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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Current knowledge on diabetic retinopathy from human donor tissues显示文摘According to the American Diabetes Association,diabetes was the seventh leading cause of death,and diabetic retinopathy the leading cause of blindness in working age adults in the United States in 2010.Diabetes is characterized by hyperglycemia associated with either hypoinsulinemia or insulin resistance,and over time,this chronic metabolic condition may lead to various complications including kidney failure,heart attacks,and retinal degeneration.In order to better understand the molecular basis of this disease and its complications,animal models have been the primary approach used to investigate the effects of diabetes on various tissues or cell types of the body,including the retina.However,inherent to these animal models are critical limitations that make the insight gained from these models challenging to apply to the human pathology.These difficulties in translating the knowledge obtained from animal studies have led a growing number of research groups to explore the diabetes complications,especially diabetic retinopathy,on tissues from human donors.This review summarizes the data collected from diabetic patients at various stages of diabetic retinopathy and classifies the data based upon their relevance to the main aspects of diabetic retinopathy:retinal vasculature dysfunction,inflammation,and neurodegeneration.This review discusses the importance of those studies to discriminate and establish the relevance of the findings obtained from animal models but also the limitations of such approaches. | Jessica H Eisma Jennifer E Dulle Patrice E Fort | 2015 | World Journal of Diabetes2015，6，2： | 19 |
| 3 | Role of soil rhizobacteria in phytoremediation of heavy metal contaminated soils显示文摘Heavy metal pollution of soil is a significant environmental problem and has its negative impact on human health and agriculture. Rhizosphere, as an important interface of soil and plant, plays a significant role in phytoremediation of contaminated soil by heavy metals, in which, microbial populations are known to affect heavy metal mobility and availability to the plant through release of chelating agents, acidification, phosphate solubilization and redox changes, and therefore, have potential to enhance phytoremediation processes. Phytoremediation strategies with appropriate heavy metal-adapted rhizobacteria have re-ceived more and more attention. This article paper reviews some recent advances in effect and significance of rhizobacteria in phytoremediation of heavy metal contaminated soils. There is also a need to improve our understanding of the mechanisms in-volved in the transfer and mobilization of heavy metals by rhizobacteria and to conduct research on the selection of microbial isolates from rhizosphere of plants growing on heavy metal contaminated soils for specific restoration programmes. | JING Yan-de1,2, HE Zhen-li1,3, YANG Xiao-e1 (1Ministry of Education Key Lab of Environment, Remediation and Ecosystem Health, School of Natural Resource and Environment Science, Zhejiang University, Hangzhou 310029, China) (2Department of Resources and Planning, Qufu Normal University, Jining 273165, China) (3University of Florida Institute of Food and Agricultural Sciences, Indian River Research and Education Center, Fort Pierce, Florida 34945, USA) | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，3： | 18 |
| 4 | Silymarin in non alcoholic fatty liver disease显示文摘AIM: This study was undertaken to evaluate the hepatic effects of silybum marianum on non alcoholic fatty liver disease (NAFLD). METHODS: In 72 patients affected by NAFLD, main metabolic, hepatic and anti-inflammatory parameters were assayed after 3 mo of a restricted diet and before silymarin treatment (twice a day orally). The brightness of liver echography texture (hepatorenal ratio brightness) was also defined at same time. These evaluations were repeated after 6 mo of treatment. RESULTS: Serum levels of some metabolic and anti-inflammatory data nonsignificantly lowered after 6 mo of silymarin. On the contrary, Steato test, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase were significantly (P < 0.001) reduced. Instead, the AST/ALT ratio unchanged. Finally, the hepatorenal brightness ratio, as an index of hepatic steatosis, significantly (P < 0.05) dropped. CONCLUSION: The obtained results indicate that silymarin appears to be effective to reduce the biochemical, inflammatory and ultrasonic indices of hepatic steatosis. Some parameters indicative of early stage of atherosclerosis were also lowered. | Fulvio Cacciapuoti Anna Scognamiglio Rossella Palumbo Raffaele Forte Federico Cacciapuoti | 2013 | World Journal of Hepatology2013，5，3： | 17 |
