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| 1 | 贵州省2003~2004年麻疹疫苗强化免疫效果评价显示文摘目的总结贵州省实施麻疹疫苗(MV)强化免疫的效果。方法综合分析强化免疫期间的现场调查、项目年度评估报告和强化免疫后1年的麻疹监测系统和法定传染病报告系统的疫情资料。结果本次强化免疫共计接种目标儿童8611528人,报告接种率和调查接种率均〉95%;共报告预防接种异常反应354例,发生率4.11/10万;接种后经过1个最长潜伏期,麻疹发病数明显减少,每周报告疑似麻疹2~34例,且近1/3为风疹;目前78.3%的麻疹病例发生在8月龄~14岁,病例71.1%无免疫史或免疫史不详。结论高质量MV强化免疫能够迅速降低麻疹发病,实施该项工作的关键环节包括广泛的社会动员、细致的培训和清晰的物流是前提保障;目标人群的确定必须结合当地流行病学监测的资料;尽可能在较大范围内开展,以形成有效的人群免疫屏障阻断麻疹病毒传播;接种时间选择在麻疹低发季节,且尽可能在15d内完成;保证〉95%接种率是活动的前提目标;必须针对可能发生的预防接种后异常反应做好充分准备;如果该地区常规免疫服务质量在1~2年内不能明显加强,需要同时考虑4~5年后的后续免疫。 | 左树岩 梁晓峰 殷大鹏 尤雪丹 郭飚 童亦兵 朱青 张大勇 杜雯 Lisa lee Yoshihiro Takashima 于竞进 | 2006 | 中国计划免疫2006，12，1： | 67 |
| 2 | Portal vein thrombosis in liver cirrhosis显示文摘Portal vein thrombosis(PVT) is considered to be a frequent complication of liver cirrhosis. However, unlike PVT in patients without cirrhosis, very few data are available on the natural history and management of PVT in cirrhosis, despite its association with potentially life-threatening conditions, such as gastroesophageal bleeding and acute intestinal ischemia. Moreover, no consensus regarding PVT in cirrhosis exists. Suggested causes of PVT in cirrhosis include reduced portal blood flow velocity, multiple congenital or acquired thrombophilic factors, inherited or acquired conditions, and derangement of liver architecture. However, the understanding of PVT in cirrhosis is incomplete. In addition, information on the management of PVT in cirrhosis is inadequate. The aims of this review are to:(1) assemble data on the physiopathological mechanism, clinical findings, diagnosis and management of PVT in cirrhosis;(2) describe the principal factors most frequently involved in PVT development; and(3) summarize the recent knowledge concerning diagnostic and therapeutic procedures. | Nao Kinjo Hirofumi Kawanaka Tomohiko Akahoshi Yoshi-hiro Matsumoto Masahiro Kamori Yoshihiro Nagao Naotaka Hashimoto Hideo Uehara Morimasa Tomikawa Ken Shirabe Yoshihiko Maehara | 2014 | World Journal of Hepatology2014，6，2： | 38 |
| 3 | 新城疫病毒某水禽分离株经鸡体传代后由非致病型转变为速发型的研究显示文摘最近 ,一株无毒力的新城疫病毒 (NDV)在鸡体内繁殖时 ,变成了强毒株。但至今尚未能证实 ,经鸡体传代的野生水禽新城疫病毒是否也具有变成速发型毒株的能力。为了通过实验证明从水禽中分离的非致病型NDV可以转变为速发型病毒 ,我们通过在鸡体内传播鹅源性无毒力株 ,经气囊接种连续传代 9次 ,随后再在鸡脑内传代 5次。结果显示 ,该病毒的毒力变得很强 ,致死率可达 1 0 0 %。通过致病性试验证实 ,其具有典型的速发型病毒特征 ;融合蛋白裂解位点的序列分析表明 ,原始的分离株含有无毒力型毒株共有的裂解序列 :E_R_Q_E_R/L,而通过鸡体反复传代后 ,该序列变为致病性毒株共有的序列 :K_R_Q_K_R/F。这些结果表明 ,野生水禽中自然存在的无毒力毒株 ,具有无毒力株相应的序列 ,但当其在鸡群中传播时 ,则具有变成高致病性病毒的能力。同时研究表明 ,鸡体提供了该病毒从非致病型向致病型转变的选择机制。 | 于圣青 丁铲 NORIKO KISHIDA HIROSHI ITO HIROSHI KIDA KOICHI OTSUKI YOSHIHIRO KAWAOKA TOSHIHIRO ITO | 2003 | 中国预防兽医学报2003，25，1： | 32 |
| 4 | Depletion of CD25^+CD4^+T cells (Tregs) enhances the HBV-specific CD8^+ T cell response primed by DNA immunization显示文摘AIM: Persistent hepatitis B virus (HBV) infection is characterized by a weak CD8+ T cell response to HBV. Immunotherapeutic strategies that overcome tolerance and boost these suboptimal responses may facilitate viral clearance in chronically infected individuals. Therefore, we examined whether CD25+CD4+ regulatory T (Treg) cells might be involved in a inhibition of CD8+T cell priming or in the modulation of the magnitude of the'peak' antiviral CD8+ T cell response primed by DNA immunization. METHODS: B10.D2 mice were immunized once with plasmid pCMV-S. Mice received 500 μg of anti-CD25 mAb injected intraperitoneally 3 d before DNA immunization to deplete CD25+ cells. Induction of HBV-specific CD8+ T ceils in peripheral blood mononuclear cells (PBMCs) was measured by S28-39 peptide loaded DimerX staining and their function was analyzed by intracellular IFN-γ staining.RESULTS: DNA immunization induced HBV-specific CD8+ T cells. At the peak T cell response (d 10), 7.1±2.0% of CD8+ T cells were HBV-specific after DNA immunization, whereas 12.7±3.2% of CD8+ T cells were HBV-specific in Treg-depleted mice, suggesting that DNA immunization induced more antigen-specific CD8+ T cells in the absence of CD25+ Treg cells (n = 6, P<0.05). Similarly, fewer HBVspecific memory T cells were detected in the presence of these cells (1.3±0.4%) in comparison to Treg-depleted mice (2.6±0.9%) on d 30 after DNA immunization (n = 6, P<0.01). Both IFN-γ production and the avidity of the HBV-specific CD8+ T cell response to antigen were higher in HBV-specific CD8+ T cells induced in the absence of Treg cells.CONCLUSION: CD25+ Treg cells suppress priming and/or expansion of antigen-specific CD8+ T cells during DNA immunization and the peak CD8+ T cell response is enhanced by depleting this cell population. Furthermore, Treg cells appear to be involved in the contraction phase of the CD8+ T ceil response and may affect the quality of memory T cell pools. The elimination of Treg cells or their inhibition may be important in immunotherapeutic strategies to control HBV infection by inducing virus-specific cytotoxic T lymphocyte responses in chronically infected subjects. | Yoshihiro Furuichi Hirotake Tokuyama Satoshi Ueha Makoto Kurachi Fuminori Moriyasu Kazuhiro Kakimi | 2005 | World Journal of Gastroenterology2005，11，24： | 30 |
| 5 | Initial management for acute lower gastrointestinal bleeding显示文摘Acute lower gastrointestinal bleeding(LGIB) is a common indication for hospital admission. Patients with LGIB often experience persistent or recurrent bleeding and require blood transfusions and interventions, such as colonoscopic,radiological, and surgical treatments. Appropriate decision-making is needed to initially manage acute LGIB, including emergency hospitalization, timing of colonoscopy, and medication use. In this literature review, we summarize the evidence for initial management of acute LGIB. Assessing various clinical factors,including comorbidities, medication use, presenting symptoms, vital signs, and laboratory data is useful for risk stratification of severe LGIB, and for discriminating upper gastrointestinal bleeding. Early timing of colonoscopy had the possibility of improving identification of the bleeding source, and the rate of endoscopic intervention, compared with elective colonoscopy. Contrast-enhanced computed tomography before colonoscopy may help identify stigmata of recent hemorrhage on colonoscopy, particularly in patients who can be examined immediately after the last hematochezia. How to deal with nonsteroidal antiinflammatory drugs(NSAIDs) and antithrombotic agents after hemostasis should be carefully considered because of the risk of rebleeding and thromboembolic events. In general, aspirin as primary prophylaxis for cardiovascular events and NSAIDs were suggested to be discontinued after LGIB. Managing acute LGIB based on this information would improve clinical outcomes. Further investigations are needed to distinguish patients with LGIB who require early colonoscopy and hemostatic intervention. | Tomonori Aoki Yoshihiro Hirata Atsuo Yamada Kazuhiko Koike | 2019 | World Journal of Gastroenterology2019，25，1： | 28 |
| 6 | Morrey Spaces for Non-doubling Measures显示文摘作者为可能非加倍,但是满足某些生长条件的氡措施给 Morrey 空格的一个自然定义,并且在泛音分析和他们的珍视向量的扩展在一些古典操作符的这些空格调查围住的海角。 | Yoshihiro SAWANO Hitoshi TANAKA | 2005 | Acta Mathematica Sinica,English Series2005，21，6： | 25 |
