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| 1 | role of the normal gut microbiota显示文摘Relation between the gut microbiota and human health is being increasingly recognised. It is now well established that a healthy gut flora is largely responsible for overall health of the host. The normal human gut microbiota comprises of two major phyla, namely Bacteroidetes and Firmicutes. Though the gut microbiota in an infant appears haphazard, it starts resembling the adult flora by the age of 3 years. Nevertheless, there exist temporal and spatial variations in the microbial distribution from esophagus to the rectum all along the individual's life span. Developments in genome sequencing technologies and bioinformatics have now enabled scientists to study these microorganisms and their function and microbehost interactions in an elaborate manner both in health and disease. The normal gut microbiota imparts specific function in host nutrient metabolism, xenobiotic and drug metabolism, maintenance of structural integrity of the gut mucosal barrier, immunomodulation, and protection against pathogens. Several factors play a role in shaping the normal gut microbiota. They include(1) the mode of delivery(vaginal or caesarean);(2) diet during infancy(breast milk or formula feeds) and adulthood(vegan based or meat based); and(3) use of antibiotics or antibiotic like molecules that are derived from the environment or the gut commensal community. A major concern of antibiotic use is the long-term alteration of the normal healthy gut microbiota and horizontal transfer of resistance genes that could result in reservoir of organisms with a multidrug resistant gene pool. | Sai Manasa Jandhyala Rupjyoti Talukdar Chivkula Subramanyam Harish Vuyyuru Mitnala Sasikala D Nageshwar Reddy | 2015 | World Journal of Gastroenterology2015，21，29： | 187 |
| 2 | Chitinase 3-Like-1 Expression in Colonic Epithelial Cells as a Potentially Novel Marker for Colitis-Associated Neoplasia显示文摘 | Chun-Chuan Chen Joel Pekow Victoria Llado Manasa Kanneganti Cindy W. Lau Atsushi Mizoguchi Mari Mino-Kenudson Marc Bissonnette Emiko Mizoguchi | 2011 | The American Journal of Pathology2011，，3： | 3 |
| 3 | Mutational Processes Molding the Genomes of 21 Breast Cancers显示文摘 | Serena Nik-Zainal Ludmil B. Alexandrov David C. Wedge Peter Van Loo Christopher D. Greenman Keiran Raine David Jones Jonathan Hinton John Marshall Lucy A. Stebbings Andrew Menzies Sancha Martin Kenric Leung Lina Chen Catherine Leroy Manasa Ramakrishna Ric | 2012 | Cell2012，，5： | 2 |
| 4 | Animal Models of Colitis-Associated Carcinogenesis显示文摘 | Manasa Kanneganti Mari Mino-Kenudson Emiko Mizoguchi Andrea Vecchione | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 2 |
| 5 | Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology显示文摘BACKGROUND The coronavirus disease 2019(COVID-19),a pandemic contributing to more than 105 million cases and more than 2.3 million deaths worldwide,was described to be frequently accompanied by extrapulmonary manifestations,including liver dysfunction.Liver dysfunction and elevated liver enzymes were observed in about 53%of COVID-19 patients.AIM To gain insight into transcriptional abnormalities in liver tissue of severe COVID-19 patients that may result in liver dysfunction.METHODS The transcriptome of liver autopsy samples from severe COVID-19 patients against those of non-COVID donors was analyzed.Differentially expressed genes were identified from normalized RNA-seq data and analyzed for the enrichment of functional clusters and pathways.The differentially expressed genes were then compared against the genetic signatures of liver diseases including cirrhosis,fibrosis,non-alcoholic fatty liver disease(NAFLD),and