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| 1 | Big Data for Precision Medicine显示文摘This article focuses on the potential impact of big data analysis to improve health, prevent and detect disease at an earlier stage, and personalize interventions. The role that big data analytics may have in interrogating the patient electronic health record toward improved clinical decision support is discussed. Weexamine developments in pharmacogenetics that have increased our appreciation of the reasons why patients respond differently to chemotherapy. We also assess the expansion of online health communications and the way in which this data may be capitalized on in order to detect public health threats and control or contain epidemics. Finally, we describe how a new generation of wearable and implantable body sensors may improve wellbeing, streamline management of chronic diseases, and improve the quality of surgical implants. | Daniel Richard Leff Guang-Zhong Yang | 2015 | Engineering2015，1，3： | 9 |
| 2 | Hypothalamic-pituitary-adrenal axis function during perinatal depression显示文摘Abnormal function of the hypothalamic–pituitary–adrenal(HPA) axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol proinflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 11β-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby. | Phillipe Leff Gelman Mónica Flores-Ramos Margarita López-Martínez Carlos Cruz Fuentes Juan Pablo Reyes Grajeda | 2015 | Neuroscience Bulletin2015，31，3： | 6 |
| 3 | High-speed water impacts of flat plates in different ditching configuration through a Riemann--ALE SPH model显示文摘The violent water entry of flat plates is investigated using a Riemann-arbitrary Eulerian-Lagrangian(ALE) smoothed particle hydrodynamics(SPH) model. The test conditions are of interest for problems related to aircraft and helicopter emergency landing in water. Three main parameters are considered: the horizontal velocity, the approach angle(i.e., vertical to horizontal velocity ratio) and the pitch angle, a. Regarding the latter, small angles are considered in this study. As described in the theoretical work by Zhao and Faltinsen(1993), for small a a very thin, high-speed jet of water is formed, and the time-spatial gradients of the pressure field are extremely high. These test conditions are very challenging for numerical solvers. In the present study an enhanced SPH model is firstly tested on a purely vertical impact with deadrise angle α=4°. An in-depth validation against analytical solutions and experimental results is carried out, highlighting the several critical aspects of the numerical modelling of this kind of flow, especially when pressure peaks are to be captured. A discussion on the main difficulties when comparing to model scale experiments is also provided. Then, the more realistic case of a plate with both horizontal and vertical velocity components is discussed and compared to ditching experiments recently carried out at CNR-INSEAN. In the latter case both 2-D and 3-D simulations are considered and the importance of 3-D effects on the pressure peak is discussed for α=4° and α=10°. | S.Marrone A.Colagrossi L.Chiron M.De Leffe D.Le Touzé | 2018 | Journal of Hydrodynamics2018，30，1： | 5 |
| 4 | Up Close: Family Therapy Challenges and Innovations Around the World显示文摘 | Janine Roberts Khawla Abu‐Baker Cristina Diez Fernández Nelly Chong Garcia Glenda Fredman Hugo Kamya Yolanda Martín Higarza Jacqueline Fortes de Leff Philip Messent Shin‐Ichi Nakamura Fatma Torun Reid Timothy Sim Chitra Subrahmanian Roxana Zevallos Vega | 2014 | Fam. Proc2014，，： | 2 |
| 5 | Simulations of helicopter ditching using smoothed particle hydrodynamics显示文摘The present work has been performed in the context of the European H2020 project increased SAfety and Robust certification for ditching of Aircrafts and Helicopters(SARAH)dedicated to improving the safety during aircraft ditching,together with a better understanding of the physics involved during those crucial events.Both numerical and experimental aspects are explored during this project.The present study focuses on the application of the smoothed particle hydrodynamics(SPH)method to the simulation of helicopter ditching,as this method has proved to be particularly adapted to free surface impact cases.Simulations are performed for three different impact configurations,for which the numerical solutions are compared with the experimental results(forces and kinematics)obtained at the wave basin of Ecole Centrale Nantes on a mock-up shape provided by Airbus Helicopters.Elements of sensitivity analysis are also provided when needed,to assess the role of some parameters involved in the helicopter behavior and the fluid pressure forces exerted during the impact. | G.Oger A.Vergnaud B.Bouscasse J.Ohana M.Abu Zarim M.De Leffe A.Bannier L.Chiron Y.Jus M.Gamier S.Halbout D.Le Touze | 2020 | Journal of Hydrodynamics2020，32，4： | 2 |
| 6 | Spatial normalization of brain images with focal lesions using cost function masking 显示文摘 | Brett M Leff AP Rorden C | 2001 | Neuroimage2001，14，2： | 1 |
| 7 | Educating Relatives of Schizophrenic Patients显示文摘 | Berkowitz R Shavit N Leff J P | 1990 | Social Psychiatry and Psychiatric Epidemiology1990，25，： | 1 |
| 8 | Dependency Rates and Savings Rates 显示文摘 | LEFF N H | 1969 | American Economic Review1969，59，5： | 1 |
| 9 | Economic Development through Bureaucratic Corruption 显示文摘 | Leff Nathaniel H | 1964 | The American Behavioural Scientists1964，，33： | 1 |
| 10 | Spatial distribution,seston removal,and potential competitive interactions of the bivalves Corbicula fluminea and Elliptio complanata,in a coastal plain stream显示文摘 | Burch J L McArthur J V | 1990 | Freshwater Biology1990，24，2： | 1 |
| 11 | Seasonal changes in planktonic bacterial assemblages of two Ohio Streams 显示文摘 | LEFF L G LEFF A A LEMKE M J | 1998 | Freshwater Biol1998，39，1： | 1 |
| 12 | Educating relatives of schigophrc- nic patients 显示文摘 | Rerkowitz R Shavit N Leff JP | 1990 | Social Psychiatry and Psychiatric Epidemiology1990，25，： | 1 |
| 13 | Colorectal cancerin the young patient显示文摘 | Leff DR Chen A Roberts D | 2007 | Am Surg2007，73，1： | 1 |
| 14 | Drug therapy of the idiopathtic inflammatory myositis:predictors of response to prednisone,azathiopine,and methotrexate and a comparison of their efficacy显示文摘 | Joffe M M Love L A Leff R L | 1993 | Am J Med1993，1994，： | 1 |
| 15 | Montelukast reduces airway eosinophilic inflammation in asthma:a randomized,controlled trial显示文摘 | Pizzichini EJA leff TF ReissL | 1999 | Eur Respir J1999，12，： | 1 |
| 16 | Endoscopic breast surgery: where are we now andwhatmight the future hotd for video-assisted breast surgery? 显示文摘 | Leff DR Vashisht R YongueG | 2011 | Breast CaneerRes Treat2011，125，3： | 1 |
| 17 | c-jun N-terminal kinase phosphory-lates peroxisome proliferator-activated receptor-gamma1 and negatively regulates its transcriptional activity显示文摘 | Camp HS Tafuri SR Leff T | 1999 | Endocrinology1999，140，： | 1 |
| 18 | Montelukast,aleukotri-ene receptor antagonist,for the mild asthma and exercise-induced broncho constriction显示文摘 | Leff JA Busse WW Pearlman D | 1998 | N Engl J Med1998，339，： | 1 |
| 19 | Painful connection for ATP显示文摘 | KENNEDY C LEFF P | 1995 | Nature1995，377，： | 1 |
| 20 | Current concepts in idiopathic inflammatory myophathies, PM, DM and related disonters显示文摘 | Plotz PH Dalaks MC Leff RL | 1989 | Ann Intent Med1989，111，： | 1 |
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