| 7 | Risk factors for bleeding after endoscopic mucosal resection显示文摘AIM: To clarify the risk factors for bleeding after endoscopic mucosal resection (EMR).METHODS: A total of 297 consecutive patients who underwent EMR were enrolled. Some of the patients had multiple lesions. Bleeding requiring endoscopic treatment was defined as bleeding after EMR. Odds ratios (OR) with 95% confidence intervals (CI), calculated by logistic regression with multivariate adjustments for covariates,were the measures of association.RESULTS: Of the 297 patients, 57 (19.2%) patients with bleeding after EMR were confirmed. With multivariate adjustment, the cutting method of ENR, diameter, and endoscopic pattern of the tumor were associated with the risk of bleeding after ENR. The multivariate-adjusted OR for bleeding after EMR using endoscopic aspiration mucosectomy was 3.07 (95%CI, 1.59-5.92) compared with strip biopsy. The multiple-adjusted OR for bleeding after EMR for the highest quartile (16-50 mm) of tumor diameter was 5.63 (95%CI, 1.84-17.23) compared with that for the lowest (4-7 mm). The multiple-adjusted OR for bleeding after EM R for depressed type of tumor was 4.21 (95%CI, 1.75-10.10) compared with elevated type.CONCLUSION: It is important to take tumor characteristics (tumor size and endoscopic pattern) and cutting method of EMR into consideration in predicting bleeding after ENR. | Masatsugu Shiba Kazuhide Higuchi Kaori Kadouchi Ai Montani Kazuki Yamamori Hirotoshi Okazaki Makiko Taguchi Tomoko Wada Atsushi Itani Toshio Watanabe Kazunari Tominaga Yoshihiro Fujiwara Tomoshige Hayashi Kei Tsumura Tetsuo Arakawa | 2005 | World Journal of Gastroenterology2005，11，46： | 25 |
| 8 | Characteristics and predictors of gastric cancer after Helicobacter pylori eradication显示文摘Helicobacter pylori(H. pylori) eradication can reduce gastric cancer. However, gastric cancer still develops after eradication, and cases who received eradication therapy are increasing. In this study, we have reviewed the characteristics and predictors of primary gastric cancer developing after H. pylori eradication. In terms of the characteristics, endoscopic, histologic, and molecular characteristics are reported. Endoscopically, gastric cancer after eradication is often depressedtype and shows a gastritis-like appearance, which sometimes makes the diagnosis difficult. Histologically, most gastric cancer after eradication is intestinal type, and non-neoplastic epithelium, also called epithelium with low-grade atypia, is frequently seen over the tumor, which is presumably the cause of the endoscopic gastritis-like appearance. As for molecular characteristics, some markers, such as Ki67, MUC2, and Wnt5a expression, are lower in cancer from patients in whom H. pylori has been eradicated. In terms of predictors, several Japanese studies have reported that severe endoscopic atrophy at eradication is a risk factor for gastric cancer development. Histologic intestinal metaplasia, especially in the corpus, and long-term use of proton pump inhibitors, are also reported as risk factors for gastric cancer after H. pylori eradication. These studies on the characteristics and predictors of gastric cancer development will become the cornerstone for establishing a novel surveillance program based on the gastric cancer risk stratification specific to H. pylori-eradicated patients. | Satoki Shichijo Yoshihiro Hirata | 2018 | World Journal of Gastroenterology2018，24，20： | 25 |
