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| 1 | Insulin resistance and chronic liver disease显示文摘Increased insulin resistance is frequently associated with chronic liver disease and is a pathophysiological feature of hepatogenous diabetes.Distinctive factors including hepatic parenchymal cell damage,portalsystemic shunting and hepatitis C virus are responsible for the development of hepatogenous insulin resistance/diabetes.Although it remains unclear whether insulin secretion from pancreatic beta cells is impaired as it is in type 2 diabetes,retinopathic and cardiovascular risk is low and major causes of death in cirrhotic patients with diabetes are liver failure,hepatocellular carcinoma and gastrointestinal hemorrhage.Hemoglobin A1c is an inaccurate marker for the assessment and management of hepatogenous diabetes.Moreover,exogenous insulin or sulfonylureas may be harmful because these agents may promote hepatocarcinogenesis.Thus,pathogenesis,cause of death,assessment and therapeutic strategy for hepatogenous insulin resistance/diabetes differ from those for lifestyle-related type 2 diabetes.In this article,we review features of insulin resistance in relationship to chronic liver disease.We also discuss the impact of anti-diabetic agents on interferon treatment and hepatocarcinogenesis. | Takumi Kawaguchi Eitaro Taniguchi Minoru Itou Masahiro Sakata Shuji Sumie Michio Sata | 2011 | World Journal of Hepatology2011，3，5： | 25 |
| 2 | Dipeptidyl peptidase-4: A key player in chronic liver disease显示文摘Dipeptidyl peptidase-4 (DPP-4) is a membrane-associated peptidase, also known as CD26. DPP-4 has widespread organ distribution throughout the body and exerts pleiotropic effects via its peptidase activity. A representative target peptide is glucagon-like peptide-1, and inactivation of glucagon-like peptide-1 results in the development of glucose intolerance/diabetes mellitus and hepatic steatosis. In addition to its peptidase activity, DPP-4 is known to be associated with immune stimulation, binding to and degradation of extracellular matrix, resistance to anti-cancer agents, and lipid accumulation. The liver expresses DPP-4 to a high degree, and recent accumulating data suggest that DPP-4 is involved in the development of various chronic liver diseases such as hepatitis C virus infection, non-alcoholic fatty liver disease, and hepatocellular carcinoma. Furthermore, DPP-4 occurs in hepatic stem cells and plays a crucial role in hepatic regeneration. In this review, we described the tissue distribution and various biological effects of DPP-4. Then, we discussed the impact of DPP-4 in chronic liver disease and the possible therapeutic effects of a DPP-4 inhibitor. | Minoru Itou Takumi Kawaguchi Eitaro Taniguchi Michio Sata | 2013 | World Journal of Gastroenterology2013，19，15： | 22 |
| 3 | Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3显示文摘 | Takumi Kawaguchi Takafumi Yoshida Masaru Harada Takao Hisamoto Yumiko Nagao Tatsuya Ide Eitaro Taniguchi Hiroto Kumemura Shinichiro Hanada Michiko Maeyama Shinji Baba Hironori Koga Ryukichi Kumashiro Takato Ueno Hisanobu Ogata Akihiko Yoshimura Michio Sat | 2004 | The American Journal of Pathology2004，，5： | 5 |
| 4 | Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3显示文摘 | Takumi Kawaguchi Takafumi Yoshida Masaru Harada Takao Hisamoto Yumiko Nagao Tatsuya Ide Eitaro Taniguchi Hiroto Kumemura Shinichiro Hanada Michiko Maeyama Shinji Baba Hironori Koga Ryukichi Kumashiro Takato Ueno Hisanobu Ogata Akihiko Yoshimura Michio Sat | 2004 | The American Journal of Pathology2004，，5： | 4 |
| 5 | Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina显示文摘 | Toshiaki Otsuka Chikao Ibuki Takeshi Suzuki Kensuke Ishii Hiroshi Yoshida Eitaro Kodani Yoshiki Kusama Hirotsugu Atarashi Hiroshi Kishida Teruo Takano Kyoichi Mizuno | 2008 | Coronary Artery Disease2008，，2： | 2 |
| 6 | High prevalence of anticardiolipin antibodies in hepatitis C virus infection: lack of effects on thrombocytopenia and thrombotic complications显示文摘 | Masaru Harada Yuko Fujisawa Shotaro Sakisaka Takumi Kawaguchi Eitaro Taniguchi Masaharu Sakamoto Shuji Sumie Kurumi Sasatomi Hironori Koga Takuji Torimura Takato Ueno Kazuhisa Gondo Hiroshi Yoshida Kyuichi Tanikawa Michio Sata | 2000 | Journal of Gastroenterology2000，，4： | 1 |
| 7 | Sulfur and strontium isotope geochemistry of tributary rivers of Lake Biwa:implications for human impact on the decadal change of lake water quality显示文摘 | Nakano Takanori Tayasu Ichiro Wada Eitaro | 2005 | Science of the Total Environment2005，345，13： | 1 |
