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| 1 | P53-mediated cell cycle arrest and apoptosis through a caspase-3-independent,but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells显示文摘瞄准:在 vitro 在导致 oridonin 的 MCF-7human 乳癌房间 apoptosis 学习 caspase-3-independent 机制。方法:oridonintreated MCF-7 房间的生存能力被 MTT (thiazole 蓝色) 测量试金。有压缩原子核的 Apoptotic 房间被阶段对比显微镜学设想。Nucleosomal DNA 破碎是由统帅玫瑰胶化电气泳动的 assayed。apoptotic 比率被决定由喂奶脱氢酶试金。房间周期引申 andmitochondrial 膜潜力被流动 cytometric 分析测量。Bax, Bcl-2, caspase-3, caspase-9,热吃惊蛋白质(Hsp ) 90, p53, p-p53, p21,(自动数据处理核糖) Poly,聚合酶(PARP ) ,和激活 caspase 的 DNase (ICAD ) 蛋白质表情的禁止者被西方的污点分析检测。结果:Oridonin 在一个时间依赖者和剂量依赖者举止禁止了房间生长。房间周期被改变通过起来 p53 和 p21 蛋白质表情的规定。Pancaspase inhibitorZ-VAD-fmk 和 calpain 禁止者 II 两个都减少了房间死亡比率。Nucleosomal DNA 破碎并且下面 DeltaPhimit 的规定在导致 oridonin 的 MCF-7 房间 apoptosis 被检测,它涉及一条 postmitochondrial caspase-9-dependent 小径。减少的 Bcl-2 和 Hsp90expression 层次和 p21 表示层次断然与 phosphorylated p53 phosphorylation 的提高的层次被相关。而且, PARP 部分被劈开 bycalpain 而非由 capase-3。结论:DNA 损坏在线粒体陆地 caspase-9 小径以及调停 p53 的房间周期拘捕挑起了引申,但是不与在导致 oridonin 的 MCF-7 房间的 caspase-3activity 有关。 | Qiao CUI Jing-hua YU Jin-nan WU Shin-ichi TASHIRO Satoshi ONODERA Mutsuhiko MINAMI Takashi IKFJIMA | 2007 | Acta Pharmacologica Sinica2007，28，7： | 30 |
| 2 | Comparing mass screening techniques for gastric cancer in Japan显示文摘瞄准:讨论为胃的癌症屏蔽的内视镜的质量的功效。方法:在这研究使用的数据是从 2002 ~ 2004 在 Niigata 城市里为胃的癌症屏蔽程序的质量的结果。参加者的数字在 2002 是 35,089, 34,557 在 2003 和 36,600 在 2004。发现比率在内视镜的文件和组织检查所见的双检查以后指了胃的癌症的最后的诊断。识别胃的癌症的一个盒子的费用为每个屏蔽节目和另外的仔细的检查基于全部的开销被计算。结果:从有内视镜检查法的单个屏蔽节目的分析,有X光检查( ISX )的单个屏蔽节目和有在胃的癌症的发现比率的参考的荧光屏图象摄影( MSP )的集体屏蔽节目,内视镜的检查是为检测早胃的癌症的最好,发现比率在 2004 是0.87%,约 2.7 和 4.6 ISX 和 MSP 组比那些高预定。另外,这个新奇方法是关于识别胃的癌症的一个盒子的费用的最便宜的工具,它被估计是在 2004 的 1,608,000 日本日元。结论:内视镜的集体屏蔽是一个有希望的方法并且如果,能有效地被使用有技能的 endoscopists 的一个足够的数字对职员变得可得到系统并且如果城市办公室支持它。 | Atsushi Tashiro Masatoshi Sano Koichi Kinameri Kazutaka Fujita Yutaka Takeuchi | 2006 | World Journal of Gastroenterology2006，12，30： | 23 |
| 3 | Pseudolaric acid B induces apoptosis,senescence,and mitotic arrest in human breast cancer MCF-7显示文摘目的:现在的学习的目的是在人的乳癌 MCF-7 cells.Methods:3-( 4,5-dimethylthiazol-2-yl )上调查 pseudolaric 酸 B ( PAB )的禁止的效果 -2,5-diphenyltetrazolium 溴化物分析,词法变化,染色的吖啶橙,并且统帅玫瑰胶化电气泳动被使用检测 apoptotic 的 apoptosis.The 百分比,坏死的房间被lactate 脱氢酶计算基于活动的细胞毒性试金;联系的老朽( SA ) -beta-galactosidase 活动被检测评估老朽; propidium 碘化物染色的流动 cytometric 分析被执行调查房间周期的分发,并且蛋白质表示被西方的污点 analysis.Results 检验:在 apoptosis 期间,半最大的禁止的集中 IC50 是在在 PAB 治疗以后的 36 和 48 h 的 3.4 和 1.35 亩 mol/L ,暴露于 PAB 的 respectively.The MCF-7 房间显示出 apoptosis 的典型特征,包括词法变化和 DNA 破碎。为 36 h 与 4 亩 mol/L PAB 对待的 MCF-7 房间经历了 apoptosis,然而并非坏死。PAB 导致的 apoptosis 独立于死亡受体小径。衰老的房间变得更大并且恭维,并且染色的 SA-p-galactosi-dase 是导致的 positive.PAB 明显的有丝分裂的拘捕和它先于 apoptosis 和老朽。p21 和 p53 的表情起来与 PAB 处理调整了,并且 cyclin B1 起来从细胞质调整了并且搬运,并且支撑了稳定的 levels.Conclusion 到原子核: PAB 在 MCF-7 房间导致了有丝分裂的拘捕并且通过 apoptosis 和老朽禁止了增长。apoptosis 独立于死亡受体小径。 | Jing-hua YU Qiao CUI Yuan-yuan JIANG Wei YANG Shin-ichi TASHIRO Satoshi ONODERA Takashi IKEJIMA | 2007 | Acta Pharmacologica Sinica2007，28，12： | 22 |
