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| 1 | Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD),the most important being Crohn's disease and ulcerative colitis,results from chronic dysregulation of the mucosal immune system in the gastrointestinal tract.Although the pathogenesis of IBD remains unclear,it is widely accepted that genetic,environmental,and immunological factors are involved.Recent studies suggest that intestinal epithelial defenses are important to prevent inflammation by protecting against microbial pathogens and oxidative stresses.To investigate the etiology of IBD,animal models of experimental colitis have been developed and are frequently used to evaluate new anti-inflammatory treatments for IBD.Several models of experimental colitis that demonstrate various pathophysiological aspects of the human disease have been described.In this manuscript,we review the characteristic features of IBD through a discussion of the various chemically induced experimental models of colitis(e.g.dextran sodium sulfate-,2,4,6-trinitrobenzene sulfonic acid-,oxazolone-,acetic acid-,and indomethacin-induced models).We also summarize some regulatory and pathogenic factors demonstrated by these models that can,hopefully,be exploited to develop future therapeutic strategies against IBD. | Mayumi Kawada Atsuko Arihiro Emiko Mizoguchi | 2007 | World Journal of Gastroenterology2007，13，42： | 12 |
| 2 | Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells显示文摘The family of mammalian chitinases includes members both with and without glycohydrolase enzymatic activity against chitin,a polymer of N-acetylglucosamine.Chitin is the structural component of fungi,crustaceans,insects and parasitic nematodes,but is completely absent in mammals.Exposure to antigens containing chitin-or chitin-like structures sometimes induces strong T helper type-I responses in mammals,which may be associated with the induction of mammalian chitinases.Chitinase 3-like-1(CHI3L1) ,a member of the mammalian chitinase family,is induced specifically during the course of inflammation in such disorders as inflammatory bowel disease,hepatitis and asthma.In addition,CHI3L1 is expressed and secreted by several types of solid tumors including glioblastoma,colon cancer,breast cancer and malignant melanoma.Although the exact function of CHI3L1 in inflammation and cancer is still largely unknown,CHI3L1 plays a pivotal role in exacerbating the inflammatory processes and in promoting angiogenesis and remodeling of the extracellular matrix.CHI3L1 may be highly involved in the chronic engagement of inflammation which potentiates development of epithelial tumorigenesis presumably by activating the mitogen-activated protein kinase and the protein kinase B signaling pathways.Anti-CHI3L1 antibodies or pan-chitinase inhibitors may have the potential to suppress CHI3L1-mediated chronic inflammation and the subsequent carcinogenic change in epithelial cells. | Katrin Eurich Mayuko Segawa Satoko Toei-Shimizu Emiko Mizoguchi | 2009 | World Journal of Gastroenterology2009，15，42： | 9 |
| 3 | Gastric calcifying fibrous tumor removed by endoscopic submucosal dissection显示文摘The World Health Organization describes calcifying fibrous tumors(CFTs) as rare, benign lesions characterized by hypocellular, densely hyalinized collagenization with lymphoplasmacytic infiltration. These tumors rarely involve the gastrointestinal(GI) tract. A routine endoscopic upper gastrointestinal screen detected a 10-mm submucosal tumor(SMT) in the lesser curvature of the lower corpus of the stomach of an apparently healthy, 37-year-old woman with no history of Helicobacter pylori infection. Endoscopic ultrasonography(EUS) localized the internally isoechoic, homogeneous SMT mainly within the submucosa. Malignancy was ruled out using endoscopic submucosal dissection(ESD). A pathological examination confirmed complete resection of the SMT, and defined a hypocellular, spindle-cell tumor with a densely hyalinized, collagenous matrix, scattered lymphoplasmacytic aggregates as well