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| 1 | Goblet cell carcinoid tumors of the appendix: An overview显示文摘Goblet cell carcinoid is an enigmatic and rare tumor involving the appendix almost exclusively. Since its identification in 1969, understanding of this disease has evolved greatly, but issues regarding its histogenesis, nomenclature and management are still conjectural. The published English language literature from 1966 to 2009 was retrieved via PubMed and reviewed. Various other names have been used for this entity such as adenocarcinoid, mucinous carcinoid, crypt cell carcinoma, and mucin-producing neuroendocrine tumor, although none have been found to be completely satisfactory or universally accepted. The tumor is thought to arise from pluripotent intestinal epithelial crypt-base stem cells by dual neuroendocrine and mucinous differentiation. GCCs present in the fifth to sixth decade and show no definite sex predominance. The most common clinical presentation is acute appendicitis, followed by abdominal pain and a mass. Fifty percent of the female patients present with ovarian metastases. The histologic hallmark of this entity is the presence of clusters of goblet cells in the lamina propria or submucosa stain for various neuroendocrine markers, though the intensity is often patchy. Atypia is usually minimal, but carcinomatous growth patterns may be seen. These may be of signet ring cell type or poorly differentiated adenocarcinoma. Recently molecular studies have shown these tumors to lack the signatures of adenocarcinoma but they have some changes similar to that of ileal carcinoids (allelic loss of chromosome 11q, 16q and 18q). The natural history of GCC is intermediate between carcinoids and adenocarcinomas of the appendix. The 5-year overall survival is 76%. The most important prognostic factor is the stage of disease. Appendectomy and right hemicolectomy are the main modalities of treatment, followed by adjuvant chemotherapy in select cases. There is some debate about the surgical approach for these tumors, and a summary of published series and recommendations are provided. | Paromita Roy Runjan Chetty | 2010 | World Journal of Gastrointestinal Oncology2010，2，6： | 7 |
| 2 | Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix显示文摘Goblet cell carcinoid is an uncommon primary tumor of the vermiform appendix, characterized by dual endocrine and glandular differentiation. Whether goblet cell carcinoid represents a morphological variant of appendiceal classical carcinoid or a mucin-producing adenocarcinoma is a matter of conjecture. Rare cases of goblet cell carcinoid with other concomitant appendiceal epithelial neoplasms have been documented. In this report, we describe a rare case of combined appendiceal goblet cell carcinoid and mucinous cystadenoma, and discuss the possible histopathogenesis of this combination. | Khaled O Alsaad Stefano Serra Runjan Chetty | 2009 | World Journal of Gastroenterology2009，15，27： | 6 |
| 3 | Hidden Markov Models Incorporating Fuzzy Measures and Integrals for Protein Sequence Identification and Alignment显示文摘Profile hidden Markov models (HMMs) based on classical HMMs have been widely applied for protein sequence identification. The formulation of the forward and backward variables in profile HMMs is made under statistical independence as-sumption of the probability theory. We propose a fuzzy profile HMM to overcome the limitations of that assumption and to achieve an improved alignment for protein sequences belonging to a given family. The proposed model fuzzifies the forward and backward variables by incorporating Sugeno fuzzy measures and Choquet inte-grals, thus further extends the generalized HMM. Based on the fuzzified forward and backward variables, we propose a fuzzy Baum-Welch parameter estimation al-gorithm for profiles. The strong correlations and the sequence preference involved in the protein structures make this fuzzy architecture based model as a suitable candidate for building profiles of a given family, since the fuzzy set can handle uncertainties better than classical methods. | Niranjan P. Bidargaddi Madhu Chetty Joarder Kamruzzaman | 2008 | Genomics, Proteomics & Bioinformatics2008，6，2： | 6 |
| 4 | Gut-associated lymphoid tissue or so-called “dome” carcinoma of the colon: Review显示文摘AIM To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or 'dome' carcinoma of the colon.METHODS The English language medical literature on gut-or gastrointestinal-associated lymphoid tissue(GALT) or 'dome' carcinoma of the colon was searched and appraised.RESULTS GALT/dome-type carcinomas of the colon are thought to arise from the M-cells of the lymphoglandular complex of the intestine. They are typically asymptomatic and have a characteristic endoscopic plaque-or 'dome'-like appearance. Although the histology of GALT/dome-type carcinomas displays some variability, they are characterized by submucosal localization, a prominent lymphoid infiltrate with germinal center formation, tumor-infiltrating lymphocytes, absence of desmoplasia, and dilated glands lined by columnar epithelial cells with bland nuclear features and cytoplasmic eosinophilia. None of the patients reported in the literature with follow-up have developed metastatic disease or local recurrence.CONCLUSION Increased awareness amongst histopathologists of this variant of colorectal adenocarcinoma is likely to lead to the recognition of more cases. | Aoife J McCarthy Runjan Chetty | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 3 |
