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| 1 | 新城疫病毒某水禽分离株经鸡体传代后由非致病型转变为速发型的研究显示文摘最近 ,一株无毒力的新城疫病毒 (NDV)在鸡体内繁殖时 ,变成了强毒株。但至今尚未能证实 ,经鸡体传代的野生水禽新城疫病毒是否也具有变成速发型毒株的能力。为了通过实验证明从水禽中分离的非致病型NDV可以转变为速发型病毒 ,我们通过在鸡体内传播鹅源性无毒力株 ,经气囊接种连续传代 9次 ,随后再在鸡脑内传代 5次。结果显示 ,该病毒的毒力变得很强 ,致死率可达 1 0 0 %。通过致病性试验证实 ,其具有典型的速发型病毒特征 ;融合蛋白裂解位点的序列分析表明 ,原始的分离株含有无毒力型毒株共有的裂解序列 :E_R_Q_E_R/L,而通过鸡体反复传代后 ,该序列变为致病性毒株共有的序列 :K_R_Q_K_R/F。这些结果表明 ,野生水禽中自然存在的无毒力毒株 ,具有无毒力株相应的序列 ,但当其在鸡群中传播时 ,则具有变成高致病性病毒的能力。同时研究表明 ,鸡体提供了该病毒从非致病型向致病型转变的选择机制。 | 于圣青 丁铲 NORIKO KISHIDA HIROSHI ITO HIROSHI KIDA KOICHI OTSUKI YOSHIHIRO KAWAOKA TOSHIHIRO ITO | 2003 | 中国预防兽医学报2003，25，1： | 32 |
| 2 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 3 | Clinical significance of visceral adiposity assessed by computed tomography: A Japanese perspective显示文摘Abdominal obesity,rather than total amount of fat,is linked to obesity-related disorders.Visceral adiposity is an important component of obesity-related disorders in Japanese individuals with a mild degree of adiposity compared with Western subjects.In 1983,our group reported techniques for body fat analysis using computed tomography(CT)and established the concept of visceral fat obesity in which intra-abdominal fat accumulation is an important factor in the development of obesity-related complications,such as diabetes,lipid disorders,hypertension and atherosclerosis.Our group also established ideal imaging conditions for determining abdominal fat area at the umbilical level CT scan.Visceral fat area(VFA)measured in a single slice at L4level correlated significantly with the total abdominal visceral fat volume measured on multislice CT scan.In a large-scale study of a Japanese population,the mean number of obesity-related cardiovascular risk factors(hypertension,low high-density lipoprotein cholesterolemia and/or hypertriglyceridemia,and hyperglycemia)was greater than 1.0 at 100 cm2 of VFA,irrespective of gender,age and body mass index.Our group also demonstrated that reduction of visceral fat accumulation subsequent to voluntary lifestyle modification,'Hokenshido',correlated with a decrease in the number of obesity-related cardiovascular risk factors.It is important to select the most appropriate subjects from the general population(e.g.,non-obese subjects with a cluster of risk factors for the metabolic syndrome)that are most suitable for body weight reduction,with the goal of preventing atherosclerotic cardiovascular diseases. | Miwa Ryo Ken Kishida Tadashi Nakamura Tohru Yoshizumi Tohru Funahashi Iichiro Shimomura | 2014 | World Journal of Radiology2014，6，7： | 11 |
| 4 | Impairment of IFN-a production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma显示文摘AIM: To determine the utility of interferon (IFN) -αproduction capacity in patients with hepatitis C virus (HCV) infection for the measurement of immunosurveillance potential and for the early detection of hepatocellular carcinoma (HCC) by investigating the Sendai virus (HVJ) stimulated IFN-α production capacity of patients with HCV infection.METHODS: HVJ stimulated IFN-α production was determined in a large number of patients with HCV infection and the development of HCC was monitored for 3 years in patients with liver cirrhosis (LC).RESULTS: IFN-α production capacity decreases gradually with the progression of liver disease from chronic hepatitis (CH) to HCC. A significant correlation between the duration of HCV infection and impaired IFN-α production capacity was observed. IFN-α production in patients who developed HCC within 3 years was significantly lower than that of patients who remained in LC without developing HCC.CONCLUSION: Measurement of IFN-α production in LC patients may be useful for the early detection of HCC. | Kazuko Uno Yoshiki Suginoshita Kazuhiro Kakimi Fuminori Moriyasu Mayumi Hirosaki Taro Shirakawa Tsunataro Kishida | 2005 | World Journal of Gastroenterology2005，11，46： | 3 |
| 5 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 2 |
| 6 | Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women显示文摘 | Shunji Fujimori Teruyuki Kishida Tsuyoshi Kobayashi Yoshihisa Sekita Tsuguhiko Seo Kazuhiro Nagata Atsushi Tatsuguchi Katya Gudis Kimiyoshi Yokoi Noritake Tanaka Kiyohiko Yamashita Takashi Tajiri Yoshiharu Ohaki Choitsu Sakamoto | 2005 | Journal of Gastroenterology2005，，9： | 2 |
| 7 | SJWD14101600000482显示文摘 | Naoyoshi Nagata Ryota Niikura Tomonori Aoki Takuro Shimbo Yoshihiro Kishida Katsunori Sekine Shohei Tanaka Kazuhiro Watanabe Toshiyuki Sakurai Chizu Yokoi Junichi Akiyama Mikio Yanase Masashi Mizokami Naomi Uemura | 2014 | J Gastroenterol Hepatol2014，，10： | 2 |