as a few psammomatous, dystrophic calcified foci. The mass was immunohistochemically positive for vimentin and negative for CD117(c-kit protein), CD34, desmin, smooth muscle actin(SMA) and S100. Therefore, the histological findings were characteristic of a CFT. To date, CFT resection by ESD has not been described. This is the first case report of a gastric calcifying fibrous tumor being completely resected by ESD after endoscopic ultrasonography. | Naotaka Ogasawara Shinya Izawa Mari Mizuno Atsushi Tanabe Tomonori Ozeki Hisatsugu Noda Emiko Takahashi Makoto Sasaki Toyoharu Yokoi Kunio Kasugai | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，9： | 8 |
| 4 | Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis显示文摘AIM: To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic cancer cell lines, particularly for gemcitabine, the first-line anti-tumor drug for pancreatic cancer. METHODS: To compare the expression level of BNIP3 with the resistance to gemcitabine, eight pancreatic cancer cell lines were subjected to gemcitabine treatment and the quantitative real-time RT-PCR method was used to evaluate BNIP3 expression. Immunohistochemical analysis was also performed using 22 pancreatic cancer specimens to study relationship between BNIP3 expression and survival rate. RESULTS: Although no significantly positive association between BNIP3 mRNA level and gemcitabine chemosensitivity was observed, pancreatic cancer cell lines that were sensitive to gemcitabine treatment tended to show high levels of BNIP3 expression. The converse, an absence of BNIP3 expression, was not correlated with gemcitabine resistance. We further compared the BNIP3 expression profiles of resected primary pancreaticcancer specimens with the prognosis of the patients, and found a tendency of favorable prognosis and low BNIP3 expression. CONCLUSION: High levels of BNIP3 expression cannot be used as one of the predicting factors for gemcitabine chemosensitivity, and some yet to be known factors will have to fill the gap for the accurate prediction of pancreatic cancer chemosensitivity to gemcitabine. However, BNIP3 expression may have an impact on prediction of prognosis of patients with pancreatic cancer. | Masaharu Ishida Makoto Sunamura Toru Furukawa Masanori Akada Hiroko Fujimura Emiko Shibuya Shinichi Egawa Michiaki Unno Akira Horii | 2007 | World Journal of Gastroenterology2007，13，34： | 8 |
| 5 | 中国某省降低艾滋病流行危害干预项目的成本效果分析显示文摘目的:开展成本效果分析,研究美沙酮维持治疗、针具交换以及针对暗娼人群的干预对G省艾滋病流行的影响。方法:采用UNAIDS和PANCEA项目提供的标准工具收集3类干预的成本,通过文献检索了解3类干预对行为改变的效果,利用PANCEA开发的多重干预、多重流行的成本效果模型预测3类干预对G省艾滋病流行的影响。结果:2005年,在高、低流行地区,针具交换最具成本效果,每避免1例新发艾滋病感染的成本分别为892美元和1801美元;美沙酮维持治疗项目每避免1例新发感染的成本分别为2687美元和5101美元;而针对暗娼人群的干预避免1例新发感染的成本分别为3029美元和6429美元。本研究还揭示对艾滋病干预长期投入的必要性。此外,为跟踪干预效果和预测其对艾滋病流行的影响,必须重视行为学、经济学资料的收集。 | 白玥 王世勇 EMIKO MASAKI ELLIOT MARSEILLE | 2010 | 医学与社会2010，23，6： | 7 |
| 6 | 1-溴丙烷引发雄性大鼠性腺基因表达谱的变化显示文摘目的研究1-溴丙烷(1-BP)诱发大鼠性腺基因表达谱的变化,探索1-BP雄性生殖毒性相关的mRNA改变。方法雄性F344/NSIc大鼠12只,随机分为2组,分别吸入新鲜空气或5030mg/m31-BP8h。染毒后16h处死大鼠取出睾丸,运用大鼠性腺cDNA微阵列和real-timePCR方法测定1-BP染毒后性腺相关基因表达谱的变化。结果在大鼠性腺芯片5087个cDNA微点阵中,有62个基因被1-BP显著下调,3个基因显著上调。其中包括性激素合成相关基因细胞色素P450芳香化酶(CYP19a),谷胱苷肽S-转移酶(GSTT1),肌酸激酶(Ckb),髓鞘和淋巴细胞蛋白(Mal)和S100的钙结合蛋白(S100a4)。归类分析结果显示绝大多数变化的基因与蛋白质/脂类代谢相关,其次与应激防御反应相关。实时定量PCR证实了1-BP可引起CYP19a、S100a4、GSTT1和Mal的下调。结论急性高剂量染毒1-BP可引起睾丸组织CYP19a、S100a4、GSTT1、Mal等基因的下调,提示其可能通过内分泌干扰和氧化应激效应而导致雄性生殖毒性。 | 李卫华 市原学 王海兰 Kitagawa Emiko Iwahashi Hitoshi 丁训诚 周志俊 | 2010 | 卫生研究2010，39，2： | 5 |
| 7 | 某省降低危害干预项目的成本分析显示文摘随着降低危害的干预在高危人群中迅速扩展,艾滋病防治资源分配和使用效益问题已越来越受到关注。本研究提示G省干预滞后于疫情发展;不同的干预在成本、产出方面差别很大。G省干预项目的单位成本较国外同类项目低;但是由于收集的资料有限,干预未能体现经济规模效应,研究提示在中国开展成本横向比较、纵向跟踪的必要性、可行性。 | 白玥 王世勇 刘伟 朱秋映 Emiko Masaki | 2009 | 医学与社会2009，22，12： | 5 |