| 5 | Obesity, hypertension and insulin resistance显示文摘 | A. M. Sharma V. T. Chetty | 2005 | Acta Diabetologica2005，，1： | 2 |
| 6 | Expression profiling by microarrays in colorectal cancer (Review)显示文摘 | Warren Shih Runjan Chetty Ming-Sound Tsao | 2005 | Oncology Reports2005，，3： | 2 |
| 7 | International study group on rectal cancer regression grading: interobserver variability with commonly used regression grading systems显示文摘 | Runjan Chetty Pelvender Gill Dhirendra Govender Adrian Bateman Hee Jin Chang Vikram Deshpande David Driman Marisa Gomez Godman Greywoode Eleanor Jaynes C. Soon Lee Michael Locketz Corwyn Rowsell Anne Rullier Stefano Serra Neil Shepherd Eva Szentgyorgyi Ra | 2012 | Human Pathology2012，，11： | 2 |
| 8 | A general formula for the optimal level of social insurance显示文摘 | Raj Chetty | 2006 | Journal of Public Economics2006，，10： | 2 |
| 9 | Epstein-Barr Virus-Associated Lymphoepithelioma-like Gastric Carcinoma显示文摘 | Herath Chaturika Harshini Pavithra Chetty Runjan | 2008 | Archives of Pathology & Laboratory Medicine2008，，4： | 2 |
| 10 | Gastric Hyperplastic Polyps: A Review显示文摘 | Richa Jain Runjan Chetty | 2009 | Digestive Diseases and Sciences2009，，9： | 2 |
| 11 | Lipid-Rich Variant of Pancreatic Endocrine Neoplasms显示文摘 | Rajendra Singh Olca Basturk David S Klimstra Giuseppe Zamboni Runjan Chetty Sanaa Hussain Stefano La Rosa Asli Yilmaz Paola Capelli Carlo Capella Jeanette D Cheng N Volkan Adsay | 2006 | The American Journal of Surgical Pathology2006，，2： | 2 |
| 12 | Cytokeratins 7 and 20 Immunoexpression Profile in Goblet Cell and Classical Carcinoids of Appendix显示文摘 | Khaled O. Alsaad Stefano Serra Anja Schmitt Aurel Perren Runjan Chetty | 2007 | Endocrine Pathology2007，，1： | 2 |
| 13 | From traditional serrated adenoma to tubulovillous adenoma and beyond显示文摘It is well established that colorectal cancer develops from a series of precursor epithelial polyps, including tubular adenomas, villous/tubulovillous adenomas(VA/TVA), sessile serrated adenomas(SSA) and traditional serrated adenomas(TSA). Of these, TSAs are least common and account for only 5% of all serrated polyps. TSAs are characterised by the presence of a 'pinecone-like' architecture, granular eosinophilic cytoplasm, luminal serrations, ectopic crypt foci(ECF) and elongated, pencillate nuclei. However, the distinct slit-like luminal serrations, reminiscent of small bowel mucosa, appear to be the most unique and reproducible feature to distinguish TSAs from other polyps. There is a contention that TSAs are not inherently dysplastic and that the majority do not show cytological atypia. Two types of dysplasia are associated with TSA. Serrated dysplasia is less well recognised and less commonly encountered than adenomatous dysplasia. In addition, it is now becoming increasingly evident that TSAs can be admixed with HP, SSA and VA/TVA. At a genetic level, polyps may switch phenotype as they accumulate genetic changes, evolving from a serrated pathway to a more conventional one, which could be the basis for a spectrum theory starting out with a TSA with serration and ECF evolving into a TSA with conventional dysplasia and, eventually, to a well-developed conventional adenoma. Nevertheless, there is an exigency for future studies to provide further illumination and bridge the gaps in our present understanding. | Sangeetha N Kalimuthu Adeline Chelliah Runjan Chetty | 2016 | World Journal of Gastrointestinal Oncology2016，8，12： | 2 |
| 14 | Increased resistin gene and protein in human abdominal adipose tissue 显示文摘 | McTerman P G Mcterman C L Chetty R | 2002 | J Clin Endocrinol Metab2002，87，5： | 1 |
| 15 | The static and dynamic characteristics of a two-lobe journal bearing lubricated with couple-stress fluid 显示文摘 | Crosby W A Chetti B | 2009 | Tribology Transactions 52:2 62 - 2682009，2009，： | 1 |
| 16 | Experimental acute pancreatitis in the rat-a new model显示文摘 | Chetty U Gilmour HM Taylor TV | 1980 | Gut1980，21，2： | 1 |
| 17 | Increased re- sistin gene and protein expression in human abdominal adi- pose tisue显示文摘 | MeTernan PG MeTernan CL Chetty R | 2002 | Clin Endocrinol Metab2002，87，5： | 1 |
| 18 | A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation显示文摘 | Runjan Chetty Pelvender Gill Dhirendra Govender Adrian Bateman Hee Jin Chang David Driman Fraser Duthie Marisa Gomez Eleanor Jaynes Cheok Soon Lee Michael Locketz Claudia Mescoli Corwyn Rowsell Anne Rullier Stefano Serra Neil Shepherd Eva Szentgyorgyi Raj | 2012 | Virchows Archiv2012，，2： | 1 |
| 19 | Internationalisation Strategy and its Impact on Learning During the Process显示文摘 | Sylvie Chetty Colin Campbell-Hunt | 2004 | Joumal of Asia Pacific Marketing2004，，32： | 1 |
| 20 | Protective effect of 17-beta-estradiol in human neurocellular models of lead exposure显示文摘 | Chetty CS Vemuri MC Suresh C | 2007 | Neurotoxicology2007，28，： | 1 |
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