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| 1 | Postoperative bleeding in patients on antithrombotic therapy after gastric endoscopic submucosal dissection显示文摘AIM To investigated the relationship between postoperative bleeding following gastric endoscopic submucosal dissection(ESD) and individual antithrombotic agents.METHODS A total of 2488 gastric neoplasms in 2148 consecutive patients treated between May 2001 and June 2016 were studied. The antithrombotic agents were categorized into antiplatelet agents, anticoagulants, and other antithrombotic agents, and we included combination therapies [e.g., dual antiplatelet therapy(DAPT)]. The risk factors associated with post-ESD bleeding, namely, antithrombotic agents overall, individual antithrombotic agents, withdrawal or continuation of antithrombotic agents, and bleeding onset period(during the first six days or thereafter), were analyzed using univariate and multivariate analyses.RESULTS The en bloc resection and complete curative resection rates were 99.2% and 91.9%, respectively. Postoperative bleeding occurred in 5.1% cases. Bleeding occurred in 10.3% of the patients administered antithrombotic agents. Being male(P = 0.007), specimen size(P < 0.001), and antithrombotic agent used(P < 0.001) were independent risk factors for postoperative bleeding. Heparin bridging therapy(HBT)(P = 0.002) and DAPT/multidrug combinations(P < 0.001) were independent risk factors associated with postoperative bleeding. The bleeding rate of the antithrombotic agent continuation group was significantly higher than that of the withdrawal group(P < 0.01). Bleeding within postoperative day(POD) 6 was significantly higher in warfarin(P = 0.015), and bleeding after POD 7 was significantly higher in DAPT/multidrug combinations(P = 0.007). No thromboembolic events were reported.CONCLUSION We must closely monitor patients administered HBT and DAPT/multidrug combinations after gastric ESD, particularly those administered multidrug combinations after discharge. | Chiko Sato Kingo Hirasawa Ryonho Koh Ryosuke Ikeda Takehide Fukuchi Ryosuke Kobayashi Hiroaki Kaneko Makomo Makazu Shin Maeda | 2017 | World Journal of Gastroenterology2017，23，30： | 14 |
| 2 | Clinicopathological features of early gastric cancers arising in Helicobacter pylori uninfected patients显示文摘BACKGROUND Persistent Helicobacter pylori(H.pylori)infection causes chronic inflammation,atrophy of the gastric mucosa,and a high risk of developing gastric cancer.In recent years,awareness of eradication therapy has increased in Japan.As H.pylori infections decrease,the proportion of gastric cancers arising from H.pylori uninfected gastric mucosa will increase.The emergence of gastric cancer arising in H.pylori uninfected patients though rarely reported,is a concern to be addressed and needs elucidation of its clinicopathological features.AIM To evaluate the clinicopathological features of early gastric cancer in H.pyloriuninfected patients.METHODS A total of 2462 patients with 3375 instances of early gastric cancers that were treated by endoscopic submucosal dissection were enrolled in our study between May 2000 and September 2019.Of these,30 lesions in 30 patients were diagnosed as H.pylori-uninfected gastric cancer(Hp UIGC).We defined a patient as H.pylori-uninfected using the following three criteria:(1)The patient did not receive treatment for H.pylori,which was determined by investigating medical recordsand conducting patient interviews;(2)Lack of endoscopic atrophy;and(3)The patient was negative for H.pylori after being tested at least twice using various diagnostic methods,including serum anti-H.pylori-Ig G antibody,urease breath test,rapid urease test,and microscopic examination.RESULTS The frequency of Hp UIGC was 1.2%(30/2462)for the patients in our study.The study included 19 males and 11 females with a mean age of 59 years.The location of the stomach lesions was divided into three sections;upper third(U),middle third(M),lower