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您的检索式：作者名="Alessandro Perrella"
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| 1 | Oxidative stress and steatosis are cofactors of liver injury in primary biliary cirrhosis显示文摘 | Paolo Sorrentino Luigi Terracciano Salvatore D’Angelo Umberto Ferbo Alessandra Bracigliano Luciano Tarantino Alessandro Perrella Oreste Perrella Giovanni Chiara Luigi Panico Noè Stefano Mariolina Lepore Raffaela Vecchione | 2010 | Journal of Gastroenterology2010，，10： | 1 |
| 2 | Boceprevir or telaprevir in hepatitis C virus chronic infection:The Italian real life experience显示文摘AIM: To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus(HCV) genotype 1 in the real-world settings. METHODS: This study was a non-randomized, observational, prospective, multicenter. This study involved 47 centers in Italy. A database was prepared for the homogenous collection of the data, was used by all of the centers for data collection, and was updated continuously. All of the patients enrolled in this study were older than 18 years of age and were diagnosed with chronic infection due to HCV genotype 1. The HCV RNA testing was performed using COBAS-Taq Man2.0(Roche, LLQ 25 IU/m L). RESULTS: All consecutively treated patients were included. Forty-seven centers enrolled 834 patients as follows: Male 64%; median age 57(range 18-78), of whom 18.3% were over 65; mean body mass index 25.6(range 16-39); genotype 1b(79.4%); diagnosis of cirrhosis(38.2%); and fibrosis F3/4(71.2%). The following drugs were used: Telaprevir(66.2%) and PEG-IFN-alpha2a(67.6%). Patients were na?ve(24.4%), relapsers(30.5%), partial responders(14.8%) and null responders(30.3%). Overall, adverse events(AEs) occurred in 617 patients(73.9%) during the treatment. Anemia was the most frequent AE(52.9% of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the patients because of adverse events or virological failure(15%). Sustained virological response was achieved in 62.7% of the cases, but was 43.8% in cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple therapy is safe but has moderate efficacy, especially for patients over 65 years of age, with advanced fibrosis, nonresponders to peginterferon + ribavirin. | Antonio Ascione Luigi Elio Adinolfi Pietro Amoroso Angelo Andriulli Orlando Armignacco Tiziana Ascione Sergio Babudieri Giorgio Barbarini Michele Brogna Francesco Cesario Vincenzo Citro Ernesto Claar Raffaele Cozzolongo Giuseppe D’Adamo Emilio D’Amico Pellegrino Dattolo Massimo De Luca Vincenzo De Maria Massimo De Siena Giuseppe De Vita Antonio Di Giacomo Rosanna De Marco Giorgio De Stefano Giulio De Stefano Sebastiano Di Salvo Raffaele Di Sarno Nunzia Farella Laura Felicioni Basilio Fimiani Luca Fontanella Giuseppe Foti Caterina Furlan Francesca Giancotti Giancarlo Giolitto Tiziana Gravina Barbara Guerrera Roberto Gulminetti Angelo Iacobellis Michele Imparato Angelo Iodice Vincenzo Iovinella Antonio Izzi Alfonso Liberti Pietro Leo Gennaro Lettieri Ileana Luppino Aldo Marrone Ettore Mazzoni Vincenzo Messina Roberto Monarca Vincenzo Narciso Lorenzo Nosotti Adriano Maria Pellicelli Alessandro Perrella Guido Piai Antonio Picardi Paola Pierri Grazia Pietromatera Francesco Resta Luca Rinaldi Mario Romano Angelo Rossini Maurizio Russello Grazia Russo Rodolfo Sacco Vincenzo Sangiovanni Antonio Schiano Antonio Sciambra Gaetano Scifo Filomena Simeone Annarita Sullo Pierluigi Tarquini Paolo Tundo Alfredo Vallone | 2016 | World Journal of Hepatology2016，8，22： | 1 |
| 3 | Flow cytometry assay of myeloid dendritic cells (mDCs)in peripheral blood during acute hepatitis C:Possible pathogenetic mechanisms显示文摘瞄准:到驴骨髓的的树枝状的房间(CD11c+) 的表示子集在在感染的自然科学的尖锐 HCV 肝炎和它的可能的参与期间。方法:我们与尖锐丙肝(AHC )( 组 A ) 注册了 11 个病人,有尖锐肝炎 A (啊哈) 的 10 个病人(同样易传染的控制 -- 组 B ) 并且在这的 10 个健康施主(组 C ) 学习。所有病人经历了选择流动血细胞计数 gating 策略估计骨髓的的树枝状的房间(mDCs ) 的外部数字在尖锐肝炎期间理解可能的角色和差别。结果:有尖锐 HCV 肝炎的 11 个病人中的八个没与健康个人相比显示出 mDCs 的任何增加,当 mDCs 的重要减少在绝对房间计数被发现时(z =-2.37;P<0.05 ) 并且百分比(z =-2.30;P<0.05 ) 同样与啊哈相比。相反,留下组 A 的三个病人有是的一个更高的 mDCs 数字和百分比发生在组 B。在六个月以后,有趣地,那些病人没证明 mDCs 子集的任何增加长期地被感染。当三在 HAV 急性感染随外部 mDCs 的增加使遭到,,时,解决了病。结论:mDCs 的增加的缺乏可能在尖锐丙肝期间是涉及感染的 chronicization 的一个重要因素。 | Alessandro Perrella Luigi Atripaldi Pasquale Bellopede Tommaso Patarino Costanza Sbreglia Giovanni Tarantino Paolo Sorrentino Paolo Conca Luca Ruggiero Oreste Perrella | 2006 | World Journal of Gastroenterology2006，12，7： | 1 |
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