| 8 | Clonal variation of carbon content in wood of Larix kaempferi (Japanese larch)显示文摘 | Eitaro Fukatsu Yoko Fukuda Makoto Takahashi Ryogo Nakada | 2008 | Journal of Wood Science2008，，3： | 1 |
| 9 | Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2 显示文摘 | Takumi K Tatsiua 1 Eitaro T | 2007 | Am J Gastroenterol2007，102，3： | 1 |
| 10 | Acupuncture regulates gut motility and secretion via nerve reflexes 显示文摘 | Eitaro Noguchi | 2010 | Autonomic Neuroscience : Basic and Clinical2010，156，： | 1 |
| 11 | Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3显示文摘 | Takumi Kawaguchi Takafumi Yoshida Masaru Harada Takao Hisamoto Yumiko Nagao Tatsuya Ide Eitaro Taniguchi Hiroto Kumemura Shinichiro Hanada Michiko Maeyama Shinji Baba Hironori Koga Ryukichi Kumashiro Takato Ueno Hisanobu Ogata Akihiko Yoshimura Michio Sat | 2004 | The American Journal of Pathology2004，，5： | 1 |
| 12 | Sulfur and strontium isotope geochemistry of tributary rivers of Lake Biwa: implications for human impact on the decadal change of lake water quality显示文摘 | Takanori N Ichiro T Eitaro W | 2005 | Science of the Total Environment2005，345，： | 1 |
| 13 | Solid-state synthesis of 70 nm Li4Ti5O12 particles by mechanically activating intermediates with amino acids显示文摘 | EITARO M YUICHI A SENNA M | 2008 | Journal of American Ceramic Society2008，91，5： | 1 |
| 14 | Significance of glucose intolerance and SHIP2 expression in hepatocellularcarcinoma patients with HCV infection显示文摘 | Shuji Sumie Takumi Kawaguchi Mina Komuta Ryoko Kuromatsu Satoshi Itano Koji Okuda Eitaro Taniguchi Eiji Ando Akio Takata Nobuyoshi Fukushima Hironori Koga Takuji Torimura Masamichi Kojiro Michio Sata | 2007 | Oncology Reports2007，，3： | 1 |
| 15 | Clinical Benefits and Cost-Effectiveness of 17-Year Treatment with Low-Dose Interferon-α 2b in a Patient with Chronic Hepatitis C: A Case Report显示文摘 | Takumi Kawaguchi Shuji Sumie Minoru Itou Eitaro Taniguchi Tsunetaka Matoba Michio Sata | 2009 | Digestive Diseases and Sciences2009，，3： | 1 |
| 16 | Protein tyrosine kinase si gnaling is necessary for NO donor-induced late preconditioning against myocardi al stunning显示文摘 | Xian-Liang T Eitaro K Hitoshi T | 2003 | Am J Physiol Heart Circ Physiol2003，284，4： | 1 |
| 17 | Distribution of greenhouse gases, nitrite, and δ13C of dissolved inorganic carbon in Lake Biwa: Implications for hypolimnetic metabolism显示文摘 | TOSHIHIRO MIYAJIMA YOSHIHIRO YAMADA EITARO WADA TAKUO NAKAJIMA TADATOSHI KOITABASHI YUKO T. HANBA KOICHI YOSHII | 1997 | Biogeochemistry1997，，2： | 1 |
| 18 | Enhanced Encapsulation of Amphotericin B into Liposomes by complex Formation with polyethylene Glycol Derivatives显示文摘 | Kunikazu Moribe Eitaro Tanaka Kazuo Maruyama Motoharu Iwatsuru | 1998 | Pharmaceusical Research1998，15，11： | 1 |
| 19 | Motor vehicle accidents: How should cirrhotic patients be managed?显示文摘Motor vehicle accidents (MVAs) are serious social issues worldwide and driver illness is an important cause of MVAs. Minimal hepatic encephalopathy (MHE) is a com- plex cognitive dysfunction with attention deficit, which frequently occurs in cirrhotic patients independent of severity of liver disease. Although MHE is known as a risk factor for MVAs, the impact of diagnosis and treatment of MHE on MVA-related societal costs is largely unknown. Recently, Bajaj et al demonstrated valuable findings that the diagnosis of MHE by rapid screening using the inhibitory control test (ICT), and subsequent treatment with lactulose could substantially reduce the societal costs by preventing MVAs. Besides the ICT and lactulose, there are various diagnostic tools and therapeutic strategies for MHE. In this commentary, we discussed a current issue of diagnostic tools for MHE, including neuropsychological tests. We also discussed the advantages of the other therapeutic strategies for MHE, such as intake of a regular breakfast and coffee, and supplementation with zinc and branched chain amino acids, on the MVA-related societal costs. | Takumi Kawaguchi Eitaro Taniguchi Michio Sata | 2012 | World Journal of Gastroenterology2012，18，21： | 1 |
| 20 | Body cell mass is a useful parameter for assessing malnutrition andseverity of disease in non-ascitic cirrhotic patients with hepatocellular carcinomaor esophageal varices显示文摘 | Takumi Kawaguchi Eitaro Taniguchi Minoru Itou Ryoko Ibi Teruyo Okada Michiko Mutou Satomi Shiraishi Yuki Uchida Momoka Otsuka Youko Umeki Tetsuharu Oriishi Hitomi Hayabuchi Suiko Tanaka Machiko Takakura Michio Sata | 2008 | International Journal of Molecular Medicine2008，，5： | 1 |
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