third(L).Of the 30 lesions,15 were U,1 was M,and 14 were L.Morphologically,17 lesions were protruded and flat elevated type(0-I,0-IIa,0-IIa+IIc),and 13 lesions were flat and depressed type(0-IIb,0-IIc).The median tumor diameter was 8 mm(range 2-98 mm).Histological analysis revealed that22 lesions(73.3%)were differentiated type.The Hp UIGC lesions were classified into fundic gland type adenocarcinoma(7 cases),foveolar type welldifferentiated adenocarcinoma(8 cases),intestinal phenotype adenocarcinoma(7 cases),and pure signet-ring cell carcinoma(8 cases).Among 30 Hp UIGCs,24 lesions(80%)were limited to the mucosa;wherein,the remaining 6 lesions showed submucosal invasion.One of the submucosal invasive lesions showed more than 500μm invasion.The mucin phenotype analysis identified 7 Hp UIGC with intestinal phenotype and 23 with gastric phenotype.CONCLUSION We elucidated the clinicopathological characteristics of Hp UIGC,revealing recognition not only undifferentiated-type but also differentiated-type.In addition,intestinal phenotype tumors were also observed and could be an important tip. | Chiko Sato Kingo Hirasawa Yoko Tateishi Yuichiro Ozeki Atsushi Sawada Ryosuke Ikeda Takehide Fukuchi Masafumi Nishio Ryosuke Kobayashi Makomo Makazu Hiroaki Kaneko Yoshiaki Inayama Shin Maeda | 2020 | World Journal of Gastroenterology2020，26，20： | 7 |
| 3 | Histopathological validation of magnifying endoscopy for diagnosis of mixed-histological-type early gastric cancer显示文摘BACKGROUND The undifferentiated-type(UDT)component profoundly affects the clinical course of early gastric cancers(EGCs).However,an accurate preoperative diagnosis of the histological types is unsatisfactory.To date,few studies have investigated whether the UDT component within mixed-histological-type(MT)EGCs can be recognized preoperatively.AIM To clarify the histopathological characteristics of the endoscopically-resected MT EGCs for investigating whether the UDT component could be recognized preoperatively.METHODS This was a single-center retrospective study.First,we attempted to clarify the histopathological characteristics of the endoscopically-resected MT EGCs with emphasis on the UDT component.Histopathological examination investigated each lesion’s UDT component:(1)Whole mucosal layer occupation of the UDT component;(2)UDT component exposure to the surface of the mucosa;and(3)existence of a clear border between the differentiated-type and UDT components.Then,preoperative endoscopic images with magnifying endoscopy with narrowband imaging(ME-NBI)were examined to identify whether the endoscopic UDT component finding was recognizable within the area where it was present in the histopathological examination.The preoperative biopsy results and comparative relationships between endoscopic and histopathological findings were also examined.RESULTS In the histopathological examination,the whole mucosal layer occupation of the UDT component and exposure of the UDT component to the mucosal surface were observed in 67.3%(33/49)and 79.6%(39/49)of samples,respectively.A clear distinction of the border between the differentiated-type and UDT components could not be drawn in 65.3%(32/49)of MT lesions.In the endoscopic examination,the preoperative endoscopic images showed that only 24.5%(12/49)of MT EGCs revealed the UDT component within the area where it was present histopathologically.Histopathological UDT predominance was the single significant factor associated with the presence of the endoscopic UDT component finding(61.5%vs 11.1%,P=0.0009).Only 26.5%(13/49)of the lesions were diagnosed from the pretreatment biopsy as having a UDT component.Combined results of the pretreatment biopsy and ME-NBI showed the preoperative presence of the UDT component in 40.8%(20/49)of MT EGCs.CONCLUSION Recognition of a UDT component within MT EGCs is difficult even when pretreatment biopsy and ME-NBI are combined.Endoscopic resection plays a significant role in both treatment and diagnosis. | Yuichiro Ozeki Kingo Hirasawa Ryosuke Kobayashi Chiko Sato Yoko Tateishi Atsushi Sawada Ryosuke Ikeda Masafumi Nishio Takehide Fukuchi Makomo Makazu Masataka Taguri Shin Maeda | 2020 | World Journal of Gastroenterology2020，26，36： | 5 |
