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| 1 | Current global trends in the incidence of pediatric-onset inflammatory bowel disease显示文摘AIM To perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease(IBD). METHODS We systematically searched the MEDLINE(source Pub Med), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines(period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatriconset(< 19 years at diagnosis) IBD in full manuscripts. Two authors carried out screening and data extraction. Choropleth interactive maps and temporal trends were used to illustrate the international differences and incidences of and changes in IBD and subtypes.RESULTS In total, one hundred forty studies reporting data from 38 countries were considered in this review. The highest annual pediatric incidences of IBD were 23/100000 person-years in Europe, 15.2/100000 in North America, and 11.4/100000 in Asia/the Middle East and Oceania. The highest annual incidences of Crohn's disease(CD) were 13.9/100000 in North America and 12.3/100000 in Europe. The highest annual incidences of ulcerative colitis(UC) were 15.0/100000 in Europe and 10.6/100000 in North America. The highest annual incidences of IBD-unclassified(IBD-U) were 3.6/100000 in Europe and 2.1/100000 in North America. In the time-trend analyses, 67% of CD, 46% of UC and 11% of IBD-U studies reported an increasing incidence(P < 0.05). The risk of IBD is increasing among firstgeneration of migrant populations.CONCLUSION Globally, the incidence of IBD varies greatly by geographical areas. The steadily increasing incidence of pediatric IBD over time indicates its emergence as a global disease, suggesting that studies should investigate the environmental risk factors among pediatric cohorts. | Josef Sykora Renta Pomahacov Marcela Kreslová Dominika Cvalínová Premysl Stych Jan Schwarz | 2018 | World Journal of Gastroenterology2018，24，25： | 27 |
| 2 | Effect of Vachellia tortilis on understory vegetation,herbaceous biomass and soil nutrients along a grazing gradient in a semi-arid African savanna显示文摘The spatial pattern and abundance of herbaceous vegetation in semi-arid savannas are dictated by a complex and dynamic interaction between trees and grasses. Scattered trees alter the composition and spatial distribution of herbaceous vegetation under their canopies. Therefore, we studied the effect of Vachellia tortilis on herbaceous vegetation composition, biomass and basal area, and soil nutrients on sites with varying grazing intensities in the central rift valley of Ethiopia. Data were collected on species composition, cover and biomass of herbs and grasses, and soil moisture and nutrient contents under light,medium, and heavy grazing pressures, both under the inside and outside of V. tortilis canopies. Species richness was similar in both locations but decreased with increased grazing. Only the overall biomass and herb cover were significantly greater under the canopy than outside, and overall biomass showed significant unchanging decline with increased grazing. However, vegetation cover was significantly greater on moderately grazed sites compared to low and heavily grazed sites. All soil variables were significantly higher under V. tortilis canopies than outside.Our findings suggest that V. tortilis has more effect on composition and diversity of herbaceous vegetation than on species richness, and that V. tortilis promotes the herbaceous layer biomass by reducing soil moisture loss and increasing soil fertility under the inside than outside the canopies. Therefore, we suggest that management practices should be directed on reducing pressure on V. tortilis by regulating grazing. Low to moderate grazing levels(i.e., a stocking rate less than 39.6 TLU ha^(-1) yr^(-1)) seems to be tolerable to ensure sustainable conservation of the species in the study area in particular and in semi-arid savannas in general. | Temesgen Yadeta Elmar Veenendaal Karle Sykora Zewdu K.Tessema Addisu Asefa | 2018 | Journal of Forestry Research2018，29，6： | 3 |
| 3 | Regulation of Enterocyte Apoptosis by Acyl-CoA Synthetase 5 Splicing显示文摘 | Nikolaus Gassler Wilfried Roth Benjamin Funke Armin Schneider Frank Herzog Jens J.W. Tischendorf Kerstin Grund Roland Penzel Ignacio G. Bravo John Mariadason Volker Ehemann Jaromir Sykora Tobias L. Haas Henning Walczak Tom Ganten Hanswalter Zentgraf Peter | 2007 | Gastroenterology2007，，2： | 2 |
| 4 | Statin use and survival outcomes in elderly patients with heart failure显示文摘 | Ray JG Gong Y Sykora K | 2005 | Arch Intern Med2005，165，1： | 1 |
| 5 | Antibioticase and development of resistance in blood culture isolates:8 year of experience from a cancer referral center显示文摘 | Kremery V Sykora P Trup I J | 2001 | J chemother2001，13，2： | 1 |
| 6 | Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset显示文摘 | DIEDLER J AHMED N SYKORA M | 2010 | Stroke2010，41，2： | 1 |
| 7 | Seven Excitons at a Cost of One: Redefining the limits for conversion efficiency of photons into charge carriers显示文摘 | Schaller R D Sykora M Pietryga J M | 2006 | Nano Letters2006，6，3： | 1 |
| 8 | Determination of very low levels of radioactivity显示文摘 | ZVARA I POVINEC P SYKORA I | 1994 | Pure & Appl Chen1994，66，12： | 1 |
| 9 | Statin use and survival outcomes in elderly patients with heart failure显示文摘 | Ray JA Gong Y Sykora K | 2005 | Arch Intern Med2005，165，1： | 1 |
| 10 | Photochemistry of copper complexes and their environmental aspects显示文摘 | Jan Sykora | 1997 | Coordination Chemistry Review1997，159，： | 1 |
| 11 | Macroevolution of plasmids : a model for plasmid spe ciation显示文摘 | Sykora P | 1992 | J Theor Bio11992，159，1： | 1 |
| 12 | An in vivo RNAi assay identifies major genetic and cellular requirements for primarypiRNA biogenesis in Drosophila显示文摘 | OLIVIERI D SYKORA M M SACHIDANANDAM R | 2010 | EMBOJ2010，29，19： | 1 |
| 13 | Blood pressure variability after intravenous thrombolysis in acute stroke does not predict intrac- erebral hemorrhage but poor outcome显示文摘 | Kellert L Sykora M Gumbinger C | 2012 | Cerebrovasc Dis2012，33，2： | 1 |
| 14 | Impaired baroreceptor reflex sensitivity in acute stroke is associated with insular involvement,but not with carotid atherosclerosis显示文摘 | Sykora M Diedler J Rupp A | 2009 | Stroke2009，40，3： | 1 |
| 15 | The mitochondrial transcription factor A functions in mitochondrial base excision repair显示文摘 | Canugovi C Maynard S Bayne A C Sykora P Tian J de Souza-Pinto N C Croteau D L Bohr V A | | 0，，： | 1 |
| 16 | Frequency of increased blood pressure levels during systemic thrombolysis and risk of intracerebral hemorrhage显示文摘 | Kellert L Rocco A Sykora M | 2011 | Stroke2011，42，6： | 1 |
| 17 | Extended Cartographic Interfaces for Open Distributed Processing 显示文摘 | SYKORA P SCHNABEL O IOSIFESCU I | 2007 | Cartographica2007，42，3： | 1 |
| 18 | Esthetic considerations in the construction of a remo vable partial denture显示文摘 | Sykora O | 1994 | Quintessence Int1994，25，： | 1 |
| 19 | TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window显示文摘 | Koschny R Ganten TM Sykora J | 2007 | Hepatology2007，45，3： | 1 |
| 20 | Statin use and survival outcomes in elderly patients with heart failure显示文摘 | Ray JG Gong Y Sykora K | 2005 | Arch Intern Med2005，165，1： | 1 |
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