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| 1 | Challenges in the management of acute peptic ulcer bleeding显示文摘 | James YW Lau Alan Barkun Dai-ming Fan Ernst J Kuipers Yun-sheng Yang Francis KL Chan | 2013 | The Lancet2013，，9882： | 3 |
| 2 | Bidirectional effect of Wnt signaling antagonist DKK1 on the modulation of anthrax toxin uptake显示文摘LRP6,a co-receptor for the morphogen Wnt,aids endocytosis of anthrax complexes.Here we report that Dickkopf1(DKK1)protein,a secreted LRP6 ligand and antagonist,is also a modulator of anthrax toxin sensitivity.shRNA-mediated gene silencing or TALEN-mediated gene knockout of DKK1 reduced sensitivity of cells to PA-dependent hybrid toxins.However,unlike the solely inhibitory effect on Wnt signaling,the effects of DKK1 overexpression on anthrax toxicity were bidirectional,depending on its endogenous expression and cell context.Fluorescence microscopy and biochemical analyses showed that DKK1 facilitates internalization of anthrax toxins and their receptors,an event mediated by DKK1-LRP6-Kremen2 complex.Monoclonal antibodies against DKK1 provided dose-dependent protection to macrophages from killing by anthrax lethal toxin(LT).Our discovery that DKK1 forms ternary structure with LRP6 and Kremen2 in promoting PA-mediated toxin internalization provides a paradigm for bacterial exploitation of mechanisms that host cells use to internalize signaling proteins. | QIAN LiLi CAI ChangZu YUAN PengFei JEONG Sun-Young YANG XiaoZhou DEALMEIDA Venita ERNST James COSTA Michael COHEN Stanley N. WEI WenSheng | 2014 | Science China(Life Sciences)2014，57，5： | 2 |
| 3 | The structures of picornaviral proteinases显示文摘 | Joachim Seipelt Alba Guarné Ernst Bergmann Michael James Wolfgang Sommergruber Ignacio Fita Tim Skern | 1999 | Virus Research1999，，2： | 1 |
| 4 | Graft-versus-host disease显示文摘 | James LM Ferrara John E Levine Pavan Reddy Ernst Holler | 2009 | The Lancet2009，，9674： | 1 |
| 5 | Challenges in the management of acute peptic ulcer bleeding显示文摘 | James YW Lau Alan Barkun Dai-ming Fan Ernst J Kuipers Yun-sheng Yang Francis KL Chan | 2013 | The Lancet2013，，9882： | 1 |
| 6 | Challenges in the management of acute peptic ulcer bleeding显示文摘 | James YW Lau Alan Barkun Dai-ming Fan Ernst J Kuipers Yun-sheng Yang Francis KL Chan | 2013 | The Lancet . 2013 (9882)2013，，9882： | 1 |
| 7 | CCBE1 Is Essential for Mammalian Lymphatic Vascular Development and Enhances the Lymphangiogenic Effect of Vascular Endothelial Growth Factor-C In Vivo显示文摘 | Frank L. Bos Maresa Caunt Josi Peterson-Maduro Lara Planas-Paz Joe Kowalski Terhi Karpanen Andreas van Impel Raymond Tong James A. Ernst Jeroen Korving Johan H. van Es Eckhard Lammert Henricus J. Duckers Stefan Schulte-Merker | 2011 | Circulation Research2011，，5： | 1 |
| 8 | Value Articula- tion: a Framework for the Strategic Management of Intellectual Property 显示文摘 | James G Conley Peter M Bican Holger Ernst | 2013 | California Management Review2013，55，4： | 1 |
| 9 | Pentoxifylline Treatment for Peripartum Cardiomyopathy?显示文摘 | James D. Fett Herryo Sanon Robert D. Carraway David W. Markham Silvia Ernst | 2013 | Journal of Cardiac Failure2013，，8： | 1 |
| 10 | Graft-versus-host disease显示文摘 | James LM Ferrara John E Levine Pavan Reddy Ernst Holler | 2009 | The Lancet2009，，9674： | 1 |
| 11 | Low-Density Lipoprotein and High-Density Lipoprotein Particle Subclasses Predict Coronary Events and Are Favorably Changed by Gemfibrozil Therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial显示文摘 | James D. Otvos Dorothea Collins David S. Freedman Irina Shalaurova Ernst J. Schaefer Judith R. McNamara Hanna E. Bloomfield Sander J. Robins | 2006 | Circulation2006，，12： | 1 |
| 12 | Validating a New Non-penetrating Sham Acupuncture Device: Two Randomised Controlled Trials显示文摘 | Jongbae Park Adrian White Clare Stevinson Edzard Ernst Martin James | 2003 | 上海针灸杂志2003，22，11： | 1 |
| 13 | Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans显示文摘 | Stanhope Kimber L Schwarz Jean Marc Keim Nancy L Griffen Steven C Bremer Andrew A Graham James L Hatcher Bonnie Cox Chad L Dyachenko Artem Zhang Wei McGahan John P Seibert Anthony Krauss Ronald M Chiu Sally Schaefer Ernst J Ai Masumi Otoko | 2009 | Journal of Clinical Investigation2009，，5： | 1 |
| 14 | Choice selection and reward anticipation: an fMRI study显示文摘 | Monique Ernst Eric E. Nelson Erin B. McClure Christopher S. Monk Suzanne Munson Neir Eshel Eric Zarahn Ellen Leibenluft Alan Zametkin Kenneth Towbin James Blair Dennis Charney Daniel S. Pine | 2004 | Neuropsychologia2004，，12： | 1 |
| 15 | An Analysis of Perioperative Surgical Mortality and Morbidity in the Asymptomatic Carotid Atherosclerosis Study显示文摘 | Byron Young Wesley S. Moore James T. Robertson James F. Toole Calvin B. Ernst Stanley N. Cohen Joseph P. Broderick Robert J. Dempsey James D. Hosking | 1996 | Stroke A Journal of Cerebral Circulation1996，，12： | 1 |
| 16 | Value articulation: A framework for the strategic management of intellectual property 显示文摘 | James G Conley Peter M Bican Holger Ernst | 2013 | California ManagementReview2013，55，4： | 1 |
| 17 | Graft-versus-host disease显示文摘 | James LM Ferrara John E Levine Pavan Reddy Ernst Holler | 2009 | The Lancet2009，，9674： | 1 |
| 18 | Long-term persistence and spectral blue shifting of quantum dots in vivo显示文摘 | James A Fitzpatrick Susan K Andreko Lauren A Ernst | | 0，，07： | 1 |
| 19 | Arterial stiffness and influences of the metabolic syndrome: A cross-countries study显示文摘 | Angelo Scuteri Pedro Guimaraes Cunha Francesco Cucca John Cockcroft Francesco U. Mattace Raso Maria Lorenza Muiesan Ligita Ryli?kyt? Ernst Rietzschel James Strait Charalambos Vlachopoulos Stephane Laurent Peter M. Nilsson Edward G. Lakatta | 2014 | Atherosclerosis2014，，： | 1 |
| 20 | Low-Density Lipoprotein and High-Density Lipoprotein Particle Subclasses Predict Coronary Events and Are Favorably Changed by Gemfibrozil Therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial显示文摘 | James D. Otvos Dorothea Collins David S. Freedman Irina Shalaurova Ernst J. Schaefer Judith R. McNamara Hanna E. Bloomfield Sander J. Robins | 2006 | Circulation2006，，： | 1 |
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