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| 1 | Transjugular intrahepatic portosystemic shunt for the management of acute variceal hemorrhage显示文摘Acute variceal hemorrhage,a life-threatening condition that requires a multidisciplinary approach for effective therapy,is defined as visible bleeding from an esophageal or gastric varix at the time of endoscopy,the presence of large esophageal varices with recent stigmata of bleeding,or fresh blood visible in the stomach with no other source of bleeding identified.Transfusion of blood products,pharmacological treatments and early endoscopic therapy are often effective;however,if primary hemostasis cannot be obtained or if uncontrollable early rebleeding occurs,transjugular intrahepatic portosystemic shunt(TIPS)is recommended as rescue treatment.The TIPS represents a major advance in the treatment of complications of portal hypertension.Acute variceal hemorrhage that is poorly controlled with endoscopic therapy is generally well controlled with TIPS,which has a 90%to 100%success rate.However,TIPS is associated with a mortality of 30%to 50%in such a setting.Emergency TIPS should be considered early in patients with refractory variceal bleeding once medical treatment and endoscopic sclerotherapy failure,before the clinical condition worsens.Furthermore,admission to specialized centers is mandatory in such a setting and regional protocols are essential to be organized effectively.This review article discusses initial management and then focuses on the specific role of TIPS as a primary therapy to control acute variceal hemorrhage,particularly as a rescue therapy following failure of endoscopic approaches. | Romaric Loffroy Louis Estivalet Violaine Cherblanc Sylvain Favelier Pierre Pottecher Samia Hamza Anne Minello Patrick Hillon Pierre Thouant Pierre-Henri Lefevre Denis Krausé Jean-Pierre Cercueil | 2013 | World Journal of Gastroenterology2013，19，37： | 25 |
| 2 | 通过手机进行健康干预报告的指南:移动医疗证据报告和评估检查表显示文摘为提升移动医疗(mHealfh)干预报告的完整性,WH0mHealth技术证据评审小组开发了mHealth证据报告和评估(mERA)检查表。该mERA开发过程包括成立专家组,提出合适的路径,召集全球专家评审小组以研发检查表,并进行小规模测试。制定这些标准的指导原则是以最少的信息集合来定义mHealth干预是什么(内容),在哪儿应用(环境),如何应用(技术特性),以便支持干预的可重复性。该文档由16个选项表构成,附带各项内容的详细解释和说明,以及说明性的报告范例。通过广泛征求意见,我们希望该指南的应用可规范mHealth证据报告的质量,间接提升mHealth证据的质量。 | Smisha Agarwal Amnesty E LeFevre Jaime Lee Kelly L'Engle Garrett Mehl Chaitali Sinha Alain Labriquel 沈锡宾(译) 涂宏钢(校) | 2016 | 英国医学杂志中文版2016，19，11： | 6 |
| 3 | 不同晶相成分及结晶态的生物活性玻璃体外降解性的研究显示文摘采用sol-gel方法合成生物活性玻璃材料,采用600℃、900℃、1100℃高温处理后,形成不同晶相成分及结晶态的三种材料SG600,SG900和SG1100。原代培养破骨细胞接种在材料表面并培养4h和48h。采用细胞化学法对破骨细胞actin进行标记,采用分光光度计测量Ca和P离子浓度,采用扫描电镜(SEM)观察破骨细胞的形态及吸收陷窝。结果显示,三种材料表面均可显示破骨细胞环状actin。SG600的钙离子浓度明显高于对照组及其他两种材料组,当破骨细胞存在时,三种材料钙磷离子浓度均比无细胞时有所增加。在三种材料表面破骨细胞均形成良好的附着与伸展,吸收陷窝的形态及深度无明显差异。说明生物活性玻璃材料由于晶相成分及结晶度的不同,在体外具有不同的溶解性。体外破骨细胞在三种材料表面均显示出明显的降解活性。 | 张玉梅 蔡玉荣 王勤涛 赵铱民 Monchau F Lefevre A Hildebrand H.F | 2005 | 生物医学工程学杂志2005，22，5： | 3 |
| 4 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 5 | Automatic regulation of activated sludge aeration-single-tank nitrification-denitrification 显示文摘 | Lefevre F Audic J M Bujon B | 1993 | Water Science & Technology1993，28，10： | 2 |
| 6 | Steroid profiling in preeclamptic women: evidence for aromatase deficiency显示文摘 | Alexandre Hertig Philippe Liere Nathalie Chabbert-Buffet Julie Fort Antoine Pianos Bernard Eychenne Annie Cambourg Michael Schumacher Nadia Berkane Guillaume Lefevre Serge Uzan Eric Rondeau Patrick Rozenberg Marie-Edith Rafestin-Oblin | 2010 | American Journal of Obstetrics and Gynecology2010，，5： | 2 |
| 7 | 迷走神经刺激和意识水平显示文摘研究表明,植物人状态的患者皮质皮质间和丘脑-皮质间远程通路中断.自我恢复的神经特征与丘脑-皮质活动的增加和前额叶功能连接改善有关.本研究通过刺激-位植物状态患者的植物神经评估来评估丘脑-皮质刺激的作用.该案例研究报道了-名35岁的有创伤性脑损伤史的男性,他15年来-直处于植物人状态.基线评估包括行为、脑电图和18F-FDGPET记录.然后患者接受了手术植入迷走神经刺激器,刺激增加至最大强度为1.5mA. | 李建华 Corazzol M Lio G Lefevre A | 2017 | 中国康复2017，32，6： | 2 |