| 4 | Resected case of eosinophilic cholangiopathy presenting with secondary sclerosing cholangitis显示文摘Eosinophilic cholangiopathy is a rare condition characterized by eosinophilic infiltration of the biliary tract and causes sclerosing cholangitis.We report a patient with secondary sclerosing cholangitis with eosinophilic cholecystitis.A 46-year-old Japanese man was admitted to our hospital with jaundice. Computed tomography revealed dilatation of both the intrahepatic and extrahepatic bile ducts,diffuse thickening of the wall of the extrahepatic bile duct,and thickening of the gallbladder wall.Under the diagnosis of lower bile duct carcinoma,he underwent pyloruspreserving pancreatoduodenectomy and liver biopsy. On histopathological examination,conspicuous fibrosis was seen in the lower bile duct wall.In the gallbladder wall,marked eosinophilic infiltration was seen.Liver biopsy revealed mild portal fibrosis.He was diagnosed as definite eosinophilic cholecystitis with sclerosing cholangitis with unknown etiology.The possible etiology of sclerosing cholangitis was consequent fibrosis from previous eosinophilic infiltration in the bile duct.The clinicopathological findings of our case and a literature review indicated that eosinophilic cholangiopathy could cause a condition mimicking primary sclerosing cholangitis(PSC).Bile duct wall thickening in patientswith eosinophilic cholangitis might be due to fibrosis of the bile duct wall.Eosinophilic cholangiopathy might be confused as PSC with eosinophilia. | Fumihiko Miura Takehide Asano Hodaka Amano Masahiro Yoshida Naoyuki Toyota Keita Wada Kenichiro Kato Tadahiro Takada Junichi Fukushima Fukuo Kondo Hajime Takikawa | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 5 | Arterio-biliary fistula as rare complication of chemoradiation therapy for intrahepatic cholangiocarcinoma显示文摘Significant hemobilia due to arterio-biliary fistula is a very rare complication of chemoradiation therapy(CRT) for unresectable intrahepatic cholangiocarcinoma(ICC).Here we report a case of arterio-biliary fistula after CRT for unresectable ICC demonstrated by angiographic examinations.This fistula was successfully treated by endovascular embolization.Hemobilia is a rare complication,but arterio-biliary fistula should be considered after CRT of ICC. | Koichi Hayano Fumihiko Miura Hodaka Amano Naoyuki Toyota Keita Wada Kenichiro Kato Tadahiro Takada Takehide Asano | 2010 | World Journal of Radiology2010，2，9： | 3 |
| 6 | Is pancreatectomy with arterial reconstruction a safe and useful procedure for locally advanced pancreatic cancer?显示文摘 | Hodaka Amano Fumihiko Miura Naoyuki Toyota Keita Wada Ken-ichirou Katoh Kouichi Hayano Susumu Kadowaki Makoto Shibuya Sawako Maeno Tomoaki Eguchi Tadahiro Takada Takehide Asano | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，6： | 2 |
| 7 | Cerebral infarction in the caudate nucleus associated with acute epidural hematoma and diffuse brain injury in a child after severe head injury显示文摘 | Miki Fujimura Motonobu Kameyama Osamu Motohashi Hiroyuki Kon Kiyoshi Ishii Takehide Onuma | 2004 | Child’s Nervous System2004，，6： | 2 |
| 8 | Use of omentum or falciform ligament does not decrease complications after pancreaticoduodenectomy: Nationwide survey of the Japanese Society of Pancreatic Surgery显示文摘 | Masaji Tani Manabu Kawai Seiko Hirono Takashi Hatori Toshihide Imaizumi Akimasa Nakao Shinichi Egawa Takehide Asano Takukazu Nagakawa Hiroki Yamaue | 2012 | Surgery2012，，2： | 2 |
