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| 1 | Current landscape in motoneuron regeneration and reconstruction for motor cranial nerve injuries显示文摘The intricate anatomy and physiology of cranial nerves have inspired clinicians and scientists to study their roles in the nervous system. Damage to motor cranial nerves may result from a variety of organic or iatrogenic insults and causes devastating functional impairment and disfigurement. Surgical innovations directed towards restoring function to injured motor cranial nerves and their associated organs have evolved to include nerve repair, grafting, substitution, and muscle transposition. In parallel with this progress, research on tissue-engineered constructs, development of bioelectrical interfaces, and modulation of the regenerative milieu through cellular, immunomodulatory, or neurotrophic mechanisms has proliferated to enhance the available repertoire of clinically applicable reconstructive options. Despite these advances, patients continue to suffer from functional limitations relating to inadequate cranial nerve regeneration, aberrant reinnervation, or incomplete recovery of neuromuscular function. These shortfalls have profound quality of life ramifications and provide an impetus to further elucidate mechanisms underlying cranial nerve denervation and to improve repair. In this review, we summarize the literature on reconstruction and regeneration of motor cranial nerves following various injury patterns. We focus on seven cranial nerves with predominantly efferent functions and highlight shared patterns of injuries and clinical manifestations. We also present an overview of the existing reconstructive approaches, from facial reanimation, laryngeal reinnervation, to variations of interposition nerve grafts for reconstruction. We discuss ongoing endeavors to promote nerve regeneration and to suppress aberrant reinnervation and the development of synkinesis. Insights from these studies will shed light on recent progress and new horizons in understanding the biomechanics of peripheral nerve neurobiology, with emphasis on promising strategies for optimizing neural regeneration and identifying future directions in the field of motor cranial neuron research. | Yanjun Xie Kevin J.Schneider Syed A.Ali Norman D.Hogikyan Eva L.Feldman Michael J.Brenner | 2020 | Neural Regeneration Research2020，15，9： | 4 |
| 2 | Stereotactic radiotherapy of histologically proven inoperable stage I non-small cell lung cancer: Patterns of failure显示文摘 | Nicolaus Andratschke Frank Zimmermann Eva Boehm Sabine Schill Christine Schoenknecht Reinhard Thamm Michael Molls Carsten Nieder Hans Geinitz | 2011 | Radiotherapy and Oncology2011，，2： | 3 |
| 3 | Structure and function of cytokinin oxidase/dehydrogenase genes of maize, rice, Arabidopsis and other species显示文摘 | Thomas Schmülling Tomá? Werner Michael Riefler Eva Krupková Isabel Bartrina y Manns | 2003 | Journal of Plant Research2003，，3： | 2 |
| 4 | International study group on rectal cancer regression grading: interobserver variability with commonly used regression grading systems显示文摘 | Runjan Chetty Pelvender Gill Dhirendra Govender Adrian Bateman Hee Jin Chang Vikram Deshpande David Driman Marisa Gomez Godman Greywoode Eleanor Jaynes C. Soon Lee Michael Locketz Corwyn Rowsell Anne Rullier Stefano Serra Neil Shepherd Eva Szentgyorgyi Ra | 2012 | Human Pathology2012，，11： | 2 |
| 5 | mTOR signaling in disease显示文摘 | Eva Dazert Michael N Hall | 2011 | Current Opinion in Cell Biology2011，，6： | 2 |
| 6 | There are differences in cerebral activation between females in distinct menstrual phases during viewing of erotic stimuli: a fMRI study显示文摘 | Elke R. Gizewski Eva Krause Sherif Karama Anneke Baars Wolfgang Senf Michael Forsting | 2006 | Experimental Brain Research2006，，1： | 1 |
| 7 | A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation显示文摘 | Runjan Chetty Pelvender Gill Dhirendra Govender Adrian Bateman Hee Jin Chang David Driman Fraser Duthie Marisa Gomez Eleanor Jaynes Cheok Soon Lee Michael Locketz Claudia Mescoli Corwyn Rowsell Anne Rullier Stefano Serra Neil Shepherd Eva Szentgyorgyi Raj | 2012 | Virchows Archiv2012，，2： | 1 |
| 8 | Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents显示文摘 | Eva M Sevick-Muraca Jessica P Houston Michael Gurfinkel | 2002 | Current Opinion in Chemical Biology2002，，5： | 1 |
| 9 | Determination of chlorhexidine digluconate and polyhexamethylene biguanide in eye drops by capillary electrophoresis with contactless conductivity detection显示文摘 | Eva M AV Susanne FE Michael AT | 2006 | Analytica Chimica Acta2006，56，561： | 1 |
| 10 | Can delu sions be self--assessed? Concordance between self-- and observer- rated delusions in schizophrenia显示文摘 | Tania Marie Lincoln Michael Ziegler Eva Lallmann | 2010 | Psychiatry Res2010，178，2： | 1 |
