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| 1 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 2 | Neo-adjuvant chemo(radio)therapy in gastric cancer: Current status and future perspectives显示文摘In the last 20 years, several clinical trials on neoadjuvant chemotherapy and chemo-radiotherapy as a therapeutic approach for locally advanced gastric cancer have been performed. Even if more data are necessary to define the roles of these approaches, the results of preoperative treatments in the combined treatment of gastric adenocarcinoma are encouraging because this approach has led to a higher rate of curative surgical resection. Owing to the results of most recent randomized phase III studies, neoadjuvant chemotherapy for locally advanced resectable gastric cancer has satisfied the determination of level I evidence. Remaining concerns pertain to the choice of the optimal therapy regimen, strict patient selection by accurate pre-operative staging, standardization of surgical procedures, and valid criteria for response evaluation. New well-designed trials will be necessary to find the best therapeutic approach in pre-operative settings and the best way to combine old-generation chemotherapeutic drugs with new-generation molecules. | Alberto Biondi Maria C Lirosi Domenico D'Ugo Valeria Fico Riccardo Ricci Francesco Santullo Antonia Rizzuto Ferdinando CM Cananzi Roberto Persiani | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 13 |
| 3 | Optimal timing and route of nutritional support after esophagectomy: A review of the literature显示文摘Some controversy surrounds the postoperative feeding regimen utilized in patients who undergo esophagectomy.Variation in practices during the perioperative period exists including the type of nutrition started,the delivery route,and its timing.Adequate nutrition is essential for this patient population as these patients often present with weight loss and have altered eating patterns after surgery,which can affect their ability to regain or maintain weight.Methods of feeding after an esophagectomy include total parenteral nutrition,nasoduodenal/nasojejunal tube feeding,jejunostomy tube feeding,and oral feeding.Recent evidence suggests that early oral feeding is associated with shorter LOS,faster return of bowel function,and improved quality of life.Enhanced recovery pathways after surgery pathways after esophagectomy with a component of early oral feeding also seem to be safe,feasible,and cost-effective,albeit with limited data.However,data on anastomotic leaks is mixed,and some studies suggest that the incidence of leaks may be higher with early oral feeding.This risk of anastomotic leak with early feeding may be heavily modulated by surgical approach.No definitive data is currently available to definitively answer this question,and further studies should look at how these early feeding regimens vary by surgical technique.This review aims to discuss the existing literature on the optimal route and timing of feeding after esophagectomy. | Richard Zheng Courtney L Devin Michael J Pucci Adam C Berger Ernest L Rosato Francesco Palazzo | 2019 | World Journal of Gastroenterology2019，25，31： | 11 |
| 4 | New fecal test for non-invasive Helicobacter pylori detection:A diagnostic accuracy study显示文摘AIM To assess the diagnostic accuracy of a new fecal test for detecting Helicobacter pylori(H. pylori), using ^(13)Curea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS We conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of H. pylori infection, referred for dyspepsia between February and October 2017. At enrollment, all participants underwent 13 C-urea breath test. Participants aged over 50 years were scheduled to undergo upper endoscopy with histology. Participants collected stool samples 1-3 d after enrollment for a new fecal investigation(THD fecal test). The detection of bacterial 23 S rRNA subunit gene indicated H. pylori infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive(PPV) and negative(NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio(LR), together with 95% confidence intervals(CI).RESULTS We enrolled 294 consecutive participants(age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninetyfive(32.3%) participants had a positive ^(13)C-urea breath test. Twenty-three(7.8%) participants underwent upper endoscopy with histology, with a full concordance between ^(13)C-urea breath test and histology in detecting H. pylori infection. Four(1.4%) out of the 294 participants withdrew from the study after the enrollment visit and did not undergo THD fecal testing. In the 290 participants who completed the study, the THD fecal test sensitivity was 90.2%(CI: 84.2%-96.3%), specificity 98.5%(CI:96.8%-100%), PPV 96.5%(CI: 92.6%-100%), NPV 95.6%(CI: 92.8%-98.4%), accuracy 95.9%(CI: 93.6%-98.2%), positive LR 59.5(CI: 19.3-183.4), negative LR 0.10(CI: 0.05-0.18). Out of 83 infected participants identified with the THD fecal test, 34(41.0%) had bacterial genotypic changes consistent with antibiotic-resistant H. pylori infection. Of these, 27(32.5%) had bacterial strains resistant to clarithromycin, 3(3.6%) to levofloxacin, and 4(4.8%) to both antibiotics. CONCLUSION The THD fecal test has high performance for the non-invasive diagnosis of H. pylori infection while additionally enabling the assessment of bacterial antibiotic resistances. | Andrea Iannone Floriana Giorgio Francesco Russo Giuseppe Riezzo Bruna Girardi Maria Pricci Suetonia C Palmer Michele Barone Mariabeatrice Principi Giovanni FM Strippoli Alfredo Di Leo Enzo Ierardi | 2018 | World Journal of Gastroenterology2018，24，27： | 5 |
