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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Neuroinflammation and comorbidities are frequently ignored factors in CNS pathology显示文摘Virtually all drug interventions that have been successful pre-clinically in experimental stroke have failed to prove their efficacy in a clinical setting. This could be partly explained by the complexity and heterogeneity of human diseases as well as the associated co-morbidities which may render neuroprotective drugs less efficacious in clinical practice. One aspect of crucial importance in the physiopathology of stroke which is not completely understood is neuroinflammation. At the present time, it is becoming evident that subtle, but continuous neuroinflammation can provide the ground for disorders such as cerebral small vessel disease. Moreover, advanced aging and a number of highly prevalent risk factors such as obesity, hypertension, diabetes and atherosclerosis could act as 'silent contributors' promoting a chronic proinflammatory state. This could aggravate the outcome of various pathological entities and can contribute to a number of subsequent post-stroke complications such as dementia, depression and neurodegeneration creating a pathological vicious cycle. Moreover, recent data suggests that the inflammatory process might be closely linked with multiple neurodegenerative pathways related to depression. In addition, pro-inflammatory cytokines could play a central role in the pathophysiology of both depression and dementia. | Raluca Elena Sandu Ana Maria Buga Adriana Uzoni Eugen Bogdan Petcu Aurel Popa-Wagner | 2015 | Neural Regeneration Research2015，10，9： | 6 |
| 3 | Dietary habits, lifestyle factors and neurodegenerative diseases显示文摘Worldwide stroke is increasing in parallel with modernization,changes in lifestyle,and the growing elderly population.Our review is focused on the link between diet,as part of‘modern lifestyle’,and health in the context of genetic predisposition of individuals to‘unhealthy’metabolic pathway activity.It is concluded that lifestyle including high sugar diets,alcohol and tobacco addiction or high fat diets as well as ageing,brain injury,oxidative stress and neuroinflammation,negatively influence the onset,severity and duration of neurodegenerative diseases.Fortunately,there are several healthy dietary components such as polyunsaturated fatty acids and the anti-oxidants curcumin,resveratrol,blueberry polyphenols,sulphoraphane,salvionic acid as well as caloric restriction and physical activity,which may counteract ageing and associated neurodegenerative diseases via increased autophagy or increased neurogenesis in the adult brain. | Aurel Popa-Wagner Dinu Iuliu Dumitrascu Bogdan Capitanescu Eugen Bogdan Petcu Roxana Surugiu Wen-Hui Fang Danut-Adrian Dumbrava | 2020 | Neural Regeneration Research2020，15，3： | 3 |
| 4 | Post‐stroke depression: mechanisms, translation and therapy显示文摘 | Isabelle Loubinoux Golo Kronenberg Matthias Endres Pascale Schumann‐Bard Thomas Freret Robert K. Filipkowski Leszek Kaczmarek Aurel Popa‐Wagner | 2012 | J. Cell. Mol. Med2012，，9： | 3 |
| 5 | Multimodality treatment strategies have changed prognosis of peritoneal metastases显示文摘For a long time, treatment of peritoneal metastases(PM) was mostly palliative and thus, this status was link with 'terminal status/despair'. The current multimodal treatment strategy, consisting of cytoreductive surgery(CRS) and hyperthermic intraperitoneal chemotherapy(HIPEC), has been strenuously achieved over time, but seems to be the best treatment option for PM patients. As we reviewed the literature data, we could emphasize some milestones and also, controversies in the history of proposed multimodal treatment and thus, outline the philosophy of this approach, which seems to be an unusual one indeed. Initially marked by nihilism and fear, but benefiting from a remarkable joint effort of human and material resources(multi-center and-institutional research), over a period of 30 years, CRS and HIPEC found their place in the treatment of PM. The next 4 years were dedicated to the refinement of the multimodal treatment, by launching research pathways. In selected patients, with requires training, it demonstrated a significant survival results(similar to the Hepatic Metastases treatment), with acceptable risks and costs. The main debates regarding CRS and HIPEC treatment were based on the oncologists' perspective and the small number of randomized clinical trials. It is important to statement the PM patient has the right to be informed of the existence of CRS and HIPEC, as a real treatment resource, the decision being made by multidisciplinary teams. | corneliu lungoci aurel ion mironiuc valentin muntean traian oniu hubert leebmann max mayr pompiliu piso | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 2 |