| 4 | Reactive oxygen species contribute to oridonininduced apoptosis and autophagy in human cervical carcinoma HeLa cells显示文摘瞄准: 在 HeLa 细胞在导致 oridonin 的 apoptosis 和 autophagy 调查反应的氧种类(ROS ) 的角色。 | Ya-hong ZHANG Ying-liang WU Shin-ichi TASHIRO Satoshi ONODERA Takashi IKEJIMA | 2011 | Acta Pharmacologica Sinica2011，32，10： | 18 |
| 5 | Protein tyrosine kinase, JNK, and ERK involvement in p seudolaric acid B- induced apoptosis of human breast cancer MCF-7 cells显示文摘瞄准:在人的乳癌 MCF-7 房间调查 pseudolaric 酸 B (PAB ) 的 apoptotic 机制。方法:3-(4,5-Dimethylthiazol-2-yl )-2, 5-di-phenyltetrazolium 溴化物分析和词法变化被使用检测 apoptosis。apoptotic 和坏死的房间的百分比被 lactate 脱氢酶计算基于活动的 cytotoxicity 试金,和蛋白质表示被西方的污点分析检验。结果:包括 p38, c-Jun-N-terminal kinase (JNK ) 和细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) , PAB 或激活 mitogen 的蛋白质家族 ases 没参予坏死。P38 没为 36 h 在 4 μmol/L PAB 治疗以后在 apoptosis 上有明显的函数,但是 PAB 导致了 JNK phosphorylation 并且在 apoptotic 进程禁止了英皇家空军之阶级最低之兵 phosphorylation。在这学习蛋白质酷氨酸 kinase (PTK ) 的禁止者 genistein 转换了 PAB 的禁止的效果,相反支持 MCF-7 房间的幸存。象 genistein 一样,另一 PTK 禁止者 AG1024 在对待 PAB 的 MCF-7 房间上有类似的效果,显示 PAB 激活 PTK 导致 apoptosis。和 PAB, genistein 增加了津贴的表示,并且减少在在 36 h 的对待 PAB 的 MCF-7 房间的 JNK 和 p-JNK 的表情。并且津贴和 p-JNK 分别地是英皇家空军之阶级最低之兵和 JNK 的活跃模式,这被考虑。结论:PTK 英皇家空军之阶级最低之兵和 JNK 是在上游的,并且 PTK 通过激活 JNK 并且在对待 PAB 的 MCF-7 房间使英皇家空军之阶级最低之兵失去活性导致了 apoptosis。 | Jing-hua YU Hong-jun WANG Xiang-ru LI Shin-ichi TASHIRO Satoshi ONODERA Takashi IKEJIMA | 2008 | Acta Pharmacologica Sinica2008，29，9： | 12 |
| 6 | Crosstalk of ROS/RNS and autophagy in silibinin- induced apoptosis of MCF-7 human breast cancer cells in vitro显示文摘反应的氧种类(ROS ) 和反应的氮种类(RNS ) 在调整细胞幸存和死亡起重要作用。Silibinin 是与反肿瘤活动从牛奶蓟孤立的自然 polyphenolic flavonoid,但是在人的乳癌 MCF-7 房间导致 cytoprotective ROS/RNS 被发现。而且,有 silibinin 下面调整的治疗嗯在 MCF-7 房间的表示,并且导致 autophagy 和 apoptosis。在这研究,我们在 MCF-7 房间探索了在嗯联系小径和 RNS/ROS 之间的关系。我们也调查了在在对待 silibinin 的 MCF-7 房间表明小径的死亡位于在 ROS/RNS 层次和 autophagy 之间的相互的规定下面的分子的机制。Silibinin (100-300 mol/L ) dose-dependently 在 MCF-7 房间增加了 ROS/RNS 产生(与高表示嗯并且低表示嗯) 并且 MDA-MB-231 房间(与低表示嗯并且高表示嗯) 。清除 ROS/RNS 显著地提高了 MCF-7 房间,然而并非 MDA-MB231 房间的导致 silibinin 的死亡。药理学激活或封锁嗯分别地,在 MCF-7,房间显著地提高了或减少导致 silibinin 的 ROS/RNS 产生,而激活或块嗯没有效果。在对待 silibinin 的 MCF-7 房间,到 ROS/RNS 捐赠者的暴露减少了 autophagic 铺平,而有 3 麻省的 autophagy 的抑制显著地增加了 ROS/RNS 层次。我们进一步证明那在 ROS/RNS 产生增加,嗯激活或 autophagy 下面规定在对待 silibinin 的 MCF-7 房间有保护的角色。在一个条件下面嗯激活,清除 ROS/RNS 或刺激 autophagy 提高了 silibinin 的 cytotoxicity。这些结果表明二的存在在 MCF-7 房间的导致 silibinin 的死亡冲突小径:一个人包含下面规定嗯并且从而下游地扩充 pro-apoptotic autophagy,导致房间死亡;其它包含支持幸存的 ROS/RNS 的起来规定;并且 ROS/RNS 和 autophagy 形式的产生平衡的一个否定反馈环被调整由嗯。 | Nan ZHENG Lu LIU Wei-wei LIU Fei LI Toshihiko HAYASHI Shin-ichi TASHIRO Satoshi ONODERA Takashi IKEJIMA | 2017 | Acta Pharmacologica Sinica2017，38，2： | 11 |
