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| 1 | Targeting the insulin-like growth factor pathway in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the third leading cause of cancer-related deaths worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments, which include surgical resection as the first option, liver transplantation and percutaneous ablation. Unfortunately, there is a high frequency of tumor recurrence after surgical resection and most HCC seem resistant to conventional chemotherapy and radiotherapy. Sorafenib, a multi-tyrosine kinase inhibitor, is the only chemotherapeutic option for patients with advanced hepatocellular carcinoma. Patients treated with Sorafenib have a significant increase in overall survival of about three months. Therefore, there is an urgent need to develop alternative treatments. Due to its role in cell growth and development, the insulin-like growth factor system is commonly deregulated in many cancers. Indeed, the insulin-like growth factor(IGF) axis has recently emerged as a potential target for hepatocellular carcinoma treatment. To this aim, several inhibitors of the pathway have been developed suchas monoclonal antibodies, small molecules, antisense oligonucleotides or small interfering RNAs. However recent studies suggest that, unlike most tumors, HCC development requires increased signaling through insulin growth factor Ⅱ rather than insulin growth factor Ⅰ. This may have great implications in the future treatment of HCC. This review summarizes the role of the IGF axis in liver carcinogenesis and the current status of the strategies designed to target the IGF-Ⅰ signaling pathway for hepatocellular carcinoma treatment. | Mónica Enguita-Germán Puri Fortes | 2014 | World Journal of Hepatology2014，6，10： | 10 |
| 2 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 3 | Biological evaluation of compost maturity显示文摘 | Zucconi F Forte M Monac A | 1981 | Biocycle1981，22，： | 2 |
| 4 | Evaluating toxicity of immature compost显示文摘 | Zucconit F Pera A Forte M | 1981 | Biocycle1981，22，： | 1 |
| 5 | Points of continuity of semicontinuous functions显示文摘 | FORT M K | 1951 | Publ Math Debrecen1951，2，： | 1 |
| 6 | Essential and nonessential fixed points 显示文摘 | Fort M K | 1950 | Am J Math1950，72，： | 1 |
| 7 | Hepatocyte growth factor effects on mesenchymal stem ceils : proliferation, migration, and differentiation 显示文摘 | Forte G Minieri M Cossa P | 2006 | Stem Cells2006，24，1： | 1 |
| 8 | Hepatocyte growth factor effects on mesenchymal stem cells:proliferation,migration,and differentiation显示文摘 | Forte G Minieri M Cossa P | | 0，，01： | 1 |
| 9 | Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation 显示文摘 | Forte G Minieri M Cossa P | 2006 | Stem cells2006，24，1： | 1 |
| 10 | Reduced beta-catenin and peroxisome proliferator- activated receptorgamma expression levels are associated with colorectal cancer metastatic progression: correlation with tumor-associated macrophages, cyclooxygenase 2, and patient outcome 显示文摘 | Pancione M Forte N Sabatino L | 2009 | Hum Pathol2009，40，5： | 1 |
| 11 | Detection of inherited monazite in the Manaslu leucogranite by 208 Pb/232 Th ion microprobe dating:Crystallization age and tectonic significance 显示文摘 | HARRISION T M MCKEEGAN K D LE FORT P | 1995 | Earth and Planetary Science Letters1995，133，： | 1 |
| 12 | Evaluating toxicity of immature compost显示文摘 | Zucconi F Pera A Forte M | 1981 | BioCycle1981，22，： | 1 |
| 13 | A comparison of DNA extraction methods for food analysis 显示文摘 | Pinto A I) Forte V T Guastadisegni M C | 2007 | Food Contr2007，18，： | 1 |
| 14 | The IGF1 pathway genes and their association with age of puber- ty in cattle显示文摘 | FORTES M R S LI Y T COLLIS E | 2015 | Animal Genetics2015，44，1： | 1 |
| 15 | Porcine circovirus type 2 (PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins显示文摘 | Fort M Sibila M Allepuz A | | 0，，08： | 1 |
| 16 | SBS and SEBS block copolymers as impact modifiers for polypropylene compounds显示文摘 | Abreu F O M S Forte M M C Liberman S A | 2005 | Journal of Polymer Science2005，95，2： | 1 |
| 17 | Differential response of leaf conductance, carbon isotope discrimination and water-use efficiency to nitrogen deficiency in maritime pine and pedunculate oak plants显示文摘 | Guehl J M Fort C Ferhi A | 1995 | New Phytologist1995，131，2： | 1 |
| 18 | The effects of power and strength training on bone mineral density in prem- enopausal women显示文摘 | Gray M Di Brezzo R Fort I L | 2013 | Journal of Sports Medicine and Physical Fitness2013，53，4： | 1 |
| 19 | Technical note: Separation of indium and iron hy solvent extraction显示文摘 | Fortes M C B Benedetto J S | 1998 | Minerals Engineering:1998，11，5： | 1 |
| 20 | Biologieal evaluation of compost maturity 显示文摘 | Zucconi F Forte M Monac A | 1981 | Biocycle1981，22，： | 1 |
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