| 8 | Who is at risk in the French mountains? Profiles of the accident victims in outdoor sports and mountain recreation显示文摘The risk of both severe and frequent injury associated with active pursuits in mountain areas is acknowledged. This phenomenon is all the most relevant to investigate in France that there is a growing enthusiasm for outdoor sports and recreation. This paper focuses on the social-demographic and sporting profiles of accident victims. Our intent is to better understand who is specifically at risk, while practicing mountain recreation, in the French mountains. Such identification doubtlessly constitutes an important asset in order to enhance prevention. Three critical activities are notably tackled, among some others: hiking, a widespread activity that exposes many practitioners to hazardous settings; mountaineering and ski touring, supposedly entailing the most severe injuries.In order to align the information collected, then provide estimations based on the reasoned crossing of these secondary data, we consulted and summarised all the databases that we knew of on the French territory: rescue team intervention reports, aggregated statistics from the sports ministry, sporting federation accident declarations, avalanche experts statistics, mountain guides union accident/incident reports, healthcare facilities admissions, etc. Only the sources consideredto be the most reliable and representative were used, owing to the number of cases processed, the exhaustive nature of data collection, or the level of information detail available. Our method also included consultation of all the parties playing an active role in prevention, training and mountain rescue, thus ensuring a participative, co-constructive approach to the study with the people that have the best knowledge of victim profiles. Around fifty such parties were interviewed on the methods implemented, the benefits and limits of current data, and the main expectations in terms of accidentology progress, thus further enhancing the credibility of the study proposed in this paper. Our results show that the parent population profiles(in terms of age, gender, place of residence, etc.), weighted by the level of exposure(frequency of participation, level of engagement, etc.) appears to have an impact on the accident victim profiles. There is certainly a very marked gender bias and a serious age impact to be taken into account, as well as the influence of the level of experience, which counter certain preconceived ideas and which, at the very least, go against instinct. However, aside from a probable over-exposure of experienced or expert participants, much remains to be explained concerning the accident mechanisms and circumstances involved. At this stage, we regret the analytic deficiencies induced by a lack ofknowledge concerning the parent populations in many cases, which makes interpretation difficult. | SOULE Bastien REYNIER Véronique LEFEVRE Brice BOUTROY Eric | 2017 | Journal of Mountain Science2017，14，8： | 2 |
| 9 | Perspectives damelioration genetique des peupliers en France显示文摘 | Villar M Lefevre F Augustin S | 1995 | Comptes Rendus de I′Academie d′Agriculture de France1995，81，3： | 2 |
