prepared through chemical activation of biochar from whole corn stalk(WCS)and corn stalk pith(CSP) at varying temperatures using potassium hydroxide as the activating agent. ACs were characterized via pore structural analysis and scanning electron microscopy(SEM). These adsorbents were then assessed for their adsorption capacity for butanol vapor. It was found that WCS activated at900 °C for 1 h(WCS-900) had optimal butanol adsorption characteristics. The BET surface area and total pore volume of the WCS-900 were 2330 m2/g and 1.29 cm3/g, respectively. The dynamic adsorption capacity of butanol vapor was 410.0 mg/g, a 185.1% increase compared to charcoal-based commercial AC(143.8 mg/g). | Yuhe Cao Keliang Wang Xiaomin Wang Zhengrong Gu Tyler Ambrico William Gibbons Qihua Fan Al-Ahsan Talukder | 2017 | Journal of Energy Chemistry2017，26，1： | 3 |
| 13 | Short-pulse laser-plasma interactions显示文摘 | Gibbon P Frster E | 1996 | Plasma Physics and Controlled Fusion1996，38，： | 2 |
| 14 | Dorsalis pedis arterial bypass: Durable limb salvage for foot ischemia in patients with diabetes mellitus显示文摘 | Frank B. Pomposelli Edward J. Marcaccio Gary W. Gibbons David R. Campbell Dorothy V. Freeman Anne M. Burgess Arnold Miller Frank W. LoGerfo | 1995 | Journal of Vascular Surgery1995，，： | 2 |
| 15 | A Simplified Tumor Regression Grade Correlates with Survival in Locally Advanced Rectal Carcinoma Treated with Neoadjuvant Chemoradiotherapy显示文摘 | D. Beddy J. M. P. Hyland D. C. Winter C. Lim A. White M. Moriarty J. Armstrong D. Fennelly D. Gibbons K. Sheahan | 2008 | Annals of Surgical Oncology2008，，12： | 2 |
| 16 | Rare presentation of actinomycosis as an abdominal mass显示文摘 | P. Meyer M.D. O. Nwariaku M.D. R. N. McCelland M.D. D. Gibbons M.D. F. Leach M.D. A. I. Sagalowsky M.D. C. Simmang M.D. Dr. D. R. Jeyarajah M.D | 2000 | Diseases of the Colon & Rectum2000，，6： | 2 |
| 17 | High-speed ultra-wideband wireless signals over fiber systems:photonic generation and DSP detection显示文摘We firstly review the efforts in the literature on ultra-wideband (UWB)-over-fiber systems. Secondly,we present experimental results on photonic generation of high-speed UWB signals by both direct modulation and external optical injecting an uncooled semiconductor laser. Furthermore,we introduce the use of digital signal processing (DSP) technology to receive the generated UWB signal at 781.25 Mbit/s. Error-free transmission is achieved. | Timothy Braidwood Gibbon Idelfonso Tafur Monroy | 2009 | The Journal of China Universities of Posts and Telecommunications2009，16，4： | 2 |
| 18 | A normal stress SPECT scan is an effective gatekeeper for coronary angiography显示文摘 | Todd D. Miller David O. Hodge James J. Milavetz Raymond J. Gibbons | 2007 | Journal of Nuclear Cardiology2007，，2： | 2 |
| 19 | The Molecular Basis of α-Thalassemia: A Model for Understanding Human Molecular Genetics显示文摘 | Douglas R. Higgs Richard J. Gibbons | 2010 | Hematology/Oncology Clinics of North America2010，，6： | 2 |
| 20 | Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome显示文摘 | Roy Freeman Wouter Wieling Felicia B. Axelrod David G. Benditt Eduardo Benarroch Italo Biaggioni William P. Cheshire Thomas Chelimsky Pietro Cortelli Christopher H. Gibbons David S. Goldstein Roger Hainsworth Max J. Hilz Giris Jacob Horacio Kaufmann Jens | 2011 | Autonomic Neuroscience: Basic and Clinical2011，，1： | 2 |
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