| 5 | 环孢霉素和强的松依赖型重症肌无力患者应用他克莫司治疗的远期预后 | Ponseti J.M. Azem J. Fort J.M. 陈海 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，9： | 11 |
| 6 | Root and leaf functional trait relations in Poaceae species: implications of differing resource- acquisition strategies显示文摘Aims root systems play an essential role in grassland functioning in both acquisition and storage of resources.Nevertheless,root functional traits have not received as much attention as those measured on above-ground organs,and little is known about their relations.our objec-tives were to test whether morphological and root system traits allowed identification of grass species’functional strategies and to determine whether a relation exists between above-and below-ground traits.Methods Functional traits of root tissues(specific root length,diameter,tissue density and nitrogen concentration),whole root systems(root mass,root length density,root mass percentage below a depth of 20 cm and fine root%)and two major leaf traits(specific leaf area and leaf dry matter content)were determined under field conditions and their rela-tions were analysed in eleven perennial temperate Poaceae species.Important Findings Canonical correspondence analysis along axis 1 revealed a gra-dient of species,from those with deep,dense and coarse root systems with a large root mass to those with shallow root sys-tems,thin roots and high specific root length;this suggests strong correlations among root traits.Correlations between specific root length and specific leaf area reveal two groups of species,which probably indicates different drought-tolerance capacities.root trait syndromes enable ranking grasses along a gradient from conservative-strategy species(from stressful habitats),which display a deep and coarse root system,to acquisitive species(from rich and moist meadows),which display a shallow and thin root system.although both types display similar above-ground strategies,drought-tolerant species have lower specific root lengths than drought-sensitive species,revealing more conservative root strategies. | Florian Fort Claire Jouany Pablo Cruz | 2013 | Journal of Plant Ecology2013，6，3： | 11 |
| 7 | Targeting the insulin-like growth factor pathway in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the third leading cause of cancer-related deaths worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments, which include surgical resection as the first option, liver transplantation and percutaneous ablation. Unfortunately, there is a high frequency of tumor recurrence after surgical resection and most HCC seem resistant to conventional chemotherapy and radiotherapy. Sorafenib, a multi-tyrosine kinase inhibitor, is the only chemotherapeutic option for patients with advanced hepatocellular carcinoma. Patients treated with Sorafenib have a significant increase in overall survival of about three months. Therefore, there is an urgent need to develop alternative treatments. Due to its role in cell growth and development, the insulin-like growth factor system is commonly deregulated in many cancers. Indeed, the insulin-like growth factor(IGF) axis has recently emerged as a potential target for hepatocellular carcinoma treatment. To this aim, several inhibitors of the pathway have been developed suchas monoclonal antibodies, small molecules, antisense oligonucleotides or small interfering RNAs. However recent studies suggest that, unlike most tumors, HCC development requires increased signaling through insulin growth factor Ⅱ rather than insulin growth factor Ⅰ. This may have great implications in the future treatment of HCC. This review summarizes the role of the IGF axis in liver carcinogenesis and the current status of the strategies designed to target the IGF-Ⅰ signaling pathway for hepatocellular carcinoma treatment. | Mónica Enguita-Germán Puri Fortes | 2014 | World Journal of Hepatology2014，6，10： | 10 |
