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| 1 | Rhabdomyolysis after midazolam administration in a cirrhotic patient treated with atorvastatin显示文摘The administration of statins in patients with liver disease is not an absolute contraindication. Hepatotoxicity is a rare and often dose-related event and in the literature there are only a few described cases of fatal rhab-domyolysis in patients with chronic liver disease after statin administration. During treatment with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors,the factors responsible for myopathy may either be related to the patient,or due to interactions with other medications that are metabolic substrates of the same isozymes and therefore able to increase blood statin concentration. The most important side effects consist of increased transaminase levels,abdominal pain or muscle weakness,increased serum levels of creatine kinase and rhabdomyolysis. In this article we report a case of fatal rhabdomyolysis with acute renal failure after gastric endoscopy,where midazolam was used as a sedation agent in a patient with chronic liver disease treated with a high dose of atorvastatin. Therefore,we suggest paying particular attention to the potential risks of associating atorvastatin and midazolam in patients with chronic liver disease who need to undergo gastric endoscopy. | Antonietta Gigante Gianluca Di Lazzaro Giraldi Maria Ludovica Gasperini Biagio Barbano Marta Liberatori Liborio Sardo Francesca Di Mario Antonella Giorgi Filippo Rossi-Fanelli Antonio Amoroso | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 6 |
| 2 | 1,8-Naphthyridines IV. 9-Substituted N , N -dialkyl-5-(alkylamino or cycloalkylamino) [1,2,4]triazolo[4,3- a ][1,8]naphthyridine-6-carboxamides, new compounds with anti-aggressive and potent anti-inflammatory activities显示文摘 | Giorgio Roma Mario Di Braccio Giancarlo Grossi Francesca Mattioli Marco Ghia | 2000 | European Journal of Medicinal Chemistry2000，，11： | 2 |
| 3 | C-Reactive Protein in Ischemic Stroke: An Independent Prognostic Factor显示文摘 | Mario Di Napoli Francesca Papa Vittorio Bocola | 2001 | Stroke: Journal of the American Heart Association2001，，4： | 2 |
| 4 | Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke: A Statement for Health Care Professionals From the CRP Pooling Project Members显示文摘 | Mario Di Napoli Markus Schwaninger Roberto Cappelli Elena Ceccarelli Giacinto Di Gianfilippo Cristina Donati Hedley C.A. Emsley Sandro Forconi Stephen J. Hopkins Luca Masotti Keith W. Muir Anna Paciucci Francesca Papa Sabina Roncacci Dirk Sander Kerstin S | 2005 | Stroke2005，，6： | 2 |
| 5 | Morning Blood Pressure Surge as a Destabilizing Factor of Atherosclerotic Plaque: Role of Ubiquitin–Proteasome Activity显示文摘 | Raffaele Marfella Mario Siniscalchi Michele Portoghese Clara Di Filippo Franca Ferraraccio Concetta Schiattarella Basilio Crescenzi Paolo Sangiuolo Giuseppe Ferraro Silvio Siciliano Francesca Cinone Gennaro Mazzarella Simone Martis Mario Verza Ludovico Co | 2007 | Hypertension2007，，4： | 2 |
| 6 | One-month strawberry-rich anthocyanins supplementation ameliorates cardiovascular risk, oxidative stress markers and platelets activation in humans显示文摘 | José M. Alvarez-Suarez Francesca Giampieri Sara Tulipani Tiziana Casoli Giuseppina Di Stefano Ana M. González-Paramás Celestino Santos-Buelga Franco Busco Josè L. Quiles Mario D. Cordero Stefano Bompadre Bruno Mezzetti Maurizio Battino | 2013 | The Journal of Nutritional Biochemistry2013，，： | 1 |
| 7 | Endothelial function and cardiovascular risk in active inflammatory bowel diseases显示文摘 | Mariabeatrice Principi Mario Mastrolonardo Pietro Scicchitano Michele Gesualdo Marco Sassara Piero Guida Antongiulio Bucci Annapaola Zito Paola Caputo Francesca Albano Enzo Ierardi Alfredo Di Leo Marco Matteo Ciccone | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 8 | Clinical Use of C-Reactive Protein for Prognostic Stratification in Ischemic Stroke: Has the Time Come for Including It in the Patient Risk Profile?显示文摘 | Mario Di Napoli Francesca Papa | 2003 | Stroke: Journal of the American Heart Association2003，，2： | 1 |