| 7 | Oridonin induces apoptosis and autophagy in murine fibrosarcoma L929 cells partly via NO-ERK-p53 positive-feedback loop signaling pathway显示文摘瞄准: 调查氮的氧化物的角色(没有) 在在鼠科的纤维肉瘤 L929 房间和内在的分子的机制的导致 oridonin 的 apoptosis 和 autophagy。 | Yuan-chao YE Hong-ju WANG Lei XU Wei-wei LIU Bin-bin LIU Shin-lchi TASHIRO Satoshi ONODERA Takashi IKEJIMA | 2012 | Acta Pharmacologica Sinica2012，33，8： | 6 |
| 8 | Anterolateral rotatory instability in vivo correlates tunnel position after anterior cruciate ligament reconstruction using bone-patellar tendon-bone graft显示文摘AIM To quantitatively assess rotatory and anterior-posterior instability in vivo after anterior cruciate ligament(ACL) reconstruction using bone-patellar tendon-bone(BTB) autografts, and to clarify the influence of tunnel positions on the knee stability.METHODS Single-bundle ACL reconstruction with BTB autograft was performed on 50 patients with a mean age of 28 years using the trans-tibial(TT)(n = 20) and trans-portal(TP)(n = 30) techniques. Femoral and tibial tunnel positions were identified from the high-resolution 3 D-CT bone models two weeks after surgery. Anterolateral rotatory translation was examined using a Slocum anterolateral rotatory instability test in open magnetic resonance imaging(MRI) 1.0-1.5 years after surgery, by measuring anterior tibial translation at the medial and lateral compartments on its sagittal images. Anterior-posterior stability was evaluated with a Kneelax3 arthrometer.RESULTS A total of 40 patients(80%) were finally followed up. Femoral tunnel positions were shallower(P < 0.01) and higher(P < 0.001), and tibial tunnel positions were more posterior(P < 0.05) in the TT group compared with the TP group. Anterolateral rotatory translations in reconstructed knees were significantly correlated with the shallow femoral tunnel positions(R = 0.42, P < 0.01), and the rotatory translations were greater in the TT group(3.2 ± 1.6 mm) than in the TP group(2.0 ± 1.8 mm)(P < 0.05). Side-to-side differences of Kneelax3 arthrometer were 1.5 ± 1.3 mm in the TT, and 1.7 ± 1.6 mm in the TP group(N.S.). Lysholm scores, KOOS subscales and reinjury rate showed no difference between the two groups.CONCLUSION Anterolateral rotatory instability significantly correlated shallow femoral tunnel positions after ACL reconstruction using BTB autografts. Clinical outcomes, rotatory and anterior-posterior stability were overall satisfactory in both techniques, but the TT technique located femoral tunnels in shallower and higher positions, and tibial tunnels in more posterior positions than the TP technique, thus increased the anterolateral rotation. Anatomic ACL reconstruction with BTB autografts may restore knee function and stability. | Yasutaka Tashiro Ken Okazaki Koji Murakami Hirokazu Matsubara Kanji Osaki Yukihide Iwamoto Yasuharu Nakashima | 2017 | World Journal of Orthopedics2017，8，12： | 5 |