hepatitis A/B/C.Gene expression of some differentially expressed genes was assessed in the blood samples of severe COVID-19 patients with liver dysfunction using qRT-PCR.RESULTS Analysis of the differential transcriptome of the liver tissue of severe COVID-19 patients revealed a significant upregulation of transcripts implicated in tissue remodeling including G-coupled protein receptors family genes,DNAJB1,IGF2,EGFR,and HDGF.Concordantly,the differential transcriptome of severe COVID-19 liver tissues substantially overlapped with the disease signature of liver diseases characterized with pathological tissue remodeling(liver cirrhosis,Fibrosis,NAFLD,and hepatitis A/B/C).Moreover,we observed a significant suppression of transcripts implicated in metabolic pathways as well as mitochondrial function,including cytochrome P450 family members,ACAD11,CIDEB,GNMT,and GPAM.Consequently,drug and xenobiotics metabolism pathways are significantly suppressed suggesting a decrease in liver detoxification capacity.In correspondence with the RNA-seq data analysis,we observed a significant upregulation of DNAJB1 and HSP90AB1 as well as significant downregulation of CYP39A1 in the blood plasma of severe COVID-19 patients with liver dysfunction.CONCLUSION Severe COVID-19 patients appear to experience significant transcriptional shift that may ensue tissue remodeling,mitochondrial dysfunction and lower hepatic detoxification resulting in the clinically observed liver dysfunction. | Sarah Musa Hammoudeh Arabella Musa Hammoudeh Poorna Manasa Bhamidimarri Bassam Mahboub Rabih Halwani Qutayba Hamid Mohamed Rahmani Rifat Hamoudi | 2021 | World Journal of Gastroenterology2021，27，21： | 2 |
| 6 | Automatic Classification of Cardiac Arrhythmias Based on Hybrid Features and Decision Tree Algorithm显示文摘Accurate classification of cardiac arrhythmias is a crucial task because of the non-stationary nature of electrocardiogram(ECG)signals.In a life-threatening situation,an automated system is necessary for early detection of beat abnormalities in order to reduce the mortality rate.In this paper,we propose an automatic classification system of ECG beats based on the multi-domain features derived from the ECG signals.The experimental study was evaluated on ECG signals obtained from the MIT-BIH Arrhythmia Database.The feature set comprises eight empirical mode decomposition(EMD)based features,three features from variational mode decomposition(VMD)and four features from RR intervals.In total,15 features are ranked according to a ranker search approach and then used as input to the support vector machine(SVM)and C4.5 decision tree classifiers for classifying six types of arrhythmia beats.The proposed method achieved best result in C4.5 decision tree classifier with an accuracy of 98.89%compared to cubic-SVM classifier which achieved an accuracy of 95.35%only.Besides accuracy measures,all other parameters such as sensitivity(Se),specificity(Sp)and precision rates of 95.68%,99.28%and 95.8%was achieved better in C4.5 classifier.Also the computational time of 0.65 s with an error rate of 0.11 was achieved which is very less compared to SVM.The multi-domain based features with decision tree classifier obtained the best results in classifying cardiac arrhythmias hence the system could be used efficiently in clinical practices. | Santanu Sahoo Asit Subudhi Manasa Dash Sukanta Sabut | 2020 | International Journal of Automation and computing2020，17，4： | 2 |
| 7 | Potential use of elicitors from Trichoderma in induced systemic resistance for the management of Phytophthora capsici in red pepper显示文摘 | Sriram S Manasa S B Savitha M J | 2009 | Journal Biology Control2009，23，4： | 1 |