| 9 | Third-look endoscopy prevents delayed bleeding after endoscopic submucosal dissection under antithrombotic therapy显示文摘BACKGROUND Postoperative delayed bleeding(PDB) after gastric endoscopic submucosal dissection(ESD) is the most common adverse event in patients receiving antithrombotics even with second-look endoscopy. Moreover, with the increasing prevalence of cardiovascular and cerebrovascular diseases in an aging population with associated lifestyle-related diseases, an increasing number of patients receive antithrombotics. Several attempts have been made to prevent PDB in aging population;however, a consensus has yet to be reached.AIM To examine the efficacy of third-look endoscopy(TLE) for PDB prevention.METHODS One hundred patients with early gastric neoplasms receiving antithrombotics were prospectively enrolled and subjected to ESD with TLE between February 2017 and July 2019. The primary endpoint was PDB rate, which was compared with our preset threshold. Furthermore, we divided the bleeding period into early-and late-onset PDB(E-PDB and L-PDB, respectively) and analyzed its rate. As a secondary analysis, we compared PDB rates with those of a historical control group, using propensity score matching, and calculated the PDB rates per antithrombotic agent use in each group.RESULTS In total, 96 patients and 114 specimens were finally evaluated. The overall PDB rate was 7.9%(9/114) [90%CI: 4.7-13.1, P = 0.005], while the late-and early-onset PDB rates(L-PDB and E-PDB) were 5.3% [90%CI: 2.7-9.9, P < 0.0001] and 2.6% [90%CI: 1.1-6.4, P = 0.51], respectively. Propensity score matching generated 58 matched pairs for TLE and control groups. No differences were found in overall PDB incidence(10.3% vs 20.7%, P = 0.12), whereas L-PDB occurrence significantly differed(5.2% vs 17.2%, P = 0.04) between groups. Considering antithrombotics' use, the overall PDB rate was higher for direct oral anticoagulants and multiple antithrombotics in the control group, while L-PDB incidence was lower in the TLE group for these agents(8.7% vs 23.1% and 5.0% vs 29.4%, respectively).CONCLUSION TLE for gastric ESD reduces overall PDB, and especially L-PDB incidence, among patients receiving antithrombotics. | Ryosuke Ikeda Kingo Hirasawa Chiko Sato Yuichiro Ozeki Atsushi Sawada Masafumi Nishio Takehide Fukuchi Ryosuke Kobayashi Makomo Makazu Masataka Taguri Shin Maeda | 2020 | World Journal of Gastroenterology2020，26，41： | 2 |
| 10 | Physical Metallurgy of Modern High Strength Steel Sheets显示文摘 | Takehide SENUMA | 2001 | ISIJ International2001，41，6： | 1 |
| 11 | Present status of and future prospects for pre- cipitation research in the steel industry 显示文摘 | Takehide Senuma | 2002 | ISIJ International2002，42，1： | 1 |
| 12 | Physical metallurgy of modern high strength steel sheets 显示文摘 | Takehide Senuma | 2001 | ISIJ International2001，41，6： | 1 |
| 13 | Production of electrically conductive paper by adding carbon nanotubes显示文摘 | Takehide Oya Toshio Ogino | | 0，，01： | 1 |
| 14 | Generalized Nb (C, N) precipitation model applicable to extra low carbon steel显示文摘 | Akamatsu Satoshi Senuma Takehide Hasebe Mitsuhiro | 1992 | ISU International1992，32，3： | 1 |
| 15 | Mathematical Models for Predicting Microstructural Evolution and Mechanical Properties of Hot Strips显示文摘 | Takehide S Masayoshi S Hiroshi Y | 1992 | ISIJ International1992，32，3： | 1 |
| 16 | Physical Metallurgy of Modern High Strength Steel Sheets显示文摘 | Takehide SENUMA | | 0，，06： | 1 |
| 17 | Simultaneous detection of RNA and protein by in situ hybridization and immunological staining 显示文摘 | Hideyuki Nagaso Takehide Murata | 2001 | J Histochem Cytochem2001，49，9： | 1 |
| 18 | Physical Metallurgy of Modem High Strength Steel Sheet 显示文摘 | Takehide Senuma | 2001 | ISIJ International2001，41，6： | 1 |
| 19 | Decreased abundance of F aecalibacterium prausnitzii in the gut microbiota of C rohn’s disease显示文摘 | Takehide Fujimoto Hirotsugu Imaeda Kenichiro Takahashi Eiji Kasumi Shigeki Bamba Yoshihide Fujiyama Akira Andoh | 2013 | J Gastroenterol Hepatol2013，，4： | 1 |
| 20 | Physical metallurgy of modem Hish strength steel sheets 显示文摘 | Takehide Senuma | 2001 | ISIJ International2001，41，6： | 1 |
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