| 9 | Autoimmune pancreatitis with IgG4-positive plasma cell infiltration in salivary glands and biliary tract显示文摘A 62-year-old male was referred to our hospital because of liver dysfunction, diffuse pancreatic swelling, and trachelophyma. At admission, the patient was free of pain.Physical examination showed enlarged and palpable bilateral submandibular masses, but no palpable mass or organomegaly in the abdomen. Laboratory findings were as follows: total protein 90 g/L with γ-globulin of 37.3% (33 g/L), total bilirubin 4 mg/L, aspartate aminotransferase 39 IU/L, alanine aminotransferase 67 IU/L, γ-glutamyl transpeptidase 1 647 IU/L, and amylase 135 IU/L. Autoantibodies were negative, and tumor markers were within the normal range. Serum IgG4 level was markedly elevated (18 900 mg/L). Computed tomography (CT) showed diffuse swelling of the pancreas and dilatation of both common and intra-hepatic bile ducts. Endoscopic retrograde pancreatography (ERP) revealed diffuse irregular and narrow main pancreatic duct and stenosis of the lower common bile duct. Biopsy specimens from the pancreas, salivary gland and liver showed marked periductal IgG4-positive plasma cell infiltration with fibrosis. We considered this patient to be autoimmune pancreatitis (AIP) with fibrosclerosis of the salivary gland and biliary tract, prescribed prednisolone at an initial dose of 40 mg/d. Three months later, the laboratory data improved almost to normal. Abdominal CT reflected prominent improvement in the pancreatic lesion. Swelling of the salivary gland also improved. At present, the patient is on 10 mg/d of prednisolone without recurrence of the pancreatitis. We present here a case of AIP with fibrosclerosis of salivary gland and biliary tract. | Masashi Taguchi Gentaro Aridome Shintaro Abe Keiichiro Kume Mitsuo Tashiro Mitsuyoshi Yamamoto Yasuyuki Kihara Hayato Nakamura Makoto Otsuki | 2005 | World Journal of Gastroenterology2005，11，35： | 5 |
| 10 | Involvement of mitochondria and caspase pathways in N-demethyl-clarithromycin-induced apoptosis in human cervical cancer HeLa cell显示文摘瞄准:学习 N-demethyl-clarithromycin (NDC ) 在 vitro 由导致人的颈的癌症 HeLa 房间 apoptosis 的机制。方法:生存能力 ofN-demethyl-clarithromycin-induced HeLa 房间被 MTT 试金测量。有压缩原子核的 Apoptotic 房间被阶段对比显微镜学设想。Nucleosomal DNA 破碎是由统帅玫瑰胶化电气泳动的 assayed。mitochondrial transmembrane 潜力的测量被 FACScan flowcytometer 分析。Caspase-3, poly-( 自动数据处理核糖) 聚合酶(PARP ) ,激活 caspase 的 DNase (ICAD ) , Bcl-2, Bax, p53,和 SIRT1 蛋白质表示和细胞色素 c 的版本被西方的污点分析检测。