| 8 | Evaluation of the Partec flow Cytometer against the BD FACSCalibur system for monitoring immune responses of human immunodeficiency virusinfected patients in Zimbabwe 显示文摘 | Manasa J Musabaike H Masimirembwa C | 2007 | Clin Vaccine Immunol2007，14，3： | 1 |
| 9 | Neighbors and Extension Agents in Ethiopia:WHO MATTERS MORE FORTECHNOLOGYADOPTION显示文摘 | PRAMILA KRISHNAN MANASA PATNAM | 2013 | Oxford UiJi- versify Press on behalf of the Agricultural and Applied Eco- nomics Association2013，96，1： | 1 |
| 10 | Incidence,RiskFactors, and Outcome of Cytomegalovirus Viremia andGastroenteritis in Patients with Gastrointestinal Graft-versus-Host Disease 显示文摘 | Bhutani D* Dyson G Manasa R | 2015 | Biol Blood Marrow Transplant2015，21，1： | 1 |
| 11 | De- tection of tomatoes using spectral-spatial methods in remotely ensed RGB images captured by UAV 显示文摘 | Senthilnath J Dokania Akanksha Kandukuri Manasa | 2016 | Biosystems Enginee- ring2016，146，： | 1 |
| 12 | Enzyme-assisted extraction of bioactive compounds from ginger ( Zingiber officinale Roscoe)显示文摘 | K.L. Nagendra chari D. Manasa P. Srinivas H.B. Sowbhagya | 2013 | Food Chemistry . 2013 (1-4)2013，，1： | 1 |
| 13 | Enzyme-assistedextraction of bioactive compounds from ginger (Zingiber officinaleRoscoe)显示文摘 | MANASA D SRINIVAS P SOWBHAGYA H B | 2013 | Food Chem2013，139，14： | 1 |
| 14 | The Life History of 21 Breast Cancers显示文摘 | Serena Nik-Zainal Peter Van Loo David C. Wedge Ludmil B. Alexandrov Christopher D. Greenman King Wai Lau Keiran Raine David Jones John Marshall Manasa Ramakrishna Adam Shlien Susanna L. Cooke Jonathan Hinton Andrew Menzies Lucy A. Stebbings Catherine Lero | 2012 | Cell2012，，5： | 1 |
| 15 | Evaluation of the Partec flow cytometer against the BD FACSCalibur system for monitoring immune responses of human immunodeficiency virus-infected patients in Zimbabwe显示文摘 | Manasa J Musabaike H Masimirembwa C | 2007 | Clin Vaccine Immunol2007，14，3： | 1 |
| 16 | Enzyme-as sisted extraction of bioactive compounds from ginger (Zingiber officinale Roscoe) 显示文摘 | Nagendra ehari K L Manasa D Srinivas P | 2013 | Food Chemistry2013，，139： | 1 |
| 17 | Synthesis,spectroscopic characterization and in vitro antitumor activities of some novel mononuclear Ru(Ⅱ) complexes显示文摘The synthesis and spectroscopic characterization of ruthenium complexes(R-l to R-8) of the type[Ru(A)_2(B)],(where A = 1,10-phenanthroline/2,2′-bipyridine and B = 3.4.5-tri-OCH_3DPC,4-CH_3-DPC,4-N-(CH_3)_2-DPC,4-NO_2-DPC arc described. These ligands form bidentate octahedral ruthenium complexes.The title complexes were subjected to in vitro cytotoxic activity measurements against the human cancer T-lymphocyte cell lines MTT assay.In vitro evaluation of these ruthenium complexes revealed cytotoxic activity from 0.24 to 1.4μg/mL against CEM,0.44 to 1.9μg/mL against Molt4/C8.0.28 to 1.5μg/mL against L1210,0.24 to 0.98μg/mL against HL60,and 0.25 to 1.2μg/mL against BEL7402,depending the nature of the compound. | Sreekanth Thota Mohammad Imran Manasa Udugula Rajeshwar Yerra Subhas S.Karki Jan Balzarini Erik De Clercq | 2012 | Chinese Chemical Letters2012，23，4： | 1 |
| 18 | Hydroxamates of para-aminoben- zoic acid as selective inhibitors of HDAC8显示文摘 | Kulandaivelu Umasankar Chilakamari Laxmi Manasa Jadav Surender Singh | 2014 | Bioorganic Chemistry2014，57，： | 1 |
| 19 | Aspergillus colonization in hydatid cyst: addition of a case 显示文摘 | Agrawal M Uppin MS Manasa PL | 2013 | Lung India2013，30，4： | 1 |
| 20 | Pharmacological evaluation of analgisic activity of aqueous extract of ricinus communis root bark显示文摘 | RAJESHKUMAR D NAGACHAITANYA V MANASA G | 2013 | International journal of toxicological and pharmacological research2013，5，4： | 1 |
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