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| 1 | How tubular epithelial cells dictate the rate of renal fibrogenesis?显示文摘The main threat to a kidney injury,whatever its cause and regardless of whether it is acute or chronic,is the initiation of a process of renal fibrogenesis,since fibrosis can auto-perpetuate and is of high prognostic significance in individual patients.In the clinic,a decrease in glomerular filtration rate correlates better with tubulointerstitial damage than with glomerular injury.Accumulation of the extracellular matrix should not be isolated from other significant cellular changes occurring in the kidney,such as infiltration by inflammatory cells,proliferation of myofibroblasts,obliteration of peritubular capillaries and atrophy of tubules.The aim of this review is to focus on tubular epithelial cells(TEC),which,necessarily involved in the repair process,eventually contribute to accelerating fibrogenesis.In the context of injury,TEC rapidly exhibit phenotypic and functional changes that recall their mesenchymal origin,and produce several growth factors known to activate myofibroblasts.Because they are high-demanding energy cells,TEC will subsequently suffer from the local hypoxia that progressively arises in a microenvironment where the matrix increases and capillaries become rarified.The combination of hypoxia and metabolic acidosis may induce a vicious cycle of sustained inflammation,at the center of which TEC dictate the rate of renal fibrogenesis. | Kevin Louis Alexandre Hertig | 2015 | World Journal of Nephrology2015，4，3： | 16 |
| 2 | Steroid profiling in preeclamptic women: evidence for aromatase deficiency显示文摘 | Alexandre Hertig Philippe Liere Nathalie Chabbert-Buffet Julie Fort Antoine Pianos Bernard Eychenne Annie Cambourg Michael Schumacher Nadia Berkane Guillaume Lefevre Serge Uzan Eric Rondeau Patrick Rozenberg Marie-Edith Rafestin-Oblin | 2010 | American Journal of Obstetrics and Gynecology2010，，5： | 2 |
| 3 | Plasminogen activator inhibitor type 1 is a potential target in renal fibrogenesis显示文摘 | Rerolle JP Hertig A Nguyen G | 2000 | Kidney Int2000，58，5： | 1 |
| 4 | Dating the endometrial biopsy显示文摘 | NOYES R W HERTIG A T ROCK J | 1975 | Am J Obstet Gynecol1975，122，2： | 1 |
| 5 | Detection of bovine viral diarrhea (VBD) virus using the polymerase chain reaction显示文摘 | Hertig C Pauli U Zanoni R | 1991 | Vet Microbio1991，26，： | 1 |
| 6 | Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A显示文摘 | Schneider P Street SL Gaide O Hertig S Tardivel A Tschopp J | 2001 | J Biol Chem2001，276，18： | 1 |
| 7 | Type 1 plasminogen activator inhibitor deficiency aggravates the course of experimental glomerulonephritis through overactivation of transforming growth factor beta 显示文摘 | Hertig A Berrou J Allory Y | 2003 | FASEB J2003，17，13： | 1 |
| 8 | Type 1 plasminogen activator inhibitor deficiency aggravates the course of experimental glomerulonephritis through over activation of transforming growth factor beta 显示文摘 | Hertig A Berrou J Allory Y | 2003 | FASEB J2003，17，13： | 1 |
| 9 | Natural killer cell cytotox- icity: a methods analysis of 51chromium release versus flow cytometry 显示文摘 | Motzer SA Tsuji J Hertig V | 2003 | Biol Res2003，5，： | 1 |
| 10 | Bovine virus di arrhea/mucosal disease: a review显示文摘 | WEISS M HERTIG C STRASSER M | 1994 | Schweix Arch Tierheilkd1994，136，5： | 1 |
| 11 | SLE and idiopathic nephrotic syndrome:Coincidence or not显示文摘 | Hertig A Droz D Lesavre P | 2002 | Am J Kidney Dis2002，40，6： | 1 |
| 12 | Early epithelial phenotypic changes predict graft fibrosis 显示文摘 | Hertig A Anglicheau D Verine J | 2008 | J Am Soc Nephrol2008，19，10： | 1 |
| 13 | Treatment of trophoblastic neoplasms, with rationale for the use of adjunctive chemotherapy at the time of indicated operation显示文摘 | Lewis JL Gore H Hertig AT | 1966 | Am J Obstet Gyneeol1966，98，3： | 1 |
| 14 | Papillomas of the uterine cervix-The malignant potentiality显示文摘 | Kistner RW Hertig AT | 1955 | Obstet Gynecol1955，6，： | 1 |
| 15 | Plasminogen activator inhibitor type 1:the two faces of the same coin显示文摘 | Hertig A Rondeau E | | 0，，01： | 1 |
| 16 | N-cadherin in adult rat cardiomyocytes in culture显示文摘 | Cecilia M Hertig Stefan B | 1996 | Journal of Cell Science1996，109，1： | 1 |
| 17 | Genetic heterogeneity within the coding region of E2 and NS2 in strain of bovine viral diarrhea virus显示文摘 | Hertig C Stalder H Peterhans E | 1995 | Gene1995，153，： | 1 |
| 18 | Plasminogen activator inhibitor type 1:the two faces of the same coin显示文摘 | Hertig A Rondeau E | 2004 | Curr Opin Nephrol Hypertens2004，13，1： | 1 |
| 19 | Groundwater recharge history and hydrogeochemical evolution in the Mianqin Basin, North West China显示文摘 | Edmunds W M Ma J Z Hertig W A Kipfer R Darbyshire DPF | 2006 | Applied Geochemistry2006，21，12： | 1 |
| 20 | Structure of an mdr-like gene from Arabidopsis thaliana:Evolutionary implications显示文摘 | Dudler R Hertig C | 1992 | J Biol Chem1992，267，： | 1 |
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