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| 1 | SMALL ORGAN SIZE 1 and SMALL ORGAN SIZE 2/DWARF AND LOW-TILLERING Form aComplex to Integrate Auxin and Brassinosteroid Signaling in Rice显示文摘尽管植物生长素和 brassinosteroid (BR ) synergistically 控制各种各样的植物回答,位于 auxin-BR 串音下面的分子的机制很好没被理解。我们以前识别了 SMOS1,一个调整植物生长素的 APETALA2 类型抄写因素,作为小机关的原因的基因缩放 1 (smos1 ) 被各种各样的机关的一种减少的最后的尺寸在米饭描绘的异种。在这研究,我们识别了另一 smos 异种, smos2,哪个表演与 smos1 难区分的显型。SMOS2 与以前报导的矮子和 LOW-TILLERING (DLT ) 相同,它编码涉及 BR 发信号的 GRAS 蛋白质。SMOS1 和 SMOS2/DLT 身体上交往合作地在酵母并且在米饭原子核提高 transcriptional transactivation 活动。一致地, OsPHI-1 的表示, SMOS1 的一个直接目标,当 SMOS1 和 SMOS2/DLT 蛋白质两个都是在米饭房间的现在时,仅仅是 upregulated。一起拿,我们的结果建议 SMOS1 和 SMOS2/DLT 在在米饭表明串音的 auxin-BR 上形成重点建筑群。 | Ko Hirano Hideki Yoshida Koichiro Aya Mayuko Kawamura Makoto Hayashi Tokunori Hobo Karma Sato-lzawa Hidemi Kitano Miyako Ueguchi-Tanaka Makoto Matsuoka | 2017 | Molecular Plant2017，10，4： | 20 |
| 2 | Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells显示文摘The family of mammalian chitinases includes members both with and without glycohydrolase enzymatic activity against chitin,a polymer of N-acetylglucosamine.Chitin is the structural component of fungi,crustaceans,insects and parasitic nematodes,but is completely absent in mammals.Exposure to antigens containing chitin-or chitin-like structures sometimes induces strong T helper type-I responses in mammals,which may be associated with the induction of mammalian chitinases.Chitinase 3-like-1(CHI3L1) ,a member of the mammalian chitinase family,is induced specifically during the course of inflammation in such disorders as inflammatory bowel disease,hepatitis and asthma.In addition,CHI3L1 is expressed and secreted by several types of solid tumors including glioblastoma,colon cancer,breast cancer and malignant melanoma.Although the exact function of CHI3L1 in inflammation and cancer is still largely unknown,CHI3L1 plays a pivotal role in exacerbating the inflammatory processes and in promoting angiogenesis and remodeling of the extracellular matrix.CHI3L1 may be highly involved in the chronic engagement of inflammation which potentiates development of epithelial tumorigenesis presumably by activating the mitogen-activated protein kinase and the protein kinase B signaling pathways.Anti-CHI3L1 antibodies or pan-chitinase inhibitors may have the potential to suppress CHI3L1-mediated chronic inflammation and the subsequent carcinogenic change in epithelial cells. | Katrin Eurich Mayuko Segawa Satoko Toei-Shimizu Emiko Mizoguchi | 2009 | World Journal of Gastroenterology2009，15，42： | 9 |
| 3 | Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer显示文摘 | Shiro Oka Shinji Tanaka Iwao Kaneko Ritsuo Mouri Mayuko Hirata Toru Kawamura Masaharu Yoshihara Kazuaki Chayama | 2006 | Gastrointestinal Endoscopy2006，，6： | 6 |
| 4 | Endoscopic submucosal dissection for colorectal neoplasia: possibility of standardization显示文摘 | Shinji Tanaka Shiro Oka Iwao Kaneko Mayuko Hirata Ritsuo Mouri Hiroyuki Kanao Shigeto Yoshida Kazuaki Chayama | 2007 | Gastrointestinal Endoscopy2007，，1： | 5 |
| 5 | Serum Neutrophil Gelatinase-associated Lipocalin(NGAL)Is Elevated in Patients with Asthma and Airway Obstruction显示文摘Neutrophilic airway inflammation is one of the features of severe asthma.Neutrophil gelatinase-associated lipocalin(NGAL),or lipocalin-2,is a glycoprotein associated with neutrophilic inflammation and can be detected in blood.Recently,blood NGAL levels have been reported to be elevated in chronic obstructive pulmonary disease.However,the clinical significance of serum NGAL levels in patients with asthma has not been elucidated.The aim of this study was to explore the association between serum NGAL level and clinical parameters in patients with asthma.Sixty.one non-smoking