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| 1 | Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development显示文摘AIM: To investigate risk factors for development of hepatocellular carcinoma(HCC) in patients with hepatitis C virus-related liver cirrhosis(LC-C).METHODS: To evaluate the relationship between clinical factors including virological response and the development of HCC in patients with LC-C treated with interferon(IFN) and ribavirin, we conducted a multicenter, retrospective study in 14 hospitals in Japan. All patients had compensated LC-C with clinical or histological data available. HCC was diagnosed by the presence of typical hypervascular characteristics on computed tomography and/or magnetic resonance imaging.RESULTS: HCC was diagnosis in 50(21.6%) of 231 LC-C patients during a median observation period of 3.8 years after IFN and ribavirin therapy. Patients who developed HCC were older(P = 0.018) and had higher serum levels of pretreatment alpha-fetoprotein(AFP)(P = 0.038). Multivariate analysis revealed the following independent risk factors for HCC development: history of treatment for HCC [P < 0.001, odds ratio(OR) = 15.27, 95%CI: 4.98-59.51], AFP levels of ≥ 10 ng/m L(P = 0.009, OR = 3.89, 95%CI: 1.38-11.94), and des-γ-carboxy prothrombin(DCP) levels of ≥ 40 m AU/mL at 24 wk after the completion of IFN and ribavirin therapy(P < 0.001, OR = 24.43, 95%CI: 4.11-238.67).CONCLUSION: We suggested that the elevation of AFP and DCP levels at 24 wk after the completion of IFN and ribavirin therapy were strongly associated with the incidence of HCC irrespective of virological response among Japanese LC-C patients. | Satoshi Shakado Shotaro Sakisaka Kazuaki Chayama Takeshi Okanoue Joji Toyoda Namiki Izumi Akihiro Matsumoto Tetsuo Takehara Akio Ido Yoichi Hiasa Kentaro Yoshioka Hideyuki Nomura Yoshiyuki Ueno Masataka Seike Hiromitsu Kumada | 2015 | World Journal of Hepatology2015，7，27： | 3 |
| 2 | Expression of cyclooxygen- ase-2 in human hepatocellular carcinoma: relevance to tumor dedi- fferentiation显示文摘 | Koga H Sakisaka S Ohishi M | 1999 | Hepotology1999，29，3： | 1 |
| 3 | Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation 显示文摘 | Koga H Sakisaka S Ohishi M | 1999 | Hepatology1999，29，3： | 1 |
| 4 | Biliary secretion of endotoxin and pathogenesis of primary biliary cirrhosis显示文摘 | Sakisaka S Koga H Sasatomi K | 1997 | Yale J Biol Med1997，70，： | 1 |
| 5 | Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia: a randomized, open-label, phase II study显示文摘 | Takumi Kawaguchi Atsumasa Komori Masataka Seike Shigetoshi Fujiyama Hiroshi Watanabe Masatoshi Tanaka Shotaro Sakisaka Makoto Nakamuta Yutaka Sasaki Makoto Oketani Toshihiro Hattori Koichi Katsura Michio Sata | 2012 | Journal of Gastroenterology2012，，12： | 1 |
| 6 | Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation显示文摘 | Koga H Sakisaka S Ohishi M | 1999 | Hepatology1999，29，3： | 1 |
| 7 | Expression of cyclooxygenase-2 in human hepatocellular carcinoma:revelance to tumor dedifferentiation显示文摘 | Koga H Sakisaka S Ohishi M | 1999 | Hepatology1999，29，3： | 1 |
| 8 | Expressionof cyclooxygenase-2 in human hepatocellular car- cinoma= relevance to tumor differentiation 显示文摘 | Koga H Sakisaka S Ohishi M | 1999 | Hepatology1999，29，3： | 1 |
| 9 | Expression of cyclooxygenase-2 in human hepatocellular carcinoma:relevance to tumor dedifferentiation显示文摘 | Koga H Sakisaka S Ohishi M | 1999 | Hepatology1999，29，： | 1 |
| 10 | Abnormal accumulation of endotoxin in biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis显示文摘 | Sasatomi K Noguchi K Sakisaka S | 1998 | J Hepatol1998，29，3： | 1 |
| 11 | Involvement of p21(WAF1/Cip1),p27(Kip1),and p18(INK4c) in troglitazone-induced cellcycle arrest in human hepatoma cell lines显示文摘 | Koga H Sakisaka S Harada M | 2001 | Hepatology2001，33，5： | 1 |
| 12 | Involvement of p21(WAF1/Cip1),p27(Kip1) and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines显示文摘 | Sakisaka S Harada M | 2001 | Hepatology2001，33，5： | 1 |
| 13 | Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation显示文摘 | Koga H Sakisaka S Ohishi M | 1999 | Hepatology1999，29，3： | 1 |
| 14 | Expression of in human hepatocellular carcinoma, relevance totumor differentiation显示文摘 | KOGA H SAKISAKA S OHISHI M | 1999 | Hepatology1999，29，： | 1 |
| 15 | Biliary fibrosis associated with altered bile compotion in a mouse model of erythropoietic protoporphyria显示文摘 | Ishibashi A Ogata R Sakisaka S | 1999 | Gastroenterology1999，117，3： | 1 |
| 16 | Expression of cyclooxygenase-2 in human hepatocellular carcinoma:relevance to tumor dedifferentiation显示文摘 | Koga H Sakisaka S Ohishi M | 1999 | Hepatology1999，29，3： | 1 |
| 17 | The roles of nectins in cell adhesions: cooperation with other cell adhesion molecules and growth factor receptors显示文摘 | Sakisaka T Ikeda W Ogita H | 2007 | Curr Opin Cell Biol2007，19，5： | 1 |
| 18 | Expression of cyclooxygenase-2 in human hepatocellular carcinoma:relevance to tumor dedifferentiation显示文摘 | Koga H Sakisaka S Ohishi M | 1999 | Hepatology1999，29，3： | 1 |
| 19 | Expression of cyclooxygenase-2 in human hepatocellular carcinoma:relevance to tumor dedifferentiation显示文摘 | Koga H Sakisaka S ohishi M | 1999 | Hepatology1999，29，： | 1 |
| 20 | Ursodeoxycholic acid re- duces expression of heat shock proteins in primary biliary cir- rhosis显示文摘 | Sakisaka S Koga H Sasatomi K | 2000 | Liver2000，20，1： | 1 |
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