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| 1 | Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan显示文摘AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. | Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi | 2016 | World Journal of Gastroenterology2016，22，5： | 20 |
| 2 | 四圈扩弓簧的临床应用及改良设计显示文摘目的 :介绍四圈扩弓簧矫治器的原理、特点、改良设计及临床应用效果。方法 :结合典型病例介绍四圈扩弓簧的制作、戴入和调节以及改良设计。结果 :通过病例分析发现经 18个月的治疗 ,6宽度可扩大 9 6 5mm ,3宽度扩大 5 2 0mm ,6宽度扩大 3 6 0mm ,3宽度减少 0 45mm。结论 :四圈扩弓簧是一种性能良好 ,值得推广使用的扩弓矫治器。 | 赖文莉 山添清文 越知佳奈子 花田晃治 Kooji Hanada | 2001 | 华西口腔医学杂志2001，19，2： | 13 |
| 3 | Applications of same-beam VLBI in the orbit determination of multi-spacecrafts in a lunar sample-return mission显示文摘Same-beam VLBI means that two spacecrafts with small separation angles that transmit multi-frequency signals specially designed are observed simultaneously through the main beam of receiving antennas. In same-beam VLBI,the differential phase delay between the two spacecrafts and the two receiving antennas can be obtained within a small error of several picoseconds. As a successful application,the short-arc orbit determination of several hours for Rstar and Vstar,which are two small sub-spacecrafts of SELENE,has been much improved by using the same-beam VLBI data together with the Doppler and range data. The long-arc orbit determination of several days has also been accomplished within an error of about 10 m with the same-beam VLBI data incorporated. These results show the value of the same-beam VLBI for the orbit determination of multi-spacecrafts. This paper introduces the same-beam VLBI and Doppler observations of SELENE and the orbit determination results. In addition,this paper introduces how to use the same-beam VLBI for a lunar sample-return mission,which usually consists of an orbiter,a lander and a return unit. The paper also offers the design for the onboard radio sources in the lunar sample-return mission,and introduces applications of S-band multi-frequency same-beam VLBI in lunar gravity exploration and applications during all stages in the position/orbit determinations such as orbiting,landing,sampling,ascending,and docking. | GOOSSENS Sander KIKUCHI Fuyuhiko MATSUMOTO Koji HANADA Hideo | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 13 |
| 4 | Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis显示文摘Sphingolipids 被建议了在植物房间为一连串的细胞的发信号活动充当第二个送信人,包括压力回答并且规划了房间死亡(PCD ) 。然而,这些过程不是的机制 underpinning 很好理解。这里,我们报导那 Arabidopsis 异种, fumonisin B1 抵抗 11-1 ( fbr 11-1 )没能产生反应的氧中介( ROI ),不能当异种被 fumonisin B ( 1 )( FB ( 1 ))质问时,开始 PCD , ceramide synthase 的一个特定的禁止者。显示的分子的分析 FBR11 编码一个长链的底 1 (LCB1 ) 丝氨酸 palmitoyltransferase (SPT ) 的子单元,它催化 de novo sphingolipid 的第一限制率的步合成。sphingolipid 集中的集体度谱的分析表明而 fbr 11-1 变化没影响 sphingoid 底的基础层次,异种响应 FB (1 ) 显示出 sphingoid 底的稀释形成。由一个直接的喂实验,我们证明免费 sphingoid 底 dihydrosphingosine, phytosphingosine 和鞘氨醇高效地导致产生由房间死亡跟随了的 ROI。相反地, dihydrosphingosine 导致的 ROI 产生和房间死亡被它的 phosphorylated 形式 dihydrosphingosine-1-phosphate 明确地以一种剂量依赖者方式堵住,建议在一个免费 sphingoid 底和它的 phosphorylated 衍生物之间的动态平衡的维护对决定房间命运批评。因为 sphingolipid 水平的改变发生在 ROI 生产以前,我们建议免费 sphingoid 库在 Arabidopsis 涉及 PCD 的控制,大概在收到不同发展或环境的暗示之上通过 ROI 的规定铺平。 | Lihua Shi Jacek Bielawski Jinye Mu Haili Dong Chong Teng Jian Zhang Xiaohui Yang Nario Tomishige Kentaro Hanada Yusuf A Hannun Jianru Zuo | 2007 | Cell Research2007，17，12： | 12 |