people with stable asthma were enrolled in this study.All patients underwent blood ollction and pulmonary function tests.The associations between serum NGAL levels and clinical parameters were analyzed retrospectively.Serum NGAL levels in patients with asthma and obstructive ventilatory defect were higher than those in patients with asthma without obstructive ventilatory defect(76.4±51.4 ng/mL vs.39.3±27.4 ng/mL,P=0.0019).Serum NGAL levels were correlated with forced expired flow at 50%of vital capacity%predicted and forced expired flow at 75%of vital capacity%predicted(r=-0.3373,P=0.0078 and r=0.2900,P=0.0234,respectively).Results of a multiple regression analysis demonstrated that serum NGAL level was independently associated with obstructive ventilatory defect.Serum NGAL levels were elevated in patients with asthma and obstructive ventilatory defect.NGAL may be involved in airway remodeling possibly mediated by neutrophilic inflammation in asthma. | Junichiro Kawagoe Yuta Kono Yuki Togashi Mayuko Ishiwari Kazutoshi Toriyama Chika Yajima Hideaki Nakayama Satoshi Kasagi Shinji Abe Yasuhiro Setoguchi | 2021 | Current Medical Science2021，41，2： | 5 |
| 6 | Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis显示文摘BACKGROUND The gut-liver axis has attracted much interest in the context of chronic liver disease pathogenesis.Prebiotics such as dietary fibers were shown to attenuate non-alcoholic fatty liver disease(NAFLD)by modulating gut microbiota.Partially hydrolyzed guar gum(PHGG),a water-soluble dietary fiber,has been reported to alleviate the symptoms of various intestinal diseases and metabolic syndromes.However,its effects on NAFLD remain to be fully elucidated.To determine whether treatment with PHGG attenuates NAFLD development in mice through the gut-liver axis.METHODS Seven-week-old male C57BL/6J mice with increased intestinal permeability were fed a control or atherogenic(Ath)diet(a mouse model of NAFLD)for 8 wk,with or without 5%PHGG.Increased intestinal permeability was induced through chronic intermittent administration of low-dose dextran sulfate sodium.Body weight,liver weight,macroscopic findings in the liver,blood biochemistry[aspartate aminotransferase(AST)and alanine aminotransferase(ALT),total cholesterol,triglyceride,free fatty acids,and glucose levels],liver histology,myeloperoxidase activity in liver tissue,mRNA expression in the liver and intestine,serum endotoxin levels in the portal vein,intestinal permeability,and microbiota and short-chain fatty acid(SCFA)profiles in the cecal samples were investigated.RESULTS Mice with increased intestinal permeability subjected to the Ath diet showed significantly increased serum AST and ALT levels,liver fat accumulation,liver inflammatory(tumor necrosis factor-αand monocyte chemotactic protein-1)and fibrogenic(collagen 1a1 andαsmooth muscle actin)marker levels,and liver myeloperoxidase activity,which were significantly attenuated by PHGG treatment.Furthermore,the Ath diet combined with increased intestinal permeability resulted in elevated portal endotoxin levels and activated toll-like receptor(TLR)4 and TLR9 expression,confirming that intestinal permeability was significantly elevated,as observed by evaluating the lumen-to-blood clearance of fluorescein isothiocyanate-conjugated dextran.PHGG treatment did not affect fatty acid metabolism in the liver.However,it decreased lipopolysaccharide signaling through the gut-liver axis.In addition,it significantly increased the abundance of cecal Bacteroides and Clostridium subcluster XIVa.Treatment with PHGG markedly increased the levels of SCFAs,particularly,butyric acid,acetic acid,propionic acid,and formic acid,in the cecal samples.CONCLUSION PHGG partially prevented NAFLD development in mice