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		题名	作者	年代	出处	被引量
	1	Proteome alterations in aqueous humour of primary open angle glaucoma patients显示文摘AIM: To unravel the primary open angle glaucoma(POAG) related proteomic changes in aqueous humour(AH).METHODS: Totally 35 patients listed for cataract surgery(controls: n=12, age: 67.4±13.6 y) or trabeculectomy for POAG(n=23, age: 72.5±8.3 y) were included. AH samples of those patients were obtained during cataract surgery or trabeculectomy. AH samples were subsequently pooled into the experimental groups under equal contribution in terms of protein amount of each individual patient. Protein samples were analyzed by a linear trap quadrupol Orbitrap Mass Spectrometry device with an upstream liquid chromatography system. The obtained raw data were analyzed using the Maxquant proteome software and compared. Proteins with a fold-change ratio higher than a cut-off of 2 were considered as noticeably altered.RESULTS: A total number of 175 proteins could be identified out of the AH from POAG and cataract by means of quantitative mass spectrometric analysis. Apolipoprotein D(fold change, 3.16 times), complement C3(2.96), pigment epithelium-derived factor(2.86), dickkopf-related protein 3(2.18) and wingless-related integration(Wnt) inhibitory factor 1(2.35) were significantly upregulated within the AH of glaucoma compared to cataract serving as controls.CONCLUSION: AH provides a tool to analyze changes in glaucoma and shows striking changes in Wnt signaling inhibitory molecules and other proteins.	Hanhan Liu Fabian Anders Sebastian Funke Karl Mercieca Franz Grus Verena Prokosch	2020	International Journal of Ophthalmology(English edition)2020，13，1：	2
	2	High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart显示文摘	Martin Andrassy Hans C. Volz John C. Igwe Benjamin Funke Sebastian N. Eichberger Ziya Kaya Sebastian Buss Frank Autschbach Sven T. Pleger Ivan K. Lukic Florian Bea Stefan E. Hardt Per M. Humpert Marco E. Bianchi Heimo Mairb?url Peter P. Nawroth Andrew Rem	2008	Circulation2008，，25：	1

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