| 5 | High-accuracy same-beam VLBI observations using Shanghai and Urumqi telescopes显示文摘The same-beam VLBI observations of Rstar and Vstar,which were two small satellites of Japanese lunar mission,SELENE,were successfully performed by using Shanghai and Urumqi 25-m telescopes. When the separation angle between Rstar and Vstar was less than 0.1 deg,the differential phase delay of the X-band signals between Rstar and Vstar on Shanghai-Urumqi baseline was obtained with a very small error of 0.15 mm rms,which was reduced by 1-2 order compared with the former VLBI results. When the separation angle was less than 0.56 deg,the differential phase delay of the S-band signals was also obtained with a very small error of several mm rms. The orbit determination for Rstar and Vstar was performed,and the accuracy was improved to a level of several meters by using VLBI and Doppler data. The high-accuracy same-beam differential VLBI technique is very useful in orbit determination for a spacecraft,and will be used in orbit determination for Mars missions of China Yinghuo-1 and Russia Phobos-grunt. | KIKUCHI Fuyuhiko KAMATA Shun'ichi MATSUMOTO Koji HANADA Hideo | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 11 |
| 6 | Endoscopic ultrasound-guided celiac ganglia neurolysis vs. celiac plexus neurolysis: a randomized multicenter trial显示文摘 | S. Doi I. Yasuda H. Kawakami T. Hayashi H. Hisai A. Irisawa T. Mukai A. Katanuma K. Kubota T. Ohnishi S. Ryozawa K. Hara T. Itoi K. Hanada K. Yamao | 2013 | Endoscopy2013，，05： | 8 |
| 7 | Al-Ti-B-RE细化剂对Al-7.0Si-0.55Mg合金显微组织和力学性能的影响(英文)显示文摘研究添加Al-5Ti-1B-RE细化剂对Al-7.0Si-0.55Mg(A357)合金的显微组织和力学性能的影响。先利用真空熔炼技术制备Al-7.0Si-0.55Mg合金,然后在Al-7.0Si-0.55Mg合金中加入不同成分的Al-5Ti-1B-RE中间合金。通过X射线衍射仪(XRD)、金相显微镜(OM)和扫描电子显微镜(SEM)对显微组织和拉伸试样的断口形貌进行观察。在室温下对合金的力学性能进行测试。观察Al-5Ti-1B-RE细化剂的形态以及内部结构,可以发现以TiB2为异质形核核心的TiAl3/Ti2Al20RE的壳层结构相。在Al-7.0Si-0.55Mg合金中加入Al-5Ti-1B-3.0RE细化剂后,抗拉强度会有明显提升,直到0.2%添加量时,抗拉强度会达到峰值。 | 王雪姣 徐聪 Arfan MUHAMMAD Shuji HANADA Hiroshi YAMAGATA 王文红 马朝利 | 2014 | Transactions of Nonferrous Metals Society of China2014，24，7： | 8 |
| 8 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 9 | Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3显示文摘 | Takumi Kawaguchi Takafumi Yoshida Masaru Harada Takao Hisamoto Yumiko Nagao Tatsuya Ide Eitaro Taniguchi Hiroto Kumemura Shinichiro Hanada Michiko Maeyama Shinji Baba Hironori Koga Ryukichi Kumashiro Takato Ueno Hisanobu Ogata Akihiko Yoshimura Michio Sat | 2004 | The American Journal of Pathology2004，，5： | 5 |
| 10 | Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3显示文摘 | Takumi Kawaguchi Takafumi Yoshida Masaru Harada Takao Hisamoto Yumiko Nagao Tatsuya Ide Eitaro Taniguchi Hiroto Kumemura Shinichiro Hanada Michiko Maeyama Shinji Baba Hironori Koga Ryukichi Kumashiro Takato Ueno Hisanobu Ogata Akihiko Yoshimura Michio Sat | 2004 | The American Journal of Pathology2004，，5： | 4 |
| 11 | Randomized phase II study of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan Clinical Cancer Research Organization PC-01 study)显示文摘 | Masato Ozaka Yuji Matsumura Hiroshi Ishii Yasushi Omuro Takao Itoi Hisatsugu Mouri Keiji Hanada Yasutoshi Kimura Iruru Maetani Yoshinobu Okabe Masaji Tani Takaaki Ikeda Susumu Hijioka Ryouhei Watanabe Shinya Ohoka Yuki Hirose Masafumi Suyama Naoto Egawa A | 2012 | Cancer Chemotherapy and Pharmacology2012，，5： | 3 |
| 12 | Structural evolution during mechanical alloying and annealing of a Nb-25at%Al alloy显示文摘 | Hye-Sung Kim Dongwha Kum Shuji Hanada | 2000 | Journal of Materials Science2000，，1： | 2 |