| 9 | Water isotope variations in the snow pack and summer precipitation at July 1 Glacier, Qilian Mountains in northwest China显示文摘This paper presents the stable isotope data of the snow pack and summer precipitation collected at the July 1 Glacier, Qilian Mountains in northwest China and analyses their relationships with meteorologi- cal factors. On an event scale, there is no temperature effect on the δ 18O values in the summer pre- cipitation, whereas the amount effect is shown to be clear. By tracing the moisture transport history and comparing the precipitation with its isotopic composition, it is shown that this amount effect not only reflects the change in moisture trajectory, which is related to the monsoon activities, but is also associated with the cooling degree of vapor in the cloud, the evaporation of falling raindrops and the isotopic exchange between the falling drops and the atmospheric vapor. As very little precipitation occurs in winter, the snow pack profile mainly represents the precipitation in the other three seasons. There are low precipitation δ 18O ratios in summer and high ratios in spring and autumn. The Meteoric Water Line (MLW) for the summer precipitation is δ D = 7.6 δ 18O + 13.3, which is similar to that at Delingha, located in the south rim of the Qilian Mountains. The MWL for the snow pack is δ D = 10.4 δ 18O + 41.4, showing a large slope and intercept. The deuterium excess (d) of the snow pack is positively correlated with δ 18O, indicating that both d and δ 18O decrease from spring to summer and increase from early autumn to early spring. This then results in the high slope and intercept of the MWL. Sea- sonal fluctuations of d in the snow pack indicate the change of moisture source and trajectory. During spring and autumn, the moisture originates from continental recycling or rapid evaporation over rela- tively warm water bodies like Black, Caspian and Aral Seas when the dry westerly air masses pass over them, hence very high d values in precipitation are formed. During summer, the monsoon is responsi- ble for the low d values. This indicates that the monsoon can reach the western part of the Qilian Mountains. | ZHOU ShiQiao NAKAWO Masayoshi SAKAI Akiko MATSUDA Yoshihiro DUAN KeQin PU JianChen | 2007 | Chinese Science Bulletin2007，52，21： | 21 |
| 10 | H5N1 influenza viruses: outbreaks and biological properties显示文摘流行性感冒的所有已知的子类型 A 病毒在野水鸟被维持,这些病毒的自然水库。流行性感冒 A 病毒被孤立从许多有改变病态和死亡率的动物种类。更重要地,流行性感冒 A 病毒与潜在地致命的结果在人引起呼吸疾病。在人的本地或全球的爆发被过量住院和死亡典型地描绘。在 1997, H5N1 子类型的高度病原的鸟的流行性感冒病毒在传给人的香港出现了,导致由鸟的流行性感冒病毒感染的人的死亡的首先记录的盒子。在越南,印度尼西亚,和泰国在家禽在 2003 年 7 月开始的新爆发,和高度病原的鸟的 H5N1 流行性感冒病毒后来在整个亚洲并且进欧洲和非洲传播了。这些病毒继续与高死亡率感染人并且引起隐约可见的世界范围的担心流行。而且, H5N1 病毒爆发在整个亚洲在家禽工业上有破坏效果。因为 H5N1 病毒爆发看起来从南部的中国发源,我们这里在中国检验 H5N1 流行性感冒病毒,与他们的生物性质上的一个重音。 | Gabriele Neuman Hualan Chen George F Gao Yuelong Shu Yoshihiro Kawaoka | 2010 | Cell Research2010，20，1： | 19 |
| 11 | 健康教育对提高农牧区新生儿乙型肝炎疫苗首针及时接种率的效果分析显示文摘目的探讨在农牧区开展健康教育推动新生儿乙型肝炎(乙肝)疫苗首针(HepB1)及时接种。方法开发宣传品、培训专业人员、动员当地知名人士开展宣传和健康教育活动。结果居民知晓率、新生儿HepB1及时接种率分别由项目前的48.84%、42.61%上升到项目后的91.27%、75.02%,差异均有非常显著的统计学意义(χ2=57.13,χ2=838.16;P均<0.001)。结论在农牧区开展乙肝预防控制健康教育,可促进新生儿HepB1及时接种率的提高。 | 李秀芹 万玛加 李青旗 李承宁 胡苑笙 张永基 乔华 王建仁 马耀军 崔富强 梁晓峰 倪大新 Yoshihiro Takashima | 2007 | 中国计划免疫2007，13，1： | 16 |
| 12 | Role of 18F-fluorodeoxyglucose positron emission tomography imaging in surgery for pancreatic cancer显示文摘AIM: To evaluate the role of positron emission tomo-graphy using 18F-fluorodeoxyglucose (FDG-PET) in the surgical management of patients with pancreatic cancer, including the diagnosis, staging, and selection of patients for the subsequent surgical treatment.METHODS: This study involved 53 patients with proven primary pancreatic cancer. The sensitivity of diagnosing the primary cancer was examined for FDG-PET, CT, cytological examination of the bile or pancreatic juice, and the serum levels of carcinoembrionic antigens (CEA) and carbohydrate antigen 19-9 (CA19-9). Next, the accuracy of staging was compared between FDG-PET and CT. Finally, FDG-PET was analyzed semiquantitatively using the standard uptake value (SUV). The impact of the SUV on patient management was evaluated