| 8 | Oncological results, functional outcomes and health-related quality-of-life in men who received a radical prostatectomy or external beam radiation therapy for localized prostate cancer: a study on long-term patient outcome with risk stratification显示文摘在激进的前列腺切除术(RP ) 或外部横梁放射治疗(EBRT ) 以后的健康相关的 quality-of-life (HRQOL ) 没在与疾病风险层化的关系与 oncological 结果一起被学习。而且,这些治疗途径的长期的结果没被学习。我们回顾地分析了在收到 RP 的连续病人之间的 oncological 结果(n = 86 ) 并且 EBRT (n = 76 ) 为局部性的前列腺癌症。HRQOL 和功能的结果能在 62 RP (79%) 和 54 EBRT (79%) 被估计在一个 3 年的后续时期上的病人(中部:41 个月) 用医药结果学习,短 Form-36 (SF-36 ) 和加利福尼亚大学洛杉机前列腺癌症索引(UCLA 一种总线标准) 。5 年的生物化学的没有前进的幸存没在 RP 和 EBRT 组之间不同为低风险(74.6% 对 75.0% , P = 0.931 ) 并且中间风险(61.3% 对 71.1% , P = 0.691 ) 病人。为高风险的病人,没有前进的幸存比在 EBRT 组(79.7%) 在 RP 组(45.1%) 是更低的(P = 0.002 ) 。一般 HRQOL 在二个组之间是可比较的。关于功能的结果, RP 组比 EBRT 组在尿功能和不太尿的麻烦和性麻烦上报导了更低的分数(P < 0.001, P < 0.05 并且 P < 0.001,分别地) 。与风险层化,在 RP 组的低风险、中间风险的病人在 EBRT 组比病人报导了更差的尿功能(P < 0.001 为各个) 。在 EBRT 组的高风险的病人的性功能比一样的风险 RP 病人的好(P < 0.001 ) 。生物化学的复发没在任何一个组与 UCLA 一种总线标准分数被联系。在结论,低 -- 可以在长期的后续期间向与 RP 对待的中间风险的病人汇报相对减少的尿功能。病人在治疗以后的 HRQOL 没取决于生物化学的复发。 | Itsuhiro Takizawa Noboru Hara Tsutomu Nishiyama Masaaki Kaneko Tatsuhiko Hoshii Emiko Tsuchida Kota Takahashi | 2009 | Asian Journal of Andrology2009，11，3： | 3 |
| 9 | The prognostic nutritional index can be a prognostic indicator in colorectal carcinoma显示文摘 | Tadahiro Nozoe Mayuko Kohno Tomohiro Iguchi Emiko Mori Takashi Maeda Akito Matsukuma Takahiro Ezaki | 2012 | Surgery Today2012，，6： | 3 |
| 10 | Effect of the anti-diabetic drug metformin in hepatocellular carcinomain vitro and in vivo显示文摘 | Hisaaki Miyoshi Kiyohito Kato Hisakazu Iwama Emiko Maeda Teppei Sakamoto Koji Fujita Yuka Toyota Joji Tani Takako Nomura Shima Mimura Mitsuyoshi Kobayashi Asahiro Morishita Hideki Kobara Hirohito Mori Hirohito Yoneyama Akihiro Deguchi Takashi Himoto Kazut | 2014 | International Journal of Oncology2014，，1： | 3 |
| 11 | Chitinase 3-Like-1 Expression in Colonic Epithelial Cells as a Potentially Novel Marker for Colitis-Associated Neoplasia显示文摘 | Chun-Chuan Chen Joel Pekow Victoria Llado Manasa Kanneganti Cindy W. Lau Atsushi Mizoguchi Mari Mino-Kenudson Marc Bissonnette Emiko Mizoguchi | 2011 | The American Journal of Pathology2011，，3： | 3 |
| 12 | Novel methylxanthine derivative-mediated anti-inflammatory effects in inflammatory bowel disease显示文摘Family 18 chitinases have a binding capacity with chitin, a polymer of N-acetylglucosamine. Recent studies strongly suggested that chitinase 3-like 1(CHI3L1, also known as YKL-40) and acidic mammalian chitinase, the two major members of family 18 chitinases, play a pivotal role in the pathogenesis of inflammatory bowel disease(IBD), bronchial asthma and several other inflammatory disorders. Based on the data from highthroughput screening, it has been found that three methylxanthine derivatives, caffeine, theophylline, and pentoxifylline, have competitive inhibitory effects against a fungal family 18 chitinase by specifically interacting with conserved tryptophans in the active site of this protein. Methylxanthine derivatives are also known as adenosine receptor antagonists, phosphodiesterase inhibitors and histone deacetylase inducers. Anti-in-flammatory effects of methylxanthine derivatives have been well-documented in the literature. For example, a beneficial link between coffee or caffeine consumption and type 2 diabetes as well as liver cirrhosis has been reported. Furthermore, theophylline has a long history of being used as a bronchodilator in asthma therapy, and pentoxifylline has an immuno-modulating effect for peripheral vascular disease. However, it is still largely unknown whether these methylxanthine derivativemediated anti-inflammatory effects are associated with the inhibition of CHI3L1-induced cytoplasmic signaling cascades in epithelial cells. In this review article we will examine the above possibility and summarize the biological significance of methylxanthine derivatives in intestinal epithelial cells. We hope that this study will provide a rationale for the development of methylxanthine derivatives, in particular caffeine,-based antiinflammatory therapeutics in the field of IBD and IBDassociated carcinogenesis. | In-Ah Lee Alan Kamba Daren Low Emiko Mizoguchi | 2014 | World Journal of Gastroenterology2014，20，5： | 3 |
| 13 | Animal Models of Colitis-Associated Carcinogenesis显示文摘 | Manasa Kanneganti Mari Mino-Kenudson Emiko Mizoguchi Andrea Vecchione | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 2 |
