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| 1 | 用遗传算法进行多流股换热器网络综合的研究显示文摘建立了多流股换热器网络综合数学模型,该模型改进了文献中等温混合的不合理假设。多流股换热器网络综合问题本质上是一个混合整数非线性规划问题(MINLP),这类问题的非凸非线性的特性使得目标函数存在多个局部最优解。传统的基于梯度的搜索方法在处理这类问题时由于计算规模庞大且极易陷于局部最优解而不再适用,而遗传算法却为解决这类问题提供了很有希望的一个方向。因而对遗传算法求解多流股换热器网络综合问题进行了研究,提出了可以自动产生可行的多流股换热器网络的方法策略,最后通过两个例题说明所提方法是可行的。 | 魏关锋 姚平经 罗行 Roetzel Wilfried | 2003 | 高校化学工程学报2003，17，4： | 19 |
| 2 | Attractive but Toxic: Emerging Roles of Glycosidically Bound Volatiles and Glycosyltransferases Involved in Their Formation显示文摘 | Chuankui Song Katja Hartl Kate McGraphery Thomas Hoffmann Wilfried Schwab | 2018 | Molecular Plant2018，11，10： | 16 |
| 3 | 电化学法快速测定茶多酚含量的研究显示文摘基于电化学循环伏安法,讨论了3种低成本自制工作电极——银电极、碳糊电极和玻碳电极在茶多酚含量测定应用上的可行性。通过分析茶多酚在电极表面的氧化还原行为,发现所制银电极不适宜检测茶多酚,碳糊电极、玻碳电极的氧化电流峰值与茶多酚含量有良好的线性关系。所制玻碳电极测定绿茶茶样中的茶多酚含量的重复性和准确性较碳糊电极好。与国标方法相比,碳糊电极、玻碳电极检测茶多酚所需时间大大缩短。结果表明,电化学方法可应用于茶多酚含量的快速测定,从而为快速、低价、便捷检测茶多酚提供一条新思路。 | 朱丹 须海荣 Martial Geiser Mario Bernabei Wilfried Andlauer | 2011 | 茶叶科学2011，31，3： | 16 |
| 4 | 不同茶树品种中黄酮苷含量的测定显示文摘本研究采用液相质谱技术分离、鉴定了茶叶中的12种黄酮苷类化合物,包括1种芹菜素苷、2种杨梅素苷、5种槲皮素苷和4种山奈酚苷。结合标准品及高效液相色谱系统,测定了8种不同茶树品种中黄酮苷类化合物的含量。结果显示,不同茶树品种中黄酮苷含量分布广泛,以槲皮苷为主。紫芽品种中12种黄酮苷含量最高,达6.12 mg/g;福建水仙品种中含量最低,仅2.31 mg/g,茶树品种间存在显著性差异(P<0.05)。 | 吴春燕 须海荣 Julien Héritier Wilfried Andlauer | 2012 | 茶叶科学2012，32，2： | 16 |
| 5 | 应用BioMod集成多种模型研究物种的空间分布——以铁杉在中国的潜在分布为例显示文摘新型统计方法和多源、多尺度空间信息数据的产生促进了物种空间分布模型的快速发展。不同的物种空间分布模型在生态学理论的运用以及前提假设上存在差异。选用不同的模型方法和输入数据会带来预测结果的不确定性。对比并集成多个物种空间分布模型,同时利用多组输入数据可降低预测的不确定性,提高物种分布模拟的精度。本文以中国特有种铁杉(Tsuga chinensis)为例,运用基于R语言开发的BioMod软件包对比9个物种空间分布模型对铁杉的模拟效果。最后以曲线下面积(ROC)为权重集成9个模型的模拟结果,产生和筛选最佳的铁杉潜在空间分布图。研究发现随机森林模型(RF)的模拟效果最好,其次是多元适应回归样条函数模型(MARS)和广义相加模型(GAM),模拟效果最差的是表面分布区分室模型(SRE)。模型集成结果显示,最适宜铁杉分布的区域集中在中国的西南及四川盆地周围,其次零星分散于华南和台湾部分地区。这一结果与前人对铁杉自然分布的描述和研究结果较为吻合。研究进一步表明,通过模型的集成能有效地降低由于单个模型所带来的模拟结果不确定性,从而提高模拟的精度和效果。 | 毕迎凤 许建初 李巧宏 Antoine Guisan Wilfried Thuiller Niklaus E.Zimmermann 杨永平 杨雪飞 | 2013 | 植物分类与资源学报2013，35，5： | 16 |
| 6 | 绿色种植屋面的研究显示文摘绿色种植屋面拥有久远的历史,我们在许多古代建筑中都可以发现绿色种植屋面的雏形.在屋面进行绿化种植,对房屋建筑和周围环境能够起到保护和改善的作用,同时对人们的活动和心理也有积极的一面.绿色种植屋面有一定的构造和层次,各个层次具有不同的功能和作用.根阻拦材料在种植屋面中显得十分重要.在屋面上进行绿化应该结合屋面的特点,根据搭配和组合的要求,选择合适的植物进行种植. | 施韬 施惠生 Wilfried Schumacher | 2006 | 浙江工业大学学报2006，34，2： | 15 |
| 7 | Synthesis of Large-scale Multistream Heat Exchanger Networks Based on Stream Pseudo Temperature显示文摘Effective temperature level of stream, namely stream pseudo temperature, is determined by its actual temperature and heat transfer temperature difference contribution value. Heat transfer temperature difference con-tribution value of a stream depends on its heat transfer film coefficient, cost per unit heat transfer area, actual tem-perature, and so on. In the determination of the suitable heat transfer temperature difference contribution values of the stream, the total annual cost of multistream heat exchanger network (MSHEN) is regarded as an objective func-tion, and genetic/simulated annealing