by examining the correlations between the SUV and the histological findings of cancer.RESULTS: The sensitivity of FDG-PET, CT, cytological examination of the bile or pancreatic juice, and the serum levels of CEA and CA19-9 were 92.5%, 88.7%, 46.4%, 37.7% and 69.8%, respectively. In staging, FDG-PET was superior to CT only in diagnosing distant disease (bone metastasis). For local staging, the sensitivity of CT was better than that of FDG-PET. The SUV did not correlate with the pTNM stage, grades, invasions to the vessels and nerve, or with the size of the tumor. However, there was a statistically significant difference (4.6 ± 2.9 vs 7.8 ± 4.5, P = 0.024) in the SUV between patients with respectable and unresectable disease.CONCLUSION: FDG-PET is thus considered to be useful in the diagnosis of pancreatic cancer. However, regarding the staging of the disease, FDG-PET is not considered to be a sufficiently accurate diagnostic modality. Although the SUV does not correlate with the patho-histological prognostic factors, it may be useful in selecting patients who should undergo subsequent surgical treatment. | Hisao Wakabayashi Yoshihiro Nishiyama Tsuyoshi Otani Takanori Sano Shinichi Yachida Keiichi Okano Kunihiko Izuishi Yasuyuki Suzuki | 2008 | World Journal of Gastroenterology2008，14，1： | 16 |
| 13 | Controversies regarding and perspectives on clinical utility of biomarkers in hepatocellular carcinoma显示文摘The prevalence of hepatocellular carcinoma(HCC)worldwide parallels that of persistent infection with the hepatitis B virus(HBV)and/or hepatitis C virus(HCV).According to recommendations by the World Health Organization guidelines for HBV/HCV,alpha-fetoprotein(AFP)testing and abdominal ultrasound should be performed in routine surveillance of HCC every 6 mo for high-risk patients.These examinations have also been recommended worldwide by many other HCC guidelines over the past few decades.In recent years,however,the role of AFP in HCC surveillance and diagnosis has diminished due to advances in imaging modalities.AFP was excluded from the surveillance and/or diagnostic criteria in the HCC guidelines published by the American Association for the Study of Liver Diseases in 2010,the European Association for the Study of the Liver in 2012,and the National Comprehensive Cancer Network in 2014.Other biomarkers,including the Lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),des-γ-carboxyprothrombin,Dickkopf-1,midkine,and micro RNA,are being studied in this regard.Furthermore,increasing attention has focused on the clinical utility of biomarkers as pre-treatment predictors for tumor recurrence and as post-treatment monitors.Serum and tissue-based biomarkers and genomics may aid in the diagnosis of HCC,determination of patient prognosis,and selection of appropriate treatment.However,further studies are needed to better characterize the accuracy and potential role of these approaches in clinical practice. | Pei-Pei Song Ju-Feng Xia Yoshinori Inagaki Kiyoshi Hasegawa Yoshihiro Sakamoto Norihiro Kokudo Wei Tang | 2016 | World Journal of Gastroenterology2016，22，1： | 15 |
| 14 | Orlicz-Hardy spaces and their duals显示文摘We establish the theory of Orlicz-Hardy spaces generated by a wide class of functions.The class will be wider than the class of all the N-functions.In particular,we consider the non-smooth atomic decomposition.The relation between Orlicz-Hardy spaces and their duals is also studied.As an application,duality of Hardy spaces with variable exponents is revisited.This work is different from earlier works about Orlicz-Hardy spaces H(Rn)in that the class of admissible functions is largely widened.We can deal with,for example,(r)≡(rp1(log(e+1/r))q1,01,with p1,p2∈(0,∞)and q1,q2∈(.∞,∞),where we shall establish the boundedness of the Riesz transforms on H(Rn).In particular,is neither convex nor concave when 00.If(r)≡r(log(e+r))q,then H(Rn)=H(logH)q(Rn).We shall also establish the boundedness of the fractional integral operators I of order∈(0,∞).For example,I is shown to be bounded from H(logH)1./n(Rn)to Ln/(n.)(log L)(Rn)for 0< | NAKAI Eiichi SAWANO Yoshihiro | 2014 | Science China Mathematics2014，57，5： | 14 |