| 8 | Early plasmapheresis and rituximab for acute humoral rejection after ABO-compatible liver transplantation显示文摘Acute humoral rejection (AHR) is uncommon after ABO-compatible liver transplantation. Herein, we report two cases of AHR treated with plasmapheresis and rituximab in two ABO-compatible liver-transplant patients with preformed anti-human leukocyte antigen donor-specif ic antibodies. Patient 1 experienced a biopsy-proven AHR at day 10 post-transplant. She was treated by steroid pulses, and OKT3. Because of persisting signs of biopsy-proven AHR at day 26, she was treated by plasmapheresis and rituximab. Liver enzyme levels did not improve, and she died on day 41. Patient 2 experienced a biopsy-proven AHR on day 10 post-transplant. She was treated by steroid pulses, plasmapheresis, and rituximab. Liver enzymes returned to within normal range 18 d after diagnosis. Liver biopsies, at 3 and 9 mo post-transplant, showed complete resolution of AHR. We conclude that plasmapheresis should be started as soon as AHR is diagnosed, and be associated with a B-cell depleting agent. Rituximab may be considered as a first-line therapy. | Nassim Kamar Laurence Lavayssière Fabrice Muscari Janick Selves Céline Guilbeau-Frugier Isabelle Cardeau Laure Esposito Olivier Cointault Marie Béatrice Nogier Jean Marie Peron Philippe Otal Marylise Fort Lionel Rostaing | 2009 | World Journal of Gastroenterology2009，15，27： | 6 |
| 9 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 10 | The high order Schwarz-Pick lemma on complex Hilbert balls显示文摘In this paper we prove a high order Schwarz-Pick lemma for holomorphic mappings between unit balls in complex Hilbert spaces.In addition,a Schwarz-Pick estimate for high order Fréchet derivatives of a holomorphic function f of a Hilbert ball into the right half-plane is obtained. | DAI ShaoYu1,2,CHEN HuaiHui1 & PAN YiFei3,4 1Department of Mathematics,Nanjing Normal University,Nanjing 210097,China 2Department of General Study Program,Jinling Institute of Technology,Nanjing 211169,China 3School of Mathematics and Informatics,Jiangxi Normal University,Nanchang 330022,China 4Department of Mathematical Sciences,Indiana University-Purdue University Fort Wayne,Fort Wayne,IN 46805-1499,USA | 2010 | Science China Mathematics2010，53，10： | 6 |
| 11 | 保守疗法治疗先天性气管狭窄的效果:一项循证长期随访研究显示文摘Background/Purpose:Surgery has been the management of choice for severe congenital tracheal stenosis (CTS). The role of conservative management of CTS however is not clear. The aim of this study is to characterize the natural history of CTS,review the radiologic evidence of tracheal growth,and evaluate the clinical outcome and selection criteria of conservative management of CTS. Methods:A retrospective study was carried out on 22 consecutive children with symptomatic CTS admitted into a single institution between 1982 and 2001. The patients were categorized into operation (n = 11) and observation(n = 11) groups. Six patients of the observation group were followed up with serial computed tomography scan. Their tracheal growth was compared with that of healthy children of the same age. Results:The mortality rates of observation and operation groups were 9%and 27%,respectively,although the latter group consisted of more severely affected patients. The pathologic categorization of the CTS influenced the survival rates (P = 0.046,χ2),with the long segment type having the worst prognosis (67%). Serial computed tomography scans of 6 conservatively managed patients revealed that all stenotic tracheas continued to grow (P = .039,2-tailed paired Student’s t test). Of the 6 stenotic tracheas,5 grew at a faster-than normalrate,and the stenotic tracheal diameters approached those of normal diameters by the age of 9 years. Conclusions:The management of patients with symptomatic CTS should be individualized. A selected group of patients with CTS can be safely managed nonoperatively. | Manson D.E. Forte V. P.C.W. Kim 刘凯 | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，0，12： | 5 |
| 12 | Negative Feedback Regulation of Auxin Signaling by ATHB8/ACL5-BUD2 Transcription Module显示文摘 | Simona Baima Valentina Forte Marco Possenti Andres Penalosa Guido Leoni Sergio Salvi Barbara Felici Ida Ruberti Giorgio Morelli | 2014 | Molecular Plant2014，7，6： | 4 |
| 13 | 巴西南部第三中心早产儿视网膜病变(英文)显示文摘目的:评估2002-10/2006-10在巴西de Clinicasde Porto Alegre医院出生的所有早产儿的早产儿视网膜病变(ROP)的发生率,其治疗和预后的比率。方法:对323例出生体质量低于或等于1500g或者出生时孕龄等于或者少于32wk的早产儿进行前瞻性队列研究。所有的新生儿都在出生后6wk内进行开睑器开睑,瞳孔散大,间接检眼镜及28D透镜眼底检查,根据疾病的分类进行复查。结果由均数表示,发病率为于95%的可信区间,主要的临床结果为任何分期的ROP发生。结果:新生儿82例发生了ROP,发生率为25.7%。患者中只有17例((5.3%)发生了阈病变,他们的病变都累及后部第II区,需要激光治疗。除了3例经治疗的患儿需要两次激光治疗外,没有一个经过治疗的患儿有I区病变或者严重的后部病变。重复治疗组的1例患儿因发展成为4期ROP而需要行赤道部硅胶带巩膜环扎术。结论:ROP的发生率和阈病变同国际其它的研究结果类似。本研究显示了孕期28wk以内或出生后体重1000g的新生儿高生存率(70.1%)、高视网膜病变发病率和激光治疗的高度必要性。这组患儿需要眼科专家和新生儿专家为发现ROP进行仔细筛查和随访。本组患儿中没有确诊1例有I区后部病变,此点是本研究值得引起注意之处。 | Joao Borges Fortes Filho Cristiano Koch Barros Gabriela Unchalo Eckert Leticia Procianoy Renato S. Procianoy | 2007 | 国际眼科杂志2007，7，1： | 3 |
