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| 1 | Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma显示文摘AIM: In the present study, the characteristics of PEI-RFA treatment were further elucidated by analyzing the relationship between the volume of coagulated necrosis and the energy requirement for ablation or the amount of ethanol injected into HCC.METHODS: The volume of coagulated necrosis, total energy requirement and energy requirement for coagulation of per unit volume were examined in the groups of PEI-RFA and RFA alone using the Cool-tip RF system.RESULTS: The results showed that the volume of coagulated necrosis induced was significantly larger in PEI-RFA group than in routine RFA group, when the total energy administered was comparable in both groups.In PEI-RFA, enlargement of coagulated necrosis was admitted in 3 dimensions and the amount of energy requirement per unit volume of coagulated necrosis was negatively correlated with the amount of ethanol injected into HCC.CONCLUSION: These results suggest that, compared to RFA alone, PEI-RFA enables to induce comparable coagulated necrosis with smaller energy requirement, and that PEI-RFA is likely to be less invasive than RFA alone irrespective of inducing enhanced coagulated necrosis.Thus, simple prior injection of ethanol may make RFA treatment more effective and less invasive for the treatment of patients with HCC. | Kazutaka Kurokohchi Seishiro Watanabe Tsutomu Masaki Naoki Hosomi Yoshiaki Miyauchi Takashi Himoto Yasuhiko Kimura Seiji Nakai Akihiro Deguchi Hirohito Yoneyama Shuhei Yoshida Shigeki Kuriyama | 2005 | World Journal of Gastroenterology2005，11，10： | 29 |
| 2 | A rare case of hyaline-type Castleman disease in the liver显示文摘Castleman disease often develops in the neck, mediastinum and pulmonary hilum. Its onset in the peritoneal cavity is very rare. The patient, a woman in her 70s, was referred to our department for a detailed examination of an abdominal mass. On abdominal ultrasonography, computed tomography scan, magnetic resonance imaging and positron emission tomography, a mass approximately 15 mm in diameter was noted in the hepatic S6. We attempted radical treatment and conducted a laparoscope-assisted right lobectomy. On the basis of histopathological findings, the patient was diagnosed as having hyaline type Castleman disease in the liver, a very rare condition. | Hisaaki Miyoshi Shima Mimura Takako Nomura Joji Tani Asahiro Morishita Hideki Kobara Hirohito Mori Hirohito Yoneyama Akihiro Deguchi Takashi Himoto Naoki Yamamoto Keiichi Okano Yasuyuki Suzuki Tsutomu Masaki | 2013 | World Journal of Hepatology2013，5，7： | 14 |
| 3 | A combination therapy of ethanol injection and radiofrequency ablation under general anesthesia for the treatment of hepatocellular carcinoma显示文摘AIM: To summarize the effects of laparoscopic ethanol injection and radiofrequency ablation (L-EI-RFA), thora- coscopic (T-EI-RFA) and open-surgery assisted EI-RFA (O-EI-RFA) under general anesthesia for the treatment of hepatocellular carcinoma (HCC). METHODS: Time-lag performance of RFA after ethanol injection (Time-lag PEI-RFA) was performed in all cases. The volume of coagulated necrosis and the applied en- ergy for total and per unit volume coagulated necrosis were examined in the groups treated under general (group G) or local anesthesia (group L). RESULTS: The results showed that the total applied energy and the applied energy per unit volume of whole and marginal, coagulated necrosis were significantly larger in group G than those in the group L, resulting in a larger volume of coagulated necrosis in the group G. The rate of local tumor recurrence within one year was extremely low in group G. CONCLUSION: These results suggest that EI-RFA, un- der general anesthesia, may be effective for the treat- ment of HCC because a larger quantity of ethanol and energy could be applied during treatment under pain- free condition for the patients. | Kazutaka Kurokohchi Seishiro Watanabe Hirohito Yoneyama Akihiro Deguchi Tsutomu Masaki Takashi Himoto Hisaaki Miyoshi Hamdy Saad Mohammad Akira Kitanaka Tomohiko Taminato Shigeki Kuriyama | 2008 | World Journal of Gastroenterology2008，14，13： | 10 |
| 4 | Effect of the anti-diabetic drug metformin in hepatocellular carcinomain vitro and in vivo显示文摘 | Hisaaki Miyoshi Kiyohito Kato Hisakazu Iwama Emiko Maeda Teppei Sakamoto Koji Fujita Yuka Toyota Joji Tani Takako Nomura Shima Mimura Mitsuyoshi Kobayashi Asahiro Morishita Hideki Kobara Hirohito Mori Hirohito Yoneyama Akihiro Deguchi Takashi Himoto Kazut | 2014 | International Journal of Oncology2014，，1： | 3 |
