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| 1 | Role of magnetic resonance imaging in the detection and characterization of solid pancreatic nodules: An update显示文摘Pancreatic ductal adenocarcinoma is the most common malignant tumor of the pancreas. The remaining pancreatic tumors are a diverse group of pancreatic neoplasms that comprises cystic pancreatic neoplasms, endocrine tumors and other uncommon pancreatic tumors. Due to the excellent soft tissue contrast resolution, magnetic resonance imaging(MRI) is frequently able to readily separate cystic from noncystic tumors. Cystic tumors are often easy to diagnose with MRI; however, noncystic non-adenocarcinoma tumors may show a wide spectrum of imaging features, which can potentially mimic ductal adenocarcinoma. MRI is a reliable technique for the characterization of pancreatic lesions. The implementation of novel motionresistant pulse sequences and respiratory gating techniques, as well as the recognized benefits of MR cholangiopancreatography, make MRI a very accurate examination for the evaluation of pancreatic masses. MRI has the distinctive ability of non-invasive assessment of the pancreatic ducts, pancreatic parenchyma, neighbouring soft tissues, and vascular network in one examination. MRI can identify different characteristics of various solid pancreatic lesions, potentially allowing the differentiation of adenocarcinoma from other benign and malignant entities. In this review we describe the MRI protocols and MRI characteristics of various solid pancreatic lesions. Recognition of these characteristics may establish the right diagnosis or at least narrow the differential diagnosis, thus avoiding unnecessary tests or procedures and permitting better management. | Najwa Al Ansari Miguel Ramalho Richard C Semelka Valeria Buonocore Silvia Gigli Francesca Maccioni | 2015 | World Journal of Radiology2015，7，11： | 9 |
| 2 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 3 | An in vitro prototype of a porcine biomimetic testis-like cell culture system: a novel tool for the study of reassembled Sertoli and Leydig cells显示文摘目前,有在 vitro 不可靠像睾丸的 biomimetic 机关文化系统设计了在 Sertoli 和 Leydig 房间上估计人的 gonadotropins 的功能的效果的装配 prepubertal。精子发生被调整由内分泌, paracrine,和 juxtacrine 因素(阴囊的串音) ,主要由象 luteinizing 荷尔蒙(LH ) 和由分别地刺激 Leydig 和 Sertoli 房间起一个枢轴的作用的刺激滤泡的荷尔蒙(FSH ) 那样的 gonadotropins 安排了。我们的学习的目的是建立一在里面 vitro prepubertal 是的猪的 bioengineered 构造为重新集合的 Sertoli 和 Leydig 房间上的试验性的研究的一个新模型。我们评估了从 15- 获得到 20-day-old 的 Sertoli 和 Leydig 房间新生的猪睾丸以纯净和功能。随后,净化了 Sertoli 并且充实 Leydig 房间受到 coincubation 获得一在里面 vitro prepubertal 猪的像睾丸的文化系统。我们为 anti-M 执行了连接酶的 immunosorbent 试金(ELISA ) | Iva Arato Giovanni Luca Francesca Mancuso Catia Bellucci Cinzia Lilli Mario Calvitti Barbara C Hansen Domenico Milardi Giuseppe Grande Riccardo Calafiore | 2018 | Asian Journal of Andrology2018，20，2： | 4 |
| 4 | Retinoic acid receptors and cancer: from molecular mechanisms to therapy显示文摘 | Alessandra di Masi Loris Leboffe Elisabetta De Marinis Francesca Pagano Laura Cicconi Cécile Rochette-Egly Francesco Lo Coco Paolo Ascenzi Clara Nervi | 2014 | Molecular Aspects of Medicine2014，，： | 2 |
| 5 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12显示文摘 | Birgit Oppmann Robin Lesley Bianca Blom Jackie C Timans Yuming Xu Brisdell Hunte Felix Vega Nancy Yu Jing Wang Komal Singh Francesca Zonin Elena Vaisberg Tatyana Churakova Man-ru Liu Daniel Gorman Janet Wagner Sandra Zurawski Yong-Jun Liu John S Abrams Ke | 2000 | Immunity2000，，5： | 2 |
| 6 | In-vitra interac tions of itraconazole with flucytosine against clinical isolates of Cryptococcus neoformans显示文摘 | Domenico G Francesca C | 1999 | J Antimicrob Chemother1999，44，1： | 1 |
| 7 | Putting BOT on the road显示文摘 | Francesca C | 1989 | Euromoney1989，，4： | 1 |
| 8 | Treatment of convul- sive status epilepticus in childhood: recommendations of the Italian League Against Epilepsy 显示文摘 | Giuseppe C Francesca B Ettore B | 2013 | Epilepsia2013，54，7： | 1 |
| 9 | Honokiol, a small molecular weight natural product,inhibits angiogenesis in vitro and tumor growth in vivo 显示文摘 | BAI Xian-he FRANCESCA C MASUKO U F | 2003 | J Biol Chem2003，278，35： | 1 |
| 10 | Microbial characterisation of fermented meat products from the Sicilian swine breed“Suino Nero Dei Nebrodi”显示文摘 | FRANCESCA N SANNINO C MOSCHETTI G | 2013 | Annals of Microbiology2013，63，1： | 1 |
| 11 | Phenotype of the tomato high pigment-2 mutant is caused by a mutation in the tomato homolog of Deetiolatedl 显示文摘 | Anna C M Francesca F Rosalia C | 1999 | The Plant Cell1999，11，： | 1 |
| 12 | Functional Brain Reorganization in Multiple Sclerosis: Evidence from fMRI Studies 显示文摘 | Patrizia P Caterina M Francesca C | 2006 | J Neuroimag2006，16，2： | 1 |
| 13 | Bonding effectiveness andsealing ability of fiber-post bonding显示文摘 | Francesca Z Eduardo C Jan DM | 2008 | Dent Mater2008，24，7： | 1 |
| 14 | Glycyrrhizic acid alters Kaposi sarcoma-associated herpesvirus latency,triggering p53-mediated apoptosis in transformed B lymphocytes显示文摘 | Francesca C Alvin E K Ornella F | 2005 | J Clin Invest2005，115，： | 1 |
| 15 | Genderrelated differences in the presentation and course of Cushing's disease 显示文摘 | Francesca PG Mirella M Francesco C | 2003 | J Clin Endocrinol Metab2003，88，12： | 1 |
| 16 | Animal-assisted interventions as innovative tools for mental health显示文摘 | Francesca C Marta B Alessandra B | 2011 | Ann Ist Super Sa- nita2011，47，34： | 1 |
| 17 | Inactivation of both FHIT and p53 cooperate in deregulating proliferation-related pathways in lung cancer显示文摘 | Francesca A Elena R Roberto C | 2012 | J Thorac Oncol2012，7，4： | 1 |
| 18 | Product shape selectivity dominates the Methanol-to-Olefins (MTO) reaction over H-SAPO-34 catalysts显示文摘 | Hereijgers Bart P C Bleken Francesca Nilsen Merete H | 2009 | Journal of Cataly- sis2009，264，1： | 1 |
| 19 | The sequential therapy regi- men for Hclicobacter pylori eradication : a pooled-data analysis 显示文摘 | Zullo A De Francesca V Hassan C | 2007 | Gut2007，56，10： | 1 |
| 20 | Yeast ecolo- gy of vineyards within Marsala wine area (western Sicily) in two consecutive vintages and selection of autochthonous Saccharomyces cerevisiae strains 显示文摘 | Settanni L Sannino C Francesca N | 2012 | Journal of Biosci- ence and Bioengineering2012，114，6： | 1 |
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