| 14 | Dietary supplementation of Rosmarinus officinalis L.leaves in sheep affects the abundance of rumen methanogens and other microbial populations显示文摘Background: Rumen microbiome has a great influence on ruminant health and productivity. Different plant extracts have been tested for their ability to modulate the rumen microbiome to improve feed digestion and fermentation. Among the evaluated plant extracts, essential oils, tannins, and saponins appeared to have positive effects on rumen protein metabolism, volatile fatty acids production, and methane and ammonia production.Methods: The objective of this study was to evaluate the effect of rosemary(Rosmarinus officinalis L.) leaves and essential oils on rumen microbial populations. Four ruminally cannulated sheep were used in a 4×4 Latin square design fed(21 d/period): 1) a control diet composed of alfalfa hay and concentrate pellet(CTR), 2) CTR supplemented with 7 g/d/sheep of rosemary essential oil adsorbed on an inert support(EO), 3) CTR with 10 g/d/sheep of dried and ground rosemary leaves(RL), and 4) CTR with 10 g/d of dried and ground rosemary leaves pelleted into concentrate(RL pellet). Abundance of total bacteria, archaea, protozoa, and some select bacterial species or groups was quantified using q PCR, while the community of bacteria and archaea was profiled using denaturing gradient gel electrophoresis.Results: No difference in abundance was noted for total bacteria, protozoa, or Ruminococcus flavefaciens between the control and the treatments, but the rosemary leaves, either in loose form or in pellet, decreased the abundance of archaea and the genus Prevotella(P < 0.001). The rosemary leaves in loose form also decreased(P < 0.001) the abundance of Ruminococcus albus and Clostridium aminophilum, while the EO increased(P < 0.001) the abundance of Fibrobacter succinogenes. The community of bacteria and archaea was not affected by any of the supplements.Conclusions: Being able to affect the abundance of several groups of rumen microbes that are known to be involved in degradation of protein and fiber and production of methane and ammonia, rosemary leaves may be used to modulate rumen microbiome and its function. | Gabriella Cobellis Zhongtang Yu Claudio Forte Gabriele Acuti Massimo Trabalza-Marinucci | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 3 |
| 15 | 实体器官移植患者中热带病和地方性感染病的流行状况显示文摘 | Martín-Dávila P Fortún J López-Vélez R 康悦 吴菊芳 | 2010 | 中国感染与化疗杂志2010，10，3： | 3 |
| 16 | Clinical epidemiology of chronic viral hepatitis B:A Tuscany real-world large-scale cohort study显示文摘AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus(HBV)-infected patients in the Tuscan public health care system.METHODS This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096(27.3%) were HBV infected. The case report form was correctly completed for only 833 patients(64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years(only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures(23%), mother-to-child(17%) and sexual transmission(12%). The most represented HBV genotypes were D(72%) and A(14%). Of the patients, 24.7% of patients were HBe Ag positive, and 75.3% were HBe Ag negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic(35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults. | Cristina Stasi Caterina Silvestri Roberto Berni Maurizia Rossana Brunetto Anna Linda Zignego Cristina Orsini Stefano Milani Liana Ricciardi Andrea De Luca Pierluigi Blanc Cesira Nencioni Donatella Aquilini Alessandro Bartoloni Giampaolo Bresci Santino Marchi Franco Filipponi Piero Colombatto Paolo Forte Andrea Galli Sauro Luchi Silvia Chigiotti Alessandro Nerli Giampaolo Corti Rodolfo Sacco Paola Carrai Angelo Ricchiuti Massimo Giusti Paolo Almi Andrea Cozzi Silvia Carloppi Giacomo Laffi Fabio Voller Francesco Cipriani | 2018 | World Journal of Hepatology2018，10，5： | 3 |
| 17 | Steroid profiling in preeclamptic women: evidence for aromatase deficiency显示文摘 | Alexandre Hertig Philippe Liere Nathalie Chabbert-Buffet Julie Fort Antoine Pianos Bernard Eychenne Annie Cambourg Michael Schumacher Nadia Berkane Guillaume Lefevre Serge Uzan Eric Rondeau Patrick Rozenberg Marie-Edith Rafestin-Oblin | 2010 | American Journal of Obstetrics and Gynecology2010，，5： | 2 |
| 18 | Up Close: Family Therapy Challenges and Innovations Around the World显示文摘 | Janine Roberts Khawla Abu‐Baker Cristina Diez Fernández Nelly Chong Garcia Glenda Fredman Hugo Kamya Yolanda Martín Higarza Jacqueline Fortes de Leff Philip Messent Shin‐Ichi Nakamura Fatma Torun Reid Timothy Sim Chitra Subrahmanian Roxana Zevallos Vega | 2014 | Fam. Proc2014，，： | 2 |
| 19 | Biological evaluation of compost maturity显示文摘 | Zucconi F Forte M Monac A | 1981 | Biocycle1981，22，： | 2 |
| 20 | Does Parkinsonμs Disease and Type-2 Diabetes Mellitus Present Common Pathophysiological Mechanisms and Treatments?显示文摘 | Marcelo M.S. Lima Adriano D.S. Targa Ana C.D. Noseda Lais S. Rodrigues Ana Marcia Delattre Fabiola V. dos Santos Mariana H. Fortes Maira J. Maturana Anete C. Ferraz | 2014 | CNS & Neurological Disorders - Drug Targets2014，，3： | 2 |
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