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| 1 | Patterns of cancer recurrence in localized resected hepatocellular carcinoma显示文摘BACKGROUND:Tumor resection in non-metastatic hepatocellular carcinoma(HCC)patients with adequate liver reserve offers a potential cure,but has a high 5-year recurrence rate.We analyzed the patterns of cancer relapse after partial hepatectomy to guide post-operative management.METHODS:A total of 144 HCC patients(1996-2011)after partial hepatectomy were reviewed.Statistical correlations were determined using univariate and partition analyses.RESULTS:A median follow-up of 20 months showed recurrence in 71(49%)patients,and the median time to recurrence was 11.9 months.Vascular invasion(P<0.01)and number of lesions(P<0.01)predicted for recurrence.Histologic grade was not correlated with recurrence.Twenty-two(31%)patients developed both surgical margin(SM)and concurrent intrahepatic recurrences,and 28(40%)had non-SM intrahepatic recurrences with no other signs of recurrence.On partition analysis,the risk of marginal recurrence in patients with SM<1 mm and SM≥1 mm was 35%and 13.5%respectively.Approximately 57%of patients with intrahepatic recurrence had recurrence≤2.5 cm from SM.CONCLUSIONS:Intrahepatic recurrence after partial hepatectomy is common and is significantly associated with vascular invasion and tumor stage.About 57%of patients with intrahepatic relapse had a recurrence close(≤2.5 cm)to the SM.Additionally,patients with SM<1 mm have a higher recurrence rate and may benefit from adjuvant local therapy. | Aryavarta MS Kumar Elisha T Fredman Christopher Coppa Galal El-Gazzaz Federico N Aucejo May Abdel-Wahab | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，3： | 7 |
| 2 | 围手术期患者的安全:正确的患者、正确的手术、正确的部位——一项多因素、跨部门的干预性研究显示文摘背景为围手术期患者提供安全的环境非常重要。基于这一点,我们在围手术期实施了“患者安全第一”的政策。方法在干预性研究的第一阶段(2001—2002年),我们首先制定并实施干预性研究中组织和教育方面的内容。2003至2005年为研究的实施阶段。根据我们的零忍受原则,在手术等候区内一旦发现患者的麻醉或手术准备工作中有重大差错,该患者就被送回病房(失败),并等到差错得到纠正后再进行手术。结果共有15856例患者参加了研究。在研究实施阶段的3年中,有112例患者被送回病房(0.71%)。与2003年的数据相比,2004年和2005年发生的重大错误明显减少,且有统计学意义(2003、2004和2005年的数据分别为1.04%、0.59%和0.49%)。而且,逐步逻辑回归方法分析结果显示,手术前准备不充分所致重大错误的发生率逐年下降,具有统计学意义(比值比=1.48,95%CI:1.16~1.87)。此外,在2003、2004和2005年中,各年的失败发生平均间隔时间分别为6.6、11.2和14.7天(P〈0.03)。最后,不仅患者手术前准备工作在研究期间有显著改善(P〈0.0001);而且,使患者手术前准备工作评分为100%的可能性也有明显增加(P〈0.001)。结论教育和提高认识能减少围手术期的错误发生率。但是,即使有详细规划的制度,也无法达到无差错的环境。因此,检查和全面分析应该持续不断地进行。 | Edna Zohar Yossi Noga Ehud Davidson Margalit Kantor Brian Fredman 周全红(译) 江伟(校) | 2008 | 麻醉与镇痛2008，4，4： | 5 |
| 3 | Xu, Guoqi, Chinese and Americans: A Shared History显示文摘 | Zach Fredman | 2015 | Frontiers of History in China2015，10，4： | 2 |
| 4 | Up Close: Family Therapy Challenges and Innovations Around the World显示文摘 | Janine Roberts Khawla Abu‐Baker Cristina Diez Fernández Nelly Chong Garcia Glenda Fredman Hugo Kamya Yolanda Martín Higarza Jacqueline Fortes de Leff Philip Messent Shin‐Ichi Nakamura Fatma Torun Reid Timothy Sim Chitra Subrahmanian Roxana Zevallos Vega | 2014 | Fam. Proc2014，，： | 2 |
| 5 | Residual pneumoperitioneum:a cause of postoperative pain after laparoscopic cholecystectomy显示文摘 | Fredman B Jedeikin R Olsfanger D | 1994 | Anesthesia and Analgesia1994，79，： | 1 |
| 6 | A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia显示文摘 | Skoog I Wallin A Fredman P | 1998 | Neurolo?gy1998，50，4： | 1 |
| 7 | Two-dimensional dynamic simulation of the thermal state of ladles显示文摘 | Fredman T P Torrkulla J Saxen H | | 0，，： | 1 |
| 8 | The AETG System:An Approach to Test Based on Combinatorial Design 显示文摘 | Cohen D M Dalal S R Fredman M L | 1997 | IEEE Transactions on Software Engineering1997，23，7： | 1 |
| 9 | Inflammation and its Resolution as Determinants of Acute Coronary Syndromes显示文摘 | Peter Libby Ira Tabas Gabrielle Fredman Edward A. Fisher | 2014 | Circulation Research2014，，12： | 1 |
| 10 | Controvensies in perioperative use of nonsteroidal antiflammatory drugs显示文摘 | Souter AJ Fredman B White PF | 1994 | Anesth Analg1994，79，： | 1 |
| 11 | Bone Source hydroxy-apatite cement:a novel biomaterial for craniofacial skeletal tissue engineering and reconstruction显示文摘 | Fredman CD Costantino PD Takagi S | 1998 | J Biomed Mater Res1998，43，4： | 1 |
| 12 | The AETG system: an approach to testing based on combinatorial design 显示文摘 | Dalal S R Fredman M L | 1997 | IEEE Trans on Software Engineering1997，23，7： | 1 |
| 13 | Impaired EDRF production by endothelial cell exposed to fibrin monomer and FDP显示文摘 | Fabian A Loscalzo J | 1995 | Am J Physiol1995，268，： | 1 |
| 14 | Self-limited versus delayed resolution of acute inflammation:temporal regulation of pro-resolving mediators and microRNA显示文摘 | Fredman G Li Y Dalli J | | 0，，： | 1 |
| 15 | The AETG system: an approach to testing based on combinatorial design 显示文摘 | COHEN D M DALAL S R FREDMAN M L PATTON G C | 1997 | IEEE Transaction On Software Engineering1997，23，7： | 1 |
| 16 | The AETG System: an Approach to Testing Based on Combinatorial Design 显示文摘 | Cohen D M Dalai S R Fredman M L | 1997 | IEEE Transaction on Software Engineering1997，23，7： | 1 |
| 17 | New techniques for designing qualitatively independent systems 显示文摘 | Fredman M L | 1998 | J Combin Designs1998，6，6： | 1 |
| 18 | Delivery Room Analgesia: Ananalysis of Maternal Satisfaction显示文摘 | Shapiro A Fredman B Zohar E | 1998 | Inter J Obstet Anesth1998，，7： | 1 |
| 19 | Decreased resistance and immune response to Escherichia infection in chicks with low or high intakes of vitamin A 显示文摘 | Fredman Meidovsky Sklan | 1991 | Journal of Nutrition1991，121，： | 1 |
| 20 | Fibonacci Heaps and their Uses in Improved Network Optimization Algorithms显示文摘 | TARJAN R E | 1987 | ACM1987，34，： | 1 |
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