| 9 | C-Reactive Protein in Ischemic Stroke: An Independent Prognostic Factor显示文摘 | Mario Di Napoli Francesca Papa Vittorio Bocola | 2001 | Stroke: Journal of the American Heart Association2001，，4： | 1 |
| 10 | Prognostic Influence of Increased C-Reactive Protein and Fibrinogen Levels in Ischemic Stroke显示文摘 | Mario Di Napoli Francesca Papa Vittorio Bocola | 2001 | Stroke: Journal of the American Heart Association2001，，1： | 1 |
| 11 | Endothelial function and cardiovascular risk in active inflammatory bowel diseases显示文摘 | Mariabeatrice Principi Mario Mastrolonardo Pietro Scicchitano Michele Gesualdo Marco Sassara Piero Guida Antongiulio Bucci Annapaola Zito Paola Caputo Francesca Albano Enzo Ierardi Alfredo Di Leo Marco Matteo Ciccone | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 12 | Boceprevir or telaprevir in hepatitis C virus chronic infection:The Italian real life experience显示文摘AIM: To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus(HCV) genotype 1 in the real-world settings. METHODS: This study was a non-randomized, observational, prospective, multicenter. This study involved 47 centers in Italy. A database was prepared for the homogenous collection of the data, was used by all of the centers for data collection, and was updated continuously. All of the patients enrolled in this study were older than 18 years of age and were diagnosed with chronic infection due to HCV genotype 1. The HCV RNA testing was performed using COBAS-Taq Man2.0(Roche, LLQ 25 IU/m L). RESULTS: All consecutively treated patients were included. Forty-seven centers enrolled 834 patients as follows: Male 64%; median age 57(range 18-78), of whom 18.3% were over 65; mean body mass index 25.6(range 16-39); genotype 1b(79.4%); diagnosis of cirrhosis(38.2%); and fibrosis F3/4(71.2%). The following drugs were used: Telaprevir(66.2%) and PEG-IFN-alpha2a(67.6%). Patients were na?ve(24.4%), relapsers(30.5%), partial responders(14.8%) and null responders(30.3%). Overall, adverse events(AEs) occurred in 617 patients(73.9%) during the treatment. Anemia was the most frequent AE(52.9% of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the patients because of adverse events or virological failure(15%). Sustained virological response was achieved in 62.7% of the cases, but was 43.8% in cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple therapy is safe but has moderate efficacy, especially for patients over 65 years of age, with advanced fibrosis, nonresponders to peginterferon + ribavirin. | Antonio Ascione Luigi Elio Adinolfi Pietro Amoroso Angelo Andriulli Orlando Armignacco Tiziana Ascione Sergio Babudieri Giorgio Barbarini Michele Brogna Francesco Cesario Vincenzo Citro Ernesto Claar Raffaele Cozzolongo Giuseppe D’Adamo Emilio D’Amico Pellegrino Dattolo Massimo De Luca Vincenzo De Maria Massimo De Siena Giuseppe De Vita Antonio Di Giacomo Rosanna De Marco Giorgio De Stefano Giulio De Stefano Sebastiano Di Salvo Raffaele Di Sarno Nunzia Farella Laura Felicioni Basilio Fimiani Luca Fontanella Giuseppe Foti Caterina Furlan Francesca Giancotti Giancarlo Giolitto Tiziana Gravina Barbara Guerrera Roberto Gulminetti Angelo Iacobellis Michele Imparato Angelo Iodice Vincenzo Iovinella Antonio Izzi Alfonso Liberti Pietro Leo Gennaro Lettieri Ileana Luppino Aldo Marrone Ettore Mazzoni Vincenzo Messina Roberto Monarca Vincenzo Narciso Lorenzo Nosotti Adriano Maria Pellicelli Alessandro Perrella Guido Piai Antonio Picardi Paola Pierri Grazia Pietromatera Francesco Resta Luca Rinaldi Mario Romano Angelo Rossini Maurizio Russello Grazia Russo Rodolfo Sacco Vincenzo Sangiovanni Antonio Schiano Antonio Sciambra Gaetano Scifo Filomena Simeone Annarita Sullo Pierluigi Tarquini Paolo Tundo Alfredo Vallone | 2016 | World Journal of Hepatology2016，8，22： | 1 |
