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| 1 | 原发性青光眼生物标志物的研究进展显示文摘生物标志物作为一种可测量的生物信号,可在机体的炎症反应、氧化应激、免疫反应、代谢等作用过程中体现。目前,大量研究人员在积极寻找参与青光眼病理生理过程的相关生物标志物,以便能够对青光眼患者进行早期诊断、监测病情发展、预估术后风险等。本文综述目前关于原发性青光眼生物标志物的研究进展,为临床选择合适的检测指标及治疗手段提供新的思路。 | 王玲 樊芳 贾志旸 | 2022 | 眼科新进展2022，42，6： | 1 |
| 2 | Recent developments of neuroprotective agents for degenerative retinal disorders显示文摘Retinal degeneration is a debilitating ocular complication characterized by the progressive loss of photoreceptors and other retinal neurons,which are caused by a group of retinal diseases affecting various age groups,and increasingly prevalent in the elderly.Age-related macular degeneration,diabetic retinopathy and glaucoma are among the most common complex degenerative retinal disorders,posing significant public health problems worldwide largely due to the aging society and the lack of effective therapeutics.Whilst pathoetiologies vary,if left untreated,loss of retinal neurons can result in an acquired degeneration and ultimately severe visual impairment.Irrespective of underlined etiology,loss of neurons and supporting cells including retinal pigment epithelium,microvascular endothelium,and glia,converges as the common endpoint of retinal degeneration and therefore discovery or repurposing of therapies to protect retinal neurons directly or indirectly are under intensive investigation.This review overviews recent developments of potential neuroprotectants including neuropeptides,exosomes,mitochondrial-derived peptides,complement inhibitors,senolytics,autophagy enhancers and antioxidants either still experimentally or in clinical trials.Effective treatments that possess direct or indirect neuroprotective properties would significantly lift the burden of visual handicap. | Kepeng Ou Youjian Li Ling Liu Hua Li Katherine Cox Jiahui Wu Jian Liu Andrew D.Dick | 2022 | Neural Regeneration Research2022，17，9： | 0 |
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