| 5 | Common immunologic mechanisms in inflammatory bowel disease and spondylarthropathies显示文摘Spondyloarthropathies(SpA) are commonly observed extra-intestinal manifestations of both Crohn's disease(CD) and ulcerative colitis(UC), the two major forms of inflammatory bowel diseases(IBD).However, the immunological link between these two clinical entities is still poorly understood.Several lines of evidence indicate that SpA may originate from the relocation to the joints of the immune process primarily induced in the gut.The transfer of the intestinal inflammatory process into the joints implicates that immune cells activated in the gut-draining lymph nodes can localize, at a certain point of the intestinal disease, either into the gut or into the joints.This is indicated by the over-lapping expression of adhesion molecules observed on the surface of intestinal and synovial endothelial cells during inflammation.Moreover bacterial antigens and HLA-B27 expression may be implicated in the reactivation of T cells at the articular level.Finally, accumulating evidence indicates that a T helper 17 cell-mediated immune response may contribute to IBD and IBD-related SpA with a crucial role played by tumor necrosis factor-α in CD and to a lesser extent in UC. | Massimo C Fantini Francesco Pallone Giovanni Monteleone | 2009 | World Journal of Gastroenterology2009，15，20： | 5 |
| 6 | Retinoic acid receptors and cancer: from molecular mechanisms to therapy显示文摘 | Alessandra di Masi Loris Leboffe Elisabetta De Marinis Francesca Pagano Laura Cicconi Cécile Rochette-Egly Francesco Lo Coco Paolo Ascenzi Clara Nervi | 2014 | Molecular Aspects of Medicine2014，，： | 2 |
| 7 | Pulmonary Vein Denervation Enhances Long-Term Benefit After Circumferential Ablation for Paroxysmal Atrial Fibrillation显示文摘 | Carlo Pappone Vincenzo Santinelli Francesco Manguso Gabriele Vicedomini Filippo Gugliotta Giuseppe Augello Patrizio Mazzone Valter Tortoriello Giovanni Landoni Alberto Zangrillo Christopher Lang Takeshi Tomita Cézar Mesas Elio Mastella Ottavio Alfieri | 2004 | Circulation: Journal of the American Heart Association2004，，3： | 2 |
| 8 | In-vitra interac tions of itraconazole with flucytosine against clinical isolates of Cryptococcus neoformans显示文摘 | Domenico G Francesca C | 1999 | J Antimicrob Chemother1999，44，1： | 1 |
| 9 | Therapeutic aspects of IgA nephropathy:an overview显示文摘 | Francesco P Giovanni C | 2002 | Nephrology2002，7，： | 1 |
| 10 | Enzymatic synthesis of various 1'-O-sucrose and 1-O-fructcse esters显示文摘 | GIACOMO C SEEFIO R FRANCESCO S | 1989 | J Chem Soc Perkin Trans I1989，5，： | 1 |
| 11 | Continuing follow-up of malignant hypertension显示文摘 | Paolo T S Marco G Francesco D C | 2002 | J Nephrol2002，15，4： | 1 |
| 12 | Cholecystoc- holedocholithiasis: a case-control study comparing the short and long-term outcomes for a 'laparoseopy-first' attitude with the outcome for sequential treatment 显示文摘 | RENATO C ANTONIO M FRANCESCO T | 2010 | Surg Endosc2010，24，1： | 1 |
| 13 | Custom- made, root-analogue direct laser metal forming im- plant: a case report 显示文摘 | Francesco M Bruno C Rachel S | 2012 | Lasers in medical science2012，27，6： | 1 |
| 14 | Oxidant stress and aspirininsensitive thromboxane biosynthesis in severe unstable angina 显示文摘 | Francesco C Giovanni C Paola P | 2000 | Circulation2000，102，3： | 1 |
| 15 | Thesequential therapy regimen for Helicobacter pylofieradication:a pooled-data analysis显示文摘 | ZuUo A De Francesco V Hassan C | 2007 | Gut2007，56，10： | 1 |
| 16 | Prevalence and distribution of single and multiple HPV infections in cytologically abnormal cervical samples from Italian women显示文摘 | Gargiulo F Francesco M A De Schreiber C | 2007 | Virus Research2007，125，2： | 1 |
| 17 | Prevalence and distribution of single and multiple HPV infections in cytologically abnormal cervical samples from Italian women显示文摘 | Gargiulo F De Francesco MA Schreiber C | 2007 | Virus Res2007，125，： | 1 |
| 18 | Percutaneous Treatment With Drug-Eluting Stent Implantation Versus Bypass Surgery' for Un- protected Left Main Stenosis, A Single-Center Experience 显示文摘 | Alaide C Nuccia M Francesco M | 2006 | Cir- culation2006，113，： | 1 |
| 19 | Life cycle assessment (LCA) of waste management strategies:landfilling,sorting plant and incineration显示文摘 | Francesco C Silvia B Sergio U | 2008 | Energy2008，23，8： | 1 |
| 20 | Pattern recognition approach to robust voiced/unvoiced speech classification using fuzzy logic显示文摘 | Salvatore C Marco R | 1999 | Int J Pattern Recog ArtifIntell1999，13，1： | 1 |
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