| 11 | mTOR signaling in disease显示文摘 | Eva Dazert Michael N Hall | 2011 | Current Opinion in Cell Biology2011，，6： | 1 |
| 12 | Sensitive detection of HIV-1 resistance to Zidovudine and impact on treatment outcomes in low-to middle-income countries显示文摘Background:Thymidine analogs,namely AZT(Zidovudine or Retrovir^(TM))and d4T(Stavudine or Zerit^(TM))are antiretroviral drugs still employed in over 75%of first line combination antiretroviral therapy(cART)in Kampala,Uganda despite aversion to prescribing these drugs for cART in high income countries due in part to adverse events.For this study,we explored how the continued use of these thymidine analogs in cART could impact emergence of drug resistance and impact on future treatment success in Uganda,a low-income country.Methods:We examined the drug resistance genotypes by Sanger sequencing of 262 HIV-infected patients failing a first line combined antiretroviral treatment containing either AZT or d4T,which represents approximately 5%of the patients at the Joint Clinical Research Center receiving a AZT or d4T containing treatment.Next generation sequencing(DEEPGEN^(TM)HIV)and multiplex oligonucleotide ligation assays(AfriPOLA)were then performed on a subset of patient samples to detect low frequency drug resistant mutations.CD4 cell counts,viral RNA loads,and treatment changes were analyzed in a cohort of treatment success and failures.Results:Over 80%of patients failing first line AZT/d4T-containing cART had predicted drug resistance to 3TC(Lamivudine)and non-nucleoside RT inhibitors(NNRTIs)in the treatment regimen but only 45%had resistance AZT/d4T associated resistance mutations(TAMs).TAMs were however detected at low frequency within the patients HIV quasispecies(1-20%)in 21 of 34 individuals who were failing first-line AZT-containing cART and lacked TAMs by Sanger.Due to lack of TAMs by Sanger,AZT was typically maintained in second-line therapies and these patients had a low frequency of subsequent virologic success.Conclusions:Our findings suggest that continued use of AZT and d4T in first-line treatment in low-to-middle income countries may lead to misdiagnosis of HIV-1 drug resistance and possibly enhance a succession of second-and third-line treatment failures. | Richard M.Gibson Gabrielle Nickel Michael Crawford Fred Kyeyune Colin Venner Immaculate Nankya Eva Nabulime Emmanuel Ndashimye Art F.Y.Poon Robert A.Salata Cissy Kityo Peter Mugyenyi Miguel E.Quinones-Mateu Eric J.Arts | 2017 | Infectious Diseases of Poverty2017，6，1： | 1 |
| 13 | Transforming growth factor-1 in fetal serum correlates with insulin-like growth factor-I and fetal growth显示文摘 | Eva O Michael T Gabriel F | 2002 | Obstet Gynecol2002，100，3： | 1 |
| 14 | Surgery for atrial fibrillation in patients with mitral valve disease: Results at five years from the International Registry of Atrial Fibrillation Surgery显示文摘 | Joao Melo Teresa Santiago Carlos Aguiar Eva Berglin Michael Knaut Ottavio Alfieri Stefano Benussi Haw Sie Mathew Williams Fernando Hornero Giuseppi Marinelli Paul Ridley Enrique Fulquet-Carreras António Ferreira | 2008 | The Journal of Thoracic and Cardiovascular Surgery2008，，4： | 1 |
| 15 | Spermidine protects against a-synuclein neurotoxicity显示文摘 | Sabrina Buttner Filomena Broeskamp Cornelia Sommer Maria Markaki Lukas Habernig Ali Alavian-Ghavanini Didac Carmona-Gutierrez1 Tobias Eisenberg Eva Michael Guido Kroemer Nektarios Tavernarakis Stephan J Sigrist and Frank Madeo1 | 2014 | Cell Cycle 13:24 3903-3908 December 152014，2014，： | 1 |
| 16 | Revealing Single-Trap Condensate Fragmentation by Measuring Density-Density Correlations after Time of Flight显示文摘 | Eva M Bookjans Christopher D Hamley Michael S Chapman | 2014 | Phys Rev Lett2014，113，14： | 1 |
| 17 | Rapid and efficient synthesis of aliphatic ester dendrons and dendrimers 显示文摘 | Michael Malkoch Eva Malmstrolm Anders Hult | 2002 | Macromolecules2002，35，： | 1 |
| 18 | Protective effect of captopril on the blood-retina barrier in normotensive insulin-dependent diabetic patients with nephropathy and background retinopathy显示文摘 | Michael Larse Eva Hommel Hans-Henrik Parving Henrik Lund-Andersen | 1990 | Graefe’s Archive for Clinical and Experimental Ophthalmology1990，，6： | 1 |
| 19 | Comparison of high-frequency QRS components and ST-segment elevation to detect and quantify acute myocardial ischemia显示文摘 | MICHAEL R JONAS P EVA P STAFFORD G W PYOTR P OLLE P GALEN S W | 2010 | Journal of Electrocardiology2010，43，： | 1 |
| 20 | Evolution of genome size in pines (Pinus) and its life-history correlates 显示文摘 | EVA GROTKOPP MARCEL REJMANEK MICHAEL SANDERSON | 2004 | Supertree Analyses Evolution2004，58，8： | 1 |
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