through the gut-liver axis by modulating microbiota and downstream SCFA profiles. | Shun Takayama Kazuhiro Katada Tomohisa Takagi Takaya Iida Tomohiro Ueda Katsura Mizushima Yasuki Higashimura Mayuko Morita Tetsuya Okayama Kazuhiro Kamada Kazuhiko Uchiyama Osamu Handa Takeshi Ishikawa Zenta Yasukawa Tsutomu Okubo Yoshito Itoh Yuji Naito | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 7 | The prognostic nutritional index can be a prognostic indicator in colorectal carcinoma显示文摘 | Tadahiro Nozoe Mayuko Kohno Tomohiro Iguchi Emiko Mori Takashi Maeda Akito Matsukuma Takahiro Ezaki | 2012 | Surgery Today2012，，6： | 3 |
| 8 | Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer显示文摘 | Shiro Oka Shinji Tanaka Iwao Kaneko Ritsuo Mouri Mayuko Hirata Toru Kawamura Masaharu Yoshihara Kazuaki Chayama | 2006 | Gastrointestinal Endoscopy2006，，6： | 2 |
| 9 | Narrow-band imaging magnification predicts the histology and invasion depth of colorectal tumors显示文摘 | Hiroyuki Kanao Shinji Tanaka Shiro Oka Mayuko Hirata Shigeto Yoshida Kazuaki Chayama | 2009 | Gastrointestinal Endoscopy2009，，3： | 2 |
| 10 | Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low density lipoprotein receptor deficient mice显示文摘 | Fukao Hideharu Ijiri Yoshinobu Miura Mayuko | 2004 | Blood Loagulation & Fibrinolysis2004，15，6： | 1 |
| 11 | Pressure and resist thickness dependency of resist time evolutions profiles in nanoimprint lithography显示文摘 | Yoshihiko Hirai Yuki Onishi Tishiaki Tanabe Mayuko Shibata Takuya lwasaki Yasuroh lriye | 2008 | Microelectronic Engineering2008，，： | 1 |
| 12 | Effeet of hydrophilicity of polymerparticles on their glass transition temperatures in the emulsion state 显示文摘 | MASAYOSHI OKUBO MAYUKO INOUE TOYOKO SUZUKI | 2004 | Colloid Polym Sci2004，，282： | 1 |
| 13 | The coevolution of altruism and punishment: Role of the selfish punisher显示文摘 | Mayuko N Yoh I | 2006 | J Theor Biol2006，240，： | 1 |
| 14 | Lidocaine spray used to capture a live clinostomum parasite causing human laryngitis显示文摘 | Norihito Kitagawa Mayuko Oda Tadahide Totoki Seiji Washizaki Masamichi Oda Teiji Kifune | 2003 | American Journal of Otolaryngology--Head and Neck Medicine and Surgery2003，，5： | 1 |
| 15 | Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer显示文摘 | Shiro Oka Shinji Tanaka Iwao Kaneko Ritsuo Mouri Mayuko Hirata Toru Kawamura Masaharu Yoshihara Kazuaki Chayama | 2006 | Gastrointestinal Endoscopy2006，，6： | 1 |
| 16 | Improvement of the storage stability and photostability of colored latex prepared by miniemulsion polymerization显示文摘 | Mayuko Takasu Toshifumi Shiroya Kimiya Takeshita Munehiro Sakamoto Haruma Kawaguchi | 2004 | Colloid and Polymer Science2004，，7： | 1 |
| 17 | Preparation of colored latex containing oil-soluble dyes with high dye content by mini-emulsion polymerization显示文摘 | Mayuko Takasu Toshifumi Shiroya Kimiya Takeshita Munehiro Sakamoto Haruma Kawaguchi | 2003 | Colloid and Polymer Science2003，，2： | 1 |
| 18 | Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer显示文摘 | Shiro Oka Shinji Tanaka Iwao Kaneko Ritsuo Mouri Mayuko Hirata Toru Kawamura Masaharu Yoshihara Kazuaki Chayama | 2006 | Gastrointestinal Endoscopy2006，，6： | 1 |
| 19 | Idiopathic sudden hearing loss in patients with type 2 diabetes显示文摘 | Michiaki Fukui Yoshihiro Kitagawa Naoto Nakamura Mayuko Kadono Shin-ichi Mogami Masayoshi Ohnishi Chizuko Hirata Naoko Ichio Katsuya Wada Chiyoko Kishimoto Hirofumi Okada Hirofumi Miyata Toshikazu Yoshikawa | 2003 | Diabetes Research and Clinical Practice2003，，3： | 1 |
| 20 | V EGF-Ehanced Prolif2 eration under Hypoxia by an Autocrine Mechanism in Human Vascular Smooth Muscle Cells显示文摘 | Mayuko O Takako I Susumu I | 2008 | Atberoscler Tbomb2008，15，1： | 1 |
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