algorithm (GA/SA) is adopted for optimizing the heat transfer temperature difference contribution values of the stream. The stream pseudo temperatures are subsequently obtained. On the ba-sis of stream pseudo temperature, optimized MSHEN can be attained by the temperature-enthalpy (T-H) diagram method. This approach is characterized with fewer decision variables and higher feasibility of solutions. The calcu-lation efficiency of GA/SA can be remarkably enhanced by this approach and more probability is shown in search-ing the global optimum solution. Hence this approach is presented for solving industrial-sized MSHEN which is difficult to deal by traditional algorithm. Moreover, in the optimization of stream heat transfer temperature differ-ence contribution values, the effects of the stream temperature, the heat transfer film coefficient, and the construc-tion material of heat exchangers are considered, therefore this approach can be used to optimize and design heat exchanger network (HEN) with unequal heat transfer film coefficients and different of construction materials. The performance of the proposed approach has been demonstrated with three examples and the obtained solutions are compared with those available in literatures. The results show that the large-scale MSHEN synthesis problems can be solved to obtain good solutions with the modest computational effort. | 肖武 董宏光 李欣强 姚平经 罗行 Wilfried Roetzel | 2006 | Chinese Journal of Chemical Engineering2006，14，5： | 12 |
| 8 | 空腹血糖受损人群炎症标志物与胰岛素抵抗、胰岛β细胞功能受损的相关性分析显示文摘目的:探讨空腹血糖受损(IFG)人群的炎症标志物与胰岛素抵抗(IR)、胰岛β细胞功能的相关性。方法:以IFG组为研究对象,2型糖尿病组(T2DM)和健康正常组(HC)为对照,分析IFG人群炎症指标如超敏C反应蛋白(Hs-CRP)、血沉(ESR)、中性粒细胞/淋巴细胞比值(NLR)、单核细胞/淋巴细胞比值(MLR)和血小板/淋巴细胞比值(PLR)与糖代谢指标[空腹血糖(FPG)和糖化血红蛋白(HbA1c)]、胰岛素代谢指标[空腹胰岛素(FINS)、稳态模型评估胰岛素抵抗指数(HOMA-IR)和稳态模型评估胰岛β细胞功能指数(HOMA-β)]等的相关性。结果:3组炎症指标Hs-CRP、NLR和ESR之间有差异(均P<0.05);IFG组Hs-CRP与FPG、HbA1c、FINS、HOMA-IR均呈正相关(r分别为0.330、0.270、0.387、0.330,均P<0.05),与HOMA-β呈负相关(r为-0.387,P<0.05));NLR与FPG、HbA1c、HOMA-IR均呈正相关(r分别为0.218、0.363、0.336,均P<0.05),与HOMA-β呈负相关(r为-0.289,P<0.05)。结论:IFG人群的炎症标志物Hs-CRP、NLR与胰岛素抵抗、胰岛β细胞功能受损具有相关性。 | 张晓莉 梁书卉 Sam Wilfried Noel 王阳 孙续国 郑芳 | 2020 | 天津医科大学学报2020，26，3： | 10 |
| 9 | 铁道车辆的防碰撞要求、设计原理和初步结果显示文摘通过对欧洲铁路碰撞事故的分析,指出有必要在铁道车辆上进一步改善防碰撞措施,并通过合作项目SAFETRAIN目前得出的结果,阐述了防碰撞车辆结构和部件的发展现状。 | Wilfried Wolter 阎锋 | 2004 | 国外铁道车辆2004，41，2： | 9 |
| 10 | 多流股换热器网络的识别与构造显示文摘多流股换热器网络是一种新型的换热器网络。本文用改进的遗传/模拟退火算法优化综合双流股换热器网络,在此基础上进行多流股换热器网络识别和构造的研究。使网络中单个多流股换热器的换热面积最大,总的多流股换热器的换热面积也最大作为将以双流股换热器为换热设备的换热网络综合成多流股换热器网络的一个标准。通过流股匹配矩阵的使用,说明程序自动实现多流股换热器网络的识别和构造过程。文献实例证明本文提出的多流股换热器网络识别和构造方法对降低网络年度化费用是有效的。 | 罗立 魏关锋 姚平经 罗行 ROETZEL Wilfried | 2004 | 计算机与应用化学2004，21，3： | 7 |
| 11 | 21世纪健康城市展望——上海的挑战显示文摘城市化为更好的生活与健康提供了前景。我们开始注意到由于未持续发展模式所造成的负面影响。全球化快速的变化使许多城市在物资、服务与人口流动上造成了困难,不论他们是旅游人员,农村流动人口,还是被迫离家的群体或难民。未来,保证城市的健康将成为保证整个人类社会健康的关键。为迎接21世纪的挑战,健康城市应提到全球健康的议程中,这一议程可称为“健康的城市化”,包括五个行动领域。对于上海来说,这是个很好去参与“健康的城市化”目标的时机。 | Wilfried Kreisel 戴俊明 | 2006 | 医学与哲学(A)2006，27，1： | 7 |
