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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 3 | Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimmers显示文摘 | Stefano R Alessandra B Manuela B | 2011 | Eur J Med Chem2011，46，5： | 1 |
| 4 | Repartition effect of aromatic polyaniline coatings on the separation of bioactive peptides in capillary electrophoresis显示文摘 | ALESSANDRA B SERGEY A P ANTHONY P F T PIER G R | 2002 | Electrophoresis2002，23，2： | 1 |
| 5 | Enantioselective 1,3-dipolar cycloadditions of unsaturated aldehydes promoted by apoly( ethylene glycol)-supported organic catalyst显示文摘 | Alessandra P M aurizio B M auro C e t a l | 2004 | E ur J Org Chem2004，344，： | 1 |
| 6 | 3-(4-{{Benzyl(methyl)amino}methyl}phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer′s disease therapy 显示文摘 | Lorna P Angela R Alessandra B | 2003 | J Med Chem2003，46，12： | 1 |
| 7 | Expression of CXC chemokine receptors 1-C5 and their ligands in human glioma tissues:Role of CXCR4 and SDFI in glioma cell proliferation and migration显示文摘 | Adriana B A Federiea B Alessandra D B | 2006 | Neurochemistry International2006，49，5： | 1 |
| 8 | Artificial vision in extreme environments for snowcat tracks etection 显示文摘 | Alberto B Roggi Alessandra Fascioli | 2002 | IEEE Transactions on Intelligent Transportation System2002，3，3： | 1 |
| 9 | Animal-assisted interventions as innovative tools for mental health显示文摘 | Francesca C Marta B Alessandra B | 2011 | Ann Ist Super Sa- nita2011，47，34： | 1 |
| 10 | Apomixis and sexuality in Paspalum simplex: characterization of the mode of reproduction in segregating progenies by different methods 显示文摘 | Caceres M E Fritz M Alessandra B | 2001 | Sex Plant Reprod2001，14，4： | 1 |
| 11 | Peptide G, containing the binding site of the 67-Kda Laminin receptor, increases and stabilizes laminin binding to cancer cells显示文摘 | Alessandra M Elda T Simona B | 1996 | J Biol Chem1996，27，31： | 1 |
| 12 | Survey on LBP based texture descriptors for image classification显示文摘 | Loris N Alessandra L Sheryl B | 2012 | Expert Systems with Applications2012，39，： | 1 |
| 13 | p^16INK4A hypermethylation detected by fluorescent methylation-specific PCR in plasmas from non-small cell lung cancer 显示文摘 | ALESSANDRA B DAVIDE C MILO F | 2002 | Clin Cancer Res2002，8，： | 1 |
| 14 | Pulse high-volume hae- mofiltration for treatment of severe sepsis : effects on hemody namics and survival 显示文摘 | Ranistha R Alessandra B Pasquale P | 2005 | Critical Care2005，9，4： | 1 |
| 15 | Application of a spectroscopic method to estimate the olive oil oxidative status 显示文摘 | Sarfaraz A M Alessandra B Lorenzo C | 2010 | European Journal of Lipid Science and Technolo- gy2010，112，12： | 1 |
| 16 | Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats显示文摘 | Simonides Warner S Mulcahey Michelle A Redout Everaldo M Muller Alice Zuidwijk Marian J Visser Theo J Wassen Frank W J S Crescenzi Alessandra da-Silva Wagner S Harney John Engel Felix B Obregon Maria-Jesús Larsen P Reed Bianco Antonio C Huan | 2008 | Journal of Clinical Investigation2008，，3： | 1 |
| 17 | Catalytic Properties in De NOx and SO2-SO3 Reactions显示文摘 | Forzatti P Nova I Alessandra B | 2000 | Catalysis Today2000，56，： | 1 |
| 18 | Lipolysis and lipid oxidation in fermented sausages depending on different processing conditions and different antioxidants显示文摘 | Emanuela Z Sergio G Alessandra B | 2004 | Meat Science2004，66，： | 1 |
| 19 | Application of mid infrared spectroscopy and i-PLS for the quantification of contanminants in lubricating oil 显示文摘 | ALESSANDRA B RONEI J P | 2005 | Vibrational Spectroscopy2005，37，1： | 1 |
| 20 | Antioxidant principles from bauhinia tarapotensis 显示文摘 | ALESSANDRA B NUNZIATINA D T LORENZO D B | 2001 | Journal of Nature Products2001，，64： | 1 |
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