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| 1 | Risk factors associated with pancreatic fistula after distal pancreatectomy, which technique of pancreatic stump closure is more beneficial?显示文摘AIM: To identify risk factors related to pancreatic fistula in patients undergoing distal pancreatectomy (DP) and to determine the effectiveness of using a stapled and a sutured closed of pancreatic stump. METHODS: Sixty-four patients underwent DP during a 10-year period. Information regarding diagnosis, operative details, and perioperative morbidity or mortality was collected. Eight risk factors were examined. RESULTS: Indications for DP included primary pancreatic disease (n = 38, 59%) and non-pancreatic malignancy (n = 26, 41%). Postoperative mortality and morbidity rates were 1.5% and 37% respectively; one patient died due to sepsis and two patients required a reoperation due to postoperative bleeding. Pancreatic fistula was developed in 14 patients (22%); 4 of fistulas were classified as Grade A, 9 as Grade B and only 1 as Grade C. Incidence of pancreatic fistula rate was significantly associated with four risk factors: pathology, use of prophylactic octreotide therapy, concomitant splenectomy, and texture of pancreatic parenchyma. The role that technique (either stapler or suture) of pancreatic stump closure plays in the development of pancreatic leak remains unclear. CONCLUSION: The pancreatic fistula rate after DP is 22%. This is reduced for patients with non-pancreatic malignancy, fibrotic pancreatic tissue, postoperative prophylactic octreotide therapy and concomitant splenectomy. | Marco Pericoli Ridolfini Sergio Alfieri Stavros Gourgiotis Dario Di Miceli Fabio Rotondi Giuseppe Quero Roberta Manghi Giovanni Battista Doglietto | 2007 | World Journal of Gastroenterology2007，13，38： | 24 |
| 2 | Systematic review of health-related quality of life after esophagectomy for esophageal cancer显示文摘This study is aimed to assess the long-term health-related quality of life(HRQL) of patients after esopha-gectomy for esophageal cancer in comparison with es-tablished norms,and to evaluate changes in HRQL during the different stages of follow-up after esopha-geal resection. A systematic review was performed bysearching medical databases(Medline,Embase andthe Cochrane Library) for potentially relevant studiesthat appeared between January 1975 and March 2011.Studies were included if they addressed the questionof HRQL after esophageal resection for esophage alcancer. Two researchers independently performed the study selection,data extraction and analysis processes.Twenty-one observational studies were included witha total of 1282(12-355) patients. Five studies were performed with short form-36(SF-36) and 16 with European Organization for Research and Treatment of Cancer(EORTC) QLQ C30(14 of them also utilized the disease-specific OES18 or its previous version OES24) .The analysis of long-term generic HRQL with SF-36showed pooled scores for physical,role and socialfunction after esophagectomy similar to United Statesnorms,but lower pooled scores for physical function,vitality and general health perception. The analysis of HRQL conducted using the Global EORTC C30 globalscale during a 6-mo follow-up showed that global scaleand physical function were better at the baseline. The symptom scales indicated worsened fatigue,dyspneaand diarrhea 6 mo after esophagectomy. In contrast,however,emotional function had significantly improved after 6 mo. In conclusion,short- and long-term HRQLis deeply affected after esophagectomy for cancer. The impairment of physical function may be a long-termconsequence of esophagectomy involving either the respiratory system or the alimentary tract. The short-and long-term improvement in the emotional function of patients who have undergone successful operationsmay be attributed to the impression that they have survived a near-death experience. | Marco Scarpa Stefano Valente Rita Alfieri Matteo Cagol Giorgio Diamantis Ermanno Ancona Carlo Castoro | 2011 | World Journal of Gastroenterology2011，17，42： | 15 |
| 3 | 基于遥感与区域化方法的无资料流域水文模型参数优化方法显示文摘针对无资料流域径流预报的难点,探讨水文模型参数优化的共性问题,综述区域化方法和遥感方法的研究现状。首先从水文模型参数优化面临的共性问题,即水文地理数据生成、目标函数构建和优化方法选择等问题出发,分析其对参数优选结果的影响,并归纳出当前广泛认可的解决方案。然后结合区域化方法的技术原理和研究进展,着重论述测站密度对区域化方法性能的影响,并分析该方法在中国的适用性。接着从研究区域、水文模型结构、遥感资料以及率定目标等方面归纳总结遥感方法优化水文模型参数的最新研究进展。最后对区域化方法和遥感方法的优缺点及未来发展前景进行对比分析,为中国无资料或缺资料流域径流预报实践提供参考。 | 姜璐璐 吴欢 Lorenzo Alfieri 李潇濛 John SKimball 陈秀万 | 2020 | 北京大学学报(自然科学版)2020，56，6： | 9 |