结果:N-demethyl-clarithromycin, ananti 煽动性的物质,在一个剂量依赖者的禁止的 HeLa 房间生长和时间依赖者 manner.N-demethyl-clarithro-mycin 通过 apoptotic 小径导致了 HeLa 房间死亡。pan-caspaseinhibitor (z-VAD-fmk ) , caspase-3 禁止者(z-DEVD-fmk ) 和 caspase-9 禁止者(z-LEHD-fmk ) 部分提高了 N-demethyl-clarithromycin 导致的房间生存能力,但是 caspase-8 禁止者(z-IETD-fmk ) 没几乎有效果。Caspase-3 被激活然后由降级 ofcaspase-3 底层列在后面, ICAD 和 PARP 的禁止者。同时, mitochondrial transmembranepotential 显著地被减少,在 cytosol 的细胞色素 c 的版本是 increased.N-demethyl-clarithromycin 在上面调整了 mitochondrial Bax/Bcl-2 的表示比率,并且显著地增加了 p53 蛋白质的表示。它也击倒调整 anti-apoptoticprotein SIRT1 表示。结论:N-demethyl-clarithromycin 经由 mitochondrial 小径在 HeLa 房间导致了 apoptosis。 | Ai-min QIAO Takashi IKEJIMA Shin-ichi TASHIRO Satoshi ONODERA Wei-ge ZHANG Ying-liang WU | 2006 | Acta Pharmacologica Sinica2006，27，12： | 5 |
| 11 | Hepatocellular 癌和在一个肝糖存储疾病病人的肝的焦点的榴状的增生显示文摘 Glycogen storage disease type Ia (GSD-Ia; also called von Gierke disease) is an autosomal recessive disorder of carbohydrate metabolism caused by glucose-6-phosphatase deficiency. There have been many reports describing hepatic tumors in GSD patients; however, most of these reports were of hepatocellular adenomas, whereas there are only few reports describing focal nodular hyperplasia (FNH) or hepatocellular carcinoma (HCC). We report a case with GSD-Ia who had undergone a partial resection of the liver for FNH at 18 years of age and in whom moderately differentiated HCC had developed. Preoperative imaging studies, including ultrasonography, dynamic computer tomography (CT) and magnetic resonance imaging, revealed benign and malignant features. In particular, fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT revealed the atypical findings that FDG accumulated at high levels in the non-tumorous hepatic parenchyma and low levels in the tumor. Right hemihepatectomy was performed. During the perioperative period, high-dose glucose and sodium bicarbonate were administered to control metabolic acidosis. He had multiple recurrences of HCC at 10 mo after surgery and was followed-up with transcatheter arterial chemoembolization. The tumor was already highly advanced when it was found by chance; therefore, a careful follow-up should be mandatory for GSD-I patients as they are at a high risk for HCC, similar to hepatitis patients. | Yoshihiro Mikuriya Akihiko Oshita Hirotaka Tashiro Hironobu Amano Tsuyoshi Kobayashi Kouji Arihiro Hideki Ohdan | 2012 | World Journal of Hepatology2012，4，6： | 4 |
| 12 | Immunotherapy against cancer-related viruses显示文摘世界范围的约 12% 所有癌症与病毒的感染被联系。迄今为止,八个病毒被显示了贡献人的癌症的发展,包括 Epstein-Barr 病毒(EBV ) ,肝炎 B 和 C 病毒,和人的乳突淋瘤病毒,在其它之中。这些 DNA 和 RNA 病毒通过不同机制生产 oncogenic 效果。首先,病毒可以通过他们表示的基因导致宿主细胞生长和幸存的持续混乱,或可以在宿主细胞导致 DNA 损坏反应,接着,增加它招待染色体不稳定性。第二,他们可以导致长期的发炎和在主人房间赞成 oncogenic 过程的发展的第二等的织物损坏。病毒相似 HIV 能通过有免疫力的抑制为癌症开发创造更容许的环境,但是我们将在这评论集中于以前的二机制。不同于不能把感染的房间与非感染的房间区分开来的传统的癌症治疗,免疫疗法特别地被装备指向联系病毒的恶意。与有免疫力的反应联系的指向并且工作的机制能被利用由种痘阻止病毒的感染,并且能也被用来在癌症建立前治疗感染。在使用免疫系统根除的成功由联系病毒的肿瘤房间的选择识别建立了恶意当前被报导。例如,产生病毒特定的 T 房间显示出的前 vivo 的采纳转移的众多的临床的试用与联系 EBV 的恶意在病人甚至为确定的肿瘤受益。在另外的联系病毒的肿瘤的另外的研究也被开始了,在这评论,我们为联系病毒的恶意描述免疫疗法的当前的地位并且讨论未来前景。 | Haruko Tashiro Malcolm K Brenner | 2017 | Cell Research2017，27，1： | 4 |
