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| 1 | Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot “Prunus mume ”显示文摘MK615, a compound extracted from the Japanese apricot 'Prunus mume ' has been reported to have in vitro anti-tumor activities against several cancer cell lines,including hepatocellular carcinoma(HCC). However, the clinical effects and feasibility of administering MK615for patients with HCC were unknown. We experienced a case with advanced HCC for which MK615 was effective against both lymph node and pulmonary metastases. A 60-year-old female underwent surgical resection of a 9 cm HCC in the right lobe. The pathological diagnosis was moderately differentiated HCC with vascular invasion. The HCC recurred in the liver 8 mo after the surgery. Radiofrequency ablation and transarterial infusion chemotherapy were performed, but the recurrence was not controlled. One year after the intrahepatic recurrence, pulmonary and lymph metastasis appeared.Sorafenib was administered, but was not effective.Then, MK615 was administered as a final alternative therapy after informed consent was obtained from the patient. Three months later, her alpha-fetoprotein level decrease and both the lymph node and pulmonary metastases decreased in size. The patient has survived for more than 17 mo after the MK615 administration, and was in good condition. Although further investigations are necessary to clarify its safety and efficacy in humans, MK615 may be useful for the treatment of HCC,without serious adverse effects. | Takashi Hoshino Hitoshi Takagi Atsushi Naganuma Eri Koitabashi Sanae Uehara Naomi Sakamoto Tomohiro Kudo Ken Sato Satoru Kakizaki | 2013 | World Journal of Hepatology2013，5，10： | 7 |
| 2 | Prognostic significance of increased serum bilirubin levels coincident with cardiac deeompensation in chronic heart failure 显示文摘 | Shinagawa H Inomata T Koitabashi T | 2008 | Circ J2008，72，3： | 1 |
| 3 | Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis显示文摘 | Koitabashi N Arai M Kogure S | | 0，，05： | 1 |
| 4 | Remifentanil close/ electroencephalogram bispectral respondse during combined propofol/regional anesthesia显示文摘 | Koitabashi T Johasew JW Sebel PS | 2002 | Anesth Analg2002，94，： | 1 |
| 5 | Remifentanil dose/electroencephalogram bispectral response during combined propofol/regional anesthesia显示文摘 | Koitabashi T Johansen JW Sebel PS | 2002 | Anesth Analg2002，94，： | 1 |
| 6 | Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure 显示文摘 | Koitabashi N Arai M Niwano K | 2008 | Eur J Heart Fail2008，10，4： | 1 |
| 7 | A novel actinomycete derived from wheat heads degrades deoxynivalenol in the grain of wheat and barley affected byFusarium head blight显示文摘 | Ito M Sato I Koitabashi M | 2012 | Applied Microbiology andBiotechnology2012，96，4： | 1 |
| 8 | Cyclic GMP/PKG- Dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition 显示文摘 | Koitabashi N Aiba T Hesketh GG et at | 2010 | J Mol Cell Cardiol2010，48，： | 1 |
| 9 | Remifentanil close/electroencephalogram bispectral respondse during combined propofol/regional anesthesia显示文摘 | Koitabashi T Johasew JW Sebel PS | 2002 | Anesth Analg2002，94，： | 1 |
| 10 | Increased eonnective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis显示文摘 | Koitabashi N Arai M Kogure S | | 0，，05： | 1 |
| 11 | New biocontrol method for parsley powdery mildew by the antifungal volatiles-producing fungus Kyu-W63显示文摘 | Motoo Koitabashi | 2005 | Journal of General Plant Pathology2005，，4： | 1 |
| 12 | Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis 显示文摘 | Koitabashi N Arai M Kogure S | 2007 | Hypertension2007，49，5： | 1 |
| 13 | Increased connective tissue growthfactor relative to brain natriuretic peptide as a determinant ofmyocardial fibrosis显示文摘 | Koitabashi N Arai M Kogure S | 2014 | Hypertension2014，49，5： | 1 |
| 14 | Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihyper- trophic effects of PDE5 inhibition in mice 显示文摘 | Takimoto E Koitabashi N Hsu S | 2009 | J Clin Invest2009，119，2： | 1 |
| 15 | Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis显示文摘 | Koitabashi N Arai M Kogure S | | 0，，05： | 1 |
| 16 | Comparison of the efficacy of ropivacaine and that of levobupivacaine for postoperative epi-dural analgesia in patients undergoing gynecological open abdomi-nal surgery 显示文摘 | Kato A Koitabashi T Masuda S | 2013 | Japan J Anesthesio12013，62，10： | 1 |
| 17 | Increased serum bilirubin levels coincident with heart failure decompensation indicate the need for intravenous inotropic agents显示文摘 | SHINAGAWA H INOMATA T KOITABASHI T | 2007 | Int Heart J2007，48，2： | 1 |
| 18 | Prognostic significance of increased serum bilirubin levels coincident with cardiac decompensation in chronic heart failure显示文摘 | Shinagawa H Inomata T Koitabashi T | | 0，，03： | 1 |
| 19 | 1,8 -Cincole inhibits root growth and DNA synthesis in the root apical meristem of Brassica campestris L 显示文摘 | Koitabashi R Suzuki T Kawazu T | 1997 | J Plant Res1997，110，： | 1 |
| 20 | Prognostic significance of increased serum bilirubin levels coincident with cardiac decompensation in chronic heart failure显示文摘 | SHINAGAWA H INOMATA T KOITABASHI T | 2008 | Circ J2008，72，3： | 1 |
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