| 4 | Alimentary regimen in non-alcoholic fatty liver disease:Mediterranean diet显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide.The mechanisms of the underlying disease development and progression are awaiting clarification.Insulin resistance and obesity-related inflammation status,among other possible genetic,dietary,and lifestyle factors,are thought to play the key role.There is no consensus concerning the pharmacological treatment.However,the dietary nutritional management to achieve weight loss is an essential component of any treatment strategy.On the basis of its components,the literature reports on the effectiveness of the Mediterranean diet in reducing cardiovascular risk and in preventing major chronic diseases,including obesity and diabetes.New evidence supports the idea that the Mediterranean diet,associated with physical activity and cognitive behaviour therapy,may have an important role in the prevention and the treatment of NAFLD. | Ludovico Abenavoli Natasa Milic Valentina Peta Francesco Alfieri Antonino De Lorenzo Stefano Bellentani | 2014 | World Journal of Gastroenterology2014，20，45： | 7 |
| 5 | Hepcidin and HFE protein: Iron metabolism as a target for the anemia of chronic kidney disease?显示文摘The anemia of chronic kidney disease and hemodialysis is characterized by chronic inflammation and release of cytokines,resulting in the upregulation of the iron hormone hepcidin,also increased by iron therapy and reduced glomerular filtration,with consequent reduction in iron absorption,recycling,and availability to the erythron.This response proves advantageous in the short-term to restrain iron availability to pathogens,but ultimately leads to severe anemia,and impairs the response to erythropoietin(Epo)and iron.Homozygosity for the common C282Y and H63D HFE polymorphisms influence iron metabolism by hampering hepcidin release by hepatocytes in response to increased iron stores,thereby resulting in inadequate inhibition of the activity of Ferroportin-1,inappropriately high iron absorption and recycling,and iron overload.However,in hemodialysis patients,carriage of HFE mutations may confer an adaptive benefit by decreasing hepcidin release in response to iron infusion and inflammation,thereby improving iron availability to erythropoiesis,anemia control,the response to Epo,and possibly survival.Therefore,anti-hepcidin therapies may improve anemia management in hemodialysis.However,HFE mutations directly favor hemoglobinization independently of hepcidin,and reduce macrophages activation in response to inflammation,whereas hepcidin might also play a beneficial anti-inflammatory and anti-microbic action during sepsis,so that direct inhibition of HFEmediated regulation of iron metabolism may represent a valuable alternative therapeutic target.Genetic studies may offer a valuable tool to test these hypotheses and guide the research of new therapies. | Elena Canavesi Carlo Alfieri Serena Pelusi Luca Valenti | 2012 | World Journal of Nephrology2012，1，6： | 5 |
| 6 | Restored Function of HBV-Specific T Cells After Long-term Effective Therapy With Nucleos(t)ide Analogues显示文摘 | Carolina Boni Diletta Laccabue Pietro Lampertico Tiziana Giuberti Mauro Viganò Simona Schivazappa Arianna Alfieri Marco Pesci Giovanni B. Gaeta Giuseppina Brancaccio Massimo Colombo Gabriele Missale Carlo Ferrari | 2012 | Gastroenterology2012，，4： | 3 |
| 7 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 8 | Synthesis and Characterization of Iron-Rich Glass Ceramic Materials:A Model for Steel Industry Waste Reuse显示文摘Wastes deriving from steel industry, containing large amounts of iron oxides and heavy metals, when collected in landfills are subjected to atmospheric agents, with consequent release of toxic substances in the soil and groundwater. The reuse of these wastes as raw materials for the production of advanced materials is a viable way both to overcome the environmental impact and to reduce the disposal costs,proposing new technologically advanced materials. This work aims to simulate these interesting glassceramics by using glass cullet coming from recycled municipal waste and high amount of iron(III) oxide(from 25 wt% to 50 wt%), the prevalent component of steel waste. The oxide was mixed with glass cullet and vitrified. The samples composition and the microstructure were investigated by scanning electron microscopy(SEM), and X-ray diffraction(XRD) was used to evaluate the nature of the crystalline phases.The chemical stability of the materials, in terms of ionic release into saline solution, was assessed. The electrical behavior of the samples was also investigated by varying the iron ions content and controlling the crystallization process. It is possible to obtain chemically stable materials with a nearly semiconducting behavior. | Riccardo Carlini Ilaria Alfieri Gilda Zanicchi Francesco Soggia Enos Gombia Andrea Lorenzi | 2016 | Journal of Materials Science & Technology2016，32，11： | 2 |
| 9 | Controversies about Interspinous Process Devices in the Treatment of Degenerative Lumbar Spine Diseases: Past, Present, and Future显示文摘 | Roberto Gazzeri Marcelo Galarza Alex Alfieri Vijay K. Goel | 2014 | BioMed Research International2014，，： | 2 |