| 15 | Dietary polyphenols and colorectal cancer risk:The Fukuoka colorectal cancer study显示文摘AIM:To investigate the associations between dietary intake of polyphenols and colorectal cancer. METHODS:The study subjects were derived from the Fukuoka colorectal cancer study, a community-based case-control study. The study subjects were 816 cases of colorectal cancer and 815 community-based controls. The consumption of 148 food items was assessed by a computer-assisted interview. We used the consumption of 97 food items to estimate dietary intakes of total, tea and coffee polyphenols. The Phenol-Explorer database was used for 92 food items. Of the 5 foods which were not listed in the Phenol-Explorer Database, polyphenol contents of 3 foods (sweet potatoes, satoimo and daikon) were based on a Japanese study and 2 foods (soybeans and fried potatoes) were estimated by ORAC-based polyphenol contents in the United States Department of Agriculture Database. Odds ratios (OR) and 95%CI of colorectal cancer risk according to quintile categories of intake were obtained by using logistic regression models with adjustment for age, sex, residential area, parental history of colorectal cancer, smoking, alcohol consumption, body mass index 10 years before, type of job, leisure-time physical activity and dietary intakes of calcium and n-3 polyunsaturated fatty acids.RESULTS:There was no measurable difference in total or tea polyphenol intake between cases and controls, but intake of coffee polyphenols was lower in cases than in controls. The multivariate-adjusted OR of colorectal cancer according to quintile categories of coffee polyphenols (from the first to top quintile) were 1.00 (referent), 0.81 (95%CI:0.60-1.10), 0.65 (95%CI:0.47-0.89), 0.65 (95%CI:0.46-0.89) and 0.82 (95%CI:0.60-1.10), respectively (P trend = 0.07). Similar, but less pronounced, decreases in the OR were also noted for the third and fourth quintiles of total polyphenol intake. Tea polyphenols and non-coffee polyphenols showed no association with colorectal cancer risk. The sitespecific analysis, based on 463 colon cancer cases and 340 rectal cancer cases, showed an inverse association between coffee polyphenols and colon cancer. The multivariate-adjusted OR of colon cancer for the first to top quintiles of coffee polyphenols were 1.00 (referent), 0.92 (95%CI:0.64-1.31), 0.75 (95%CI:0.52-1.08), 0.69 (95%CI:0.47-1.01), and 0.68 (95%CI:0.46-1.00), respectively (P trend = 0.02). Distal colon cancer showed a more evident inverse association with coffee polyphenols than proximal colon cancer. The association between coffee polyphenols and rectal cancer risk was U -shaped, with significant decreases in the OR at the second to fourth quintile categories. There was also a tendency that the OR of colon and rectal cancer decreased in the intermediate categories of total polyphenols. The decrease in the OR in the intermediate categories of total polyphenols was most pronounced for distal colon cancer. Intake of tea polyphenols was not associated with either colon or rectal cancer. The associations of coffee consumption with colorectal, colon and rectal cancers were almost the same as observed for coffee polyphenols. The trend of the association between coffee consumption and colorectal cancer was statistically significant. CONCLUSION:The present findings suggest a decreased risk of colorectal cancer associated with coffee consumption. | Zhen-Jie Wang Keizo Ohnaka Makiko Morita Kengo Toyomura Suminori Kono Takashi Ueki Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiya Reiji Terasaka | 2013 | World Journal of Gastroenterology2013，19，17： | 12 |
