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| 1 | Role and mechanisms of action of escherichia coli nissle 1917 in the maintenance of remission in ulcerative colitis patients: an update显示文摘Ulcerative colitis(UC) is a chronic inflammatory disease, whose etiology is still unclear. Its pathogenesis involves an interaction between genetic factors, immune response and the 'forgotten organ', Gut Microbiota. Several studies have been conducted to assess the role of antibiotics and probiotics as additional or alternative therapies for Ulcerative Colitis. Escherichia coli Nissle(Ec N) is a nonpathogenic Gram-negative strain isolated in 1917 by Alfred Nissle and it is the active component of microbial drug Mutaflor®(Ardeypharm Gmb H, Herdecke, Germany and Ec N, Cadigroup, In Italy) used in many gastrointestinal disorder including diarrhea, uncomplicated diverticular disease and UC. It is the only probiotic recommended in ECCO guidelines as effective alternative to mesalazine in maintenance of remission in UC patients. In this review we propose an update on the role of Ec N 1917 in maintenance of remission in UC patients, including data about efficacy and safety. Further studies may be helpful for this subject to further the full use of potential of Ec N. | Franco Scaldaferri Viviana Gerardi Francesca Mangiola Loris Riccardo Lopetuso Marco Pizzoferrato Valentina Petito Alfredo Papa Jovana Stojanovic Andrea Poscia Giovanni Cammarota Antonio Gasbarrini | 2016 | World Journal of Gastroenterology2016，22，24： | 19 |
| 2 | Current approach in the treatment of hepatocellular ca显示文摘Hepatocellular carcinoma (HCC) is the most common malignant hepatobiliary disease; it is responsible for about 1 million deaths per year. Risk factors include hepatitis B and C, hepatic cirrhosis, including alcohol related hepatitis, metabolic and nutritional hepatic damage. The main modality of diffusion is intrahepatic in the natural course of the disease. There are two leading types of treatment: local and systemic. Surgical resection and liver transplantation constitute the most appropriate local treatments and are considered the only real possibility for recovery. Other local approaches include: radiofrequency ablation, percutaneous ethanol ablation, hepatic endoarterial chemoembolization and intrahepatic radiotherapy (SIRT: selective internal radiation therapy). These last treatments are used to control the disease when surgery or transplantation is not achievable; in some cases they are able to prolong survival while theyconstitute mainly a palliative treatment. Systemic treatments include: chemotherapy, immunological and hormonal therapies and, more recently, the introduction of new specific molecular target drugs. At the moment, in this group, the only drug that has given positive results during phase trials (SHARP study) is Sorafenib.Sorafenib represents the only primary systemic therapy that has demonstrated, unlike the other treatments previously described, an increase in survival rate in patients affected with advanced HCC. Currently, other studies are taking place that are further developing the potential of this drug. These studies, including phase trials, aredirected in order to test the activity and safety of new emerging drugs with targeted activity. Examples of these new agents are: Sunitinib, Gef itinib, Cetuximab, Bevacizumab and Erlotinib. | Luigi Rossi Federica Zoratto Anselmo Papa Francesca Iodice Marina Minozzi Luigi Frati Silverio Tomao | 2010 | World Journal of Gastrointestinal Oncology2010，2，9： | 11 |
| 3 | Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes显示文摘Fas/CD95 表面受体调停各种各样的房间的快速的死亡打字,包括有为触发 autoimmunity 的潜力的 autoreactive T 房间。这里,我们表明那的船边交货的现在的新奇方面定义一种“社会”的尺寸到导致受体的 apoptosis。船边交货刺激很快导致在附近的 T 房间之间的广泛的膜 nanotube 形成。这极其依赖于 Rho GTPases 然而并非在 caspase 激活上。包括活跃 caspases 的膜和 cytosolic 元素的双向转移能被观察经由这些 nanotubes 发生。Nanotube 形成和死亡信号的细胞间的交换在从有在船边交货受体的自体免疫的 lymphoproliferative 症候群 harbouring 变化的病人的 T 淋巴细胞是有缺点的。我们断定调停 nanotube 的交换组成扩充在附近的 T 房间之间发信号的死亡的繁殖的细胞间的通讯的一种新奇形式。 | Peter D Arkwright Francesca Luchetti Julien Tour Charlotte Roberts Rahna Ayub Ana P Morales Jose J Rodriguez Andrew Gilmore Barbara Canonico Stefano Papa Mauro Degli Esposti | 2010 | Cell Research2010，20，1： | 4 |
| 4 | C-Reactive Protein in Ischemic Stroke: An Independent Prognostic Factor显示文摘 | Mario Di Napoli Francesca Papa Vittorio Bocola | 2001 | Stroke: Journal of the American Heart Association2001，，4： | 2 |
| 5 | Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke: A Statement for Health Care Professionals From the CRP Pooling Project Members显示文摘 | Mario Di Napoli Markus Schwaninger Roberto Cappelli Elena Ceccarelli Giacinto Di Gianfilippo Cristina Donati Hedley C.A. Emsley Sandro Forconi Stephen J. Hopkins Luca Masotti Keith W. Muir Anna Paciucci Francesca Papa Sabina Roncacci Dirk Sander Kerstin S | 2005 | Stroke2005，，6： | 2 |