| 13 | Pancreaticobiliary maljunction: retrospective and nationwide survey in Japan显示文摘 | Seiki Tashiro T. Imaizumi H. Ohkawa A. Okada T. Katoh Y. Kawaharada H. Shimada H. Takamatsu H. Miyake T. Todani | 2003 | Journal of Hepato - Biliary - Pancreatic Surgery2003，，5： | 4 |
| 14 | The prospects of regenerative medicine combined with rehabilitative approaches for chronic spinal cord injury animal models显示文摘Regenerative medicine has opened a window for functional recovery in acute-to-subacute phase spinal cord injury(SCI).By contrast,there are still only a few studies have focused on the treatment of the chronically injured spinal cord,in which cell-based regenerative medicine seems less effective.Since the majority of SCI patients are in the chronic phase,representing a major challenge for the clinical application of cellbased regenerative medicine.Although combined therapies for the treatment of chronic SCI have attracted attention of researchers and its potential importance is also widely recognized,there had been very few studies involving rehabilitative treatments to date.In a recent study,we have demonstrated for the first time that treadmill training combined with cell transplantation significantly promotes functional recovery even in chronic SCI,not only in additive but also in synergistic manner.Even though we have succeeded to outline the profiles of recovery secondary to the combination therapy,the mechanism underlying the effects remain unsolved.In this review article,we summarize the present progress and consider the prospect of the cell-based regenerative medicine particularly combined with rehabilitative approaches for chronic SCI animal models. | Syoichi Tashiro Masaya Nakamura Hideyuki Okano | 2017 | Neural Regeneration Research2017，12，1： | 4 |
| 15 | The Relationships between Rheological Properties and Structural Changes of Chilled Abalone Meat显示文摘The quantitative correlation between theological properties and structural characteristic values of chilled abalone meat was studied. Structural changes were observed, and these values were enumerated using image processing and analysis technique. Structural changes in the myofibrils and collagen fibrils were the greatest in chilling for 24 h. After chilling for 48 h, similar structures of vertical and cross sections were observed. For chilling from 0h to 72h, the instantaneous modulus E0 of the both section meat decreases gradually with time, but no significant differences were observed after chilling