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| 1 | 湍流流动中鲨鱼皮表面流体减阻研究进展显示文摘快速游动的鲨鱼,其皮肤表面沿流动方向有序地排列着沟槽状结构,人们认为这种结构能在湍流流动中减小表面摩擦阻力.人们仿真这种生物结构来进行实验研究和应用,通过复制和改善鲨鱼皮肤表面沟槽状结构,使得摩擦阻力最大减小了近10%.在实验和模拟仿真中,人们不断讨论和研究湍流流动阻力的形成机制和沟槽减阻的理论特性.本文综述了沟槽减阻理论特性的一些研究方法,并且归纳定义了沟槽减阻最优几何形状及其尺寸;详细考虑流体流动的特点,给出了一种用来选择最优沟槽形状及其尺寸的方法;综述了目前的沟槽加工制造技术.由于鲨鱼皮肤表面存在少量黏液,从仿生学的角度,文章最后综述并展望了通过局部应用疏水性材料来改变沟槽附近流场属性,从而达到更大程度上减小阻力的目标. | Brian Dean Bharat Bhushan 杨绍琼(译) 李山(译) 田海平(译) 李一凡(译) 姜楠(校) | 2012 | 力学进展2012，42，6： | 13 |
| 2 | Glutamate transporters, EAAT1 and EAAT2, are potentially important in the pathophysiology and treatment of schizophrenia and affective disorders显示文摘Glutamate is the predominant excitatory neurotransmitter in the human brain and it has been shown that prolonged activation of the glutamatergic system leads to nerve damage and cell death. Following release from the pre-synaptic neuron and synaptic transmission, glutamate is either taken up into the presynaptic neuron or neighbouring glia by transmembrane glutamate transporters. Excitatory amino acid transporter(EAAT) 1 and EAAT2 are Na+-dependant glutamate transporters expressed predominantly in glia cells of the central nervous system. As the most abundant glutamate transporters, their primary role is to modulate levels of glutamatergic excitability and prevent spill over of glutamate beyond the synapse. This role is facilitated through the binding and transportation of glutamate into astrocytes and microglia. The function of EAAT1 and EAAT2 is heavily regulated at the levels of gene expression, post-transcriptional splicing, glycosylation states and cell-surface trafficking of the protein. Both glutamatergic dysfunction and glial dysfunction have been proposed to be involved in psychiatric disorder. This review will present an overview of the roles that EAAT1 and EAAT2 play in modulating glutamatergic activity in the human brain, and mount an argument that these two transporters could be involved in the aetiologies of schizophrenia and affective disorders as well as represent potential drug targets for novel therapies for those disorders. | Georgia M Parkin Madhara Udawela Andrew Gibbons Brian Dean | 2018 | World Journal of Psychiatry2018，8，2： | 9 |
| 3 | Biomarkers in schizophrenia:A focus on blood based diagnostics and theranostics显示文摘Identifying biomarkers that can be used as diagnostics or predictors of treatment response(theranostics) in people with schizophrenia(Sz) will be an important step towards being able to provide personalized treatment. Findings from the studies in brain tissue have not yet been translated into biomarkers that are practical in clinical use because brain biopsies are not acceptable and neuroimaging techniques are expensive and the results are inconclusive. Thus, in recent years, there has been search for blood-based biomarkers for Sz as a valid alternative. Although there are some encouraging preliminary data to support the notion of peripheral biomarkers for Sz, it must be acknowledged that Sz is a complex and heterogeneous disorder which needs to be further dissected into subtype using biological based and clinical markers. The scope of this review is to critically examine published blood-based biomarker of Sz, focusing on possible uses for diagnosis, treatment response, or their relationship with schizophreniaassociated phenotype. We sorted the studies into six categories which include:(1) brain-derived neurotrophic factor;(2) inflammation and immune function;(3) neurochemistry;(4) oxidative stress response and metabolism;(5) epigenetics and micro RNA; and(6) transcriptome and proteome studies. This review also summarized the molecules which have been conclusively reported as potential blood-based biomarkers for Sz in different blood cell types. Finally, we further discusses the pitfall of current blood-based studies and suggest that a prediction model-based, Sz specific, bloodoriented study design as well as standardize blood collection conditions would be useful for Sz biomarker development. | Chi-Yu Lai Elizabeth Scarr Madhara Udawela Ian Everall Wei J Chen Brian Dean | 2016 | World Journal of Psychiatry2016，6，1： | 6 |
| 4 | The spectrum of neuromyelitis optica显示文摘 | Dean M Wingerchuk Vanda A Lennon Claudia F Lucchinetti Sean J Pittock Brian G Weinshenker | 2007 | Lancet Neurology2007，，9： | 3 |
| 5 | Allosteric modulation of cholinergic system:Potential approach to treating cognitive deficits of schizophrenia显示文摘Schizophrenia is a psychiatric disorder affecting approximately 1% of the population worldwide and is characterised by the presence of positive and negative symptoms and cognitive deficits. Whilst current therapeutics ameliorate positive symptoms, they are largely ineffective in improving negative symptoms and cognitive deficits. The cholinergic neurotransmitter system heavily influences cognitive function and there is evidence that implicates disruption of the central cholinergic system in schizophrenia. Historically, targeting the cholinergic system has been impeded by poor selectivity leading to intolerable side effects warranting the need to develop more targeted therapeutic compounds. In this review we will summarise evidence supporting the roles of the cholinergic system, particularly the muscarinic M1 receptor, in the pathophysiology of schizophrenia and discuss the potential of a promising new class of candidate compounds, allosteric ligands, for addressing the difficulties involved in targeting this system. The body of evidence presented here highlights the dysfunction of the cholinergic system in schizophrenia and that targeting this system by taking advantage of allosteric ligands is having clinically meaningful effect on cognitive deficits. | Shaun Hopper Madhara Udawela Elizabeth Scarr Brian Dean | 2016 | World Journal of Pharmacology2016，5，1： | 3 |