| 14 | Roles of galectins in inflammatory bowel disease显示文摘Protein/carbohydrate interactions through specific protein families termed lectin control essential biological processes. Galectins, a family of animal lectins defined by shared amino acid sequence with affinity for β-galactosides, appear to be functionally polyvalent in a wide range of biological activity. Recent studies have identified immunoregulatory roles of galectins in intestinal inflammatory disorders. Galectin-1 and galectin -2 contribute to the suppression of intestinal inflammation by the induction of apoptosis of activated T cells, whereas galectin-4 is involved in the exacerbation of this inflammation by specifically stimulating intestinal CD4+ T cells to produce IL-6. We review how different members of the galectins provide inhibitory or stimulatory signals to control intestinal immune response under intestinal inflammation. | Akira Hokama Emiko Mizoguchi Atsushi Mizoguchi | 2008 | World Journal of Gastroenterology2008，14，33： | 2 |
| 15 | 99mTc-DISIDA Uptake in Liver Lesion and Pulmonary Metastases Shown on SPECT/CT in a Patient With Hepatocellular Carcinoma显示文摘 | Cristina Emiko Ueda Wilson André Ichiki Mariana Ferraz de Campos Mazo Ruiz Allan Oliveira Santos Elba Cristina Sá de Camargo Etchebehere | 2014 | Clinical Nuclear Medicine2014，，1： | 2 |
| 16 | Altered Cognitive Function of Prefrontal Cortex During Error Feedback in Patients With Irritable Bowel Syndrome, Based on fMRI and Dynamic Causal Modeling显示文摘 | Emiko Aizawa Yasuhiro Sato Takanori Kochiyama Naohiro Saito Masahiro Izumiyama Joe Morishita Motoyori Kanazawa Keisetsu Shima Hajime Mushiake Michio Hongo Shin Fukudo | 2012 | Gastroenterology2012，，5： | 2 |
| 17 | How do resident stem cells repair the damaged myocardium?显示文摘It has been a decade since the monumental discovery of resident stem cells in the mammalian heart, and the following studies witnessed the continuous turnover of cardiomyocytes and vascular cells, maintaining the homeostasis of the organ. Recently, the autologous administration of c-kit-positive cardiac stem cells in patients with ischemic heart failure has led to an incredible outcome; the left ventricular ejection fraction of the celltreated group improved from 30% at the baseline to 38% after one year and to 42% after two years of cell injection. The potential underlying mechanisms, before and after cell infusion, are explored and discussed in this article. Some of them are related to the intrinsic property of the resident stem cells, such as direct differentiation, paracrine action, and immunomodulatory function, whereas others involve environmental factors, leading to cellular reverse remodeling and to the natural selection of 'juvenile' cells. It has now been demonstrated that cardiac stem cells for therapeutic purposes can be prepared from tiny biopsied specimens of the failing heart as well as from frozen tissues, which may remarkably expand the repertoire of the strategy against various cardiovascular disorders, including non-ischemic cardiomyopathy and congenital heart diseases. Further translational investigations are needed to explore these possibilities. | Emiko Hayashi Toru Hosoda | 2015 | World Journal of Stem Cells2015，7，1： | 2 |
| 18 | Knowledge Governance in a Japanese Project-based Organization显示文摘 | Vesa Peltokorpi Emiko Tsuyuki | 2006 | Knowledge Management Research & Practice2006，4，1： | 1 |
| 19 | Gene expression profiles predicting the response to IFN-β and a combinationof temozolomide and IFN-β in malignant gliomas显示文摘 | Atsuo Yoshino Shinya Tashiro Akiyoshi Ogino Kazunari Yachi Takashi Ohta Takao Fukushima Takao Watanabe Yoichi Katayama Yutaka Okamoto Emiko Sano Kouhei Tsumoto | 2011 | International Journal of Oncology2011，，3： | 1 |
| 20 | Effects on development of the reproductive system in male offspring of rats given butylbenzyl phthalate during late pregnancy显示文摘 | Makoto E Emiko M | 2002 | Reproductive Toxicology2002，16，： | 1 |
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