| 8 | Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina显示文摘 | Toshiaki Otsuka Chikao Ibuki Takeshi Suzuki Kensuke Ishii Hiroshi Yoshida Eitaro Kodani Yoshiki Kusama Hirotsugu Atarashi Hiroshi Kishida Teruo Takano Kyoichi Mizuno | 2008 | Coronary Artery Disease2008，，2： | 2 |
| 9 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 2 |
| 10 | Anti-anginal Effect of Fasudil, a Rho-Kinase Inhibitor, in Patients With Stable Effort Angina: A Multicenter Study显示文摘 | Hiroaki Shimokawa Katsuhiko Hiramori Hiroyuki Iinuma Saichi Hosoda Hiroshi Kishida Hirofumi Osada Takashi Katagiri Kazunobu Yamauchi Yoshiki Yui Takazo Minamino Mitsuyoshi Nakashima Kazuzo Kato | 2002 | Journal of Cardiovascular Pharmacology2002，，5： | 2 |
| 11 | Study of Optical Fibers Strain-Temperature Sensitivities Using Hybrid Brillouin-Rayleigh System显示文摘在这份报纸,象在工业应用的分布式的光纤维察觉到的挑战(DOFS ) 一样的最近的进步被讨论。比作过去常测量紧张或温度的传感器的广阔市场,在工业水平的分布式的光纤维察觉到的成功(DOFS ) 很最多被限制。为更宽的接受的这缺乏的原因之一是在商业地可得到的系统和实际工业要求之间的失配,特别为空间分辨率和精确。这些要求在纸被组织并且澄清。它也描述混合 Brillouin-Rayleigh 系统,它展出紧张计量器超过那些的能力。系统的原则就纤维刻度方法论而言被说明。为决定紧张,温度,和水疗院压力要求的公式被导出并且讨论。最后,应用的例子被举。 | Kinzo Kishida Yoshiaki Yamauchi Artur Guzik | 2014 | Photonic Sensors2014，4，1： | 2 |
| 12 | Lower GI bleeding risk of nonsteroidal anti-inflammatory drugs and antiplatelet drug use alone and the effect of combined therapy显示文摘 | Naoyoshi Nagata Ryota Niikura Tomonori Aoki Takuro Shimbo Yoshihiro Kishida Katsunori Sekine Shohei Tanaka Hidetaka Okubo Kazuhiro Watanabe Toshiyuki Sakurai Chizu Yokoi Junichi Akiyama Mikio Yanase Masashi Mizokami Naomi Uemura | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 13 | Distribution characteristics and source identification of polychlorinated dibenzo-p-dioxin and dibenzofurans,and dioxin-like polychlorinated biphenyls in the waters from River Kanzaki,running through Osaka urban area,Japan显示文摘This is the first to elucidate the distribution and sources of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/PCDFs),and dioxin-like polychlorinated biphenyls in the waters from Kanzaki River,which is one of the most heavily polluted rivers in Japan.The World Health Organization (WHO)-toxic equivalent quantities (TEQs) in waters from the mainstream exceeded the Japanese environmental standard (1.0 pg-TEQ/L).The PCDD/PCDFs were dominated by highly chlorinated DFs,which predominantly contributed to the WHO-TEQs,suggesting that the main causes would be the incineration-related wastes.To find the sources,the dioxin congener concentrations in water and sediment samples from its tributary small waterways were determined.Abnormally high WHO-TEQs were detected in a water (50 pg-TEQ/L) and a sediment sample (41,000 ng-TEQ/kg dry weight) near the industrial solid waste incinerators (ISWIs).The PCDD/PCDF characteristics agreed well with those of the incinerator-related wastes as seen in the mainstream.These facts indicate that the dioxin pollution in the mainstream could be largely related to the industrial wastes from the ISWIs.Here,a TEQ apportionment method was used to understand the contribution of the pyrogenic sources to the WHO-TEQs.The average contribution ratios of the pyrogenic sources to WHO-TEQs were more than 80% for river waters from the mainstream,indicating that the elevated WHO-TEQs in the mainstream had been largely caused by the ISWIs. | Masao Kishida | 2013 | Journal of Environmental Sciences2013，25，3： | 2 |
| 14 | Experimental study on the distribution of earth pressure and surface settlement through three-dimensional trapdoor tests显示文摘 | Toshihisa Adachi Makoto Kimura Kiyoshi Kishida | 2003 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2003，，2： | 2 |
| 15 | Preservation of the bone mineral density of the femur after surface replacement of the hip显示文摘 | Kishida Y Sugano N Nishii T | 2004 | J Bone Joint Surg Br2004，，86： | 1 |
| 16 | Quantitative analysis of ceramide molecular species by high perform ante liquid chromatography显示文摘 | Yano M Kishida E Muneyuki Y | 1998 | J Lipid Res1998，39，： | 1 |
| 17 | Review of konjac glucomannan显示文摘 | Kishida N Okimasu S | 1978 | Agric Biol Chem1978，42，3： | 1 |
| 18 | Breeding a fermentative yeast at high temperature using protoplast fusion 显示文摘 | Kazunobu Sakanaka Wen Yan Masao Kishida | 1996 | Journal of Fermentation and Bioengineering1996，81，2： | 1 |
| 19 | Matrix solid-phase dispersion extraction and high-performance liquid chromatographic determination of residual sulfonamides in chicken显示文摘 | Kunihiro Kishida Naoto Furusawa | 2001 | Journal of Chromatography A2001，937，： | 1 |
| 20 | Preparation of water-soluble methyl Konjac glucomannan显示文摘 | Kishida N Okimasu S | 1978 | Agric Biol Chem1978，42，3： | 1 |
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