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| 1 | Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma显示文摘AIM:To compare the clinicopathological characteristics of human epidermal growth factor receptor 2 (HER2)-positive and HER2-negative Barrett's adenocarcinoma in Japan. METHODS:We performed immunohistochemical analysis of HER2 in 30 samples taken from patients with Barrett's adenocarcinoma and dual color in situ hybridization in cases showing 2+ reactions. We compared the clinicopathological characteristics of HER2-positive and HER2-negative patients.RESULTS:HER2 positivity was identified in 8 (27%) carcinoma samples. We found that HER2 expression was associated with p53 overexpression (100% vs 52.6% in pT1 tumor; 100% vs 54.5% in all stage tumor, P < 0.05) and protruding lesions at the early disease stage. There was no association between the mucin phenotype of the carcinomas and prognosis. HER2 expression and low clinical stage were unexpectedly different between Barrett's adenocarcinoma patients and gastric cancer patients, but the macroscopic features may be associated with earlier diagnosis in these patients. CONCLUSION:Our results suggest that HER2-positive Barrett's adenocarcinomas are associated with p53 overexpression and lesion protrusion at the early disease stage. | Takehiro Tanaka Atsushi Fujimura Koichi Ichimura Hiroyuki Yanai Yasuharu Sato Katsuyohi Takata Hiroyuki Okada Seiji Kawano Shunsuke Tanabe Tadashi Yoshino | 2012 | World Journal of Gastroenterology2012，18，43： | 2 |
| 2 | A rapid PCR-aided selection of a rice line containing the Rf-1 gene which is involved in restoration of the cytoplasmic male sterility显示文摘 | Norio Ichikawa Noaki Kishimoto Akiko Inagaki Atsushi Nakamura Yoko Koshino Yumi Yokozeki Masaaki Oka Shiro Samoto Hiromori Akagi Kenichi Higo Choyu Shinjyo Tatsuhito Fujimura Hiroaki Shimada | 1997 | Molecular Breeding1997，，3： | 1 |
| 3 | A rapid PCR-aided selection of a rice line containing the Rf-1 gene which is involved in restoration of the cytoplasmic male sterility显示文摘 | Norio Ichikawa Noaki Kishimoto Akiko Inagaki Atsushi Nakamura Yoko Koshino Yumi Yokozeki Masaaki Oka Shiro Samoto Hiromori Akagi Kenichi Higo Choyu Shinjyo Tatsuhito Fujimura Hiroaki Shimada | 1997 | Molecular Breeding1997，，3： | 1 |
| 4 | Pre- dictive role of modified clinical diffusion mismatch in early neurological deterioration due to atherothrombotic ischemia in the anterior circulation 显示文摘 | Atsushi Saito Hiroaki Shimizu Miki Fujimura | 2011 | Acta Neuro- chir2011，153，： | 1 |
| 5 | Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus显示文摘 | Atsushi Yamashita Kensaku Nishihira Yunosuke Matsuura Takashi Ito Kouichi Kawahara Kinta Hatakeyama Teruto Hashiguchi Ikuro Maruyama Hideo Yagi Masanori Matsumoto Yoshihiro Fujimura Kazuo Kitamura Yoshisato Shibata Yujiro Asada | 2012 | Atherosclerosis2012，，： | 1 |
| 6 | Stachybotrys microspora triprenyl phenol-7, a novel fibrinolytic agent, suppresses superoxide production, matrix metalloproteinase-9 expression, and thereby attenuates ischemia/reperfusion injury in rat brain显示文摘 | Yosuke Akamatsu Atsushi Saito Miki Fujimura Hiroaki Shimizu Moataz Mekawy Keiji Hasumi Teiji Tominaga | 2011 | Neuroscience Letters2011，，2： | 1 |
| 7 | Stachybotrys microspora triprenyl phenol-7, a novel fibrinolytic agent, suppresses superoxide production, matrix metalloproteinase-9 expression, and thereby attenuates ischemia/reperfusion injury in rat brain显示文摘 | Yosuke Akamatsu Atsushi Saito Miki Fujimura Hiroaki Shimizu Moataz Mekawy Keiji Hasumi Teiji Tominaga | 2011 | Neuroscience Letters2011，，2： | 1 |
| 8 | A rapid PCR-aided selection of a rice line containing the Rf-1 gene which is involved in restoration of the cytoplasmic male sterility显示文摘 | Norio Ichikawa Noaki Kishimoto Akiko Inagaki Atsushi Nakamura Yoko Koshino Yumi Yokozeki Masaaki Oka Shiro Samoto Hiromori Akagi Kenichi Higo Choyu Shinjyo Tatsuhito Fujimura Hiroaki Shimada | 1997 | Molecular Breeding1997，，3： | 1 |
| 9 | Delivery of sodium borocaptate to glioma cells using immunoliposome conjugated with anti-EGFR antibodies by ZZ-His显示文摘 | Bin Feng Kazuhito Tomizawa Hiroyuki Michiue Shin-ichi Miyatake Xiao-Jian Han Atsushi Fujimura Masaharu Seno Mitsunori Kirihata Hideki Matsui | 2008 | Biomaterials2008，，9： | 1 |
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