| 13 | Structure, regulation and function of PKB/AKT—a major therapeutic target显示文摘 | Masahito Hanada Jianhua Feng Brian A Hemmings | 2004 | BBA - Proteins and Proteomics2004，，1： | 2 |
| 14 | Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses显示文摘 | Li-Fan Lu Mark P. Boldin Ashutosh Chaudhry Ling-Li Lin Konstantin D. Taganov Toshikatsu Hanada Akihiko Yoshimura David Baltimore Alexander Y. Rudensky | 2010 | Cell2010，，6： | 2 |
| 15 | Determination of the free lunar libration modes from ephemeris DE430显示文摘The Moon's physical librations have been extensively studied, and elaborate researches have been developed for the purpose of deriving accurate modes of free librations. Our motivation comes from the Planetary and Lunar Ephemeris DE430 by JPL/NASA, which was created in April 2013,and is reported to be the most accurate lunar ephemeris today using the data from Gravity Recovery and Interior Laboratory(GRAIL). Therefore, the residuals after fitting the model have reduced owing to improvement in the libration models, and the free librations embedded in the Euler angles have also improved. We use Fourier analysis to extract the approximate frequencies from DE430 and then a quadratic interpolation method is used to determine higher accuracy frequencies. With the frequencies,the linear least-squares fitting method is employed to fit the lunar physical librations to DE430. From this analysis we identified the three modes of free physical librations, and estimated the amplitudes as 1.471′′in longitude, 0.025′′in latitude and 8.19′′× 3.31′′for the wobble, with the respective periods of1056.16, 8806.9 and 27262.99 d. Since the free librations damp with time, they require recent excitation or a continuous stimulating mechanism in order to sustain. | Yong-Zhang Yang Jin-Ling Li Jin-Song Ping Hideo Hanada | 2017 | Research in Astronomy and Astrophysics2017，17，12： | 2 |
| 16 | RESEARCH ON SUPERPLASTICITY IN SiCp/2024Al AND SiCp/8090Al-Li COMPOSITES显示文摘The superplasticity in SiCp/Al alloy and SiCp/Al Li Composites is introduced The composites are prepared by powder metallurgy and cast methods The superplastic parameters are measured Superplastic treatment processing,secondary plastic working and the study of mirostructure are conducted. | Zhang Libin, Wang Zongren (School of Materials Science and Engineering,Harbin Institute of Technology) Hai Jintao (China Academy of Machinery Science and Technology) Sano T Murakoshi Y Takahashi M Hanada K Mechanical Engineering Laboratory,AIST,MITI,J | 2001 | Chinese Journal of Mechanical Engineering2001，14，4： | 2 |
| 17 | Dexmedetomidine was safely used for sedation during spinal anesthesia in a very elderly patient显示文摘 | Takayuki Kunisawa Satoshi Hanada Atsushi Kurosawa Akihiro Suzuki Osamu Takahata Hiroshi Iwasaki | 2010 | Journal of Anesthesia2010，，6： | 2 |
| 18 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 19 | IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a显示文摘 | Mickey C.-T Hu Dung-Fang Lee Weiya Xia Leonard S Golfman Fu Ou-Yang Jer-Yen Yang Yiyu Zou Shilai Bao Norihisa Hanada Hitomi Saso Ryuji Kobayashi Mien-Chie Hung | 2004 | Cell2004，，2： | 2 |
| 20 | Successful treatment of topical photodynamic therapy using 5-aminolevulinic acid for plane warts显示文摘 | Mizuki D Kaneko T Hanada K | 2003 | Br-J-Dermatol2003，149，5： | 1 |
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