| 10 | Similar long-term results of mitral valve repair for anterior compared with posterior leaflet prolapse显示文摘 | Michele De Bonis Roberto Lorusso Elisabetta Lapenna Samer Kassem Giuseppe De Cicco Lucia Torracca Francesco Maisano Giovanni La Canna Ottavio Alfieri | 2006 | The Journal of Thoracic and Cardiovascular Surgery2006，，2： | 2 |
| 11 | Management of duodeno-pancreato-biliary perforations after ERCP: outcomes from an Italian tertiary referral center显示文摘 | Sergio Alfieri Fausto Rosa Caterina Cina Antonio Pio Tortorelli Andrea Tringali Vincenzo Perri Guido Costamagna Giovanni Battista Doglietto | 2013 | Surgical Endoscopy2013，，6： | 2 |
| 12 | Pulmonary Vein Denervation Enhances Long-Term Benefit After Circumferential Ablation for Paroxysmal Atrial Fibrillation显示文摘 | Carlo Pappone Vincenzo Santinelli Francesco Manguso Gabriele Vicedomini Filippo Gugliotta Giuseppe Augello Patrizio Mazzone Valter Tortoriello Giovanni Landoni Alberto Zangrillo Christopher Lang Takeshi Tomita Cézar Mesas Elio Mastella Ottavio Alfieri | 2004 | Circulation: Journal of the American Heart Association2004，，3： | 2 |
| 13 | The hemodynamic effects of double-orifice valve repair for mitral regurgitation: a 3D computational model 1显示文摘 | Francesco Maisano Alberto Redaelli Giancarlo Pennati Roberto Fumero Lucia Torracca Ottavio Alfieri | 1999 | European Journal of Cardio-Thoracic Surgery1999，，4： | 2 |
| 14 | An effective technique to correct anterior mitral leaflet prolapse 显示文摘 | Alfieri O Maisano F | 1999 | J Card Surg1999，14，6： | 2 |
| 15 | Impact of jejunostomy during esophagectomy for cancer on health related quality of life显示文摘Background: The aim of this study was to evaluate the impact of jejunostomy during esophagectomy for cancer on postoperative health-related quality of life(HRQL).Methods: We evaluate all consecutive patients who underwent esophagectomy for cancer at the surgical oncology unit of the Veneto Institute of Oncology(IOV-IRCCS) between January 2008 and March 2014. The primary outcome was HRQL, which was assessed using nine scales of EORTC C30 and OES18 questionnaires. General linear models were estimated to evaluate mean score difference(MD) of each selected scale in patients with and without jejunostomy, adjusting for clinically relevant confounders. The secondary outcomes were morbidity, hospital stay, postoperative weight loss and postoperative albumin impairment. Results: Jejunostomy was performed in 40 on 109 patients(41.3%) who participated in quality of life investigation. A clinically and statistically significantly worse eating at admission(P=0.009) became not clinically significant at 3 months after surgery(MD =9.1). Jejunostomy was associated to clinically and statistically significantly poorer emotional function(EF) at 3 months after surgery(MD =-15.6; P=0.04). Hospital stay was longer in jejunostomy group(median, 20 vs. 17 days, P=0.02).Conclusions: In our series patients who had a jejunostomy during esophagectomy had been selected for their risk for postoperative complication. However, their postoperative outcome was actually similar compared to those without jejunostomy. Nevertheless, jejunostomy was associated to clinically and statistically significantly poorer EF at 3 months after surgery. Therefore, patient candidate to esophagectomy and feeding jejunostomy should receive additional psychological support. | Marco Scarpa Francesco Cavallin Giulia Noaro Eleonora Pinto Rita Alfieri Matteo Cagol Carlo Castoro | 2014 | Chinese Journal of Cancer Research2014，26，6： | 2 |
| 16 | Single Screw fixation for acute type Ⅱ odontoid fracture显示文摘 | ALFIERI A | 2001 | J Neurosurg Sci2001，45，1： | 1 |
| 17 | Transcatheter valveimplantation for patients with aortic stenosis: a position statement fromthe European Association of Cardio-Thoracic Surgery (EACTS) and theEuropean Society of Cardiology (ESC), in collaboration with the Euro-pean Association of Percutaneous Cardiovascular Interventions (EAPCI)显示文摘 | VAHANIAN A ALFIERI OR Al-ATTAR N | 2008 | Eur J Cardiothorac Surg2008，34，： | 1 |
| 18 | Detection of canine distemper virus by reverse transcriptase-polymerase chain reaction in the urine of dogs with clinical signs of distemper encephalitis显示文摘 | Saito T B Alfieri A A Wosiacki S R | 2006 | Research in Veterinary Science2006，80，： | 1 |
| 19 | A novel strategy for reducing phospholipids-based matrix effect in LC-ESI-MS bio- analysis by means of HybridSPE 显示文摘 | PUCCI V DI PALMA S ALFIERI A | 2009 | J Pharm Biomed Anal2009，50，5： | 1 |
| 20 | Operational early warning systems for water-related hazards in Europe显示文摘 | Alfieri L Salamon P Pappenberger F | 2012 | Envi- ronmental Science & Policy2012，21，： | 1 |
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