| 6 | Clinical Use of C-Reactive Protein for Prognostic Stratification in Ischemic Stroke: Has the Time Come for Including It in the Patient Risk Profile?显示文摘 | Mario Di Napoli Francesca Papa | 2003 | Stroke: Journal of the American Heart Association2003，，2： | 1 |
| 7 | C-Reactive Protein in Ischemic Stroke: An Independent Prognostic Factor显示文摘 | Mario Di Napoli Francesca Papa Vittorio Bocola | 2001 | Stroke: Journal of the American Heart Association2001，，4： | 1 |
| 8 | Prognostic Influence of Increased C-Reactive Protein and Fibrinogen Levels in Ischemic Stroke显示文摘 | Mario Di Napoli Francesca Papa Vittorio Bocola | 2001 | Stroke: Journal of the American Heart Association2001，，1： | 1 |
| 9 | Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species显示文摘 | Can G. Pham Concetta Bubici Francesca Zazzeroni Salvatore Papa Joy Jones Kellean Alvarez Shanthi Jayawardena Enrico De Smaele Rong Cong Carole Beaumont Frank M. Torti Suzy V. Torti Guido Franzoso | 2004 | Cell2004，，： | 1 |
| 10 | C-reactive protein in ischemic显示文摘 | Marko Di Napoli Francesca Papa Vitt ori o Bocola | 2001 | stroke2001，32，： | 1 |
| 11 | Prognostic Influence of Increased C-Reactive Protein and Fibrinogen Levels in Ischemic Stroke显示文摘 | Francesca Papa Vittorio Bocola | 2001 | Stroke2001，32，1： | 1 |
| 12 | Hyperglycemia and Short-term Outcome in Patients with Spontaneous Intracerebral Hemorrhage显示文摘 | Daniel A. Godoy Gustavo R. Pi?ero Silvana Svampa Francesca Papa Mario Di Napoli | 2008 | Neurocritical Care2008，，2： | 1 |
| 13 | Rall System Development and Urban Transformations:Towards a Spatial Decision Support System显示文摘 | Papa Enrica Pagliara Francesca Bertolini Luca | 2007 | Railway Development2007，，： | 1 |
| 14 | Angiotensin-Converting Enzyme Inhibitor Use Is Associated With Reduced Plasma Concentration of C-Reactive Protein in Patients With First-Ever Ischemic Stroke显示文摘 | Mario Di Napoli Francesca Papa | 2003 | Stroke2003，34，： | 1 |
| 15 | Urban Rail Systems Investments: An Analysis of the Impacts on Property Values and Residents' Location显示文摘 | Francesca Pagliara Enrica Papa | 2010 | Journal of Transport Geography2010，19，2： | 1 |
| 16 | C - reactive protein in ischemic 显示文摘 | Mario Di Napoli Francesca Papa | 2002 | stroke2002，33，9： | 1 |
| 17 | C-Reactive Protein Level Measurement Improves Mortality Prediction When Added to the Spontaneous Intracerebral Hemorrhage Score显示文摘 | Mario Di Napoli Daniel Agustin Godoy Veronica Campi Marta del Valle Gustavo Pi?ero Matias Mirofsky Aurel Popa-Wagner Luca Masotti Francesca Papa Alejandro A. Rabinstein | 2011 | Stroke A Journal of Cerebral Circulation2011，，5： | 1 |
| 18 | C-Reactive Protein in Ischemic Stroke: An Independent Prognostic Factor 显示文摘 | Mario Di Napoli Francesca Papa Vittorio Bocola | 2001 | Stroke2001，32，： | 1 |
| 19 | Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways显示文摘 | Salvatore Papa Concetta Bubici Francesca Zazzeroni Guido Franzoso | 2009 | Biological Chemistry2009，，10： | 1 |
| 20 | Negative association between trunk fat, insulin resistance and skeleton in obese women显示文摘AIM: To evaluate the potential interference of trunk fat (TF) mass on metabolic and skeletal metabolism. METHODS: In this cross-sectional study, 340 obese women (mean age: 44.8 ± 14 years; body mass index: 36.0 ± 5.9 kg/m 2 ) were included. Patients were evaluated for serum vitamin D, osteocalcin (OSCA), inflammatory markers, lipids, glucose and insulin (homeostasis model assessment of insulin resistance, HOMA-IR) levels, and hormones profile. Moreover, all patients underwent measurements of bone mineral density (BMD;at lumbar and hip site) and body composition (lean mass, total and trunk fat mass) by dual-energy X-ray absorptiometry. RESULTS: Data showed that: (1) high TF mass was inversely correlated with low BMD both at lumbar (P < 0.001) and hip (P < 0.01) sites and with serum vitamin D (P < 0.0005), OSCA (P < 0.0001) and insulin-like growth factor-1 (IGF-1; P < 0.0001) levels; (2) a positive correlation was found between TF and HOMA-IR (P < 0.01), fibrinogen (P < 0.0001) and erythrocyte sedimentation rate (P < 0.0001); (3) vitamin D levels were directly correlated with IGF-1 (P < 0.0005), lumbar (P < 0.006) and hip (P < 0.01) BMD; and (4) inversely with HOMA-IR (P < 0.001) and fibrinogen (P < 0.0005). Multivariate analysis demonstrated that only vitamin D was independent of TF variable. CONCLUSION: In obese women, TF negatively correlates with BMD independently from vitamin D levels. Reduced IGF-1 and increased inflammatory markers might be some important determinants that account for this relationship. | Emanuela A Greco Davide Francomano Rachele Fornari Chiara Marocco Carla Lubrano Vincenza Papa Francesca Wannenes Luigi Di Luigi Lorenzo M Donini Andrea Lenzi Antonio Aversa Silvia Migliaccio | 2013 | World Journal of Diabetes2013，4，2： | 0 |
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