| 16 | NF-κB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection显示文摘AIM: To elucidate the sequential gene expression profile in AGS cells co-cultured with wild-type Hellcobacter pylori (Hpylon) as a model of H pylori-infected gastric epithelium, and to further examine the contribution of cag-pathogenicity islands (cagPAI)-coding type Ⅳ secretion system and the two pathways, nuclear factor kappa B (NF-κB) and extracellular signal-regulated kinases (ERK) on wild-type H pylori-induced gene expression. METHODS: Gene expression profiles induced by H pylori were evaluated in AGS gastric epithelial cells using cDNA microarray, which were present in the 4 600 independent clones picked up from the human gastric tissue. We also analyzed the contribution of NF-κB and ERK signaling on H pylori-induced gene expression by using inhibitors of specific signal pathways. The isogenic mutant with disrupted capE (△cagE) was used to elucidate the role of capPAI-encoding type Ⅳ secretion system in the gene expression profile. RESULTS: According to the expression profile, the genes were classified into four clusters. Among them, the clusters characterized by continuous upregulation were most conspicuous, and it contained many signal transducer activity-associated genes. The role of cagPAI on cultured cells was also investigated using isogenic mutant cagE, which carries non-functional cagPAI. Then the upregulation of more than 80% of the induced genes (476/566) was found to depend on cagPAI. Signal transducer pathway through NF-κB or ERK are the major pathways which are known to be activated by cagPAI-positive H pylori. The role of these pathways in the whole signal activation by cagPAI- positive H pylori was analyzed. The specific inhibitors against NF-κB or ERK pathway blocked the activation of gene expression in 65% (367/566) or 76% (429/566) of the genes whose activation appealed to depend on cagPAI. CONCLUSION: These results suggest that more than half of the genes induced by cagPAI-positive H pylori depend on NF-κB and ERK signaling activation, and these pathways may play a role in the gene expression induced by host-bacterial interaction which may associate with H pylori-related gastro-duodenal diseases. | Wataru Shibata Yoshihiro Hirata Haruhiko Yoshida Motoyuki Otsuka Yujin Hoshida Keiji Ogura Shin Maeda Tomoya Ohmae Ayako Yanai Yuzo Mitsuno Naohiko Seki Takao Kawabe Masao Omata | 2005 | World Journal of Gastroenterology2005，11，39： | 12 |
| 17 | ^(18)F-fluorodeoxyglucose positron emission tomography in the diagnosis of small pancreatic cancer显示文摘AIM:To investigate the role of 18 F-fluorodeoxyglucose positron emission tomography(FDG-PET) in the diagnosis of small pancreatic cancer. METHODS:This study involved 31 patients with proven invasive ductal cancer of the pancreas.The patients were divided into 3 groups according to the maximum diameter of the tumor:TS1(maximum tumor size≤2.0 cm) ,TS2(>2.0 cm and≤4.0 cm) or TS3-4(>4.0 cm) .The relationships between the TS and various diagnostic tools,including FDG-PET with dual time point evaluation,were analyzed. RESULTS:The tumors ranged from 1.3 to 11.0 cm in diameter.Thirty of the 31 patients(97%) had a positive FDG-PET study.There were 5 patients classified as TS1,15 