| 6 | Exercise-induced albuminuria and circadian blood pressure abnormalities in type 2 diabetes显示文摘AIM To investigate the relationship between circadian variations in blood pressure(BP) and albuminuria at rest,and during exercise in non-hypertensive type 2 diabetes(T2D) patients.METHODS We conducted a cross-sectional study in well controlled T2D patients,non-hypertensive,without clinical proteinuria and normal creatinine clearance.In each participant,we recorded the BP using ambulatory bloodpressure monitoring(ABPM) for 24-h,and albuminuria at rest and after a standardized treadmill exercise.RESULTS We enrolled 27 type 2 patients with a median age of 52;and a mean duration of diabetes and HbA 1c of 3.6 ± 0.8 years and 6.3% ± 0.5% respectively.Using a 24-h ABPM,we recorded a mean diurnal systolic blood pressure(SBP) of 128 ± 17 mmH g vs nocturnal of 123 ± 19 mmH g(P = 0.004),and mean diurnal diastolic blood pressure(DBP) of 83 ± 11 mmH g vs nocturnal 78 ± 14 mmH g(P = 0.002).There was a significant difference between albuminuria at rest [median = 23 mg,interquartile range(IQR) = 10-51] and after exercise(median = 35 mg,IQR = 23-80,P < 0.001).Patients with exercise induced albuminuria had an increase in nocturnal BP values on all three components(128 mmH g vs 110 mmH g,P = 0.03 for SBP;83 mmH g vs 66 mmH g,P = 0.04;106 vs 83,P = 0.02 for mean arterial pressure),as well as albuminuric patients at rest.Moreover,exercise induced albuminuria detect a less increase in nocturnal DBP(83 vs 86,P = 0.03) than resting albuminuria.CONCLUSION Exercise induced albuminuria is associated with an increase in nocturnal BP values in T2D patients. | Aurel T Tankeu Fran,ois Folefack Kaze Jean Jacques Noubiap David Chelo Mesmin Yefou Dehayem Eugene Sobngwi | 2017 | World Journal of Nephrology2017，6，4： | 2 |
| 7 | Report of the radionuclides in nephrourology committee on renal clearance 显示文摘 | Blaufox MD Aurell M Bubeck B | 1996 | J Nucl Med1996，37，： | 2 |
| 8 | Cytokeratins 7 and 20 Immunoexpression Profile in Goblet Cell and Classical Carcinoids of Appendix显示文摘 | Khaled O. Alsaad Stefano Serra Anja Schmitt Aurel Perren Runjan Chetty | 2007 | Endocrine Pathology2007，，1： | 2 |
| 9 | Report of the radionuclides in nephrourology committee on renal clearance 显示文摘 | Blaufox M D Aurell M Bubeck B | 1996 | J Nucl Med1996，37，11： | 1 |
| 10 | Hormones,vitamins,and growth factors in cancer treatment and prevention: A critical appraisal 显示文摘 | Aurel P Lupulescu | 1996 | Cancer1996，11，10： | 1 |
| 11 | Experimental study of ozone action on glycine显示文摘 | Duguet J P Jaulin L Aurelle Y | 1980 | Ozone Sci Eng1980，2，1： | 1 |
| 12 | Recent developments in the treatment of oily effluents显示文摘 | Roques H Aurelle Y | 1986 | Water Sci Technol1986，18，9： | 1 |
| 13 | Impact echo Q-factor measurements towards non-destructive quality control of the backfill in segmental lined tunnels显示文摘 | Ryden N Aurell O | 2013 | Nondestructive Testing of Materials and Structures2013，6，： | 1 |
| 14 | Membrane Technology in Wastewater Treatment显示文摘 | Lee S Aurelle Y Roques H | 1984 | J Membr Sci1984，19，： | 1 |
| 15 | Effect of Plasma Treatments on Wettability of Polysulfone and Polyetherimide显示文摘 | Asfardjani K Segui Y Aurelle Y Abidine N | 1991 | Journal of Applied Polymer Science1991，43，2： | 1 |
| 16 | Membrane Technology in Wastewater Treatment显示文摘 | LEE S AURELLE Y ROQUES H | 1984 | J Membr Sci1984，19，： | 1 |
| 17 | Clinical experience with recombinant follicle-stimulating hormone (FSH) and urinary FSH: a retrospective case-controlled analysis显示文摘 | Ravhon A Lavery S Aurell R | 2001 | Fertil Steril2001，75，5： | 1 |
| 18 | Potential of freezing in wastewater treatment:soluble pollutant applications显示文摘 | Lorain O Thiebaud P Badorc E Aurelle Y | 2001 | Water Research2001，35，2： | 1 |
| 19 | Angiotensin coverting enzyme inhibitor and progressive renal insufficiency 显示文摘 | Keane WF Andersen S Aurell M | 1989 | Ann Intern Med1989，111，6： | 1 |
| 20 | Unstable secondary oil/water emulsion treatment using ultrafiltration:fouling control by backflushing显示文摘 | Srijaroorrat P Julien E Aurelle Y 1999 | 1999 | J Membr Sci1999，159，： | 1 |
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