| 13 | Hyperglycemia and Short-term Outcome in Patients with Spontaneous Intracerebral Hemorrhage显示文摘 | Daniel A. Godoy Gustavo R. Pi?ero Silvana Svampa Francesca Papa Mario Di Napoli | 2008 | Neurocritical Care2008，，2： | 1 |
| 14 | Angiotensin-Converting Enzyme Inhibitor Use Is Associated With Reduced Plasma Concentration of C-Reactive Protein in Patients With First-Ever Ischemic Stroke显示文摘 | Mario Di Napoli Francesca Papa | 2003 | Stroke2003，34，： | 1 |
| 15 | C - reactive protein in ischemic 显示文摘 | Mario Di Napoli Francesca Papa | 2002 | stroke2002，33，9： | 1 |
| 16 | C-Reactive Protein Level Measurement Improves Mortality Prediction When Added to the Spontaneous Intracerebral Hemorrhage Score显示文摘 | Mario Di Napoli Daniel Agustin Godoy Veronica Campi Marta del Valle Gustavo Pi?ero Matias Mirofsky Aurel Popa-Wagner Luca Masotti Francesca Papa Alejandro A. Rabinstein | 2011 | Stroke A Journal of Cerebral Circulation2011，，5： | 1 |
| 17 | C-Reactive Protein in Ischemic Stroke: An Independent Prognostic Factor 显示文摘 | Mario Di Napoli Francesca Papa Vittorio Bocola | 2001 | Stroke2001，32，： | 1 |
| 18 | Child abuse and psychopathy: Interplay, gender differences and biological correlates显示文摘Child abuse is an important source of mental and physical adverse consequences for victims,their family,and their community.The impact of violence during childhood on the development of the victim is a very sensitive theme.Other than internalizing symptoms,it is interesting to analyze the possibility that a victim may assume the role of persecutor.With this aim,we evaluate Literature and examine the interplay among different types of child abuse(emotional neglect,emotional abuse,physical neglect,physical abuse and sexual abuse)and the development of psychopathy.We consider the role of post-traumatic stress disorder and that of personal environment as potential mediators between abuse and psychopathy.Furthermore,an in-depth analysis on possible differences due to the victim's gender is performed.Finally,analysis focused on genetic variants,such as the polymorphism of 5HTT and MAO-A,or a biological alteration,like the difference in daily cortisol levels that could be related to the development of psychopathy after a trauma. | Ester di Giacomo Mario Santorelli Rodolfo Pessina Daniele Rucco Valeria Placenti Francesca Aliberti Fabrizia Colmegna Massimo Clerici | 2021 | World Journal of Psychiatry2021，11，12： | 0 |
| 19 | Therapeutic termination of pregnancy and women’s mental health:Determinants and consequences显示文摘The therapeutic termination of pregnancy(TToP)is an induced abortion following a diagnosis of medical necessity.TToP is applied to avoid the risk of substantial harm to the mother or in cases of fetal unviability.This type of induced abortion is provided after the second semester of gestation if fetal illness or the pregnancy cause physical danger or pathological mental distress to the mother.Sociocultural and economic determinants could influence the desire for children and family planning in couples,as well as the use of effective contraception and the choice to perform an induced abortion.Also,pre-existing mental health problems could affect the decision between carrying on a problematic pregnancy or having TToP.Furthermore,the TToP is a reproductive event with an important traumatic burden,but also with an intrinsic therapeutic effect and it can produce different psychological and psychopathological effects on women and couples.The aim of this review is to evaluate what demographic,reproductive and psychopathological determinants are involved in the choice of undergoing a TToP in women.Also,we will examine both positive and negative consequences of this procedure on women’s mental health,underlying which factors are related to a worse outcome in order to provide the best clinical support to vulnerable groups. | Ester di Giacomo Rodolfo Pessina Mario Santorelli Daniele Rucco Valeria Placenti Francesca Aliberti Fabrizia Colmegna Massimo Clerici | 2021 | World Journal of Psychiatry2021，11，11： | 0 |
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