| 12 | Data-driven estimates of global nitrous oxide emissions from croplands显示文摘Croplands are the single largest anthropogenic source of nitrous oxide(N2O) globally, yet their estimates remain difficult to verify when using Tier 1 and 3 methods of the Intergovernmental Panel on Climate Change(IPCC). Here, we re-evaluate global cropland-N2O emissions in 1961–2014, using N-rate-dependent emission factors(EFs) upscaled from 1206 field observations in 180 global distributed sites and high-resolution N inputs disaggregated from sub-national surveys covering 15593 administrative units. Our results confirm IPCC Tier 1 default EFs for upland crops in 1990–2014, but give a ~15% lower EF in 1961–1989 and a ~67% larger EF for paddy rice over the full period. Associated emissions(0.82 ±0.34 Tg N yr–1) are probably one-quarter lower than IPCC Tier 1 global inventories but close to Tier 3 estimates. The use of survey-based gridded N-input data contributes 58% of this emission reduction, the rest being explained by the use of observation-based non-linear EFs. We conclude that upscaling N2O emissions from site-level observations to global croplands provides a new benchmark for constraining IPCC Tier 1 and 3 methods. The detailed spatial distribution of emission data is expected to inform advancement towards more realistic and effective mitigation pathways. | Qihui Wang Feng Zhou Ziyin Shang Philippe Ciais Wilfried Winiwarter Robert B.Jackson Francesco N.Tubiello Greet Janssens-Maenhout Hanqin Tian Xiaoqing Cui Josep G.Canadell Shilong Piao Shu Tao | 2020 | National Science Review2020，7，2： | 7 |
| 13 | A dual positional specific lipoxygenase functions in the generation of flavor compounds during climacteric ripening of apple显示文摘Lipoxygenase(LOX)is an important contributor to the formation of aroma-active C6 aldehydes in apple(Malus×domestica)fruit upon tissue disruption but little is known about its role in autonomously produced aroma volatiles from intact tissue.We explored the expression of 22 putative LOX genes in apple throughout ripening,but only six LOXs were expressed in a ripening-dependent manner.Recombinant LOX1:Md:1a,LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b proteins showed 13/9-LOX,9-LOX,13/9-LOX and 13-LOX activity with linoleic acid,respectively.While products of LOX1:Md:1c and LOX2:Md:2b were S-configured,LOX1:Md:1a and LOX2:Md:2a formed 13(R)-hydroperoxides as major products.Site-directed mutagenesis of Gly567 to an alanine converted the dual positional specific LOX1:Md:1a to an enzyme with a high specificity for 9(S)-hydroperoxide formation.The high expression level of the corresponding MdLOX1a gene in stored apple fruit,the genetic association with a quantitative trait locus for fruit ester and the remarkable agreement in regio-and stereoselectivity of the LOX1:Md:1a reaction with the overall LOX