for 48 h.The relaxation time and viscosity of both sections attained the same values for the same chilling time, but increased gradually with increasing chilling time. Meanwhile, a negative correlation between the structural characteristic values (Dm, Am,Rvm), and rheological properties (E1,τi,η1) clearly exists. Some logarithmic expressions have been obtained for these negative correlations. These results suggest that the difference in rheological properties between the cross and vertical sections was mainly due to the structural changes of myofibrils and collagen fibrils, and rheological properties are influenced quantitatively by the structural characteristic values for chilling from 0 h to 72 h. | TASHIRO Yuri OGAWA Hiroo | 2003 | Journal of Ocean University of Qingdao2003，2，2： | 4 |
| 16 | Blocking the utilization of glucose induces the switch from senescence to apoptosis in pseudolaric acid B-treated human lung cancer cells in vitro显示文摘Pseudolaric 酸 B (PAB ) ,从根孤立的 diterpene 酸金钱松属 kaempferi Gordon 吠叫,在几根癌症房间线施加反肿瘤效果。我们的以前的学习证明 PAB 主要在人的肺癌症 A549 细胞的生长的抑制经由 p53-p21 激活而非 apoptosis 导致了老朽(p53 野类型) 。在 p53 空的人的肺癌症 H1299 房间,然而,没有老朽, PAB 引起了 apoptosis。在这研究,我们调查了什么机制为从老朽的开关负责到在对待 PAB 的人的肺癌症房间线的 apoptosis。衰老的房间被 SA 检验 -- 染色的女郎。葡萄糖举起和 apoptosis 比率用 FACScan 流动 cytometer 被估计。商业试金工具包被用来测量 ATP 的层次并且喂奶。siRNA 的 Transfection 习惯于击倒 p53 或 p21 的表示。西方的污点分析被使用测量蛋白质表示层次。在 p53 野类型的 A549 房间, PAB (20 mol/L ) 引起了老朽,和 time-dependently 增加的葡萄糖利用;p53 或 p21 击倒显著地减少了葡萄糖的举起和新陈代谢但是提高的导致 PAB 的 apoptosis。用 glycolytic 禁止者 2-DG (1 mmol/L ) 的葡萄糖利用的抑制显著地提高了 apoptosis 正式就职。类似的结果在野类型的 H460 房间与 PAB 对待的另一 p53 被观察。在 PAB time-dependently 减少了的地方,相反的结果在 p53 空的 H1299 房间被发现葡萄糖利用,并且导致了仅仅 apoptosis。我们的结果证明导致 PAB 的老朽与提高的葡萄糖利用被联系,并且降低葡萄糖利用可能贡献 apoptosis 感应。因此,堵住葡萄糖利用从老朽贡献开关到 apoptosis,并且 p53 在这个过程起一个重要作用。 | Guo-dong YAO Jing YANG Xiu-xiu LI Xiao-yu SONG Toshihiko HAYASHI Shin-ichi TASHIRO Satoshi ONODERA Shao-jiang SONG Takashi IKEJIMA | 2017 | Acta Pharmacologica Sinica2017，38，10： | 4 |
| 17 | Influence of Helicobacter pylori status and eradication on the serum levels of trefoil factors and pepsinogen test: serum trefoil factor 3 is a stable biomarker显示文摘 | Mitsuru Kaise Jun Miwa Ai Fujimoto Jun Tashiro Daisuke Tagami Hiromi Sano Yasukazu Ohmoto | 2013 | Gastric Cancer2013，，3： | 3 |
| 18 | 高拉伸强度钢帘线的先进生产技术显示文摘固化子午线轮胎钢帘线的拉伸强度正在稳步提高,以满足轻型汽车的需要。通过改善0.9%C过共析钢盘条拉拔期间的延展性,使4000M Pa级钢帘线实现商业化。介绍了强化概念、强化方法和微观结构特点,探讨了线材拉拔期间的延展性和最大强度级别以及未来的技术课题。 | Hitoshi TASHIRO 李晓非 | 2006 | 鞍钢技术2006，，6： | 3 |