as TS2 and 11 as TS3-4.The sensitivity of FDG-PET,computed tomography(CT) and magnetic resonanceimaging(MRI) were 100%,40%,0%in TS1,93%,93%,89%in TS2 and 100%,100%,100%in TS3-4. The sensitivity of FDG-PET was significantly higher in comparison to CT and MRI in patients with TS1(P< 0.032) .The mean standardized uptake values(SUVs) did not show a significant difference in relation to the TS(TS1:5.8±4.5,TS2:5.7±2.2,TS3-4:8.2±3.9) ,respectively.All the TS1 tumors(from 13 to 20 mm) showed higher SUVs in FDG-PET with dual time point evaluation in the delayed phase compared with the early phase,which suggested the lesions were malignant. CONCLUSION:These results indicate that FDG-PET with dual time point evaluation is a useful modality for the detection of small pancreatic cancers with a diameter of less than 20 mm. | Keiichi Okano Keitaro Kakinoki Shintaro Akamoto Masanobu Hagiike Hisashi Usuki Yuka Yamamoto Yoshihiro Nishiyama Yasuyuki Suzuki | 2011 | World Journal of Gastroenterology2011，17，2： | 12 |
| 18 | Spatial Spillovers from Foreign Direct Investment: Evidence from the Yangtze River Delta in China显示文摘这份报纸在国内公司上从外国直接投资检验空间外表皮。用为 2004 的中国公司级的数据,并且在为一个 endogeneity 问题的财务以后,我们发现外国公司在类似的县和工业在国内公司的地区性的生产率上产生显著地积极的溢出效果。估计一个 spatial-autoregressive 模型,我们推进如此的本地溢出能在国内公司之中通过相互作用在另外的县和工业传给国内公司的表演。然而,这些空间更多样地,效果与距离衰退,从而减少外国直接投资溢出在远地点为国内公司完成。 | Kiyoyasu Tanaka Yoshihiro Hashiguchi | 2015 | China & World Economy2015，23，2： | 12 |
| 19 | Effectiveness of exercise for osteoarthritis of the knee:A review of the literature显示文摘Osteoarthritis(OA)of the knee is the most common type of arthritis and the major cause of chronic musculoskeletal pain and mobility disability in the elderly.The objective of this paper is to discuss the effectiveness of exercise for OA of the knee based on a review of the literature.We reviewed the relevant literature,i.e.systematic reviews and meta-analyses searched using PubMed.Muscle strengthening and aerobic exercises are effective in reducing pain and improving physical function in patients with mild to moderate OA of the knee. | Jun Iwamoto Yoshihiro Sato Tsuyoshi Takeda Hideo Matsumoto | 2011 | World Journal of Orthopedics2011，2，5： | 11 |
| 20 | Diagnosis of mild chronic pancreatitis (Cambridge classification):Comparative study using secretin injection-magnetic resonance cholangiopancreatography and endoscopic retrograde pancreatography显示文摘AIM:To investigate the usefulness of secretin injection-MRCP for the diagnosis of mild chronic pancreatitis. METHODS:Sixteen patients having mild chronic pancreatitis according to the Cambridge classification and 12 control subjects with no abnormal findings on the pancreatogram were examined for the diagnostic accuracy of secretin injection-MRCP regarding abnormal branch pancreatic ducts associated with mild chronic pancreatitis (Cambridge Classification), using endoscopic retrograde cholangiopancreatography (ERCP) for comparison. RESULTS:The sensitivity and specificity for abnormal branch pancreatic ducts determined by two reviewers were respectively 55%-63% and 75%-83% in the head, 57%-64% and 82%-83% in the body, and 44%-44% and 72%-76% in the tail of the pancreas. The sensitivity and specificity for mild chronic pancreatitis were 56%-63% and 92%-92%, respectively. Interobserver agreement (κ statistics) concerning the diagnosis of an abnormal branch pancreatic duct and of mild chronic pancreatitis was good to excellent. CONCLUSION:Secretin injection-MRCP might be useful for the diagnosis of mild chronic pancreatitis. | Masafumi Suyama Yoshihiro Kubokawa Sumio Watanabe | 2008 | World Journal of Gastroenterology2008，14，8： | 11 |
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