activity found in mature apple fruits,suggest a major physiological function of LOX1:Md:1a during climacteric ripening of apples.While LOX1:Md:1c,LOX2:Md:2a and LOX2:Md:2b may contribute to aldehyde production in immature fruit upon cell disruption our results furnish additional evidence that LOX1:Md:1a probably regulates the availability of precursors for ester production in intact fruit tissue. | Doreen Schiller Carolina Contreras Jörg Vogt Frank Dunemann Bruno G Defilippi Randolph Beaudry Wilfried Schwab | 2015 | Horticulture Research2015，2，1： | 6 |
| 14 | The Strawberry Fruit Fra a Allergen Functions in Flavonoid Biosynthesis显示文摘1 变应原是的草莓兄弟主要桦树花粉变应原的一个相当或相同的事物赌了 v 1。当变异的遗传型的白水果,被知道被过敏症影响的个人容忍,缺乏它时,它被 Fragaria x ananassa 的红成熟水果综合。Proteomic 分析显示出 1 是的那个兄弟在与 anthocyanin 颜料小径的酶一起的容忍的白水果的遗传型下面调整。在这研究,我们报导三个兄弟的空间、时间的表示一编码不同 isoforms 的基因,和兄弟的短暂调停 RNAi 的 silencing 一在有 ihpRNA 的红水果的栽培变种 Elsanta 的草莓水果的基因构造。作为兄弟的减少的层次的后果 mRNAs,水果被获得那生产了 anthocyanins 和在上游的代谢物的显著地减少的层次。这效果与本氨基丙酸氨 lyase (FaPAL ) 的平行下面规定一致,到 chalcone synthase (FaCHS ) 的更小的程度,抄本层次也在这些水果发现。在 F 的自然地发生的白水果的遗传型。chiloensis 和 F。vesca,一个抄本铺平的兄弟比红水果的变化的那些高,可能在这些变异的遗传型补偿 FaPAL 和 FaCHS 的低表示层次。结果表明那个兄弟表情直接被连接到 flavonoid 生合成和表演变应原有的兄弟在在草莓的颜料形成的必要生物功能水果。 | Cristina Munoz Thomas Hoffmann Nieves Medina Escobar Felix Ludemann Miguel A. Botella Victoriano Valpuesta Wilfried Schwab | 2010 | Molecular Plant2010，3，1： | 6 |
| 15 | 德国应用科技大学教授聘任体制研究——以德国下萨克森州应用科技大学为例显示文摘与德国综合性大学相比,德国应用科技大学具有培养应用型人才为主要任务的鲜明特点。本文阐述了应用科技大学聘任教授的前提条件和教授承担的工作任务。应聘应用科技大学的教授,不仅要具备突出的科研和教学业绩,而且要具有丰富的实践经验。这一严格的应聘体制为德国应用科技大学培养出应用型人才提供了有效保证。 | 翁震华 Wilfried Stiller | 2009 | 中国高校师资研究2009，，5： | 6 |
| 16 | Mesenchymal stem cells as a therapeutic tool to treat sepsis显示文摘Sepsis is a clinical syndrome caused by a deregulated host response to an infection. Sepsis is the most frequent cause of death in hospitalized patients. Although knowledge of the pathogenesis of sepsis has increased substantially during the last decades, attempts to design effective and specific therapiestargeting components of the derailed host response have failed. Therefore, there is a dramatic need for new and mechanistically alternative therapies to treat this syndrome. Based on their immunomodulatory properties, adult mesenchymal stem or stromal cells(MSCs) can be a novel therapeutic tool to treat sepsis. Indeed, MSCs reduce mortality in experimental models of sepsis by modulating the deregulated inflammatory response against bacteria through the regulation of multiple inflammatory networks, the reprogramming of macrophages and neutrophils towards a more antiinflammatory phenotype and the release of antimicrobial peptides. This report will review the current knowledge on the effects of MSC treatment in preclinical experimental small animal models of sepsis. | Eleuterio Lombardo Tom van der Poll Olga Dela Rosa Wilfried Dalemans | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 17 | UGT74AF3 enzymes specifically catalyze the glucosylation of 4-hydroxy-2,5-dimethylfuran-3(2H)-one,an important volatile compound in Camellia sinensis显示文摘4-Hydroxy-2,5-dimethylfuran-3(2H)-one(HDMF)is an important odorant in some fruits,and is proposed to play a crucial role in the caramel-like notes of some teas.However,its biosynthesis and metabolism in tea plants are still unknown.Here,HDMF glucoside was unambiguously identified as a native metabolite in tea plants.A novel glucosyltransferase UGT74AF3a and its allelic protein UGT74AF3b specifically catalyzed the glucosylation of HDMF and the commercially important structural homologues 2(or 5)-ethyl-4-hydroxy-5(or 2)-methylfuran-3(2H)-one(EHMF)and 4-hydroxy-5-methylfuran-3(2H)-one(HMF)to their correspondingβ-D-glucosides.Site-directed mutagenesis of UGT74AF3b to introduce a single A456V mutation resulted in improved HDMF and EHMF glucosylation activity and affected the sugar donor preference compared with that of the wild-type control enzyme.The accumulation of HDMF glucoside was consistent with the transcript levels of UGT74AF3 in different tea cultivars.In addition,transient UGT74AF3a overexpression in tobacco significantly increased the HDMF glucoside contents,and downregulation of UGT74AF3 transcripts in tea leaves significantly reduced the concentration of HDMF glucoside compared with the levels in the controls.The identification of HDMF glucoside in the tea plant and the discovery of a novel-specific UDP-glucose:HDMF glucosyltransferase in tea plants provide the foundation for improvement of tea flavor and the biotechnological production of HDMF glucoside. | Yongxian Chen Xiangyang Guo Ting Gao Na Zhang Xiaochun Wan Wilfried Schwab Chuankui Song | 2020 | Horticulture Research2020，7，1： | 6 |
| 18 | 植物根阻拦材料与绿色种植屋面显示文摘绿色种植屋面在我国拥有广阔的前景,在种植屋面系统中阻拦根系对防水材料的破坏是其成败的关键。分析植物根系对屋面系统可能产生的破坏,探讨植物根系穿透一般防水材料的机理,阐述了在种植屋面中使用根阻拦材料的重要性和必要性。就德国在根阻拦材料方面的研究情况和材料认证实验的规定作了相关的介绍,这些成果和经验可以供我国的防水材料生产和设计人员参考与借鉴。 | 施韬 Wilfried Schumacher 施惠生 | 2006 | 新型建筑材料2006，33，2： | 5 |
| 19 | 大规模学生评估的影响力与重要性:德国视角显示文摘二十年来,大规模学生评估对教育研究、学校体系和教育政策产生了深远影响。'国际中学生评估项目'(PISA)、'国际学生数学与科学能力动态项目'(TIMSS)和'国际学生阅读能力进步研究项目'(PIRLS)使各个国家学生成绩值具有一定可比性,由此,人们能更细致地从学校内部来观察不同国家学校工作的差异度。大规模学生评估还为学校发展、教育领导以及学生成绩的改进提供必要数据。本文以PIRLS为例,旨在从德国视角为中国今后开展大规模国际学生评估提供借鉴。 | Wilfried Bos Miriam M.Gebauer 俞可 | 2010 | 复旦教育论坛2010，8，4： | 5 |
| 20 | Residual dynamics of thiacloprid in medical herbs marjoram,thyme,and camomile in soil显示文摘Thiacloprid 是 chloronicotinyl family.To 的新杀虫药剂在申请,在茉乔栾那属植物的 thiacloprid 的剩余特征,百里香,和甘菊和 insoil 在领域 conditions.The 下面被学习以后,估计 itsrisk 活跃成分用 acetone-water.After 过滤的混合物从 plantmaterial 被提取,摘录被集中到 theaqueous 阶段,在矩阵固体 phasedispersion column.Thiacloprid 上对乙醇醋酸盐与水,和 portioned 冲淡了从土壤 usin | YU Yun-long WU Jia-lun STAHLER Matthias PESTEMER Wilfried | 2007 | Journal of Environmental Sciences2007，19，2： | 5 |
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