| 19 | possible role of soluble fibrin monomer complex after gastroenterological surgery显示文摘AIM To examine the role of soluble fibrin monomer complex(SFMC) in the prediction of hypercoagulable state after gastroenterological surgery.METHODS We collected data on the clinical risk factors and fibrin-related makers from patients who underwent gastroenterological surgery at Hiroshima University Hospital between April 1, 2014 and March 31, 2015. We investigated the clinical significance of SFMC, which is known to reflect the early plasmatic activation of coagulation, in the view of these fibrin related markers.RESULTS A total of 123 patients were included in the present study. There were no patients with symptomatic VTE. Thirty-five(28%) patients received postoperative anticoagulant therapy. In the multivariate analysis, a high SFMC level on POD 1 was independently associated with D-dimer elevation on POD 7(OR = 4.31, 95%CI: 1.10-18.30, P = 0.03). The cutoff SFMC level was 3.8 μg/ml(AUC = 0.78, sensitivity, 63%, specificity, 89%). The D-dimer level on POD 7 was significantly reduced in high-SFMC patients who received anticoagulant therapy in comparison to highSFMC patients who did not.CONCLUSION The SFMC on POD 1 strongly predicted the hypercoagulable state after gastroenterological surgery than the clinical risk factors and the other fibrin related markers. | Masatoshi Kochi Manabu Shimomura Takao Hinoi Hiroyuki Egi Kazuaki Tanabe Yasuyo Ishizaki Tomohiro Adachi Hirotaka Tashiro Hideki Ohdan | 2017 | World Journal of Gastroenterology2017，23，12： | 3 |
| 20 | Pediatric living donor liver transplantation for congenital hepatic fibrosis using a mother's graft with von Meyenburg complex: A case report显示文摘This is the first report of living donor liver transplantation(LDLT) for congenital hepatic fibrosis(CHF) using a mother's graft with von Meyenburg complex. A 6-year-old girl with CHF, who suffered from recurrent gastrointestinal bleeding, was referred to our hospital for liver transplantation. Her 38-year-old mother was investigated as a living donor and multiple biliary hamartoma were seen on her computed tomography and magnetic resonance imaging scan. The mother's liver function tests were normal and she did not have any organ abnormality, including polycystic kidney disease. LDLT using the left lateral segment(LLS) graft from the donor was performed. The donor LLS graft weighed 250 g; the graft recipient weight ratio was 1.19%. The operation and post-operative course of the donor were uneventful and she was discharged on post-operative day(POD) 8. The graft liver function was good, and the recipient was discharged on POD 31. LDLT using a graft with von Meyenburg complex is safe and useful. Long-term follow-up is needed with respect to graft liver function and screening malignant tumors. | Naoya Yamada Yukihiro Sanada Takumi Katano Masahisa Tashiro Yuta Hirata Noriki Okada Yoshiyuki Ihara Atsushi Miki Hideki Sasanuma Taizen Urahashi Yasunaru Sakuma Koichi Mizuta | 2016 | World Journal of Gastroenterology2016，22，44： | 2 |
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