| 10 | Belgium experience in disaster victim identification applied in handling terrorist attack at Brussels Airport 2016显示文摘The Belgian disaster victim identification(DVI)team is involved in many investigations in our country.Indeed,this specialized team of the federal police oversees searching for and investigating criminally buried dead bodies,identification of unknown putrefied corpses,and more.The Belgian DVI team also assists with the identification of victims of mass disasters(natural,accidental,and mass murders).In this article,we consider the contributions of different teams(forensic pathology,anthropology,and odontology,federal police,and crime scene investigation)both on the scene of the attack at the Brussels National Airport(Zaventem)and in the laboratory work(autopsies,sample studies). | Francois Beauthier Wim Van de Voorde Philippe Lefevre Jean-Pol Beauthier | 2020 | Forensic Sciences Research2020，5，3： | 2 |
| 11 | Belief functions combination and conflict management 显示文摘 | Lefevre E Color O Vannoorenberghe P | 2002 | Information Fusion2002，3，2： | 1 |
| 12 | The rodent uterotrophic assay critical protocol features, Studies with nonyl phenols, and comparison with a Yeast Estrogenicity Assay 显示文摘 | Odum J Lefevre P A Tittensor S | 1997 | Regulatory Toxicology and Pharmacology1997，25，： | 1 |
| 13 | Contribution des mesures d'information à la modélisation crédibiliste de connaissances显示文摘 | Lefevre E Colot O Vannoorenberghe P | 2000 | Traitement du signal 20002000，，2： | 1 |
| 14 | Characterization of Mediterranean Magnetotactic Bacteria显示文摘Magnetotactic bacteria are a diverse group of motile prokaryotes that are ubiquitous in aquatic habitats and cosmopolitan in distribution. In this study, we collected magnetotactic bacteria from the Mediterranean Sea. A remarkable diversity of morphotypes was observed, including multicellular types that seemed to differ from those previously found in North and South America. Another interesting organism was one with magnetosomes arranged in a six-stranded bundle which occupied one third of the cell width. The magnetosome bundle was evident even under optic microscopy. These cells were connected together and swam as a linear entire unit. Magnetosomes did not always align up to form a straight linear chain. A chain composed of rectangle magnetosomes bent at a posi- tion with an oval crystal. High resolution transmission electron microscopy analysis of the crystal at the pivotal position suggested uncompleted formation of the crystal. This is the first report of Mediterranean magnetotactic bacteria, which should be useful for studies of biogeochemical cycling and geohistory of the Mediterranean Sea. | Lefevre Christopher Bemadac Alain Pradel Nathalie WU Longfei Yu-Zhang Kui XIAO Tian Yonnet Jean-Paul Lebouc Afef SONG Tao Fukumori Yoshihiro | 2007 | Journal of Ocean University of China2007，6，4： | 1 |
| 15 | Some new classes of stochastic order relations among arithmetic random variables with applica-tions in actuarial sciences 显示文摘 | DENUIT M LEFEVRE C L | 1997 | Insurance:Mathematics and Economics1997，20，3： | 1 |
| 16 | Modelling the global ocean tides: modern insights from FES2004显示文摘 | Florent Lyard Fabien Lefevre Thierry Letellier Olivier Francis | 2006 | Ocean Dynamics (-)2006，，5： | 1 |
| 17 | Soluble endoglin in preeclamptic patients with or without HELLP syndrome显示文摘 | HertigA Fort J Lefevre G | | 0，，06： | 1 |
| 18 | FES99: A global tide finite element solution assimilating tide gauge and altimetric information 显示文摘 | Lefevre F Lyard F H Le Provost C | 2002 | Journal of Atmospheric and Oceanic Technology2002，19，9： | 1 |
| 19 | Neuropathic pain depends upon d - serine co - activation of spinal NMDA eceptors in rats显示文摘 | Lefevre Y Amadio A Vincent P | 2015 | Neurosci Lett2015，603，： | 1 |
| 20 | The effect on sperm production in adult Sprague-Dawley rats exposed by gavage to bisphenol A between postnatal days 91-97显示文摘 | Ashby J Tinwell H Lefevre PA | 2003 | Toxicol Sci2003，74，： | 1 |
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