| 6 | Developing a global interconnected power system model显示文摘Decarbonizing the power sector is a necessary step towards a low-carbon future. Interconnecting power systems on different continents could be a method to contribute to such a future, by utilizing highly efficient renewable resources around the globe, while simultaneously providing additional benefits of power system integration. In this paper, we describe the process of constructing and simulating a global interconnected power system model with high technical and temporal resolution. Being the first of its kind on the global scale, this paper is designed to showcase the proof of concept as an intermediate step to a high resolution global model, by integrating an existing European power system model with the North-American continent. The work to date has been focused on testing the methodology and building up necessary knowledge to realistically simulate the functionality of a possible future global grid. Some initial results are analysed to support the viability of the model and the concept in general. Furthermore, key factors influencing the development and optimal performance of the global interconnected power system model are identified. | Maarten Brinkerink Paul Deane Seán Collins Brian Ó Gallachóir | 2018 | Global Energy Interconnection2018，1，3： | 2 |
| 7 | Formulation Development and Antitumor Activity of a Filter-Sterilizable Emulsion of Paclitaxel显示文摘 | Panayiotis P. Constantinides Karel J. Lambert Alex K. Tustian Brian Schneider Salima Lalji Wenwen Ma Bryan Wentzel Dean Kessler Dilip Worah Steven C. Quay | 2000 | Pharmaceutical Research2000，，2： | 2 |
| 8 | Fluocinolone Acetonide Intravitreal Implant for Diabetic Macular Edema: A 3-Year Multicenter, Randomized, Controlled Clinical Trial显示文摘 | P. Andrew Pearson Timothy L. Comstock Michael Ip David Callanan Lawrence S. Morse Paul Ashton Brian Levy Eric S. Mann Dean Eliott | 2011 | Ophthalmology2011，，8： | 2 |
| 9 | The clinical course of neuromyelitis optica (Devic’s syndrome)显示文摘 | Dean M. Wingerchuk William F. Hogancamp Peter C. O’Brien Brian G. Weinshenker | 1999 | Neurology1999，，5： | 2 |
| 10 | Betaine administration corrects ethanol-induced defective VLDL secretion显示文摘 | Kusum K. Kharbanda Sandra L. Todero Brian W. Ward John J. Cannella Dean J. Tuma | 2009 | Molecular and Cellular Biochemistry2009，，： | 2 |
| 11 | The Effect of Progressive, Reinforcing Telephone Education and Counseling Versus Brief Educational Intervention on Knowledge, Self-Care Behaviors and Heart Failure Symptoms显示文摘 | David W. Baker Darren A. DeWalt Dean Schillinger Victoria Hawk Bernice Ruo Kirsten Bibbins-Domingo Morris Weinberger Aurelia Macabasco-O’Connell Kathy L. Grady George M. Holmes Brian Erman Kimberly A. Broucksou Michael Pignone | 2011 | Journal of Cardiac Failure2011，，10： | 1 |
| 12 | Ileal ureter substitution: a contemporary series显示文摘 | Brian R Matlaga Ojas D Shah Lois J Hart Dean G Assimos | 2003 | Urology2003，，6： | 1 |
| 13 | A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings显示文摘 | Andrea Gogos Alyssa M. Sbisa Jeehae Sun Andrew Gibbons Madhara Udawela Brian Dean Haifei Shi | 2015 | International Journal of Endocrinology2015，，： | 1 |
| 14 | Morphology and mechanical properties of Nylon 6/MWNT nanofibers显示文摘 | Moncy V. Jose Brian W. Steinert Vinoy Thomas Derrick R. Dean Mohamed A. Abdalla Gary Price Gregg M. Janowski | 2006 | Polymer2006，，4： | 1 |
| 15 | Osteopontin is a negative regulator of proliferation and differentiation in MC3T3-E1 pre-osteoblastic cells显示文摘 | Weibiao Huang Brian Carlsen George Rudkin Micah Berry Kenji Ishida Dean T Yamaguchi Timothy A Miller | 2004 | Bone2004，，5： | 1 |
| 16 | Ureteroscopic management of renal calculi in anomalous kidneys显示文摘 | Alon Z. Weizer W. Patrick Springhart Wesley O. Ekeruo Brian R. Matlaga Yeh H. Tan Dean G. Assimos Glenn M. Preminger | 2005 | Urology2005，，2： | 1 |
| 17 | A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis显示文摘 | Vanda A Lennon Dean M Wingerchuk Thomas J Kryzer Sean J Pittock Claudia F Lucchinetti Kazuo Fujihara Ichiro Nakashima Brian G Weinshenker | 2004 | 2004 (9451)2004，，9451： | 1 |
| 18 | Prophylactic vaccination against human papillomavirus infection and disease in women: a systematic reviewofrandomized controlled trials显示文摘 | Lisa Rambout BSc Phm Laura Hopkins MD MSC Brian HuHon MSC Dean Fergusson PhD | 2007 | CMAJ2007，17，5： | 1 |
| 19 | Water flow influences oxygen transport and photosynthetic efficiency in corals显示文摘 | Christopher M Finelli Brian S T Helmuth N Dean Pentcheff | 2006 | Coral Reefs2006，25，： | 1 |
| 20 | A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis显示文摘 | Vanda A Lennon Dean M Wingerchuk Thomas J Kryzer Sean J Pittock Claudia F Lucchinetti Kazuo Fujihara Ichiro Nakashima Brian G Weinshenker | 2004 | The Lancet2004，，9451： | 1 |
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