| 5 | Usefulness of liver infiltrating CD86-positive mononuclear cells for diagnosis of autoimmune hepatitis显示文摘瞄准:尽管位于自体免疫的肝炎(AIH ) 下面的病原的机制仍然保持不清楚,免疫系统被认为为疾病的前进批评。细胞的有免疫力的回答可以在 AIH 被连接到肝细胞损坏。最近,许多注意集中于在有效 T 调停房间的有免疫力的回答的产生在单音的原子房间上表示的 costimulatory 分子的批评功能。与 AIH 从病人在单音的原子房间上表示的 costimulatory 分子的分析可以在 AIH 给我们卓见进肝细胞损坏的病原的机制。方法:单音的原子房间(PBMC ) 与 AIH (34 个盒子) 和健康控制(25 个盒子) 从病人被拿的外部血。渗透的单音的原子房间(LIMC ) 与 AIH (18 个盒子) 从病人被拿的肝,有长期的丙肝(CH-C )(13 个盒子) 的病人和有脂肝(2 个盒子) 的病人。用流动血细胞计数,房间为 costimulatory 分子的表示被分析,例如 CD80, CD86,和 CD152 (CTLA-4 ) 。结果与象到 corticosteroids 的 corticosteroids 管理和反应的 gammaglobulin,组织学的等级,存在或缺席的水平那样的临床的数据相比。结果:CD80+ , CD86+ 和 CD152+ PBMC 的层次显著地作为与健康控制相比与 AIH 在病人被减少。由对比,那些房间比在有 AIH 的病人的 PBMC 在 LIMC 是显著地更高的。特别,不管疾病活动的度, CD86+ LIMC 的水平与 AIH 在病人显示出显著增加,尽管 CD86+ 房间是很少在 PBMC 在场。CD86+ 房间的层次显著地是在场的在里面在有 AIH 的病人的高频率比在有 CH-C 的病人。而且,有有 CD86+ LIMC 的高水平的 AIH 的病人显示出好回答到 corticosteroids,而有 CD86+ LIMC 的底层的 AIH 的 2 个盒子没反应很好。结论:这些结果建议那 LIMC 过去表示的 costimulatory 分子象 CD80 和 CD86 那样看起来在 AIH 的致病起一个作用。特别,在 LIMC 上表示的 CD86 分子可能为 AIH 的诊断并且为 AIH 上的 corticosteroids 的治疗学的效果的预言是有用的。 | Kazutaka Kurokohchi Tsutomu Masaki Takashi Himoto Akihiro Deguchi Seiji Nakai Asahiro Morishita Hirohito Yoneyama Yasuhiko Kimura Seishiro Watanabe Shigeki Kuriyama | 2006 | World Journal of Gastroenterology2006，12，16： | 2 |
| 6 | Local steroid injection into the artificial ulcer created by endoscopic submucosal dissection for gastric cancer: prevention of gastric deformity显示文摘 | H. Mori K. Rafiq H. Kobara S. Fujihara N. Nishiyama M. Kobayashi T. Himoto R. Haba M. Hagiike K. Izuishi K. Okano Y. Suzuki T. Masaki | 2012 | Endoscopy2012，，07： | 2 |
| 7 | Early detection of hypertension in a patient treated with sunitinib by measuring cardio-ankle vascular index 显示文摘 | H MASUGATA S SENDA T HIMOTO | 2009 | Tohoku J Exp Med2009，218，2： | 1 |
| 8 | Modeling the trajectory of window flames with regard to flow attachment to the adjacent wall显示文摘 | Himoto K Tsuchihashi T Tanaka Y | 2009 | Fire Safety Journal2009，44，2： | 1 |
| 9 | Analyses of autoantibodies against tumor-associated antigens in patients with hepatocellular carcinoma显示文摘 | Himoto T Kuriyama S Zhang JY | 2005 | Int J Oncol2005，27，4： | 1 |
| 10 | Significance of autoantibodies against insulin-like growth factorⅡmRNA-binding proteins in patients with hepatocellular carcinoma显示文摘 | Himoto T Kuriyama S Zhang JY | 2005 | Int J Oncol2005，26，2： | 1 |
| 11 | Spin correlations in the triangular-lattice random mixed antiferromagnet显示文摘 | Kikuta C Himoto E | 1998 | J Phys: Condens Matter1998，10，： | 1 |
| 12 | Angiotensin receptorbloek-ers in chronic heart failure显示文摘 | Umemoto S Kawahara S H himoto R et a1 | 2003 | Nippon Rinsho2003，61，16： | 1 |
| 13 | Seleni- um deficiency is associated with insulin resistance in patients with hepatitis C virus - related chronic liver disease显示文摘 | HIMOTO T YONEYAMA H KUROKOHCHI K | 2011 | Nutr Res2011，31，11： | 1 |
| 14 | Modeling the trajectory of window flames with regard to flow attachment to the adjacent wall显示文摘 | Keisuke Himoto Tsuneto Tsuchihashi Yoshiaki Tanaka Takeyoshi Tanaka | 2008 | Fire Safety Journal2008，，2： | 1 |
| 15 | Analyses of autoantibodies against tumor-associated antigens in patients with hepatocellular carcinoma显示文摘 | Himoto T Kuriyaama S ZhangJY | 2005 | Int J Oncol2005，27，4： | 1 |
| 16 | Analyses of au- toantibodies against tumor-associated antigens in patients with hepatocellular carcinoma 显示文摘 | Himoto T Kuriyama S Zhang JY | 2005 | Int J Oncol2005，27，4： | 1 |
| 17 | Analysis of apple quality by near infrared reflectance spectroscopy显示文摘 | Murakami M Himoto J Itoh K | | 0，，01： | 1 |
| 18 | Development and validation of a physics-based urban fire spread model显示文摘 | Himoto K and Tanaka T | 2008 | Fire Safety Journal2008，43，7： | 1 |
| 19 | Prenatal differential diagnosis of complete hydafidiform mole with a twin live fetus and placental mes- enchymal dysplasia by magnetic resonance imaging 显示文摘 | Himoto Y Kido A Minamiguchi S | 2014 | J Obstet Gynaecol Res2014，40，7： | 1 |
| 20 | Analysis of apple quality by near infrared reflectance spectroscopy显示文摘 | Makoto Murakami Jun-ichi Himoto Kazuhiko Itoh | 1994 | J Fac Agr Hokkaido Univ1994，66，1： | 1 |
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